一种替代模板分子印迹聚合物凝胶膜在苯丙胺类毒品分析中的应用

By replacing template molecularly imprinted polymer gel membranes, the problem of enrichment and analysis of amphetamine-type drugs in complex matrices has been solved, achieving drug detection with high selectivity and high recovery rate, avoiding template leakage, and making it suitable for large-volume water samples.

CN116359421BActive Publication Date: 2026-07-17DALIAN MARITIME UNIVERSITY

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN MARITIME UNIVERSITY
Filing Date
2023-03-28
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are difficult to effectively enrich and analyze ultra-low concentrations of amphetamine-type drugs in complex environments and biological matrices, and suffer from problems such as template leakage and poor selectivity.

Method used

A molecularly imprinted polymer gel membrane with alternative templates was developed. Using synephrine as an alternative template, the molecularly imprinted polymer was prepared by bulk polymerization and combined with membrane extraction technology to achieve highly selective adsorption and enrichment of amphetamine-type drugs.

Benefits of technology

It achieves highly selective enrichment and high recovery rate of trace amphetamine-type drugs in water, avoids template leakage, and has a simple and low-cost preparation process, making it suitable for the analysis of large-volume water samples.

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Abstract

本发明涉及一种替代模板分子印迹聚合物凝胶膜在苯丙胺类毒品分析中的应用。包括:首先,以辛弗林为替代模板分子,采用本体聚合法制备苯丙胺类替代模板分子印迹聚合物。其次,将以上分子印迹聚合物制备成凝胶膜。然后,应用该凝胶膜选择性吸附水体中痕量水平的苯丙胺类毒品。结合高效液相色谱串联质谱,检测苯丙胺类毒品的含量。本发明中提供的制备方法简单、成本低、原料易得、制备过程可控、设备要求低,且制备出的材料比表面积大、粒径分布均匀、类选择性好,可用于水体中苯丙胺类毒品的高效吸附富集。该方法可适用于水体中痕量苯丙胺类毒品的检测分析。
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