X-ray imaging system for radiotherapy

Abstract

The radiation system (100) can include a treatment head (210), a detector (250), a plurality of imaging sources (220, 230, 240), and a gantry (111). The treatment head (210), the detector (250), and the plurality of imaging sources (220, 230, 240) can be mounted on the gantry (111). The treatment head (210) can be configured to deliver a treatment beam to a subject. The plurality of imaging sources (220, 230, 240) can be configured to deliver a plurality of imaging beams to the subject. At least two of the plurality of imaging sources can share the detector (250). The detector (250) can be configured to detect at least two of the plurality of imaging beams. The at least two detected imaging beams can be emitted by different imaging sources of the at least two imaging sources.

Description

[0001] Cross-references to related applications

[0002] This application claims priority to U.S. Patent Application No. 17 / 015,033, filed September 8, 2020; Chinese Patent Application No. 202011234813.9, filed November 7, 2020; Chinese Patent Application No. CN202011271345.2, filed December 13, 2020; and Chinese Patent Application No. CN202011468108.5, filed December 14, 2020, the contents of which are incorporated herein by reference. Technical Field

[0003] This application relates generally to medical technology, and more specifically to systems and methods for imaging systems used in radiotherapy. Background Technology

[0004] Radiation therapy is a localized treatment targeting a specific tissue (target volume), such as a cancerous tumor. Dose and geometry data are checked before, after, or during treatment to ensure proper patient placement and that the radiation therapy being administered matches the previously planned treatment. This process is called image-guided radiation therapy (IGRT), and it involves using an imaging system to visualize the target tissue while radiation is being administered. Summary of the Invention

[0005] According to one aspect of this application, a radiation system may be provided. The radiation system may include: a gantry; a treatment head configured to deliver a treatment beam to a subject; a detector; and a plurality of imaging sources configured to emit a plurality of imaging beams to the subject. The treatment head, detector, and plurality of imaging sources may be mounted on the gantry. At least two of the plurality of imaging sources may share a detector. The detector may be configured to detect at least two of the plurality of imaging beams. The at least two detected imaging beams may be emitted by different imaging sources among the at least two imaging sources.

[0006] In some embodiments, the treatment head, detector, and multiple imaging sources may be located in the same plane.

[0007] In some embodiments, the plane may be perpendicular to the rack axis of the rack.

[0008] In some embodiments, the plurality of imaging sources may include a computed tomography (CT) imaging source and at least one digital radiography (DR) imaging source.

[0009] In some embodiments, the plurality of imaging sources may include two DR imaging sources.

[0010] In some embodiments, the angle between the axes of the two imaging beams emitted by the two DR imaging sources may be less than or equal to 90 degrees.

[0011] In some embodiments, the angle between the axis of the imaging beam emitted by the CT imaging source and the axis of the treatment beam emitted by the treatment head can be 90 degrees.

[0012] In some embodiments, the axis of the imaging beam emitted by the CT imaging source may be perpendicular to the detector at the center of the detector.

[0013] In some embodiments, at least one DR imaging source may include at least two DR imaging sources. A CT imaging source may be located between two of the at least two DR imaging sources.

[0014] In some embodiments, the radiation system may include a collimator configured to adjust the fan angle of an imaging beam emitted by a CT imaging source.

[0015] In some embodiments, the detector may include an anti-scattering grid.

[0016] In some embodiments, the anti-scattering grid may include multiple sections. The arrangement of each of the multiple sections may be adjustable relative to at least one of the at least one DR imaging sources.

[0017] In some embodiments, the arrangement of at least one of the plurality of portions of the anti-scattering grid may be adjustable to correspond to the direction of at least one imaging beam emitted by at least one DR imaging source.

[0018] In some embodiments, the detector's detection range may cover the sum of the fields of view of multiple imaging sources.

[0019] In some embodiments, at least two of the plurality of imaging beams may have different energy levels.

[0020] In some embodiments, at least one of the plurality of imaging sources can be configured to emit imaging beams of different energy levels.

[0021] In some embodiments, the width of the detector may exceed a threshold.

[0022] In some embodiments, the detector may include an arc-shaped detector.

[0023] In some embodiments, the gantry may include rotatable rollers. The treatment head, detector, and multiple imaging sources may be mounted on and rotate with the rotatable rollers.

[0024] According to another aspect of this application, a system may be provided. This system may include at least one storage device, a set of instructions, and at least one processor communicating with the at least one storage device and a radiation system. The radiation system may include multiple imaging sources and detectors. At least two of the multiple imaging sources may share a detector. The detector may be configured to detect at least two imaging beams emitted by at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. When the instruction set is executed, at least one processor may be configured to cause the system to perform operations including: generating a pre-treatment image by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam into the radiation system; determining location information of a target region of an object within the radiation system based on the pre-treatment image; and locating the target region of the object within the radiation system according to the location information.

[0025] In some embodiments, at least one processor may be configured to cause the system to perform the following operations: generate a second pre-treatment image by causing at least one of a plurality of imaging sources to emit at least one second pre-treatment image, wherein the second pre-treatment image is a multi-energy image; and adjust a treatment plan for a target region of the object based on the pre-treatment image and the second pre-treatment image.

[0026] In some embodiments, adjusting the treatment plan for the target region of the object based on the pre-treatment image and the second pre-treatment image may include: generating a fused image by fusing the pre-treatment image and the second pre-treatment image; determining information about the target region in the fused image; and adjusting the treatment plan for the target region based on the information about the target region.

[0027] In some embodiments, at least one second pre-treatment imaging beam may include at least two second pre-treatment imaging beams having different energy levels and being emitted by at least two of a plurality of imaging sources.

[0028] In some embodiments, at least one of the plurality of imaging sources may include an imaging source configured to emit imaging beams of different energy levels.

[0029] In some embodiments, at least one second pre-treatment imaging beam emitted by the CT imaging source can be adjustable and limited by the collimator of the radiation system.

[0030] In some embodiments, the first sector angle of the second pre-treatment imaging beam may be less than or equal to the second sector angle of the pre-treatment imaging beam.

[0031] In some embodiments, at least one processor may be configured to cause the system to perform operations including: delivering a treatment beam from a treatment head of a radiation system to the target region of the object based on the object's treatment plan and the location information of the target region; generating multiple images of the object by delivering multiple treatment imaging beams to the object from multiple imaging sources of the radiation system; and adjusting the emission of the treatment beams or adjusting the location information of the target region based on the multiple images of the object.

[0032] In some embodiments, adjusting the delivery of the treatment beam may include adjusting the direction of the treatment beam to allow the treatment beam to be directed toward at least one of the target areas; adjusting the treatment plan; or pausing the delivery of the treatment beam.

[0033] In some embodiments, the imaging beam emitted by the CT imaging source in one of a plurality of therapeutic imaging beams can be adjustablely limited by the collimator of the radiation system.

[0034] In some embodiments, the first sector angle of one of the plurality of therapeutic imaging beams emitted by the CT imaging source may be less than or equal to the second sector angle of the pre-treatment imaging beam.

[0035] In some embodiments, the image may include at least one organ of the object. Adjusting the emission of the treatment beam or adjusting the location information of the target region may include: determining motion information of at least one organ based on the image; and adjusting the emission of the treatment beam or adjusting the location information of the target region based on the motion information of at least one organ.

[0036] In some embodiments, motion information of at least one organ may be related to the motion of at least one organ.

[0037] According to another aspect of this application, a system may be provided. The system may include at least one storage device containing a set of instructions and at least one processor communicating with the at least one storage device and a radiation system. The radiation system may include a first detector and a plurality of imaging sources, one of which is a CT imaging source. At least two of the plurality of imaging sources may share the first detector. The first detector may be configured to detect at least two imaging beams emitted by the at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. When the instruction set is executed, at least one processor may be configured to cause the system to perform the following operations: generating a pre-treatment image by causing the CT imaging source of the radiation system to emit a pre-treatment imaging beam towards a subject; positioning a target region of the subject within the radiation system based on the pre-treatment image; delivering at least one treatment beam to the target region of the subject by a treatment head of the radiation system based on the subject's treatment plan; generating at least one treatment image based on at least a portion of the at least one treatment beam detected by a second detector of the radiation system; and determining, based on the pre-treatment image and the at least one treatment image, whether the delivery of the treatment beam conforms to the planned delivery of the treatment beam according to the treatment plan.

[0038] In some embodiments, at least one treatment image may include a treatment image. Determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan based on the pre-treatment image and at least one treatment image may include: determining a reference treatment image based on the pre-treatment image; the treatment image and treatment plan of the object; generating a comparison result by comparing the reference treatment image and the treatment image; and determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan based on the comparison result.

[0039] In some embodiments, both the treatment image and the reference treatment image can be two-dimensional and come from the same viewpoint of the object.

[0040] In some embodiments, at least one treatment image may include multiple treatment images from at least two different viewpoints of the object. Determining whether the delivery of the treatment beam conforms to the planned treatment beam delivery according to the treatment plan, based on the pre-treatment image and at least one treatment image, may include: estimating the radiation dose distribution of the treatment beam in the object based on the pre-treatment image and multiple treatment images; generating a comparison result by comparing the radiation dose distribution of the treatment beam with the planned radiation dose distribution in the object; and determining whether the delivery of the treatment beam conforms to the planned treatment beam delivery according to the treatment plan based on the comparison result.

[0041] In some embodiments, the radiation dose distribution of the treatment beam in the object may include a three-dimensional radiation dose distribution.

[0042] According to another aspect of this application, a system may be provided. The system may include: at least one storage device containing a set of instructions; and at least one processor communicating with the at least one storage device and a radiation system, the radiation system including a detector and a plurality of imaging sources, one of which is a CT imaging source. When executing the set of instructions, the at least one processor may be configured to cause the system to perform operations including: causing the treatment head of the radiation system to deliver a treatment beam to a target region of the object based on the object's treatment plan; causing the plurality of imaging sources of the radiation system to emit a plurality of imaging beams toward the object and the detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the CT imaging source, the fan angle of which is achievable by adjusting the aperture of the collimator of the CT imaging source; generating an image set of the object based on at least a portion of the plurality of imaging beams detected by the detector; and determining location information of the target region based on the image set of the object.

[0043] In some embodiments, each of the plurality of imaging beams can illuminate a detection region of the detector. The plurality of detection regions can be at least partially separated from each other.

[0044] In some embodiments, at least one of the plurality of imaging sources may rotate together with the treatment head.

[0045] In some embodiments, at least one of multiple imaging beams and therapeutic beams may be emitted simultaneously.

[0046] In some embodiments, at least two of the multiple images may be from different perspectives of the object.

[0047] In some embodiments, at least one image in the image group may be two-dimensional.

[0048] In some embodiments, multiple images may include organ information of at least one organ of the object and motion of a target region related to the motion of the at least one organ. Determining the location information of the target region based on multiple images of the object may include: determining motion information of at least one organ based on the organ information; and determining the location information of the target region based on the motion information of the at least one organ.

[0049] In some embodiments, at least one processor may be configured to cause the system to perform operations including: generating a second image set containing multiple images of the object by causing multiple imaging sources to transmit a second set of multiple imaging beams to the object, and a detector, the multiple second imaging beams including a second CT imaging beam having the fan angle emitted by a CT imaging source; and determining second location information of a target region based on the second image set of the object.

[0050] In some embodiments, a group of images of an object may correspond to a first time point. A second group of images of an object may correspond to a second time point different from the first time point.

[0051] According to another aspect of this application, a system may be provided. The system may include at least one storage device containing a set of instructions and at least one processor communicating with the at least one storage device and a radiation system. The radiation system may include a detector and a plurality of imaging sources, one of which is a CT imaging source. When the instruction set is executed, the at least one processor may be configured to cause the system to perform operations including: causing the plurality of imaging sources of the radiation system to emit a plurality of imaging beams of different energy levels toward a subject, and a detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the CT imaging source, the fan angle of which can be achieved by adjusting the aperture of the collimator of the CT imaging source; and generating an image of the subject based on at least a portion of the plurality of imaging beams of different energy levels detected by the detector.

[0052] In some embodiments, the image of the object can be a multi-energy image.

[0053] In some embodiments, at least one processor may be configured to cause the system to perform operations including: causing a CT imaging source to emit a second CT imaging beam with a second sector angle, the second sector angle being achieved by adjusting the aperture of the collimator of the CT imaging source, the second sector angle being greater than the sector angle; generating a second image based on at least a portion of the second CT imaging beam detected by the detector; generating a fused image by fusing the image and the second image; and determining information about a target region in the fused image.

[0054] In some embodiments, information about the target region in the fused image may include at least one of the contour of the target region or the contour of the tissue surrounding the target region.

[0055] In some embodiments, at least one processor may be configured to cause the system to perform operations including: adjusting a treatment plan for a target region of an object based on information about the target region in the fused image.

[0056] According to another aspect of this application, a method can be provided. This method can be implemented in a radiation system and a computing device having at least one processor and at least one storage device. The radiation system may include multiple imaging sources and detectors. At least two of the multiple imaging sources may share a detector. The detector may be configured to detect at least two imaging beams emitted by at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The method may include: generating a pre-treatment image by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam towards a subject; determining location information of a target region of the subject within the radiation system based on the pre-treatment image; and locating the target region of the subject within the radiation system according to the location information.

[0057] In some embodiments, the method may include: generating a second pre-treatment image by causing at least one of a plurality of imaging sources to emit at least one second pre-treatment imaging beam toward the object, wherein the second pre-treatment image is a multi-energy image; and adjusting a treatment plan for a target region of the object based on the pre-treatment image and the second pre-treatment image.

[0058] In some embodiments, adjusting the treatment plan for the target region of the object based on the pre-treatment image and the second pre-treatment image may include: generating a fused image by fusing the pre-treatment image and the second pre-treatment image; determining information about the target region in the fused image; and adjusting the treatment plan for the target region based on the information about the target region.

[0059] In some embodiments, at least one second pre-treatment imaging beam may include at least two second pre-treatment imaging beams having different energy levels and being emitted by at least two of a plurality of imaging sources.

[0060] In some embodiments, at least one of the plurality of imaging sources may include one of the plurality of imaging sources configured to emit imaging beams of different energy levels.

[0061] In some embodiments, one of at least one of the second pre-treatment imaging beams emitted by the CT imaging source can be adjustablely limited by the collimator of the radiation system.

[0062] In some embodiments, the first sector angle of the second pre-treatment imaging beam may be less than or equal to the second sector angle of the pre-treatment imaging beam.

[0063] In some embodiments, the method may include causing the treatment head of the radiation system to deliver a treatment beam to the target region of the object based on the object's treatment plan and the location information of the target region; generating multiple images of the object by causing multiple imaging sources of the radiation system to deliver multiple treatment imaging beams to the object; and adjusting the emission of the treatment beams or adjusting the location information of the target region according to the multiple images of the object.

[0064] In some embodiments, adjusting the delivery of the treatment beam may include adjusting the direction of the treatment beam to allow the treatment beam to be directed toward at least one of the target areas; adjusting the treatment plan; or pausing the delivery of the treatment beam.

[0065] In some embodiments, one of the multiple therapeutic imaging beams emitted by a CT imaging source can be adjustablely limited by a collimator of the radiation system.

[0066] In some embodiments, the first sector angle of one of a plurality of therapeutic imaging beams emitted by a CT imaging source may be less than or equal to the second sector angle of the pre-treatment imaging beam.

[0067] In some embodiments, the image may include at least one organ of the object. Adjusting the emission of the treatment beam or adjusting the location information of the target region may include: determining motion information of at least one organ based on the image; and adjusting the emission of the treatment beam or adjusting the location information of the target region based on the motion information of at least one organ.

[0068] In some embodiments, motion information of at least one organ may be related to the motion of at least one organ.

[0069] According to another aspect of this application, a method can be provided. This method can be implemented in a radiation system and a computing device having at least one processor and at least one storage device. The radiation system may include a first detector and a plurality of imaging sources, one of which is a CT imaging source. At least two of the plurality of imaging sources may share the first detector. The first detector may be configured to detect at least two imaging beams emitted by the at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The method may include: generating a pre-treatment image by causing the CT imaging source of the radiation system to emit a pre-treatment imaging beam towards a subject; positioning a target region of the subject within the radiation system based on the pre-treatment image; delivering at least one treatment beam to the target region of the subject via a treatment head of the radiation system based on the subject's treatment plan; generating at least one treatment image based on at least a portion of the at least one treatment beam detected by a second detector of the radiation system; and determining, based on the pre-treatment image and the at least one treatment image, whether the delivery of the treatment beam conforms to the planned delivery of the treatment beam according to the treatment plan.

[0070] In some embodiments, at least one treatment image may include a treatment image. Determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan based on the pre-treatment image and at least one treatment image may include: determining a reference treatment image based on the pre-treatment image; the treatment image and treatment plan of the object; generating a comparison result by comparing the reference treatment image and the treatment image; and determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan based on the comparison result.

[0071] In some embodiments, both the treatment image and the reference treatment image can be two-dimensional and come from the same viewpoint of the object.

[0072] In some embodiments, at least one treatment image may include multiple treatment images from at least two different viewpoints of the object. Determining whether the delivery of the treatment beam conforms to the planned treatment beam delivery according to the treatment plan, based on the pre-treatment image and at least one treatment image, may include: estimating the radiation dose distribution of the treatment beam in the object based on the pre-treatment image and multiple treatment images; generating a comparison result by comparing the radiation dose distribution of the treatment beam with the planned radiation dose distribution in the target; and determining whether the delivery of the treatment beam conforms to the planned treatment beam delivery according to the treatment plan based on the comparison result.

[0073] In some embodiments, the radiation dose distribution of the treatment beam in the object may include a three-dimensional radiation dose distribution.

[0074] According to another aspect of this application, a method can be provided. This method can be implemented in a radiation system and a computing device having at least one processor and at least one storage device. The radiation system may include a detector and multiple imaging sources, one of which is a CT imaging source. The method may include: causing a treatment head of the radiation system to deliver a treatment beam to a target region of the object based on a treatment plan for the object; causing multiple imaging sources of the radiation system to emit multiple imaging beams toward the object and the detector, wherein the multiple imaging beams include CT imaging beams emitted by the CT imaging source, the fan angle of the CT imaging beams being achievable by adjusting the aperture of the collimator of the CT imaging source; generating an image set of the object based on at least a portion of the multiple imaging beams detected by the detector; and determining location information of the target region based on the image set of the object.

[0075] In some embodiments, each of the plurality of imaging beams can illuminate a detection region of the detector. The plurality of detection regions can be at least partially separated from each other.

[0076] In some embodiments, at least one of the plurality of imaging sources may rotate together with the treatment head.

[0077] In some embodiments, at least one of multiple imaging beams and therapeutic beams may be emitted simultaneously.

[0078] In some embodiments, at least two of the multiple images may be from different perspectives of the object.

[0079] In some embodiments, at least one image in the image group may be two-dimensional.

[0080] In some embodiments, multiple images may include at least one organ of an object. Motion of the target region may be related to the motion of at least one organ. Determining the location information of the target region based on multiple images of an object may include: determining motion information of at least one organ based on the multiple images; and determining the location information of the target region based on the motion information of at least one organ.

[0081] In some embodiments, the method may include: generating a second image set of an object by transmitting a plurality of second imaging beams to an object and a detector by causing a plurality of imaging sources, the plurality of second imaging beams including a fan-angle imaging beam emitted by a second CTCT imaging source; and determining second location information of a target region based on the second image set of the object.

[0082] In some embodiments, a group of images of an object may correspond to a first time point. A second group of images of an object may correspond to a second time point different from the first time point.

[0083] According to another aspect of this application, a method can be provided. This method can be implemented in a radiation system and a computing device having at least one processor and at least one storage device. The radiation system may include a detector and multiple imaging sources, one of which is a CT imaging source. The method may include: causing the multiple imaging sources of the radiation system to emit multiple imaging beams of different energy levels toward an object and a detector, wherein the multiple imaging beams include a CT imaging beam emitted by the CT imaging source, the fan angle of the CT imaging beam being achieved by adjusting the aperture of the collimator of the CT imaging source; generating an image of the object based on at least a portion of the multiple imaging beams of different energy levels detected by the detector.

[0084] In some embodiments, the image of the object can be a multi-energy image.

[0085] In some embodiments, the method may include: causing a CT imaging source to emit a second CT imaging beam with a second sector angle, the second sector angle being achieved by adjusting the aperture of the collimator of the CT imaging source, the second sector angle being greater than the sector angle; generating a second image based on at least a portion of the second CT imaging beam detected by the detector; generating a fused image by fusing the image and the second image; and determining information about a target region in the fused image.

[0086] In some embodiments, information about the target region in the fused image may include at least one of the contour of the target region or the contour of the tissue surrounding the target region.

[0087] In some embodiments, the method may include: adjusting a treatment plan for the target region of an object based on information from the target region in the fused image.

[0088] According to another aspect of this application, a non-transitory computer-readable medium may be provided. The non-transitory computer-readable medium may include instructions executable by at least one processor, causing the at least one processor to implement a method on a radiation system. The radiation system may include a plurality of imaging sources and detectors. At least two of the plurality of imaging sources may share a detector. The detector may be configured to detect at least two imaging beams emitted by at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The method may include: generating a pre-treatment image by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam toward a subject; determining location information of a target region of the subject within the radiation system based on the pre-treatment image; and locating the target region of the subject within the radiation system according to the location information.

[0089] According to another aspect of this application, a non-transitory computer-readable medium may be provided. The non-transitory computer-readable medium may include instructions executable by at least one processor, causing the at least one processor to perform a method on a radiation system. The radiation system may include a first detector and a plurality of imaging sources, one of which is a CT imaging source. At least two of the plurality of imaging sources may share the first detector. The first detector may be configured to detect at least two imaging beams emitted by the at least two imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The method may include: generating a pre-treatment image by causing the CT imaging source of the radiation system to emit a pre-treatment imaging beam towards a subject; positioning a target region of the subject in the radiation system based on the pre-treatment image; delivering at least one treatment beam to the target region of the subject by a treatment head of the radiation system based on a treatment plan for the subject; generating at least one treatment image based on at least a portion of the at least one treatment beam detected by a second detector of the radiation system; and determining, based on the pre-treatment image and the at least one treatment image, whether the delivery of the treatment beam conforms to the planned delivery of the treatment beam according to the treatment plan.

[0090] According to another aspect of this application, a non-transitory computer-readable medium may be provided. The non-transitory computer-readable medium may include instructions executable by at least one processor, causing the at least one processor to implement a method on a radiation system. The radiation system may include a detector and a plurality of imaging sources, one of which is a CT imaging source. The method may include: causing a treatment head of the radiation system to deliver a treatment beam to a target region of the object based on a treatment plan for the object; causing the plurality of imaging sources of the radiation system to emit a plurality of imaging beams toward the object and the detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the CT imaging source, and the CT imaging beam has a fan angle achieved by adjusting the collimator aperture of the CT imaging source; generating an image set of the object based on at least a portion of the plurality of imaging beams detected by the detector; and determining location information of the target region based on the image set of the object.

[0091] According to another aspect of this application, a non-transitory computer-readable medium may be provided. The non-transitory computer-readable medium may include instructions executable by at least one processor, causing the at least one processor to implement a method on a radiation system. The radiation system may include a detector and a plurality of imaging sources, one of which is a CT imaging source. The method may include: causing the plurality of imaging sources of the radiation system to emit a plurality of imaging beams of different energy levels toward an object and a detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the CT imaging source, the fan angle of the CT imaging beam being achieved by adjusting the aperture of a collimator of the CT imaging source; generating an image of the object based on at least a portion of the plurality of imaging beams of different energy levels detected by the detector.

[0092] According to another aspect of this application, a radiation system can be provided. The system may include: a gantry; a treatment head configured to deliver a treatment beam to a subject; a plurality of imaging sources configured to deliver a plurality of imaging beams to the subject, the plurality of imaging sources including a first imaging source of a first type and a second imaging source of a second type different from the first type, and the first imaging source of the first type being a CT imaging source; at least one detector configured to detect the plurality of imaging beams emitted by the plurality of imaging sources. The at least one detector and the plurality of imaging sources may be mounted on the gantry. The plurality of imaging beams and the treatment beam may pass through the same plane of the subject.

[0093] In some embodiments, at least one detector may include a single detector. The first imaging source and the second imaging source may share the detector, such that the detector can be configured to detect the imaging beam emitted by the first imaging source and the second imaging source.

[0094] In some embodiments, the radiation system may also include a third imaging source of a third type, which is different from the first imaging source of the first type.

[0095] In some embodiments, at least one detector may include a single detector. The first imaging source, the second imaging source, and the third imaging source may share the detector, such that the detector can be configured to detect the imaging beam emitted by the first imaging source, the second imaging source, and the third imaging source.

[0096] In some embodiments, the second type of second imaging source may be a DR imaging source.

[0097] In some embodiments, the third type of third imaging source may be a DR imaging source.

[0098] Some of the additional features of this application will be described in the following description. These additional features will be apparent to those skilled in the art from the following description and the accompanying drawings, or from an understanding of the production or operation of the embodiments. The features of this application can be implemented and obtained by practice or by using various aspects of the methods, means, and combinations set forth in the detailed examples discussed below. Attached Figure Description

[0099] This application will be further described through exemplary embodiments. These exemplary embodiments will be described in detail with reference to the accompanying drawings. These embodiments are non-limiting exemplary embodiments, in which the same numbers in the figures denote similar structures, wherein:

[0100] Figure 1 These are schematic diagrams of exemplary radiation systems according to some embodiments of this application;

[0101] Figure 2AThis is a schematic diagram illustrating an exemplary configuration of a radiation device according to some embodiments of this application;

[0102] Figure 2B This is a schematic diagram of an imaging beam detector according to some embodiments of this application;

[0103] Figures 3 to 5 This is a schematic diagram illustrating the configuration of a radiation device according to some embodiments of this application;

[0104] Figure 6 These are schematic diagrams of the hardware and / or software components of a computing device according to some embodiments of this application;

[0105] Figure 7 These are schematic diagrams of hardware and / or software components of a mobile device according to some embodiments of this application;

[0106] Figure 8 This is a block diagram of a processing device according to some embodiments of this application;

[0107] Figure 9 This is a flowchart illustrating the imaging process of a radiation system according to some embodiments of this application;

[0108] Figure 10 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application;

[0109] Figure 11 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application; and

[0110] Figure 12 This is a flowchart of an exemplary imaging process of a radiation system according to some embodiments of this application. Detailed Implementation

[0111] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. However, those skilled in the art should understand that this application can be implemented without these details. In other instances, to avoid unnecessarily obscuring various aspects of this application, well-known methods, processes, systems, components, and / or circuits have been described at a higher level. It will be apparent to those skilled in the art that various changes can be made to the disclosed embodiments, and the general principles defined in this application can be applied to other embodiments and application scenarios without departing from the principles and scope of this application. Therefore, this application is not limited to the embodiments shown, but conforms to the broadest scope consistent with the scope of the claims.

[0112] The terminology used in this application is for the purpose of describing particular exemplary embodiments only and is not restrictive. The singular forms “a,” “an,” and “the” used in this application may also include the plural forms unless the context clearly indicates otherwise. It should also be understood that, when used in this specification, the terms “comprising,” “including,” and / or “including,” “comprising,” and / or “including” specify the presence, integers, steps, operations, elements, and / or components of the stated features, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof.

[0113] It should be understood that the terms “system,” “engine,” “unit,” “module,” and / or “block” used herein are a method of distinguishing different components, elements, parts, components, or parts at different levels in ascending order. However, other expressions may be used if these terms serve the same purpose.

[0114] Generally, the terms "module," "unit," or "block" as used herein refer to logic embodied in hardware or firmware, or a collection of software instructions. The modules, units, or blocks described herein can be implemented as software and / or hardware and can be stored on any type of non-transitory computer-readable medium or other storage device. In some embodiments, software modules / units / blocks can be compiled and linked into an executable program. It should be understood that software modules can be called from other modules / units / blocks or from themselves, and / or can be called in response to detected events or interrupts. Configured for use in computing devices (e.g., Figure 6 Software modules / units / blocks executing on the processor 610 shown herein may be provided on a computer-readable medium or as digital downloads (and may be initially stored in a compressed or installable format, requiring installation, decompression, or decryption before execution). The software code herein may be stored, in part or in whole, in the storage device of the computing device performing the operation and applied in the operation of the computing device. Software instructions may be embedded in firmware, such as EPROM. It should also be understood that hardware modules / units / blocks may be included in connected logical components, such as gates and flip-flops, and / or may include programmable units, such as programmable gate arrays or processors. The modules / units / blocks or computing device functions described herein may be implemented as software modules / units / blocks, but may be represented in hardware or firmware. Generally, the modules / units / blocks described herein refer to logical modules / units / blocks that may be combined with other modules / units / blocks or divided into sub-modules / sub-units / sub-blocks, although they are physical organizations or storage devices. This description may apply to a system, an engine, or a part thereof.

[0115] It is understood that, unless the context explicitly states otherwise, when a unit, engine, module, or block is referred to as being "on," "connected," or "coupled to" another unit, engine, module, or block, it may be directly on, connected to, coupled to, or communicate with that other unit, engine, module, or block, or there may be intermediate units, engines, modules, or blocks. In this application, the term "and / or" may include any one or more of the relevant listed items or a combination thereof.

[0116] These and other features, characteristics, functions and operating methods of related structural elements, as well as component combinations and manufacturing economics, will become more apparent from the following description of the accompanying drawings, which form part of the specification of this application. However, it should be understood that the drawings are for illustrative and descriptive purposes only and are not intended to limit the scope of this application. It should be understood that the drawings are not drawn to scale.

[0117] For illustrative purposes, the following description is provided to aid in better understanding. It should be understood that this is not intended to limit the scope of this application. For those skilled in the art, certain variations, alterations, and / or modifications can be deducted from the scope of this application. These variations, alterations, and / or modifications do not depart from the scope of this application.

[0118] In this application, the terms “radiotherapy,” “radiotherapy,” “treatment,” and “treatment phase” are used interchangeably to refer to the use of radiation to treat cancer and other diseases in biological (e.g., human and animal) tissues. The terms “treatment plan,” “treatment plan,” and “radiotherapy plan” are used interchangeably to refer to a plan for performing radiation therapy.

[0119] One aspect of this application relates to a radiation system. The radiation system may include a gantry, a treatment head, a detector, and multiple imaging sources. The treatment head, detector, and multiple imaging sources may be mounted on the gantry. The treatment head may be configured to emit a treatment beam toward a subject. The multiple imaging sources may be configured to emit multiple imaging beams toward the subject. At least two of the multiple imaging sources may share a detector. The detector (also referred to as an imaging beam detector) may be configured to detect at least two of the multiple imaging beams, and the detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources.

[0120] According to some embodiments of this application, at least two of the multiple imaging sources can share an imaging beam detector, allowing sufficient space to arrange the treatment head, multiple imaging sources, and the imaging beam detector on the same plane, thereby providing one or more of the following advantages: the length of the gantry can be reduced (e.g., along...). Figure 1(As shown in the y-direction), this facilitates the transport and / or positioning of the radiation system, and / or reduces the space required to house it. Furthermore, since the treatment head and multiple imaging sources are located on the same plane, the need to move the object between different treatment and imaging positions is avoided, mitigating the problem of patient support table sagging between different treatment and imaging positions, which can lead to errors in treatment caused by imaging based on the imaging position. Moreover, it allows for imaging during treatment, facilitating monitoring or tracking of the object or parts thereof during treatment, enabling timely adjustments to the treatment accordingly.

[0121] Another aspect of this application may relate to a radiation system. The radiation system may include multiple imaging sources and detectors (also referred to as imaging beam detectors, e.g., arc detectors). At least two of the multiple imaging sources may share a detector. The detector may be configured to detect at least two imaging beams emitted by at least two imaging sources, respectively. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The radiation system can generate a pre-treatment image (e.g., a 3D image) by having the CT imaging sources of the radiation system emit pre-treatment imaging beams toward the subject. The radiation system can determine location information (e.g., position, contour) of a target region of the subject based on the pre-treatment image and locate the target region of the subject within the radiation system according to the location information. In some embodiments, the radiation system may also use the pre-treatment image to determine a treatment plan for the target region of the subject or to determine whether to adjust a treatment plan determined based on a planned image of the subject.

[0122] According to another aspect of this application, based on the treatment plan for the subject, the radiation system can cause the treatment head of the radiation system to fire at least one treatment beam toward a target area of ​​the subject to perform radiotherapy on the target area. The radiation system can also generate at least one treatment image based on at least a portion of the at least one treatment beam detected by the radiation system's detectors (also referred to as treatment beam detectors, e.g., an electronic field imaging device (EPID)). Before radiotherapy of the target area, the radiation system can generate a pre-treatment image (e.g., a 3D image) by firing a pre-treatment imaging beam toward the subject from the CT imaging source of the radiation system. Furthermore, the radiation system can determine whether the firing of the treatment beam conforms to the planned firing of the treatment beam determined according to the treatment plan based on the pre-treatment image and at least one treatment image. In some embodiments, the radiation system can estimate the actual radiation dose distribution (e.g., 2D radiation dose distribution, 3D radiation dose distribution) of the treatment beam in the subject based on at least one treatment image. The radiation system can determine the difference between the actual radiation dose distribution and the planned radiation dose distribution in the subject, and then determine whether the firing of the treatment beam conforms to the planned firing of the treatment beam determined according to the treatment plan based on that difference. In this case, the radiation system can achieve in-treatment monitoring by (essentially) monitoring the actual radiation dose distribution in the subject during treatment in real time. If it is determined that the actual radiation dose distribution deviates from the planned radiation dose distribution, the radiation system can adjust the emission of the treatment beam or the location information of the target area (e.g., its location) accordingly, thereby improving the accuracy of the treatment.

[0123] According to another aspect of this application, a radiation system can cause the treatment head of the radiation system to fire a treatment beam toward a target area of ​​the object based on the object's treatment plan to perform radiation therapy on the target area. During radiation therapy, the radiation system can generate multiple image sets (e.g., multiple sets of 2D images) of the object, each image set at a single point in time. The image sets can be obtained by having multiple imaging sources of the radiation system fire multiple imaging beams toward the object and detectors to provide multiple perspectives of the object from different directions / angles at a single point in time. The radiation system can track the object's positional information (e.g., its location) at different points in time based on the multiple image sets. If a change in the detected positional information of the target area exceeds a threshold, the radiation system can adjust the firing of the treatment beam or the positional information of the target area (e.g., its location) accordingly, thereby improving the accuracy of the radiation therapy.

[0124] Compared to images from one (e.g., a viewpoint perpendicular to the direction of motion of interest) or two (e.g., two views, one of which is perpendicular to the direction of motion of interest) viewpoints, multiple images from multiple different viewpoints of an object can provide anatomical and / or motion information of the target region of the object, improving monitoring quality and thus increasing monitoring accuracy. For example, multiple imaging sources can include axes (e.g., Figure 2AThe two DR imaging sources and one CT imaging source (axis 272 and 274 shown) are at an angle to each other (e.g., perpendicular to each other), thus providing three images from three different perspectives of the object.

[0125] In some embodiments, the multiple imaging beams may include CT imaging beams emitted from a CT imaging source, the fan angle of which can be adjusted by adjusting the aperture of the collimator of the CT imaging source. By adjusting the fan angle of the CT imaging source, multiple 2D images can be generated without performing an image reconstruction process, thereby reducing the image acquisition and processing time to a relatively short time (e.g., 1 ms, 5 ms, 10 ms, 50 ms, 100 ms), thereby improving tracking efficiency and / or allowing tracking / monitoring during treatment.

[0126] In some embodiments, tomographic synthesis (also known as digital tomography (DTS)) imaging can be performed by emitting multiple imaging beams from multiple imaging sources. Each of the multiple imaging sources only needs to rotate within a small angular range to perform tomographic imaging; that is, the imaging sources only need to rotate for a short time, improving the temporal resolution of the tracking. In some embodiments, if each of the multiple imaging sources rotates within the same angular range as when performing tomographic synthesis imaging with only one imaging source, the quality of the image generated by tomographic synthesis imaging with multiple imaging sources can be improved compared to the image generated by tomographic synthesis imaging performed by only one imaging source.

[0127] According to another aspect of this application, a radiation system may cause multiple imaging sources of the radiation system to emit multiple imaging beams, at least two of which have different energy levels. The multiple imaging beams may include CT imaging beams emitted by CT imaging sources, the fan angle of which can be achieved by adjusting the aperture of the collimator of the CT imaging sources. The radiation system may generate an image of the object (e.g., a multi-energy image) based on at least a portion of the multiple imaging beams with different energy levels detected by a detector. The radiation system may also generate a second image (e.g., a 3D image) by causing the CT imaging sources to emit a second CT imaging beam with a second fan angle, which is achieved by adjusting the aperture of the collimator of the CT imaging sources. In some embodiments, the radiation system may generate a fused image by fusing the image and the second image. The contrast of the target region and / or surrounding tissue (e.g., soft tissue) is enhanced in the fused image. The radiation system may determine information about the target region in the fused image (e.g., the contour of the target region, the contour of the target region and / or surrounding tissue). In some embodiments, the radiation system may also adjust the treatment plan based on the information about the target region in the fused image. Furthermore, during treatment of the target area, the treatment beam can be accurately delivered to the target area based on the identified target area information and the treatment plan or adjusted treatment plan, thereby reducing damage to organs or tissues near the target area due to exposure to treatment radiation and / or improving the efficacy of radiotherapy.

[0128] In some embodiments, the second sector angle can be greater than the sector angle. By dynamically adjusting the sector angle of the CT imaging source, the radiology system can generate 3D images with more anatomical information or generate 2D images in a relatively short time, thereby improving the utilization efficiency of the radiology system while making minimal or acceptable compromises on the quality of the acquired images relative to their intended use.

[0129] Figure 1 This is a schematic diagram of an exemplary radiation system according to some embodiments of this application. In some embodiments, the radiation system 100 may be configured to provide radiation therapy (e.g., stereotactic radiosurgery and / or precision radiotherapy) to any lesion, tumor, or condition in a patient that requires radiation therapy. In some embodiments, the radiation system 100 may include a treatment planning system (TPS), an image-guided radiotherapy (IGRT) system, etc.

[0130] like Figure 1As shown, the radiation system 100 may include a radiation device 110, a processing device 120, a storage device 130, one or more terminals 140, and a network 150. The components in the radiation system 100 may be connected in one or more ways. By way of example only, the radiation device 110 may be connected to the processing device 120 via the network 150. For example, the radiation device 110 may be directly connected to the processing device 120, as indicated by the dashed double-headed arrows connecting the radiation device 110 and the processing device 120. As another example, the storage device 130 may be connected to the processing device 120 directly or via the network 150. As yet another example, the terminal 140 may be directly connected to the processing device 120 (as indicated by the dashed double-headed arrows connecting the terminal 140 and the processing device 120) or via the network 150.

[0131] In some embodiments, the radiation system 100 can perform image-guided radiotherapy (IGRT), which uses X-ray imaging to monitor the target volume (also referred to as the target region, such as a tumor, lesion, etc.) within a subject (e.g., a patient). In this case, the radiation device 110 may include a treatment component (also referred to as a treatment device) and an imaging component (also referred to as an imaging device). The treatment component may be configured to deliver a treatment beam to the target volume to perform radiotherapy on the target volume. The imaging component may be configured to perform imaging (e.g., two-dimensional (2D), three-dimensional (3D), or four-dimensional (4D) imaging) of the target volume (also referred to as a “risk organ”) and / or the normal tissue surrounding the target volume before, after, or simultaneously with radiotherapy. In this way, the anatomy and movement or deformation of the target volume can be detected, and the patient’s position and / or the treatment beam can be adjusted to deliver a more precise radiation dose to the target volume.

[0132] In some embodiments, the imaging assembly may include multiple imaging sources and detectors (also referred to as imaging beam detectors, e.g., arc detectors). The term "multiple" as used herein may refer to two or more. Multiple imaging sources may be configured to emit multiple imaging beams toward an object. In some embodiments, at least two of the multiple imaging sources may share a detector. The detector may be configured to detect at least two imaging beams emitted by at least two of the multiple imaging sources. The detected at least two imaging beams may be emitted by different imaging sources among the at least two imaging sources. The detector's detection range may cover the sum of the fields of view (FOV) of at least two of the multiple imaging sources. In some embodiments, the at least two imaging sources may be all imaging sources, and the detector's detection range may include the sum of the fields of view of all imaging sources. In some embodiments, the at least two imaging sources may be a subset of multiple imaging sources, and the detector's detection range may cover the sum of the fields of view of a subset of the multiple imaging sources. In some embodiments, an imaging dataset or image generated based on the detected at least two imaging beams may be used to monitor an object (e.g., its motion). The detector's width (e.g., along...) Figure 1 The detector (in the y-direction shown) can be large enough to ensure that the imaging dataset or image contains sufficient anatomical and / or motion information of the target region, thereby achieving the desired monitoring accuracy. In some embodiments, the detector width can exceed a threshold (e.g., 10 cm). For example, the detector width can be 16 cm.

[0133] In some embodiments, the plurality of imaging sources may include at least one (e.g., one or two) computed tomography (CT) imaging source and at least one (e.g., two or three) digital radiography (DR) imaging source. For example, the plurality of imaging sources may include one CT imaging source and two DR imaging sources. In some embodiments, the detector may be configured to detect the imaging beams emitted by the CT imaging source and the two DR imaging sources. The detector's detection range may cover the sum of the fields of view of at least two of the plurality of imaging sources (e.g., the CT imaging source and the two DR imaging sources in the exemplary configuration described above).

[0134] In some embodiments, the detector described above can be configured to detect two imaging beams emitted by two DR imaging sources, and the radiology system may include an additional detector configured to detect imaging beams emitted by CT imaging sources. The additional detector may be located on or outside the gantry 111. For example, the additional detector may be mounted on a first rotating ring of the plurality of imaging sources or on a second rotating ring different from the first rotating ring. In some embodiments, the detection range of the detector may cover the sum of the fields of view of at least two of the plurality of imaging sources (e.g., the two DR imaging sources in the exemplary configuration described above).

[0135] In some embodiments, the detector may be configured to detect the imaging beam emitted by a CT imaging source and one of two DR imaging sources (also referred to as the first DR imaging source), while the radiology system may include an additional detector configured to detect the imaging beam from the other of the two DR imaging sources. The additional detector may be located on or outside the gantry 111. For example, the additional detector may be mounted on a first rotating ring of multiple imaging sources or a second rotating ring different from the first rotating ring. In some embodiments, the detector's detection range may cover the sum of the fields of view of at least two of the multiple imaging sources (e.g., the CT imaging source and the first DR imaging source in the exemplary configuration described above).

[0136] In some embodiments, the imaging beam detector may include an antiscattering grid configured to filter out scattered portions of a plurality of imaging beams. The antiscattering grid may be located between the object and the imaging beam detector. In some embodiments, the arrangement of the antiscattering grid (e.g., its angles, its position) may correspond to the direction of the non-scattering portion of an imaging beam (also referred to as a CT imaging beam) emitted by a CT imaging source. The antiscattering grid can filter out the scattered portion of the corresponding CT imaging beam without preventing the non-scattering portion of the CT imaging beam from being detected by the imaging beam detector. In some embodiments, at least a portion of the imaging beam detector may also be configured to detect imaging beams (or non-CT imaging beams) emitted by non-CT imaging sources (e.g., DR imaging sources) among a plurality of imaging sources, where a non-CT imaging source may refer to an imaging source other than a CT imaging source. Since the direction of such a non-CT imaging beam may differ from the direction of the CT imaging beam (e.g., as...), Figure 2A , Figure 3 , Figure 4 or Figure 5 As shown, if the antiscattering grid is configured solely based on the direction of the CT imaging beam, it may fail to filter out the scattered portion from non-CT imaging beams, and at least a portion of the scattered portion from non-CT imaging beams may be detected by the imaging beam detector. To resolve these issues, it may be necessary to adjust the orientation of the antiscattering grid.

[0137] In some embodiments, the antiscattering grid may include multiple portions, the arrangement of which is adjustable relative to at least one of a plurality of imaging sources. The arrangement of at least one of the multiple portions of the antiscattering grid configured to detect non-CT imaging beams can be adjusted to correspond to the direction of the non-CT imaging beam. In some embodiments, the arrangement of each of the multiple portions of the antiscattering grid may be adjusted based on piezoelectric technology. Again, taking a plurality of imaging sources including a CT imaging source and at least one DR imaging source as an example, the arrangement of at least one portion of the multiple portions of the antiscattering grid is adjustable relative to at least one of the at least one DR imaging source, such that when at least one of the at least one DR imaging source emits at least one corresponding imaging beam toward an object, the arrangement of at least one portion of the multiple portions of the antiscattering grid can be adjusted to correspond to the direction of the at least one imaging beam.

[0138] In some embodiments, the treatment assembly may include a treatment head 112. The treatment head 112 may be configured to deliver a treatment beam to a subject to perform radiotherapy on a target region within the subject and / or to image a region of interest (ROI) of the subject (e.g., including the target volume and / or the subject's organs at risk (OARs)). For example, the treatment head 112 may include an accelerator tube, a treatment source (e.g., an X-ray target), a primary collimator, a filter (e.g., a homogenizer), at least one tungsten gate, a multi-leaf collimator (MLC), etc. In some embodiments, the treatment head 112 may include a particle accelerator tube. Particles include, for example, photons, electrons, protons, or heavy ions. In some embodiments, the treatment beam may include a relatively high-energy beam (e.g., an MV beam). In some embodiments, the treatment beam may include a fan-shaped beam, a cone-shaped beam, or a tetrahedral beam.

[0139] In some embodiments, the treatment head 112, multiple imaging sources, and detectors (i.e., imaging beam detectors) may be mounted on a rack 111 (e.g., an O-frame). For example, detectors may be fixedly mounted on the rack 111. Similarly, multiple imaging sources may be fixedly mounted on the rack 111. In some embodiments, the treatment head 112, multiple imaging sources, and detectors may be located in the same plane. For example, this plane may be perpendicular to the axis of the rack 111 (also referred to as the rack axis) (e.g., ...). Figure 1 As shown, along the y-axis. The treatment head 112, multiple imaging sources, and imaging beam detector can rotate with or independently of the gantry 111. For example, the gantry 111 may include rotatable rollers. The treatment head, imaging beam detector, and multiple imaging sources can be mounted on the rotatable rollers and rotate with them.

[0140] In some embodiments, the plurality of imaging sources can rotate independently of the treatment head 112 or the gantry 111. For illustrative purposes, at least one of the plurality of imaging sources and imaging beam detectors can be operatively coupled to or mounted on a rotating ring other than the gantry 111. For example, the rotating ring can be inside the gantry 111. At least one of the plurality of imaging sources and imaging beam detectors can rotate together with the rotating ring. The rotating ring can be operatively coupled to, mounted on, or detached from the gantry 111. The rotating ring can rotate with the gantry 111 or independently of the gantry 111.

[0141] In some embodiments, the plurality of imaging sources and imaging beam detectors may be stationary or substantially stationary relative to each other. As used herein, two devices (e.g., two imaging sources, imaging beam detectors) being stationary relative to each other means that the relative positions of the two devices remain unchanged, regardless of whether at least one of the two devices moves relative to gantry 111 or patient support 113.

[0142] In some embodiments, the treatment head 112 can rotate synchronously with the gantry to perform coplanar radiotherapy on the object. During coplanar radiotherapy, the radiation beams emitted by the treatment head 112 at different time points can share the same geometric plane relative to the object. In some embodiments, this can be achieved by tilting (e.g., relative to the object). Figure 1 (shown in the x-direction) rack or surrounding Figure 1 The patient support 113 is rotated in the z-direction to perform non-coplanar radiotherapy on the object. During non-coplanar radiotherapy, the radiation beams emitted by the treatment head 112 at different times may be in different geometric planes.

[0143] In some embodiments, the plurality of imaging sources may include a CT imaging source and at least one DR imaging source. In some embodiments, the angle between the axis of the imaging beam emitted by the CT imaging source and the axis of the treatment beam emitted by the treatment head 112 may be within a range of angles, such as a range between 70 degrees and 110 degrees, a range between 80 degrees and 100 degrees, a range between 85 degrees and 95 degrees, a range between 30 degrees and 130 degrees, etc. As an example only, the angle between the axis of the imaging beam emitted by the CT imaging source and the axis of the treatment beam emitted by the treatment head 112 may be (substantially) 90 degrees, for example, 90° ± 10°. As another example, the angle between the axis of the imaging beam emitted by the CT imaging source and the axis of the treatment beam emitted by the treatment head 112 may be less than 90 degrees.

[0144] In some embodiments, the axis of the treatment beam emitted by the treatment head 112 is parallel to the center of the detector (e.g., Figure 2A and 2BThe angle between the axes of the detectors at point 280 (shown in the diagram) can be within a range, such as 70 to 110 degrees, 85 to 95 degrees, 50 to 110 degrees, 40 to 120 degrees, 30 to 130 degrees, etc. The axis of the detector can refer to the axis connecting the center of the gantry 111 (on the plane where the detector is located) and the center of the detector. For example, the axis of the imaging beam emitted by the CT imaging source can be perpendicular to the detector at the center of the detector. That is, the angle between the axis of the treatment beam emitted by the treatment head 112 and the axis of the detector can be (essentially) 90 degrees, for example, 90° ± 10°.

[0145] In some embodiments, the detector may include a plurality of detection units arranged in at least one row and at least one column. The center of the detector may refer to the detection unit at the intersection of the at least one row and at least one column. For example, the center of the detector may refer to the detection unit at the intersection of the center row and the center column of the plurality of detection units of the detector.

[0146] In some embodiments, at least one DR imaging source may include at least two DR imaging sources. The angle between the axes of the two imaging beams emitted by two of the at least two DR imaging sources may be within a range of angles, such as 70 to 110 degrees, 80 to 100 degrees, 85 to 95 degrees, 40 to 120 degrees, 30 to 130 degrees, etc. By way of example only, at least one DR imaging source may include two DR imaging sources. The angle between the axes of the two imaging beams emitted by the two DR imaging sources may be (substantially) 90 degrees, for example, 90° ± 10°. It should be noted that the number of the at least one DR imaging source may be non-limiting, such as one, two, three, four, five, etc.

[0147] In some embodiments, each of the plurality of imaging beams may cover the imaging region. The treatment beam may cover the treatment region. The plurality of imaging sources and treatment head 112 may be configured such that the treatment region and the plurality of imaging regions at least partially overlap. In some embodiments, the target region of an object (e.g., the region to be treated) may be located in the overlapping region of the treatment region and the plurality of imaging regions.

[0148] In some embodiments, the treatment head 112 and at least one of the plurality of imaging sources can be configured to alternately emit radiation beams. For example, at least one of the plurality of imaging sources can be configured to emit at least one imaging beam when the delivery of the treatment beam toward the object is paused. In some embodiments, the treatment head 112 and the plurality of imaging sources can be positioned and moved within the same rotation ring. At least one of the plurality of imaging sources is capable of moving once or multiple times within a 360-degree range of the rotation ring.

[0149] In some embodiments, the treatment head 112 and at least one of the plurality of imaging sources can be configured to simultaneously emit radiation beams. For example, at least one of the plurality of imaging sources can be configured to emit at least one imaging beam while the treatment head 112 is delivering the treatment beam. In some embodiments, the treatment head 112 and the plurality of imaging sources can be positioned and moved within the same rotation ring. At least one of the plurality of imaging sources is capable of moving independently within a limited range of less than 360 degrees of the rotation ring without interfering with the treatment beam once or multiple times.

[0150] In some embodiments, the treatment assembly may include a detector (also referred to as a treatment beam detector) configured to detect at least a portion of the treatment beam emitted by the treatment head 112 and / or the imaging beam(s) emitted from a plurality of imaging sources. For example, the treatment beam detector may include an Electron Field Imaging Device (EPID). In some embodiments, the treatment beam detector may be stationary. In some embodiments, the treatment beam detector may move independently of the treatment head 112. In some embodiments, the treatment beam detector may be diametrically opposed to and rotate with the treatment head 112. In some embodiments, the treatment beam detector may be configured to detect both a kV beam and a MV beam. In some embodiments, the treatment beam detector may be configured to detect only a kV beam or only a MV beam. Further description of the radiation device 110 can be found elsewhere in this application (e.g., Figure 2A-5 (Description).

[0151] In some embodiments of this application, the radiation system 100 may include a gantry 111, a treatment head 112, a plurality of imaging sources, and at least one detector. The treatment head 112 may be configured to deliver a treatment beam to a subject. The plurality of imaging sources may be configured to deliver a plurality of imaging beams to a subject. At least one detector may be configured to detect the plurality of imaging beams emitted by the plurality of imaging sources. In some embodiments, the plurality of imaging sources may include a first imaging source of a first type and a second imaging source of a second type different from the first type. For example, the first imaging source of the first type may be a CT imaging source, and the second imaging source of the second type may be a DR imaging source.

[0152] In some embodiments, at least one detector and multiple imaging sources may be mounted on a rack. Multiple imaging beams and treatment beams may pass through the same plane of the object. In some embodiments, at least one detector may include a single detector. The first and second imaging sources may share this detector, such that the detector can be configured to detect imaging beams emitted by the first and second imaging sources.

[0153] In some embodiments, the radiation system 100 may further include a third imaging source of a third type, different from the first type. For example, the third type of imaging source may be a DR imaging source. In some embodiments, at least one detector may include a detector. The first imaging source, the second imaging source, and the third imaging source may share the detector, such that the detector can be configured to detect imaging beams emitted by the first imaging source, the second imaging source, and the third imaging source.

[0154] In this application, Figure 1 The x-axis, y-axis, and z-axis shown can form an orthogonal coordinate system. Figure 1 The x-axis and y-axis shown can be horizontal, while the z-axis can be vertical. As shown, the positive x-direction along the x-axis can be viewed from the front of the radiation device 110, from right to left; along... Figure 1 The positive z-direction of the z-axis shown can be the direction from the lower part to the upper part of the radiation device 110; along Figure 1 The positive y-direction of the y-axis shown can refer to the direction in which the object is moved out of the hole of the radiation device 110.

[0155] In some embodiments, the radiation device 110 may include a gantry 111 and a patient support 113. In some embodiments, the gantry 111 may be configured to support at least one of a treatment head 112, a plurality of imaging sources, an imaging beam detector, or a treatment beam detector. The gantry 111 may be configured to rotate about an object (such as a patient or a portion thereof) that has moved into or is located within the field of view (FOV) of the radiation device 110 (e.g., the area covered by a radiation beam emitted by the treatment head 112 or at least one of the plurality of imaging sources). In some embodiments, the patient support 113 may be configured to support the object. The patient support 113 may have six degrees of freedom, for example, three translational degrees of freedom along three coordinate directions (i.e., the x, y, and z directions) and three rotational degrees of freedom about the three coordinate directions. Therefore, the patient support 113 can move the object along the orientation of a 3D coordinate system. As an example only, the patient support 113 can move along... Figure 1 The object is moved into the FOV of the radiation device 110 in the y-direction.

[0156] In some embodiments, the object may be biological or non-biological. By way of example only, the object may include a patient, an artificial object, etc. As another example, the object may include a specific part, organ, and / or tissue of a patient. For example, the object may include the head, brain, neck, body, shoulder, arm, chest, heart, stomach, blood vessels, soft tissue, knee, foot, etc., or any combination thereof. In this application, the terms "object" and "object" are used interchangeably.

[0157] Network 150 can facilitate the exchange of information and / or data. In some embodiments, one or more components of radiation system 100 (e.g., radiation device 110, processing device 120, storage device 130, or terminal 140) can send information and / or data to another component(s) of radiation system 100 via network 150. For example, processing device 120 can obtain user instructions from terminal 140 via network 150. As another example, processing device 120 can obtain scan data (e.g., projection data) from radiation device 110 via network 150. In some embodiments, network 150 can be any type of wired or wireless network, or a combination thereof. Network 150 may be and / or include public networks (e.g., the Internet), private networks (e.g., local area networks (LANs), wide area networks (WANs), etc.), wired networks (e.g., Ethernet), wireless networks (e.g., 802.11 networks, Wi-Fi networks), cellular networks (e.g., LTE networks), Frame Relay networks, virtual private networks (“VPNs”), satellite networks, telephone networks, routers, hubs, switches, server computers, and / or any combination thereof. By way of example only, network 150 may include wired networks, fiber optic networks, telecommunications networks, intranets, the Internet, local area networks (LANs), wide area networks (WANs), wireless local area networks (WLANs), metropolitan area networks (MANs), wide area networks (WANs), public switched telephone networks (PSTNs), Bluetooth™ networks, ZigBee™ networks, near field communication (NFC) networks, etc., or any combination thereof. In some embodiments, network 150 may include one or more network access points. For example, network 150 may include wired or wireless network access points, such as base stations and / or internet exchange points, through which one or more components of radiation system 100 may connect to network 150 to exchange data and / or information.

[0158] Terminal 140 may include mobile device 140-1, tablet computer 140-2, laptop computer 140-3, etc., or any combination thereof. In some embodiments, mobile device 140-1 may include smart home devices, wearable devices, smart mobile devices, virtual reality devices, augmented reality devices, etc., or any combination thereof. In some embodiments, smart home devices may include smart lighting devices, smart appliance control devices, smart monitoring devices, smart TVs, smart cameras, walkie-talkies, etc., or any combination thereof. In some embodiments, wearable devices may include bracelets, shoes and socks, glasses, helmets, watches, clothing, backpacks, accessories, etc., or any combination thereof. In some embodiments, smart mobile devices may include smartphones, personal digital assistants (PDAs), gaming devices, navigation devices, point-of-sale (POS) devices, etc., or any combination thereof. In some embodiments, virtual reality devices and / or augmented reality devices may include virtual reality helmets, virtual reality glasses, virtual reality patches, augmented reality helmets, augmented reality glasses, augmented reality patches, etc., or any combination thereof. For example, virtual reality devices and / or augmented reality devices may include Google Glass, Oculus Rift, HoloLens, GearVR, etc. In some embodiments, terminal 140 may remotely operate radiation device 110. In some embodiments, terminal 140 can operate radiation device 110 via a wireless connection. In some embodiments, terminal 140 can receive information and / or instructions input by a user and transmit the received information and / or instructions to radiation device 110 or processing device 120 via network 150. In some embodiments, terminal 140 can receive data and / or information from processing device 120. In some embodiments, terminal 140 may be part of processing device 120. In some embodiments, terminal 140 may be omitted.

[0159] In some embodiments, processing device 120 can process data obtained from radiation device 110, storage device 130, or terminal 140. For example, processing device 120 can obtain projection data of an object from radiation device 110 and generate an image of the object based on the projection data. As another example, processing device 120 can position one or more components of radiation device 110 (e.g., treatment head, imaging source, detector, collimator, patient support, gantry, etc.) in a specific location. Processing device 120 can be a central processing unit (CPU), digital signal processor (DSP), system-on-chip (SoC), microcontroller unit (MCU), etc., or any combination thereof.

[0160] In some embodiments, processing device 120 may be a single server or a group of servers. The server group may be centralized or distributed. In some embodiments, processing device 120 may be local or remote. For example, processing device 120 may access information and / or data stored in radiation device 110, storage device 130, and / or terminal 140 via network 150. As another example, processing device 120 may be directly connected to radiation device 110, storage device 130, and / or terminal 140 to access stored information and / or data. In some embodiments, processing device 120 may be implemented on a cloud platform. By way of example only, the cloud platform may include private cloud, public cloud, hybrid cloud, community cloud, distributed cloud, internal cloud, multi-tiered cloud, etc., or any combination thereof.

[0161] Storage device 130 may store data and / or instructions. In some embodiments, storage device 130 may store data obtained from terminal 140 and / or processing device 120. For example, storage device 130 may store one or more images generated by processing device 120. In some embodiments, storage device 130 may store data and / or instructions that processing device 120 may execute or use to perform the exemplary methods described in this application. For example, storage device 130 may store instructions that processing device 120 may execute or use to generate one or more images based on projection data. In some embodiments, storage device 130 may include mass storage, removable storage, volatile read-write storage, read-only storage (ROM), etc., or any combination thereof. Exemplary mass storage may include a disk, optical disk, solid-state drive, etc. Exemplary removable storage may include a flash drive, floppy disk, optical disk, memory card, compact disk, magnetic tape, etc. Exemplary volatile read-write storage may include random access memory (RAM). Exemplary RAMs may include Dynamic Random Access Memory (DRAM), Double Data Rate Synchronous Dynamic Random Access Memory (DDRSDRAM), Static Random Access Memory (SRAM), Thyristor Random Access Memory (T-RAM), and Zero Capacitor Random Access Memory (Z-RAM), etc. Exemplary ROMs may include Mask ROM (MROM), Programmable ROM (PROM), Erasable Programmable ROM, Electrically Erasable Programmable ROM (EEPROM), Compact Disc ROM (CD-ROM), and Digital Universal Disk ROM, etc. In some embodiments, the storage device 130 may be implemented on a cloud platform. By way of example only, the cloud platform may include private cloud, public cloud, hybrid cloud, community cloud, distributed cloud, internal cloud, multi-tiered cloud, etc., or any combination thereof.

[0162] In some embodiments, storage device 130 may be connected to network 150 to communicate with one or more components of radiation system 100 (e.g., radiation device 110, processing device 120, terminal 140). One or more components of radiation system 100 may access data or instructions stored in storage device 130 via network 150. In some embodiments, storage device 130 may be directly connected to or communicate with one or more components of radiation system 100 (e.g., processing device 120, terminal 140). In some embodiments, storage device 130 may be part of processing device 120.

[0163] Figure 2A This is a schematic diagram illustrating an exemplary configuration of a radiation device according to some embodiments of this application. Figure 2B This is a schematic diagram of an imaging beam detector according to some embodiments of this application.

[0164] according to Figure 2A The illustrated configuration 200 shows that the radiation device 110 may include a treatment head 210, a first DR imaging source 220, a CT imaging source 230, a second DR imaging source 240, a first detector 250 (also referred to as an imaging beam detector), and a second detector 260 (also referred to as a treatment beam detector). The CT imaging source 230 may be located between the first DR imaging source 220 and the second DR imaging source 240. The first DR imaging source 220, the CT imaging source 230, and the second DR imaging source 240 may share the first detector 250. In some embodiments, the first detector 250 (e.g., Figure 2A and 2B The detection range of the arc-shaped detector shown may include the sum of the fields of view of the first DR imaging source 220, the CT imaging source 230, and the second DR imaging source 240. The first detector 250 may be configured to detect at least one imaging beam (e.g., a kV beam) emitted by at least one of the first DR imaging source 220, the CT imaging source 230, or the second DR imaging source 240. For example, the first detector 250 may detect the imaging beam emitted by the first DR imaging source 220, the CT imaging source 230, and the second DR imaging source 240. The second detector 260 (e.g., EPD) may be configured to detect the treatment beam emitted by the treatment head 210. In some embodiments, the second detector 260 may be configured to detect both the kV beam and the MV beam. In some embodiments, the second detector 260 may be configured to detect only the kV beam or only the MV beam.

[0165] In some embodiments, the radiation device 200 may be configured such that the area through which at least one imaging beam passes may partially overlap with the area through which a treatment beam passes in an overlapping region. An object (e.g., a patient) may be positioned such that a target area of ​​the object (e.g., the area to be imaged or treated) lies within this overlapping region.

[0166] like Figure 2A As shown, the treatment head 210, the first DR imaging source 220, the CT imaging source 230, the second DR imaging source 240, the first detector 250, and the second detector 260 can be located in the same plane. For example, this plane can be perpendicular to the gantry axis of the radiation device 110 (e.g., its central axis along the y-direction). The angle between the axes 272 and 274 of the two imaging beams emitted by the first DR imaging source 220 and the second DR imaging source 240 can be 90 degrees. The angle between the axis 273 of the imaging beam emitted by the CT imaging source 230 and the axis 271 of the treatment beam emitted by the treatment head 210 can be 90 degrees. Axis 273 can be at the center of the first detector 250 (e.g., Figure 2A and 2B Point 280 shown is perpendicular to the first detector 250.

[0167] Figure 3 This is a schematic diagram of an exemplary configuration of a radiation device according to some embodiments of this application. As shown in configuration 300, radiation device 110 may include Figure 2A The treatment head 210, the first DR imaging source 220, the CT imaging source 230, the second DR imaging source 240, the first detector 250, and the second detector 260 shown are included.

[0168] According to configuration 300, the CT imaging source 230 can be controlled to emit an imaging beam 232 toward the object. In some embodiments, the imaging beam 232 may have a relatively large fan angle. For example, the radiation range of the imaging beam 232 may be the maximum fan angle of the imaging beam emitted by the CT imaging source 230. As used herein, the fan angle of the radiation beam (e.g., the imaging beam 232) refers to the expansion angle of the radiation beam emitted by the source in a predetermined plane (e.g., the plane of rotation) of the source when the source is stationary.

[0169] In some embodiments, the CT imaging source 230 may rotate or oscillate relative to the treatment head 210 (rotating back and forth by an angle in opposite directions during an imaging scan) while emitting the imaging beam 232. The radiation range of the CT imaging source 230 may be the sum of the fan angle and the rotation angle. The imaging dataset of the imaging beam 232 corresponding to the radiation range (e.g., the sum of the fan angle and the rotation angle) can be used to generate a 3D image.

[0170] In some embodiments, an imaging dataset may be generated based on at least a portion of the imaging beam 232 detected by the first detector 250. Furthermore, an image (e.g., a 3D image) may be generated based on at least a portion of the imaging dataset. In some embodiments, the image may be used to determine a treatment plan for a subject's radiotherapy or to adjust a treatment plan determined based on the subject's planned image and / or monitor the subject's radiotherapy. Further descriptions of determining treatment plans based on images, adjusting treatment plans, and / or monitoring radiotherapy can be found elsewhere in this application, such as... Figures 8 to 12 And its description.

[0171] Figure 4 This is a schematic diagram illustrating an exemplary configuration of a radiation device according to some embodiments of this application. As shown in configuration 400, radiation device 110 may include... Figure 2A or Figure 3 The treatment head 210, the first DR imaging source 220, the CT imaging source 230, the second DR imaging source 240, the first detector 250, and the second detector 260 are shown.

[0172] According to configuration 400, treatment head 210 can be controlled to emit treatment beam 212 toward a target area of ​​the subject (e.g., the area to be treated). The treatment beam can be delivered to the target area to perform radiotherapy on the target area. A first DR imaging source 220, a CT imaging source 230, and a second DR imaging source 240 can be controlled to emit imaging beams 222, 234, and 242 toward the subject, respectively. As used herein, a first sector angle of imaging beam 234 can be less than or equal to a second sector angle of imaging beam 232, wherein imaging beam 232 is delivered by CT imaging source 230 when the first DR imaging source 220 and the second DR imaging source 240 are not emitting imaging beams, and imaging beam 234 is delivered by CT imaging source 230 when at least one of the first DR imaging source 220 or the second DR imaging source 240 emits an imaging beam.

[0173] In some embodiments, the radiation device 110 may include a collimator configured to adjust the fan angle of an imaging beam emitted by a corresponding imaging source (e.g., a CT imaging source). The collimator may be located in the path of the imaging beam. Imaging beam 232 or imaging beam 234 may be generated by adjusting the aperture of the collimator, through which a portion of the imaging beam may be transmitted to the object and / or through which a portion of the imaging beam may be blocked by the collimator.

[0174] In some embodiments, the regions traversed by imaging beams 222, 234, and / or 242 may partially overlap with the regions traversed by treatment beam 212 in an overlapping region. An object can be positioned such that its target region lies within the overlapping region.

[0175] In some embodiments, the delivery of one or more imaging beams (e.g., imaging beams 222, 234, and 242) may be performed simultaneously with the delivery of the treatment beam 212. In some embodiments, the delivery of one or more imaging beams (e.g., imaging beams 222, 234, and 242) and the delivery of the treatment beam 212 may be performed alternately. That is, imaging beams 222, 234, and 242 may be delivered while the treatment beam 212 is paused. In some embodiments, an imaging dataset may be generated based on each of the imaging beams 222, 234, and 242 detected by the first detector 250. In some embodiments, an image (e.g., a 2D image) may be generated for each imaging dataset. For example, a first image may be generated based on at least a portion of the imaging beam 234 detected by the first detector 250. A second image may be generated based on at least a portion of the imaging beam 222 detected by the first detector 250. A third image may be generated based on at least a portion of the imaging beam 242 detected by the first detector 250.

[0176] In some embodiments, each of imaging beams 222, 234, and 242 may illuminate a detection region of the first detector 250. In some embodiments, the plurality of detection regions may be separated from each other. The signal sources corresponding to the imaging beams 222, 234, and 242 detected by the first detector 250 may be distinguished from each other based on the location of the signals detected in the plurality of separate detection regions of the first detector 250. As used herein, a signal source corresponding to an imaging beam detected by a detector refers to an imaging source that emits an imaging beam detected by a detector (e.g., the first detector 250) and generates a signal.

[0177] In some embodiments, at least two of the plurality of detection regions may at least partially overlap. In some embodiments, imaging beams 222, 234, and 242 may be emitted at different times, such that the signal sources corresponding to imaging beams 222, 234, and 242 can be distinguished from each other. In some embodiments, the signal sources corresponding to imaging beams 222, 234, and 242 detected by the first detector 250 may be distinguished from each other using an antiscattering grid located between the object and the first detector 250. In some embodiments, the detection region corresponding to imaging beam 222 and the detection region corresponding to imaging beam 234 may have overlapping regions. The signal sources corresponding to imaging beams 222 and 234 can be distinguished by adjusting the orientation of at least a portion of the antiscattering grid. For example, the arrangement of at least a portion of the antiscattering grid can be adjusted to filter out a portion of imaging beam 234 illuminating the overlapping region without preventing a portion of imaging beam 222 from being detected by the first detector, thereby enabling detector 250 to determine the signal source corresponding to imaging beam 222. As another example, the arrangement of at least a portion of the antiscattering grid can be adjusted to filter out a portion of the imaging beam 222 that illuminates the overlapping area without preventing the first detector 250 from detecting a portion of the imaging beam 234, thereby determining the signal source corresponding to the imaging beam 234.

[0178] In some embodiments, imaging beams 222, 234, and 242 may have the same energy level. In some embodiments, imaging beams 222, 234, and 242 may have different energy levels. A multi-energy image can be generated based on a first image, a second image, and a third image. At least one of the first image, the second image, the third image, or the multi-energy image can be used to determine a treatment plan for radiotherapy of a subject or to adjust a treatment plan determined based on a subject's planning image and / or to monitor the subject's radiotherapy. Further descriptions regarding determining a treatment plan for radiotherapy of a subject or adjusting a treatment plan determined based on a subject's planning image and / or monitoring the subject's radiotherapy can be found elsewhere in this application, for example... Figures 8 to 12 And its description.

[0179] Figure 5 This is a schematic diagram illustrating an exemplary configuration of a radiation device according to some embodiments of this application. As shown in configuration 500, radiation device 110 may include... Figure 2A-4 The treatment head 210, the first DR imaging source 220, the CT imaging source 230, the second DR imaging source 240, the first detector 250, and the second detector 260 are shown.

[0180] According to configuration 500, the CT imaging source 230 can be controlled to emit an imaging beam 236 toward the object. Similar to imaging beam 232, imaging beam 236 may have a relatively large fan angle. For example, the fan angle of imaging beam 236 may be the maximum fan angle of the imaging beam emitted by the CT imaging source 230. In some embodiments, an imaging dataset may be generated based on at least a portion of the imaging beam 236 detected by the first detector 250. Furthermore, a first image (e.g., a 3D image) may be generated based on the imaging dataset.

[0181] In some embodiments, the treatment head 210 can be controlled to emit a treatment beam 212 toward the object. The treatment beam can be delivered to a target area of ​​the object to perform radiotherapy on the target area. A second image can be generated based on at least a portion of the treatment beam detected by the second detector 260. The area traversed by the imaging beam 236 may partially overlap with the area traversed by the treatment beam 212 in an overlapping region. The object can be positioned such that the target area of ​​the object lies within the overlapping region. In some embodiments, the first and second images can be used to monitor the execution of a treatment plan for radiotherapy of the object, and / or to execute deviations from the treatment plan, or to adjust a treatment plan determined based on the object's plan image and / or to monitor the object's radiotherapy. Further description of determining a treatment plan for radiotherapy of the object or adjusting a treatment plan determined based on the object's plan image and / or monitoring the object's radiotherapy can be found elsewhere in this application, for example, Figures 8 to 12 And its description.

[0182] Figure 6 These are schematic diagrams illustrating exemplary hardware and / or software components of a computing device on which processing device 120 may be implemented, according to some embodiments of this application. Figure 6 As shown, computing device 600 may include processor 610, memory 620, input / output (I / O) 630 and communication port 640.

[0183] Processor 610 is capable of executing computer instructions (program code) and performing the functions of processing device 120 according to the techniques described herein. Computer instructions may include routines, programs, objects, components, signals, data structures, procedures, modules, and functions that perform the specific functions described herein. For example, processor 610 may process data obtained from radiation device 110, storage device 130, terminal 140, or any other component of radiation system 100. In some embodiments, processor 610 may include a microcontroller, microprocessor, reduced instruction set computer (RISC), application-specific integrated circuit (ASIC), application-specific instruction set processor (ASIP), central processing unit (CPU), graphics processing unit (GPU), physical processing unit (PPU), microcontroller unit, digital signal processor (DSP), field-programmable gate array (FPGA), advanced RISC machine (ARM), programmable logic device (PLD), any circuit or processor capable of performing one or more functions, etc., or any combination thereof.

[0184] For illustrative purposes only, only one processor is described in computing device 600. However, it should be noted that computing device 600 in this application may also include multiple processors, and therefore the operations and / or method steps described in this application that are performed by one processor may also be performed jointly or individually by multiple processors. For example, if the processors of computing device 600 in this application simultaneously execute step A and step B, it should be understood that steps A and B may also be performed jointly or individually by two different processors in computing device 600 (e.g., the first processor executes step A, the second processor executes step B, or the first processor and the second processor jointly execute steps A and B).

[0185] The memory 620 can store data / information obtained from the radiation device 110, storage device 130, terminal 140, or any other component of the radiation system 100. In some embodiments, the memory 620 may include a mass storage device, a removable storage device, a volatile read-write memory, a read-only memory (ROM), or any combination thereof. For example, a mass storage device may include a hard disk, an optical disk, a solid-state drive, etc. A removable storage device may include a flash drive, a floppy disk, an optical disk, a memory card, a compact disk, a magnetic tape, etc. A volatile read-write memory may include random access memory (RAM). RAM may include dynamic RAM (DRAM) or dual data rate synchronous dynamic RAM.

[0186] ROMs can include DDR SDRAM, SRAM, Thyristor RAM (T-RAM), and zero-capacitor RAM (Z-RAM), etc. ROMs can include mask ROM (MROM), programmable ROM (PROM), erasable programmable ROM, electrically erasable programmable ROM (EEPROM), CD-ROM, and digital universal disk ROM, etc. In some embodiments, memory 620 may store one or more programs and / or instructions to perform the exemplary methods described in this application.

[0187] I / O 630 can input or output signals, data, or information. In some embodiments, I / O 630 can enable user interaction with processing device 120. For example, processing device 120 can display images through I / O 630. In some embodiments, I / O 630 may include input devices and output devices. Exemplary input devices may include a keyboard, mouse, touchscreen, microphone, etc., or combinations thereof. Exemplary output devices may include display devices, speakers, printers, projectors, etc., or combinations thereof. Exemplary display devices may include liquid crystal displays (LCDs), light-emitting diode (LED) based displays, flat panel displays, curved screens, television equipment, cathode ray tubes (CRTs), etc., or combinations thereof.

[0188] Communication port 640 can be connected to a network (e.g., network 150) to facilitate data communication. Communication port 640 can establish a connection between processing device 120 and radiological device 110, storage device 130, or terminal 140. This connection can be a wired connection, a wireless connection, or a combination of both, capable of data transmission and reception. Wired connections can include cables, optical fibers, telephone lines, etc., or any combination thereof. Wireless connections can include Bluetooth, Wi-Fi, WiMax, WLAN, ZigBee, mobile networks (e.g., 3G, 4G, 5G, etc.), etc., or combinations thereof. In some embodiments, communication port 640 can be a standardized communication port, such as RS232, RS485, etc. In some embodiments, communication port 640 can be a specially designed communication port. For example, communication port 640 can be designed according to the Digital Imaging and Medical Communications (DICOM) protocol.

[0189] Figure 7 This is a schematic diagram illustrating exemplary hardware and / or software components of a mobile device on which a terminal 140 can be implemented, according to some embodiments of this application. See the figure. (Refer to...) Figure 7The mobile device 700 may include a communication platform 710, a display 720, a graphics processing unit (GPU) 730, a central processing unit (CPU) 740, I / O 750, memory 760, and storage 790. In some embodiments, any other suitable components, including a system bus or controller (not shown), may also be included in the mobile device 700. In some embodiments, a mobile operating system 770 (e.g., iOS, Android, Windows Phone, etc.) and one or more applications 780 may be loaded from storage 790 into memory 760 for execution by CPU 740. Application 780 may include a browser or any other suitable mobile application for receiving and presenting radiotherapy-related information or other information from processing device 120. User interaction with the information flow may be achieved through I / O 750 and provided to processing device 120 and / or other components of radiation system 100 via network 150.

[0190] To implement the various modules, units, and functions described herein, a computer hardware platform may be used as the hardware platform for one or more of the components described herein. The hardware components, operating system, and programming language of such a computer are conventional in nature, and it is assumed that those skilled in the art are fully familiar with these technologies to adapt them to the radiotherapy described herein. A computer with user interface elements may be used to implement a personal computer (PC) or another type of workstation or terminal device, although the computer may also act as a server if properly programmed. It is understood that those skilled in the art will be familiar with the structure, programming, and general operation of this computer device; therefore, the figures should be self-evident to them.

[0191] Figure 8 This is a block diagram of an exemplary processing device according to some embodiments of this application. The processing device 120 may include an image generation module 810, a position determination module 820, a position control module 830, a beam control module 840, and a monitoring module 850.

[0192] The image generation module 810 can be configured to generate at least one image of an object (e.g., a patient, a part of a patient's body). In some embodiments, the image generation module 810 may include a first image generation unit 812 and / or a second image generation unit 814.

[0193] The location determination module 820 can be configured to determine location information (e.g., position, contour) of a target region of an object in a radiation system based on at least one of at least one of at least one images. In some embodiments, the processing device 120 may use an image segmentation algorithm to determine the location information of the target region. The location control module 830 can be configured to position the target region of the object within the radiation system based on the location information.

[0194] The beam control module 840 can be configured to control a source (e.g., an imaging source, a treatment head of a radiation system) to emit a radiation beam (e.g., an imaging beam, a treatment beam) towards a subject. In some embodiments, the beam control module 840 may include a first beam control unit 842 and / or a second beam control unit 844. The monitoring module 850 can be configured to monitor the treatment period of the subject.

[0195] In some embodiments, the image generation module 810 (e.g., image generation unit 812) can generate a pre-treatment image (e.g., a 3D image) by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam toward the object. The position determination module 820 can determine the position information of the target region of the object within the radiation system based on the pre-treatment image. The position control module 830 can position the target region of the object within the radiation system according to the position information. Further description of the functionality of the modules described herein can be found elsewhere in this application. See, for example, Figure 9 And its explanation.

[0196] In some embodiments, the image generation module 810 (e.g., imaging generation unit 812) can generate a pre-treatment image (e.g., a 3D image) by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam toward the object. The position control module 830 can position a target area of ​​the object within the radiation system based on the pre-treatment image. The beam control module 840 (e.g., a first beam control unit 842) can cause the treatment head of the radiation system to deliver at least one treatment beam to the target area of ​​the object based on the object's treatment plan. The image generation module 810 (e.g., a second image generation unit 814) can generate at least one treatment image based on at least a portion of the at least one treatment beam detected by a second detector of the radiation system. The monitoring module 850 can determine whether the delivery of the treatment beam conforms to the planned delivery of the treatment beam according to the treatment plan based on the pre-treatment image and at least one treatment image. Further description of the functionality of the modules described herein can be found elsewhere in this application. See, for example, Figure 10 And its explanation.

[0197] In some embodiments, beam control module 840 (e.g., first beam control unit 842) can cause the treatment head of the radiation system to deliver a treatment beam to a target region of the object based on the object's treatment plan. Beam control module 840 (e.g., second beam control unit 844) can cause multiple imaging sources of the radiation system to emit multiple imaging beams toward the object and a detector (e.g., an imaging beam detector). The multiple imaging beams may include CT imaging beams emitted by CT imaging sources. The fan angle of the CT imaging beams can be achieved by adjusting the aperture of the collimator of the CT imaging source. Image generation module 810 (e.g., first image generation unit 812) can generate a set of images (e.g., 2D images) of the object based on at least a portion of the multiple imaging beams detected by the detector. Location determination module 820 can determine location information of the target region based on the set of images of the object. Further description of the functionality of the modules described herein can be found elsewhere in this application. See, for example, Figure 11 And its explanation.

[0198] In some embodiments, beam control module 840 (e.g., first beam control unit 842) can cause multiple imaging sources of a radiation system to emit multiple imaging beams of different energy levels toward an object and a detector (e.g., an imaging beam detector). The multiple imaging beams may include CT imaging beams emitted by CT imaging sources. The fan angle of the CT imaging beams can be achieved by adjusting the aperture of the collimator of the CT imaging source. Image generation module 810 (e.g., first image generation unit 812) can generate an image of the object based on at least a portion of the multiple imaging beams of different energy levels detected by the detector. Further description of the functionality of the modules described herein can be found elsewhere in this application. See, for example, Figure 12 And its explanation.

[0199] In some embodiments, the processing device 120 may not necessarily include all of the above-described modules and / or units; it may include only some of them. For example, the processing device 120 may include an image generation module 810, a position determination module 820, and a position control module 830. As another example, the processing device 120 may include an image generation module 810, a position control module 830, a beam control module 840, and a monitoring module 850. As a further example, the processing device 120 may include an image generation module 810, a position determination module 820, and a beam control module 840. As yet another example, the processing device 120 may include an image generation module 810 and a beam control module 840.

[0200] The modules in processing device 120 can be interconnected or communicate with each other via wired or wireless connections. Wired connections may include metal cables, optical fibers, hybrid cables, or any combination thereof. Wireless connections may include local area networks (LANs), wide area networks (WANs), Bluetooth, ZigBee, near field communication (NFC), or any combination thereof. Two or more modules can be combined into a single module, and any single module can be divided into two or more units.

[0201] It should be noted that the above description is for illustrative purposes only and is not intended to limit the scope of this application. Those skilled in the art can make various changes and modifications based on the description in this application. However, these changes and modifications do not depart from the scope of this application. For example, the processing device 120 may also include a storage module. The storage module may be configured to store data generated during any process performed by any component of the processing device 120. As another example, each component of the processing device 120 may include a storage device. Additionally or alternatively, the components of the processing device 120 may share a common storage device.

[0202] Figure 9 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application. Process 900 can be performed in... Figure 1 This is implemented in the radiation system 100 shown. For example, process 900 may be stored in storage device 130 and / or memory 620 in the form of instructions (e.g., application programs) and invoked and / or executed by processing device 120 (e.g., processor 610 shown). Figure 6 In, or in Figure 8 (One or more modules in the processing device 120 shown). The operation of the process shown below is for illustrative purposes only. In some embodiments, process 900 may be performed with one or more additional operations not described and / or without one or more of the operations discussed. Furthermore, as Figure 9 The order of operations of process 900 shown and described below is not intended to be restrictive.

[0203] In some embodiments, the radiation system may include multiple imaging sources and detectors (e.g., Figures 1 to 5 The imaging beam detector shown is, for example, an arc detector. At least two of the multiple imaging sources can share the detector. The detector can be configured to detect at least two imaging beams emitted by at least two different imaging sources. The detected at least two imaging beams can be emitted by different imaging sources. The radiation system can be similar to... Figures 1 to 5 The radiation system 100 shown here will not be described again.

[0204] In 910, processing device 120 (e.g., image generation module 810, e.g., first image generation unit 812) can generate a pre-treatment image (e.g., a 3D image) by causing a CT imaging source of the radiation system to emit a pre-treatment imaging beam toward an object (e.g., a patient or a portion thereof). In some embodiments, processing device 120 can obtain information about the detectors of the radiation system (e.g., Figures 1 to 5 The processing device 120 generates a pre-treatment image based on at least a portion of the imaging beam detected by the imaging beam detector shown in the diagram. In some embodiments, the processing device 120 may use a reconstruction algorithm to reconstruct the pre-treatment image. For example, the reconstruction algorithm may include iterative reconstruction algorithms (e.g., statistical reconstruction algorithms), Fourier slice theorem algorithms, filtered back projection (FBP) algorithms, fan-beam reconstruction algorithms, analytical reconstruction algorithms, etc., or any combination thereof.

[0205] In some embodiments, the fan angle of the pre-treatment imaging beam can be achieved by adjusting the aperture of the collimator of the CT imaging source. In some embodiments, the CT imaging source can rotate or oscillate (rotate back and forth by an angle in opposite directions during an imaging scan) by a rotation angle relative to the treatment head of the radiation system while emitting the pre-treatment imaging beam. The radiation range of the CT imaging source can be the sum of the fan angle and the rotation angle. The imaging dataset of the pre-treatment imaging beam corresponding to the radiation range (e.g., the sum of the fan angle and the rotation angle) can be used to generate 3D images.

[0206] In some embodiments, the radiation apparatus operating the radiation system in 910 may have a configuration 300. (As in conjunction with...) Figure 3 As shown, the radiation device may include a treatment head, two DR imaging sources, a CT imaging source, and an imaging beam detector. The pre-treatment imaging beam may have a large fan angle. The pre-treatment imaging beam is transmitted by the CT imaging source when the two DR imaging sources are not emitting imaging beams.

[0207] In 920, processing device 120 (e.g., location determination module 820) can determine the location information of a target region of an object in the radiation system based on a pre-treatment image. For example, the location information of the target region may include the location of the target region, the outline of the target region, etc. In some embodiments, processing device 120 can determine the location information of the target region by segmenting the pre-treatment image using an image segmentation algorithm. For example, the image segmentation algorithm may include thresholding algorithms, clustering algorithms, motion and interactive segmentation algorithms, compression-based algorithms, histogram-based algorithms, edge detection algorithms, region growing algorithms, model-based segmentation algorithms (e.g., neural network models), etc., or any combination thereof.

[0208] In 930, the processing device 120 (e.g., position control module 830) can locate the target area of ​​an object in the radiation system based on the position information.

[0209] In some embodiments, the processing device 120 can generate a second pre-treatment image by causing at least one of a plurality of imaging sources to emit at least one second pre-treatment imaging beam toward the object. In some embodiments, the at least one second pre-treatment imaging beam may include at least two second pre-treatment imaging beams having the same energy level emitted by at least two of the plurality of imaging sources, respectively. In some embodiments, the at least one second pre-treatment imaging beam may include at least two second pre-treatment imaging beams having different energy levels emitted by at least two of the plurality of imaging sources, respectively.

[0210] For example, the second pre-treatment image can be a multi-energy image. In some embodiments, at least one second pre-treatment imaging beam may include at least two second pre-treatment imaging beams with different energy levels. In some embodiments, the at least two second pre-treatment imaging beams with different energy levels may be emitted by at least two of a plurality of imaging sources of the radiation system. In some embodiments, the at least two second pre-treatment imaging beams with different energy levels may be emitted by one of the plurality of imaging sources configured to emit imaging beams with different energy levels. For example, the imaging beams with different energy levels can be emitted by adjusting the voltage of the imaging source.

[0211] In some embodiments, the detector (e.g., a layer detector) can detect signals generated by a second pre-treatment imaging beam irradiated onto the detector. The detector can determine the imaging source emitting the irradiating imaging beam. Further description of imaging source determination can be found elsewhere in this application. See, for example... Figure 4 And its description.

[0212] In some embodiments, if at least one imaging source includes a CT imaging source, the CT imaging source can be adjustably collimated by a collimator of the radiation system. The first sector angle of one of at least one second pre-treatment imaging beams emitted by the CT imaging source can be less than or equal to the second sector angle of the pre-treatment imaging beam. The second pre-treatment imaging beam emitted by the CT imaging source can be the second sector angle achieved by adjusting the aperture of the CT imaging source collimator.

[0213] The processing device 120 can generate a second pre-treatment image based on imaging datasets corresponding to each of at least two second pre-treatment imaging beams with different energy levels detected by the detector. For example, the processing device 120 can generate at least two images (e.g., 2D images) based on at least two imaging datasets corresponding to at least two imaging beams, and generate the second pre-treatment image by fusing (e.g., according to a fusion algorithm) the at least two images. For example, the fusion algorithm may include an averaging algorithm, the Brovey algorithm, principal component analysis (PCA) algorithm, etc., or any combination thereof.

[0214] Furthermore, the processing device 120 can adjust the treatment plan for the target region of the object based on the pre-treatment image and the second pre-treatment image. In some embodiments, the processing device 120 can generate a fused image by fusing the pre-treatment image and the second pre-treatment image. During image fusion, detailed contour information of the target region and / or surrounding tissue (e.g., soft tissue) can be extracted. Therefore, in the fused image, the tissue (e.g., soft tissue) in and / or around the target region has better contrast.

[0215] In some embodiments, the processing device 120 may determine information about a target region in the fused image. For example, the information about the target region may include the outline of the target region in the fused image, the outline of the tissue inside and / or surrounding the target region in the fused image, etc. The processing device 120 may identify changes in the target region by comparing the information about the target region in the fused image with planning information about the target region (e.g., the location of the plan, the outline of the plan). For example, the planning information about the target region may be determined based on a planning image of the object. In some embodiments, the planning image may be used to determine a treatment plan for the object. In response to determining that a change exceeds a threshold, the processing device 120 may adjust the treatment plan based on the information or changes in the target region in the fused image. In some embodiments, in response to determining that a change exceeds a second threshold greater than the threshold, the processing device 120 may determine a new treatment plan based on the fused image.

[0216] It should be noted that the above description is for illustrative purposes and not restrictive. In some embodiments, the pre-treatment image can be used as a planning image and for determining the treatment plan for the object. In some embodiments, the pre-treatment image can be used to adjust the treatment plan for a target region determined based on the planning image of the object. For illustrative purposes, the processing device 120 can generate a registration result by registering the pre-treatment image and the planning image, and adjust the treatment plan based on the registration result. By way of example only, if the registration result indicates that the change in planning information (e.g., planning location, planning outline) of the target region relative to the target region exceeds a threshold, the processing device 120 can adjust at least one parameter (e.g., radiation dose, radiation duration, radiation dose distribution) of the target region in the treatment plan. As another example, the processing device 120 can supplement the treatment plan with at least one new parameter of a newly grown target region (e.g., a region different from (and not in) the target region) (e.g., a newly grown tumor) determined based on the registration result.

[0217] In some embodiments, if the registration result indicates that the change in the target region relative to the planned information of the target region exceeds a threshold, the processing device 132 may generate a notification related to the registration result. In some embodiments, the processing device 132 may transmit the notification to a user of the radiology system (e.g., a physician), and the user may provide further instructions in response to the notification. In some embodiments, the processing device 132 may automatically determine how to proceed to the next step based on the registration result.

[0218] In some embodiments, processing device 120 may cause the treatment system to emit treatment beams to the target region of the treated head object based on a treatment plan (or an adjusted treatment plan for the object) and location information of the target region (e.g., information about the target region in a fused image). Processing device 120 may generate multiple images (e.g., 2D images) of the object by causing multiple imaging sources of the radiation system to deliver multiple treatment imaging beams to the object during treatment. Imaging beams may be delivered simultaneously or alternately with treatment beams. As used herein, an imaging beam delivered during treatment is referred to as a treatment imaging beam. Imaging performed by an imaging source that delivers an imaging beam during treatment is referred to as treatment imaging, as used herein. Treatment imaging may be performed to monitor the execution of the treatment plan by monitoring the location of the target region and / or tracking the delivery of the treatment beams.

[0219] In some embodiments, the location of the target area may change over time due to various movements of the target organ, such as cardiac movement (and its effects on other organs), respiratory movement (lungs and / or diaphragm, and its effects on other organs), blood flow and movement caused by vascular pulsation, muscle contraction and relaxation, pancreatic secretory activity, filling / emptying of the bladder, rectum, and digestive system, or any combination thereof. In some embodiments, the entire object may be moved along one direction (e.g., the gantry axis of the radiation apparatus of the treatment system). At least one of multiple images may be used to monitor at least one of the location and / or movement (or motion), its changes, or the rate of change of the target area during radiotherapy.

[0220] In some embodiments, processing device 120 may determine the location of a target region based on motion information of at least one organ represented in at least one of a plurality of images. Taking a specific organ as an example, processing device 132 may determine the motion information of that organ based on organ information represented by at least one image. For example, organ information may include organ location information, organ contour information, etc. In some embodiments, processing device 132 may determine the motion information of an organ based on motion information of another organ related to the motion of the organ. In some embodiments, at least one implant may be inserted near an organ and displayed on at least one of at least one of at least one images. Processing device 132 may determine the motion information of the organ based on the motion information of at least one implant (e.g., location information, contour information).

[0221] Therefore, the processing device 120 can adjust the delivery of the treatment beam or adjust the positional information (e.g., its location) of the target region based on at least one of a plurality of images of the object. In some embodiments, the processing device 120 can determine whether any changes or adjustments regarding radiotherapy are needed based on at least one of a plurality of images. In some embodiments, when movement or change in the target region is detected, the processing device 120 can adjust the delivery of the treatment beam or the position of the object based on at least one of a plurality of images of the object. For example, the processing device 120 can adjust the delivery of the treatment beam or the position of the object by adjusting at least one machine parameter of the radiation equipment of the radiation system. In some embodiments, the processing device 120 can adjust the position of the target region relative to the treatment beam to allow the treatment beam to be aimed at the target region. In some embodiments, the processing device 120 can adjust the direction of the treatment beam to allow the treatment beam to be aimed at the target region. In some embodiments, the processing device 120 can adjust the treatment plan (e.g., radiation dose to the target region, radiation duration to the target region) and deliver the adjusted treatment beam from the treatment head to the object based on the adjusted treatment plan. In some embodiments, the processing device 120 can pause the delivery of the treatment beam. For example, the processing device 120 can pause the delivery of the treatment beam and then adjust the treatment head to aim at the moved or changed position of the target region. As another example, the processing device 120 may pause the delivery of the treatment beam and then adjust the position of the target area relative to the treatment beam so that the treatment beam is aimed at the target area. After the delivery of the treatment beam or the position of the object has been adjusted, the treatment head may resume the delivery of the treatment beam. In some embodiments, the treatment head may terminate the delivery of the treatment beam when movement or change in the target area is detected. In some embodiments, the processing device 120 may generate a notification based on the detected movement or change in the target area. In some embodiments, the notification may include information about the movement or change in the target area. The notification may be in the form of text, video, audio, or a combination thereof.

[0222] According to the system and method described in this application, during radiotherapy to a target area, processing device 120 can automatically generate and / or analyze images to record radiotherapy, monitor the location of the target area, assess changes in the location of the target area, and / or determine how to proceed with radiotherapy (e.g., continue radiotherapy as planned, continue radiotherapy with a revised plan, or terminate radiotherapy, etc.). In some embodiments, monitoring, assessment, and / or adjustment can be performed semi-automatically through user (e.g., physician) input. For example, processing device 120 can transmit images to be presented on terminal 140 (e.g., a display), allowing the user to analyze the images and provide instructions on how to proceed with radiotherapy (e.g., continue radiotherapy as planned, continue radiotherapy with a revised plan, terminate radiotherapy, etc.). As another example, processing device 120 can first analyze the images and determine whether any changes have occurred in the target area and how significant those changes are. Processing device 120 can then determine whether any adjustments to the radiotherapy are necessary. If the changes in the target area or the required adjustments to the radiotherapy are within a threshold, processing device 120 can automatically make adjustments. In some embodiments, a notification can be generated when processing device 120 makes such a determination. If changes to the target area or adjustments required during radiotherapy exceed a threshold, the processing device 120 can generate a notification to, for example, a user, seeking instructions from the user on how to proceed.

[0223] It should be noted that the above description is provided for illustrative purposes only and is not intended to limit the scope of this application. Various changes and modifications can be made by those skilled in the art based on the description herein. However, these changes and modifications do not depart from the scope of this application.

[0224] Figure 10 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application. Process 1000 can be... Figure 1 This is implemented in the radiation system 100 shown. For example, process 1000 may be stored in storage device 130 and / or memory 620 in the form of instructions (e.g., application programs) and invoked and / or executed by processing device 120 (e.g., processor 610 shown). Figure 6 In, or in Figure 8 (One or more modules in the processing device 120 shown). The operation of the process shown below is for illustrative purposes only. In some embodiments, process 1000 may be performed with one or more additional operations not described and / or without one or more of the operations discussed. Furthermore, as Figure 10 The order of operations of process 1000 shown and described below is not intended to be restrictive.

[0225] In some embodiments, the radiation system may include multiple imaging sources and a first detector (e.g., Figures 1 to 5 The imaging beam detector shown is, for example, an arc detector. At least two of the multiple imaging sources can share a first detector. The first detector can be configured to detect at least two imaging beams emitted by at least two different imaging sources. The detected at least two imaging beams can be emitted by different imaging sources among the at least two imaging sources. The radiation system can be similar to... Figures 1 to 5 The radiation system 100 shown here will not be described again.

[0226] In 1010, the processing device 120 (e.g., image generation module 810, e.g., first image generation unit 812) can generate a pre-treatment image (e.g., a 3D image) by causing the CT imaging source of the radiology system to emit a pre-treatment imaging beam toward the object. Operation 1010 can be similar to operation 910, and its description will not be repeated here.

[0227] In 1020, the processing device 120 (e.g., position control module 830) can locate the target area of ​​the object within the radiation system based on pre-treatment images. Operation 1020 can be similar to operations 920 and 930, and will not be described again here.

[0228] In 1030, the processing device 120 (e.g., beam control module 840, first beam control unit 842) can cause the treatment head of the radiation system to deliver a treatment beam to the target area of ​​the object based on the object's treatment plan. The treatment beam can be delivered to the target area of ​​the object to perform radiotherapy on the target area.

[0229] In 1040, the processing device 120 (e.g., image generation module 810, second image generation unit 814) can be based on the second detector of the radiation system (e.g., Figures 1 to 5 At least one treatment image is generated based on at least a portion of at least one treatment beam detected by the treatment beam detector shown. In some embodiments, the processing device 120 may obtain an imaging dataset based on at least a portion of each of the at least one treatment beam detected by the second detector, and further generate a treatment image (e.g., a 2D image) based on the imaging dataset.

[0230] In 1050, processing device 120 (e.g., monitoring module 850) can determine whether the delivery of the treatment beam (also referred to as treatment beam delivery) conforms to the planned treatment beam delivery according to the treatment plan, based on a pre-treatment image and at least one treatment image. In some embodiments, at least one treatment image may include a treatment image. Processing device 120 can determine a reference treatment image based on the pre-treatment image and the object's treatment plan or adjusted treatment plan. For example, both the treatment image and the reference treatment image may be two-dimensional and from the same viewpoint of the object. In some embodiments, processing device 120 can estimate a reference radiation dose distribution (e.g., 2D radiation dose distribution) of the treatment beam in the object based on the reference treatment image, and assess the actual radiation dose distribution (e.g., 2D radiation dose distribution) of the treatment beam in the object based on the treatment image. Furthermore, processing device 120 can generate a comparison result by comparing the reference radiation dose distribution and the actual radiation dose distribution. Processing device 120 can determine whether the delivery of the treatment beam conforms to the planned treatment beam of the treatment plan based on the comparison result. In response to determining that the comparison result, including the difference between the reference radiation dose distribution and the actual radiation dose distribution, exceeds a threshold, the processing device 120 can determine that the delivery of the treatment beam does not conform to the planned delivery of the treatment beam in the treatment plan. In some embodiments, the processing device 120 can, according to... Figure 9 The process shown further adjusts the delivery of the treatment beam or the location information of the target area (e.g., its location).

[0231] In some embodiments, at least one treatment image may include multiple treatment images from at least two different viewpoints of the object. The processing device 120 may estimate the radiation dose distribution (also referred to as the actual distribution, e.g., 3D radiation dose distribution) of the treatment beam in the object based on the pre-treatment image and the multiple treatment images. The processing device 120 may generate a comparison result by comparing the actual radiation dose distribution of the treatment beam with the planned radiation dose distribution in the object. The processing device 120 may determine, based on the comparison result, whether the delivery of the treatment beam conforms to the planned treatment beam of the treatment plan. For example, in response to determining that the comparison result includes a difference between the actual radiation dose distribution and the planned radiation dose distribution exceeding a threshold, the processing device 120 may determine that the delivery of the treatment beam does not conform to the planned treatment beam delivery of the treatment plan. In some embodiments, the processing device 120 may, based on... Figure 9 The process shown further adjusts the delivery of the treatment beam or the location information of the target area (e.g., its location).

[0232] In some embodiments, if the comparison result includes a difference between a reference radiation dose distribution and an actual radiation dose distribution exceeding a threshold, the processing device 132 may generate a notification related to the comparison result. In some embodiments, the processing device 132 may transmit the notification to a user of the radiation system, and the user may respond to the notification by providing instructions on how to proceed. In some embodiments, the processing device 132 may automatically determine how to proceed based on the comparison result.

[0233] It should be noted that the above description is provided for illustrative purposes only and is not intended to limit the scope of this application. Various changes and modifications can be made by those skilled in the art based on the description herein. However, these changes and modifications do not depart from the scope of this application.

[0234] Figure 11 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application. Process 1100 can be performed in... Figure 1 This is implemented in the radiation system 100 shown. For example, process 1100 may be stored in storage device 130 and / or storage device 620 in the form of instructions (e.g., application program), and processed by processing device 120 (e.g., Figure 6 The processor 610 shown, or Figure 8 One or more modules in the processing device 120 shown are invoked and / or executed. The operation of the process shown below is for illustrative purposes only. In some embodiments, process 1100 may be performed with one or more additional operations not described and / or without one or more of the operations discussed. Furthermore, as Figure 11 The order of operations of process 1100 shown and described below is not intended to be restrictive.

[0235] In some embodiments, a radiation system may include multiple imaging sources and detectors (e.g., Figures 1 to 5 The diagram shows an imaging beam detector (e.g., an arc detector) and a treatment head. At least two of the multiple imaging sources may share the detector. The detector may be configured to detect at least two imaging beams emitted by at least two different imaging sources. The detected at least two imaging beams may be emitted by different imaging sources. In some embodiments, at least one of the multiple imaging sources may rotate together with the treatment head. In some embodiments, at least one of the multiple imaging beams and the treatment beam of the treatment head may be emitted simultaneously. The radiation system may be similar to... Figures 1 to 5 The radiation system 100 shown here will not be described in detail here.

[0236] In 1110, the processing device 120 (e.g., beam control module 840, such as first beam control unit 842) can cause the treatment head of the radiation system to deliver a treatment beam to the target area of ​​the object based on the object's treatment plan. The treatment beam can be delivered to the target area of ​​the object to perform radiotherapy on the target area.

[0237] In 1120, processing device 120 (e.g., image generation module 810, e.g., first image generation unit 812) can cause multiple imaging sources of a radiation system to emit multiple imaging beams toward an object and a detector. The multiple imaging beams may include CT imaging beams emitted by CT imaging sources. In some embodiments, the fan angle of the CT imaging beam can be achieved by adjusting the aperture of the collimator of the CT imaging source. In some embodiments, the CT imaging source may be stationary when emitting the CT imaging beam. The radiation range of the CT imaging source can be a fan angle. The imaging dataset of the CT imaging beam corresponding to this fan angle can be used to generate a two-dimensional image. In some embodiments, the CT imaging source may rotate or oscillate (rotate back and forth by an angle in opposite directions during an imaging scan) by a rotation angle while emitting the CT imaging beam. The radiation range of the CT imaging source can be the sum of the fan angle and the rotation angle. A two-dimensional image can be generated using the imaging dataset corresponding to the CT imaging beam with the radiation range (e.g., the sum of the fan angle and the rotation angle).

[0238] In some embodiments, each of a plurality of imaging beams may illuminate a detection region of the detector. The plurality of detection regions may be at least partially separated from each other. In some embodiments, the detector may detect signals generated by the imaging beams illuminating the detector. The detector may determine the imaging source emitting the illuminating imaging beams. Further description of imaging source determination can be found elsewhere in this application. See, for example... Figure 4 And its description.

[0239] In some embodiments, in 910 and 920, the radiation device of the radiation system may have a configuration 400. (As in conjunction with...) Figure 4 The radiation device may include a treatment head, two DR imaging sources, a CT imaging source, and an imaging beam detector. The imaging beam may have a small fan angle before treatment. While the two DR imaging sources emit their imaging beams, the CT imaging source emits its own imaging beam.

[0240] In 1130, processing device 120 (e.g., image generation module 810, e.g., first image generation unit 812) can generate an image set of the object based on at least a portion of a plurality of imaging beams detected by the detector. In some embodiments, processing device 120 can generate an imaging dataset based on at least a portion of each of the plurality of imaging beams detected by the detector, and further generate an image (e.g., a 2D image) based on the imaging dataset. Processing device 120 can generate an image set based on a plurality of imaging datasets corresponding to the plurality of imaging beams. In some embodiments, at least two of the plurality of images can be from different perspectives of the object and are two-dimensional. For example, different perspectives of the object can include the object's sagittal perspective, coronal perspective, lateral perspective, etc., or any combination thereof.

[0241] In 1140, processing device 120 (e.g., location determination module 820) can determine the location information (e.g., its position) of a target region based on a group of images of the object. (As in conjunction with...) Figure 9 The location of the target region may change over time due to various movements of the target organ. In some embodiments, the processing device 120 may determine the location information of the target region based on the motion information of at least one organ represented in the image set. Taking a specific organ as an example, the processing device 132 may determine the motion information of that organ based on the organ information in the image set. For example, the organ information may include the organ's location information, the organ's contour information, etc. In some embodiments, the processing device 132 may determine the motion information of the organ based on the motion information of another organ related to the motion of the target organ. In some embodiments, at least one implant may be inserted near the organ and presented in at least one image. The processing device 132 may determine the motion information of the organ based on the motion information of at least one implant (e.g., location information, contour information).

[0242] In some embodiments, the processing device 120 can generate a second image set containing multiple images of the object by transmitting multiple second imaging beams to the object and the detector via multiple imaging sources. The multiple second imaging beams may include second CT imaging beams emitted by CT imaging sources having the aforementioned fan angle. The processing device 120 can determine second location information (e.g., position) of a target region based on the second image set of the object. The process of generating the second image set and determining the second location information can be similar to the process of generating the image set and determining the location information of the target region described above, and will not be repeated here. In some embodiments, the image set of the object may correspond to a first time point, and the second image set of the object may correspond to a second time point different from the first time point.

[0243] In some embodiments, processing device 120 may determine whether to adjust the delivery of the treatment bundle and / or the position of the target region based on location information and / or second location information. In some embodiments, if the difference between the location information (or second location information) of the target region determined in 1140 and the initial location information of the target region exceeds a threshold, processing device 120 may adjust the delivery of the treatment bundle and / or the position of the target region based on the difference. As used herein, the initial location information of the target region may refer to the location information of the target region when the treatment bundle begins delivery during the same treatment period. Further descriptions of adjusting the delivery of the treatment bundle or the position of the target region can be found elsewhere in this application, for example, Figure 9 And its description.

[0244] In some embodiments, if the difference between the location information (or second location information) of the target area determined in 1140 and the initial location information of the target area exceeds a threshold, the processing device 132 may generate a notification related to the difference. In some embodiments, the processing device 132 may transmit the notification to a user of the radiation system, and the user may respond to the notification by providing instructions on how to proceed. In some embodiments, the processing device 132 may automatically determine how to proceed based on the difference.

[0245] It should be noted that the above description is provided for illustrative purposes only and is not intended to limit the scope of this application. Various changes and modifications can be made by those skilled in the art based on the description of this application. However, these changes and modifications do not depart from the scope of this application. In some embodiments, while the imaging source emits a first imaging beam (also referred to as tomographic synthesis imaging), the processing device 132 can obtain a first image generated based on a first imaging dataset. This first imaging dataset is obtained by oscillating a first rotation angle relative to one of a plurality of imaging sources (e.g., a CT imaging source) with respect to the treatment head of the radiation system during a first time period. While the imaging source emits a second imaging beam, the processing device 132 can obtain a second image generated based on a second imaging dataset. This second imaging dataset is obtained by oscillating a second rotation angle relative to one of a plurality of imaging sources (e.g., a CT imaging source) with respect to the treatment head of the radiation system during a second time period. The first and second images can be used to track the positional information of an object.

[0246] Figure 12 This is a flowchart illustrating an exemplary imaging process of a radiation system according to some embodiments of this application. Process 1200 can be performed in... Figure 1 This is implemented in the radiation system 100 shown. For example, process 1200 may be stored in storage device 130 and / or storage device 620 in the form of instructions (e.g., application programs) and processed by processing device 120 (e.g., Figure 6The processor 610 shown, or Figure 8 One or more modules in the processing device 120 shown are invoked and / or executed. The operation of the process shown below is for illustrative purposes only. In some embodiments, process 1200 may be performed with one or more additional operations not described and / or without one or more of the operations discussed. Furthermore, as Figure 12 The order of operations of process 1200 shown and described below is not intended to be restrictive.

[0247] In some embodiments, the radiation system may include multiple imaging sources and detectors (e.g., Figures 1 to 5 The imaging beam detector shown is, for example, an arc detector. At least two of the multiple imaging sources can share the detector. The detector can be configured to detect at least two imaging beams emitted by at least two imaging sources. The detected at least two imaging beams can be emitted by different imaging sources among the at least two imaging sources. The radiation system can be similar to... Figures 1 to 5 The description of the radiation system 100 shown will not be repeated.

[0248] In 1210, processing device 120 (e.g., beam control module 840, first beam control unit 842) can cause multiple imaging sources of a radiation system to emit multiple imaging beams of different energy levels toward an object and a detector. The multiple imaging beams may include CT imaging beams emitted by CT imaging sources. The fan angle of the CT imaging beam can be achieved by adjusting the aperture of the collimator of the CT imaging source. In some embodiments, the CT imaging source may be stationary when emitting the CT imaging beam. The radiation range of the CT imaging source can be the fan angle. In some embodiments, the CT imaging source may rotate or oscillate (rotate back and forth by an angle in opposite directions during imaging scans) by a rotation angle while emitting the CT imaging beam. The radiation range of the CT imaging source can be the sum of the fan angle and the rotation angle. A two-dimensional image can be generated using the imaging dataset corresponding to the CT imaging beam with the radiation range (e.g., the sum of the fan angle and the rotation angle).

[0249] In some embodiments, each of a plurality of imaging beams may illuminate a detection region of the detector. The plurality of detection regions may be at least partially separated from each other. In some embodiments, the detector may detect signals generated by the imaging beams illuminating the detector. The detector may determine the imaging source emitting the illuminating imaging beams. Further description of imaging source determination can be found elsewhere in this application. See, for example... Figure 4 And its description.

[0250] In 1220, processing device 120 (e.g., image generation module 810, first image generation unit 812) can generate an image of the object (e.g., a multi-energy image) based on at least a portion of a plurality of imaging beams with different energy levels detected by the detector. In some embodiments, processing device 120 can generate a primary image of the object based on an imaging dataset corresponding to each of the plurality of imaging beams detected by the detector. Processing device 120 can generate an image by fusing at least two of the plurality of primary images.

[0251] In some embodiments, the processing device 120 may cause a CT imaging source to emit a second CT imaging beam having a second sector angle. The second sector angle can be achieved by adjusting the aperture of the collimator of the CT imaging source. The second sector angle may be larger than the sector angle described in operation 1210. For example, a three-dimensional image can be reconstructed using an imaging dataset corresponding to the second CT imaging beam having the second sector angle, and a two-dimensional image can be generated using an imaging dataset corresponding to the CT imaging beam having the sector angle. In some embodiments, the second CT imaging beam may be emitted before or during radiotherapy of a target region of an object.

[0252] Furthermore, the processing device 120 (e.g., the second image generation unit 814) can generate a second image based on at least a portion of the second CT imaging beam detected by the detector. The processing device 120 can generate a fused image by fusing the first image and the second image. In the fused image, the target region and / or surrounding tissue (e.g., soft tissue) has better contrast compared to the first or second image. The processing device 120 can determine information about the target region in the fused image. For example, the information about the target region may include the outline of the target region, the outline of the target region and / or surrounding tissue, etc. In some embodiments, the processing device 120 can adjust a treatment plan for the target region of an object based on the information about the target region in the fused image. Further descriptions of adjusting the treatment plan can be found elsewhere in this application, for example, Figure 5 , 9 And its explanation.

[0253] It should be noted that the above description is provided for illustrative purposes only and is not intended to limit the scope of this application. Various changes and modifications can be made by those skilled in the art based on the description herein. However, these changes and modifications do not depart from the scope of this application.

[0254] The basic concepts have been described above. Obviously, for those skilled in the art who have read this application, the above disclosure is merely illustrative and does not constitute a limitation of this application. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and corrections to this application. Such modifications, improvements, and corrections are suggested in this application, and therefore, such modifications, improvements, and corrections still fall within the spirit and scope of the exemplary embodiments of this application.

[0255] Furthermore, this application uses specific terms to describe its embodiments. For example, "an embodiment," "one embodiment," and / or "some embodiments" refer to a particular feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that "an embodiment," "one embodiment," or "an alternative embodiment" mentioned twice or more in different locations in this specification do not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this application can be appropriately combined.

[0256] Furthermore, those skilled in the art will understand that aspects of this application can be described and illustrated through several patentable types or situations, including any new and useful combination of processes, machines, products, or substances, or any new and useful improvements thereof. Therefore, aspects of this application can be implemented entirely in hardware, entirely in software (including firmware, resident software, microcode, etc.), or a combination of software and hardware, implementations of which are generally referred to herein as “units,” “modules,” or “systems.” Furthermore, aspects of this application can take the form of computer program products embodied in one or more computer-readable media having computer-readable program code embodied thereon.

[0257] Non-transitory computer-readable signal media can include propagated data signals containing computer-readable program code, for example, in baseband or as part of a carrier wave. Such propagated signals can take many forms, including electromagnetic, optical, and other suitable combinations. A computer-readable signal medium can be any computer-readable medium other than a computer-readable storage medium, which can be used to communicate, propagate, or transmit a program for use by being connected to an instruction execution system, device, or apparatus. Program code located on a computer-readable signal medium can be propagated through any suitable medium, including radio, cable, fiber optic cable, RF, and any combination of the above.

[0258] Computer program code used to perform the operations of aspects of this application may be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java, Scala, Smalltalk, Eiffel, JADE, Emerald, C++, C#, VB.NET, Python, Visual Basic, Fortran2003, Perl, COBOL2002, PHP, ABAP, dynamic programming languages ​​(such as Python, Ruby, and Groovy), or other programming languages. The program code may run entirely on the user's computer, or as a standalone software package on the user's computer, or partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the latter case, the remote computer may be connected to the user's computer via any type of network (including a local area network (LAN) or a wide area network (WAN)), or may be connected to an external computer (e.g., through the network of an internet service provider) or in a cloud computing environment, or provided as a service, such as a software service (SaaS).

[0259] Furthermore, unless expressly stated in the claims, the order of processing elements and sequences, the use of numbers and letters, or other names described in this application are not intended to limit the order of the processes and methods of this application. Although the foregoing disclosure has discussed some currently considered useful embodiments of the invention through various examples, it should be understood that such details are for illustrative purposes only, and the appended claims are not limited to the disclosed embodiments; rather, the claims are intended to cover all modifications and equivalent combinations that conform to the substance and scope of the embodiments of this application. For example, while the implementation of the various components described above can be embodied in a hardware device, it can also be implemented as a purely software solution, such as an installation on an existing server or mobile device.

[0260] Similarly, it should be noted that, in order to simplify the description of the present application and thus aid in the understanding of one or more embodiments of the invention, the foregoing description of the embodiments of the present application sometimes combines multiple features into a single embodiment, drawing, or description thereof. However, the method of the present application should not be construed as reflecting an intention that the claimed object to be scanned requires more features than expressly recited in each claim. Rather, the subject of the invention should possess fewer features than in any single embodiment described above.

[0261] In some embodiments, the numbers expressing quantities, properties, etc., used to describe and require certain embodiments of this application should be understood to be modified in certain circumstances by the terms "approximately," "approximately," or "generally." Unless otherwise stated, "approximately," "approximately," or "generally" indicates that the numbers are allowed to vary by ±20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, which may be changed according to the characteristics required by individual embodiments. In some embodiments, numerical parameters should take into account specified significant digits and employ a general method of digit reservation. Although the numerical ranges and parameters used to confirm their breadth of application in some embodiments of this application are approximate values, in specific embodiments, such values ​​are set as precisely as feasible.

[0262] All patents, patent applications, patent application publications, and other materials (such as papers, books, specifications, publications, records, things, and / or similar items) mentioned herein are incorporated herein by reference in their entirety for all purposes, except for any prosecution documents relating to the foregoing, any foregoing documents that are inconsistent with or conflict with this document, or any foregoing documents that limit the broad scope of the claims sooner or later to this document. For example, if there is any inconsistency or conflict between the description, definitions, and / or use of terminology associated with any incorporated material and the terminology associated with this document, the terminology used in the description, definitions, and / or this document shall prevail.

[0263] Finally, it should be understood that the embodiments described in this application are merely illustrative of the principles of the embodiments of this application. Other modifications may also fall within the scope of this application. Therefore, alternative configurations of the embodiments of this application are considered as examples and not limitations, and are regarded as consistent with the teachings of this application. Accordingly, the embodiments of this application are not limited to the embodiments explicitly described and illustrated in this application.

Claims

1. A radiation system, comprising: frame; The treatment head is configured to deliver a treatment beam to the object. detector; as well as Multiple imaging sources are configured to deliver multiple imaging beams to the object; The treatment head, the detector, and the plurality of imaging sources are mounted on the frame. At least two of the plurality of imaging sources share the detector, and The detector is configured to detect at least two of the plurality of imaging beams, the at least two detected imaging beams being emitted by different types of imaging sources among the at least two imaging sources; the different types of imaging sources include computed tomography (CT) imaging sources and digital radiography (DRG) imaging sources; the CT imaging source emits the imaging beams before treatment, the DRG imaging source does not emit the imaging beams before treatment, and the DRG imaging source emits the imaging beams during treatment.

2. The radiation system as claimed in claim 1, characterized in that, The treatment head, the detector, and the plurality of imaging sources are located in the same plane.

3. The radiation system as claimed in claim 2, characterized in that, The plane is perpendicular to the frame axis of the frame.

4. The radiation system as claimed in claim 1, characterized in that, The plurality of imaging sources includes two digital radiography imaging sources.

5. The radiation system as claimed in claim 4, characterized in that, The angle between the axes of the two imaging beams emitted by the two digital radiographic imaging sources is less than or equal to 90 degrees.

6. The radiation system as claimed in claim 1, characterized in that, The angle between the axis of the imaging beam emitted by the computed tomography imaging source and the axis of the treatment beam emitted by the treatment head is 90 degrees.

7. The radiation system as claimed in claim 1, characterized in that, The axis of the imaging beam emitted by the computed tomography imaging source is perpendicular to the detector at the center of the detector.

8. The radiation system according to claim 1, characterized in that, The at least one digital radiography imaging source includes at least two digital radiography imaging sources, with the computed tomography imaging source located between two of the at least two digital radiography imaging sources.

9. The radiological system of claim 1, further comprising a collimator configured to adjust the fan angle of an imaging beam emitted by the computed tomography imaging source.

10. The radiation system as claimed in claim 1, characterized in that, The detector includes an anti-scattering grid.

11. The radiation system according to claim 10, characterized in that, The anti-scattering grid comprises multiple sections, each of which is arranged in an adjustable manner relative to at least one of the at least one digital radiography imaging sources.

12. The radiation system according to claim 11, characterized in that, The arrangement of at least one of the plurality of portions of the anti-scattering grid can be adjusted to correspond to the direction of the at least one imaging beam emitted by the at least one digital radiographic imaging source.

13. The radiation system according to any one of claims 1-12, characterized in that, The detector's detection range covers the sum of the fields of view of the multiple imaging sources.

14. The radiation system according to any one of claims 1-12, characterized in that, At least two of the plurality of imaging beams have different energy levels.

15. The radiation system as claimed in any one of claims 1-12, characterized in that, At least one of the plurality of imaging sources is configured to emit imaging beams of different energy levels.

16. The radiation system according to any one of claims 1-12, characterized in that, The detector includes an arc-shaped detector.

17. The radiation system according to any one of claims 1-12, characterized in that, The width of the detector exceeds the threshold.

18. The radiation system as claimed in any one of claims 1-12, characterized in that, The frame includes rotatable rollers; and The treatment head, the detector, and the plurality of imaging sources are mounted on the rotatable roller and rotate with the rotatable roller.

19. A system comprising: At least one storage device, including a set of instructions; At least one processor communicating with the at least one storage device and the radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRG) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRG imaging source not emitting an imaging beam prior to treatment, the DRG imaging source emitting an imaging beam during treatment, at least two of the plurality of imaging sources sharing the detector, the detector being configured to detect at least two imaging beams emitted by the at least two imaging sources, the detected at least two imaging beams being emitted by different imaging sources among the at least two imaging sources, and the at least one processor being configured to cause the system to perform the following operations when executing an instruction set: A pre-treatment image is generated by emitting a pre-treatment imaging beam toward the subject from the computed tomography imaging source of the radiology system. Based on the pre-treatment images, determine the location information of the target region of the object within the radiation system; and Based on the location information, the target area of ​​the object is located in the radiation system.

20. The system as described in claim 19, characterized in that, The at least one processor is configured to cause the system to perform the following operations: A second pre-treatment image is generated by emitting at least one second pre-treatment imaging beam toward the object from at least one of the plurality of imaging sources, wherein the second pre-treatment image is a multi-energy image; and The treatment plan for the target region of the object is adjusted based on the pre-treatment image and the second pre-treatment image.

21. The system as claimed in claim 20, characterized in that, The treatment plan for adjusting the target region of the object based on the pre-treatment image and the second pre-treatment image includes: A fused image is generated by fusing the pre-treatment image with the second pre-treatment image; Determine information about the target region in the fused image; and The treatment plan for the target area is adjusted based on the information from the target area.

22. The system according to claim 20 or claim 21, characterized in that, The at least one second pre-treatment imaging beam comprises at least two second pre-treatment imaging beams, the at least two second pre-treatment imaging beams having different energy levels and being emitted by at least two of the plurality of imaging sources.

23. The system according to claim 20 or 21, characterized in that, The at least one of the plurality of imaging sources includes an imaging source configured to emit imaging beams of different energy levels.

24. The system according to claim 20, characterized in that, The imaging beam emitted by the computed tomography imaging source in at least one second pre-treatment imaging beam can be adjustablely limited by the collimator of the radiation system.

25. The system as described in claim 24, characterized in that, The first sector angle of the second pre-treatment imaging beam is less than or equal to the second sector angle of the pre-treatment imaging beam.

26. The system as described in claim 19, characterized in that, The at least one processor is configured to cause the system to perform the following operations: Based on the treatment plan for the object and the location information of the target area, the treatment head of the radiation system delivers a treatment beam to the target area of ​​the object; Multiple images of the object are generated by causing the multiple imaging sources of the radiation system to deliver multiple therapeutic imaging beams to the object; as well as Adjusting the delivery of the treatment beam or adjusting the positional information of the target region based on the multiple images of the object.

27. The system as claimed in claim 26, characterized in that, Adjusting the delivery of the treatment beam includes at least one of the following: Adjust the direction of the treatment beam to allow it to be directed toward the target area; Adjust the treatment plan; or Pause the firing of the treatment beam.

28. The system according to claim 26, characterized in that, The imaging beam emitted by the computed tomography imaging source, one of the plurality of therapeutic imaging beams, is adjustablely limited by the collimator of the radiation system.

29. The system as claimed in claim 26, characterized in that, The first sector angle of the imaging beam emitted by the computed tomography imaging source in the plurality of therapeutic imaging beams is less than or equal to the second sector angle of the pre-treatment imaging beam.

30. The system of claim 26, wherein the image includes at least one organ of the object, wherein, Adjusting the delivery of the treatment beam or adjusting the position information of the target area includes: Based on the image, determine the motion information of the at least one organ; and The delivery of the treatment beam or the location information of the target area is adjusted based on the motion information of the at least one organ.

31. The system according to claim 30, characterized in that, The motion information of the at least one organ is related to the motion of the at least one organ.

32. A system comprising: At least one storage device, including a set of instructions; At least one processor communicates with the at least one storage device and a radiation system, wherein the radiation system includes a first detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRG) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRG imaging source not emitting an imaging beam prior to treatment, and the DRG imaging source emitting an imaging beam during treatment, at least two of the plurality of imaging sources sharing a first detector, the first detector being used to detect at least two imaging beams emitted by the at least two imaging sources, the detected at least two imaging beams being emitted by different imaging sources among the at least two imaging sources, and, when executing an instruction set, the at least one processor is configured to cause the system to perform operations including: Pre-treatment images are generated by emitting a pre-treatment imaging beam toward the subject through the computed tomography imaging source of the radiation system. Based on the pre-treatment image, the target region of the object is located in the radiation system; Based on the treatment plan for the object, the treatment head of the radiation system delivers at least one treatment beam toward the target area of ​​the object; At least one treatment image is generated based on at least a portion of the at least one treatment beam detected by the second detector of the radiation system; and Based on the pre-treatment image and the at least one treatment image, determine whether the delivery of the treatment bundle conforms to the planned delivery of the treatment bundle according to the treatment plan.

33. The system according to claim 32, characterized in that, The at least one treatment image includes a treatment image, wherein determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan, based on the pre-treatment image and the at least one treatment image, includes: A reference treatment image is determined based on the object's pre-treatment image and the treatment plan; A comparison result is generated by comparing the reference treatment image and the treatment image; and Based on the comparison results, it is determined whether the delivery of the treatment beam conforms to the planned treatment beam delivery of the treatment plan.

34. The system as described in claim 33, characterized in that, Both the treatment image and the reference treatment image are two-dimensional and originate from the same viewpoint of the object.

35. The system according to claim 32, characterized in that, The at least one treatment image includes multiple treatment images from at least two different perspectives of the object, wherein determining whether the delivery of the treatment bundle conforms to the planned treatment bundle delivery according to the treatment plan, based on the pre-treatment image and the at least one treatment image, includes: The radiation dose distribution of the treatment beam in the object is estimated based on the pre-treatment image and the plurality of treatment images; A comparison result is generated by comparing the radiation dose distribution of the treatment beam with the planned radiation dose distribution in the subject; and Based on the comparison results, it is determined whether the delivery of the treatment beam conforms to the planned delivery of the treatment beam in the treatment plan.

36. The system as described in claim 35, characterized in that, The radiation dose distribution of the treatment beam in the object includes a three-dimensional radiation dose distribution.

37. A system comprising: At least one storage device, including a set of instructions; At least one processor communicating with the at least one storage device and the radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRG) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRG imaging source not emitting an imaging beam prior to treatment, the DRG imaging source emitting an imaging beam during treatment, and, when executing the set of instructions, the at least one processor is configured to cause the system to perform operations including: Object-based treatment planning enables the treatment head of the radiation system to deliver a treatment beam to the target area of ​​the object; The plurality of imaging sources of the radiation system emit a plurality of imaging beams toward the object and the detector, wherein the plurality of imaging beams include a CT imaging beam emitted by the computed tomography imaging source, and the fan angle of the CT imaging beam can be achieved by adjusting the aperture of the collimator of the computed tomography imaging source; An image set of the object is generated based on at least a portion of the plurality of imaging beams detected by the detector; and The location information of the target region is determined based on the image group of the object.

38. The system as described in claim 37, characterized in that, Each of the plurality of imaging beams illuminates the detection area of ​​the detector, and The multiple detection areas are at least partially separated from each other.

39. The system according to claim 37 or claim 38, characterized in that, At least one of the plurality of imaging sources rotates together with the treatment head.

40. The system according to claim 37, characterized in that, At least one of the plurality of imaging beams and the therapeutic beam is emitted simultaneously.

41. The system according to claim 37, characterized in that, At least two of the plurality of images are from different perspectives of the object.

42. The system as claimed in claim 37, characterized in that, At least one image in the image group is two-dimensional.

43. The system as described in claim 37, characterized in that, The plurality of images include at least one organ of the object, motion of a target region related to the motion of the at least one organ, and Determining the location information of the target region based on the multiple images of the object includes: Based on the plurality of images, determine the motion information of at least one organ; and The location information of the target region is determined based on the motion information of the at least one organ.

44. The system according to claim 37, characterized in that, The at least one processor is configured to cause the system to perform the following operations: A second image set containing multiple images of the object is generated by transmitting multiple second imaging beams to the object and the detector by causing the multiple imaging sources to transmit multiple second imaging beams, the multiple second imaging beams including a second CT imaging beam having the fan angle emitted by the computed tomography imaging source; as well as The second location information of the target region is determined based on the second image group of the object.

45. The system as described in claim 44, characterized in that, The image group of the object corresponds to a first time point, and The second image group of the object corresponds to a second time point different from the first time point.

46. ​​A system comprising: At least one storage device, including a set of instructions; At least one processor communicating with the at least one storage device and the radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRG) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRG imaging source not emitting an imaging beam prior to treatment, the DRG imaging source emitting an imaging beam during treatment, and, when executing the group of instructions, the at least one processor is configured to cause the system to perform the following operations: The radiation system causes the plurality of imaging sources to emit multiple imaging beams of different energy levels toward the object and the detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the computed tomography imaging source, the fan angle of which can be adjusted by adjusting the aperture of the collimator of the computed tomography imaging source; and An image of the object is generated based on at least a portion of the plurality of imaging beams with different energy levels detected by the detector.

47. The system as claimed in claim 46, characterized in that, The image of the object is a multi-energy image.

48. The system as described in claim 46, characterized in that, The at least one processor is configured to cause the system to perform the following operations: The computed tomography imaging source emits a second CT imaging beam with a second sector angle, the second sector angle being achieved by adjusting the aperture of the collimator of the computed tomography imaging source, the second sector angle being larger than the sector angle; A second image is generated based on at least a portion of the second CT imaging beam detected by the detector; A fused image is generated by fusing the first image and the second image; as well as Determine the information of the target region in the fused image.

49. The system as described in claim 48, characterized in that, The information of the target region in the fused image includes at least one of the outline of the target region or the outline of the tissue surrounding the target region.

50. The system as claimed in claim 48 or claim 49, characterized in that, The at least one processor is configured to cause the system to perform the following operations: Based on the information of the target region in the fused image, the treatment plan for the target region of the object is adjusted.

51. A radiation system comprising a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRK) imaging source, wherein the CT imaging source emits an imaging beam prior to treatment, the DK imaging source does not emit an imaging beam prior to treatment, the DK imaging source emits an imaging beam during treatment, at least two of the plurality of imaging sources share the detector, the detector being configured to detect at least two imaging beams emitted by the at least two imaging sources, the detected at least two imaging beams being emitted by different imaging sources among the at least two imaging sources, and the radiation system comprising an image generation module, a position determination module, and a position control module; The image generation module generates a pre-treatment image by causing the computed tomography imaging source of the radiology system to emit a pre-treatment imaging beam toward the object. The location determination module determines the location information of the target region of the object within the radiation system based on the pre-treatment image; and The position control module positions the target area of ​​the object within the radiation system based on the position information.

52. The system of claim 51, further comprising: A second pre-treatment image is generated by emitting at least one second pre-treatment imaging beam toward the object from at least one of the plurality of imaging sources, wherein the second pre-treatment image is a multi-energy image; and Based on the pre-treatment image and the second pre-treatment image, the treatment plan for the target region of the object is adjusted.

53. The system as described in claim 52, characterized in that, Based on the pre-treatment image and the second pre-treatment image, the treatment plan for adjusting the target region of the object includes: A fused image is generated by fusing the pre-treatment image with the second pre-treatment image; Determine information about the target region in the fused image; and Based on the information about the target area, the treatment plan for the target area is adjusted.

54. The system according to claim 52 or 53, characterized in that, The at least one second pre-treatment imaging beam comprises at least two second pre-treatment imaging beams having different energy levels and emitted by at least two of the plurality of imaging sources.

55. The system according to claim 52 or 53, characterized in that, At least one of the plurality of imaging sources includes an imaging beam configured to emit different energy levels from the plurality of imaging sources.

56. The system as described in claim 52 or 53, characterized in that, The imaging beam emitted by the computed tomography imaging source in at least one second pre-treatment imaging beam is adjustablely limited by the collimator of the radiation system.

57. The system as described in claim 56, characterized in that, The first sector angle of the second pre-treatment imaging beam is less than or equal to the second sector angle of the pre-treatment imaging beam.

58. A radiation system, wherein, The radiation system includes a detector and multiple imaging sources, wherein the multiple imaging sources include a computed tomography (CT) imaging source and a digital radiography (DRG) imaging source, the CT imaging source emits an imaging beam before treatment, the DRG imaging source does not emit an imaging beam before treatment, the DRG imaging source emits an imaging beam during treatment, and the radiation system includes a beam control module and an image generation module. The beam control module causes the plurality of imaging sources of the radiation system to emit multiple imaging beams of different energy levels toward the object and the detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the computed tomography imaging source, and the fan angle of the CT imaging beam can be adjusted by adjusting the aperture of the collimator of the computed tomography imaging source; and The image generation module generates an image of the object based on at least a portion of the plurality of imaging beams with different energy levels detected by the detector.

59. The system as described in claim 58, characterized in that, The image of the object is a multi-energy image.

60. The system of claim 58, further comprising: The computed tomography imaging source emits a second CT imaging beam with a second sector angle, the second sector angle being achieved by adjusting the aperture of the collimator of the computed tomography imaging source, and the first sector angle being larger than the sector angle. A second image is generated based on at least a portion of the second CT imaging beam detected by the detector; A fused image is generated by fusing the image and the second image; as well as Determine the information of the target region in the fused image.

61. The system as described in claim 60, characterized in that, The information of the target region in the fused image includes at least one of the outline of the target region or the outline of the tissue surrounding the target region.

62. The system of claim 60 or claim 61, further comprising: Based on the information of the target region in the fused image, the treatment plan for the target region of the object is adjusted.

63. A non-transitory computer-readable medium comprising: Instructions executed by at least one processor cause the at least one processor to implement a method on a radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRT) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRT imaging source not emitting an imaging beam prior to treatment, the DRT imaging source emitting an imaging beam during treatment, at least two of the plurality of imaging sources sharing the detector, the detector being configured to detect at least two imaging beams emitted by the at least two imaging sources, the detected at least two imaging beams being emitted by different imaging sources among the at least two imaging sources, and the method comprising: A pre-treatment image is generated by emitting a pre-treatment imaging beam toward the subject from the computed tomography imaging source of the radiology system. Based on the pre-treatment images, determine the location information of the target region of the object within the radiation system; and Based on the location information, the target area of ​​the object is positioned in the radiation system.

64. A non-transitory computer-readable medium comprising: Instructions executed by at least one processor cause the at least one processor to implement a method on a radiation system, wherein the radiation system includes a first detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRT) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRT imaging source not emitting an imaging beam prior to treatment, the DRT imaging source emitting an imaging beam during treatment, at least two of the plurality of imaging sources sharing the first detector, the first detector being configured to detect at least two imaging beams emitted by the at least two imaging sources, the detected at least two imaging beams being emitted by different imaging sources among the at least two imaging sources, and the method comprising: A pre-treatment image is generated by emitting a pre-treatment imaging beam toward the subject from the computed tomography imaging source of the radiology system. Based on the pre-treatment image, the target area of ​​the object is located in the radiation system; Based on the treatment plan for the object, the treatment head of the radiation system delivers at least one treatment beam toward the target area of ​​the object; At least one treatment image is generated based on at least a portion of the at least one treatment beam detected by the second detector of the radiation system; and Based on the pre-treatment image and the at least one treatment image, determine whether the delivery of the treatment bundle conforms to the planned delivery of the treatment bundle according to the treatment plan.

65. A non-transitory computer-readable medium comprising: Instructions executed by at least one processor cause the at least one processor to implement a method on a radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRT) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRT imaging source not emitting an imaging beam prior to treatment, and the DRT imaging source emitting an imaging beam during treatment, and the method includes: Object-based treatment planning enables the treatment head of the radiation system to deliver a treatment beam to the target area of ​​the object; The plurality of imaging sources of the radiation system emit a plurality of imaging beams toward the object and the detector, wherein the plurality of imaging beams include a CT imaging beam emitted by the computed tomography imaging source, and the fan angle of the CT imaging beam can be achieved by adjusting the aperture of the collimator of the computed tomography imaging source; An image set of the object is generated based on at least a portion of the plurality of imaging beams detected by the detector; and The location information of the target region is determined based on the image group of the object.

66. A non-transitory computer-readable medium comprising: Instructions executed by at least one processor cause the at least one processor to implement a method on a radiation system, wherein the radiation system includes a detector and a plurality of imaging sources, the plurality of imaging sources including a computed tomography (CT) imaging source and a digital radiography (DRT) imaging source, the CT imaging source emitting an imaging beam prior to treatment, the DRT imaging source not emitting an imaging beam prior to treatment, and the DRT imaging source emitting an imaging beam during treatment, and the method includes: The radiation system causes the plurality of imaging sources to emit multiple imaging beams of different energy levels toward the object and the detector, wherein the plurality of imaging beams includes a CT imaging beam emitted by the computed tomography imaging source, and the fan angle of the CT imaging beam can be adjusted by adjusting the aperture of the collimator of the computed tomography imaging source; and An image of the object is generated based on at least a portion of the plurality of imaging beams with different energy levels detected by the detector.

67. A radiation system, comprising: frame; The treatment head is configured to deliver a treatment beam to the object. Multiple imaging sources are configured to deliver multiple imaging beams to the object; the multiple imaging sources include a computed tomography (CT) imaging source and a digital radiography (DRK) imaging source, wherein the CT imaging source emits imaging beams prior to treatment, the DK imaging source does not emit imaging beams prior to treatment, and the DK imaging source emits imaging beams during treatment. as well as At least one detector is configured to detect the plurality of imaging beams emitted by the plurality of imaging sources, wherein, The at least one detector and the plurality of imaging sources are mounted on the rack; and The plurality of imaging beams and the therapeutic beam pass through the same plane of the object.

68. The radiation system of claim 67, wherein, The at least one detector includes a single detector; The computed tomography (CT) imaging source and the digital radiography (DRG) imaging source share the detector, such that the detector is configured to detect the imaging beams emitted by the CT imaging source and the DRG imaging source.

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