Methods for promoting autophagy in an organism using the tm9sf1 gene and applications
By knocking out the TM9SF1 gene through gene editing and enhancing autophagy using the CRISPR/Cas9 system, the safety risks of regulating autophagy with chemical drugs were resolved, achieving safe and effective autophagy enhancement to treat acute lung injury and protect lung tissue.
CN116426485BActive Publication Date: 2026-07-21HUBEI UNIV OF ARTS & SCI
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUBEI UNIV OF ARTS & SCI
- Filing Date
- 2022-10-11
- Publication Date
- 2026-07-21
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Figure CN116426485B_ABST
Abstract
The present application provides a method and application of TM9SF1 gene in promoting autophagy of organisms. The method for promoting autophagy of organisms comprises: reducing the expression of TM9SF1 gene to improve lung tissue autophagy. In the present application, by reducing the expression of TM9SF1 gene, not only the lung tissue autophagy of organisms is effectively improved, but also the acute lung injury can be effectively treated; the gene regulation is used instead of the traditional drug regulation, and the method has higher targeting and safety.
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