用于含硼化合物的方法

By preparing compound of formula (III) and reacting it with (1S,2S,3R,5S)-(+)-pinenediol, an effective β-lactamase inhibitor is formed, which solves the problem of β-lactamase inhibitors against bacterial resistance in the prior art and restores the antibacterial effect of β-lactam antibiotics.

CN116490509BActive Publication Date: 2026-07-17VENATORX PHARMACEUTICALS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
VENATORX PHARMACEUTICALS INC
Filing Date
2021-08-05
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing β-lactamase inhibitors are ineffective against antibiotic resistance caused by bacterial β-lactamases, limiting the treatment options for β-lactam antibiotics.

Method used

By preparing compound (III), using oxidants such as potassium permanganate and specific reaction steps, an intermediate for β-lactamase inhibitor is formed, which is further reacted with (1S,2S,3R,5S)-(+)-pinenediol to form a compound with β-lactamase inhibitory activity.

Benefits of technology

A method for preparing an effective β-lactamase inhibitor is provided, which can restore the antibacterial effect of β-lactam antibiotics and solve the problem of bacterial resistance.

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Abstract

本文所描述的是含硼化合物、组合物以及它们的制备方法。
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