多功能羧甲基壳聚糖 / 透明质酸水凝胶及制备方法和应用
The multifunctional hydrogel formed by combining quaternized carboxymethyl chitosan and aldehyde-modified hyaluronic acid with adipic acid dihydrazide and calcium chloride crosslinking agent solves the problems of preparation complexity and performance deficiencies of existing hydrogels in drug delivery systems, and achieves injectability, mechanical properties, self-healing and antibacterial properties, making it suitable for drug delivery systems.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHAANXI UNIV OF SCI & TECH
- Filing Date
- 2023-05-11
- Publication Date
- 2026-07-17
AI Technical Summary
Existing hydrogels have limitations in drug delivery systems due to issues such as complex preparation processes, shape mismatch, poor mechanical properties, inability to self-heal, and the potential to cause in vivo infections and inflammation.
Using quaternized carboxymethyl chitosan and aldehyde-modified hyaluronic acid as the base material, and combined with adipic acid dihydrazide and calcium chloride as crosslinking agents, a multifunctional hydrogel is formed through dynamic Schiff base bonds, acylhydrazone bonds and ionic bonds. It has injectability, excellent mechanical properties, self-healing, pH responsiveness and antibacterial properties.
It achieves injectability, excellent mechanical properties, self-healing ability, antibacterial properties and high drug loading capacity of hydrogel, meeting the requirements of drug delivery systems, and possessing high sustained drug release capability and good biocompatibility.
Smart Images
Figure CN116376061B_ABST