Composition containing pyrazole carboxamide compound and use thereof for preventing or controlling powdery mildew

Abstract

The application relates to a composition containing a pyrazole amide compound and the use of the composition for preventing or controlling powdery mildew, and relates to a composition containing a pyrazole amide compound, and the application also relates to the use of the composition for preventing and controlling fungal diseases, in particular the use for preventing or controlling powdery mildew, more particularly the use for preventing or controlling powdery mildew of melons. The application also relates to a method for preventing or controlling the invasion of plant pathogenic fungi on plants, plant parts, plant propagation materials and plant organs grown subsequently. A composition containing a pyrazole amide compound comprises fluazinam and metrafenone, and the weight ratio of the fluazinam and the metrafenone is 20:1-1:20.

Description

Technical Field

[0001] This invention relates to a composition containing pyrazole amide compounds and its use in preventing or controlling powdery mildew, belonging to the field of pesticide technology. It relates to a composition containing pyrazole amide compounds, specifically a composition containing fluopyram and benomyl. This invention also relates to the use of the composition in preventing or controlling fungal diseases, particularly in preventing or controlling powdery mildew, and even more particularly in preventing or controlling powdery mildew in cucurbits. Background Technology

[0002] Powdery mildew is a significant disease affecting cucurbit crops. It is a common and frequently occurring disease that affects various cucurbits grown in both open fields and greenhouses, and is particularly prevalent in melons, cucumbers, and pumpkins. Once it occurs, it can spread rapidly, causing substantial losses to farmers.

[0003] Pydiflumetofen, developed by Syngenta, is a pyrazole amide fungicide and one of the most valuable products among succinate dehydrogenase inhibitors (SDHI) fungicides. It possesses excellent systemic activity, superior protective, curative, and eradicative activity, and a long-lasting effect. Extensive field efficacy trials have demonstrated that pydiflumetofen exhibits good safety for crops, effective disease control, and significant yield increases. Compared to triazole fungicides, pydiflumetofen has a broader spectrum of fungicidal activity. However, its single mechanism of action carries a higher risk of resistance.

[0004] Metrafenone belongs to the benzophenone class of fungicides. It mainly inhibits the germination of powdery mildew spores and controls the spread of the disease by interfering with the development and formation of appressorium during the germination of pathogenic fungi. At the same time, it can interfere with the establishment and formation of polar actin tissue, thereby interfering with and inhibiting the formation of mycelial apical cells of the pathogen, thus hindering the normal development and growth of mycelium, inhibiting and preventing the invasion of powdery mildew, and effectively controlling the damage caused by powdery mildew. It has a certain protective and curative effect.

[0005] Single-active-ingredient fungicides often present the following problems in disease control: a narrow fungicidal spectrum; continuous use easily leads to resistance, and increased application frequency pollutes the environment; while mixing two active ingredients can produce a synergistic effect, significantly improving efficacy. At the same time, reducing the amount of active ingredient used will delay the development of resistance and reduce environmental pollution. Summary of the Invention

[0006] The present invention aims to provide a composition containing pyrazole amide compounds and its use in preventing or controlling powdery mildew. The composition contains fluopyram and benomyl. This composition exhibits good synergistic effects, broadens the fungicidal spectrum, delays the development of resistance, improves the fungicidal effect, extends the life cycle of the active ingredient, reduces the amount of pesticide used, and protects the environment.

[0007] When different pesticides are mixed, they typically exhibit three types of action: additive, synergistic, and antagonistic. However, these three types of action are unpredictable, as they vary depending on factors such as the chemical properties of the active ingredient, the type of formulation, and the composition of the formulation. Regarding reducing application rates and improving the fungicidal spectrum of known compounds, the compositions of this invention produce a synergistic effect on crop diseases while reducing the total application rate of the active ingredient, and are safe for crops.

[0008] The synergistic effect is particularly pronounced when the active compound is present in the composition of the present invention containing pyrazole amide compounds in a specific weight ratio.

[0009] Compositions containing pyrazole amide compounds and their use in the prevention or control of powdery mildew are achieved through the following technical solutions: The present invention relates to a composition containing pyrazole amide compounds, comprising fluopyram and benomyl, wherein the weight ratio of fluopyram to benomyl is 20:1-1:20, preferably 20:1-1:10, preferably 20:1-1:5, preferably 15:1-1:5, further preferably 10:1-1:5, more preferably 5:1-1:5, more preferably 4:1-1:4, more preferably 4:1-1:2, and even more preferably 4:1-1:1.

[0010] The fluopyram and benomyl in the compositions of the present invention are, for example, in the form of a single ready-mix, in the form of a combined spray mixture (e.g., a tank-mix) consisting of individual formulations of the respective active ingredients, and applied sequentially over a suitably short period of time, such as a few hours or days.

[0011] The compositions of the present invention containing pyrazole amide compounds contain one or more inert fillers or surfactants in addition to the active ingredient. The active ingredient may account for 0.05 to 75% by weight of the composition.

[0012] The present invention relates to compositions containing pyrazole amide compounds, which can be formulated into various forms such as powders, emulsions, granules, microparticles, wettable powders, tablets, aerosols, liquids, suspensions, pastes, microcapsules, dry suspensions, water-dispersible granules, and suspending agents. More preferably, these forms include granules, wettable powders, water-dispersible granules, suspending agents, microparticles, aerosols, microcapsules, emulsions, liquids, powders, and tablets. Even more preferably, these forms include granules, wettable powders, water-dispersible granules, suspending agents, water-emulsions, microparticles, aerosols, and microcapsules. Most preferably, these forms include granules, wettable powders, water-dispersible granules, suspending agents, and water-emulsions.

[0013] Suitable inert fillers can be divided into liquid carriers and solid carriers. Liquid carriers include water, isopropanol, butanol, tetrahydrofuran, ethylene glycol, propylene glycol, ethyl acetate, methyl oleate, dimethylformamide, dimethylacetamide, dimethyl sulfoxide, and vegetable oils. Solid carriers include animal and plant powders such as starch, activated carbon, soybean flour, wheat flour, wood flour, fish meal, and milk powder; and mineral powders such as talc, kaolin, bentonite, calcium carbonate, zeolite, diatomaceous earth, silica, clay, bauxite, and sulfur powder. Suitable surfactants can be dispersants, emulsifiers, wetting agents, penetrants, thickeners, spreading agents, stabilizers, etc. Examples include polyoxyethylene alkyl aryl ethers, phosphate esters of polyoxyethylene alcohols or phenols, fatty alcohol polyoxyethylene ethers, fatty acid esters of polyols, higher fatty acid esters of polyoxyethylene, lignin sulfonates, branched copolymers of polymeric combs, naphthalene sulfonic acid polymers, alkyl sulfosuccinates, butyl naphthalene sulfonates, alkyl aryl sulfonates, fatty alcohols and ethylene oxide condensates, oils and fats, protein hydrolysates, polyacrylates of alkyl naphthalene sulfonates, suitable oligosaccharides or polymers, such as those based on acrylic acid, ethylene monomers, polyoxypropylene and / or polyoxyethylene, or combinations thereof with, for example, (poly)ols or (poly)amines.

[0014] In addition, it can be mixed or used in combination with other pesticides, such as insecticides, acaricides, nematicides, fungicides, antiviral agents, attractants, herbicides, and plant growth regulators, as needed. In such cases, it can sometimes show better results.

[0015] The composition containing pyrazole amide compounds is used for the prevention or control of fungal diseases.

[0016] The composition containing pyrazole amide compounds is used for the prevention or control of fungal diseases caused by *Erysiphe*, *Puccinia*, *Botrytis*, *Pyricularia*, *Helminthosporium*, *Fusarium*, *Septoria*, *Cercospora*, *Alternaria*, *Rhizoctonia*, and *Hemileia*.

[0017] The composition containing pyrazole amide compounds is used for the prevention or control of fungal diseases caused by Erysiphe spp.

[0018] The composition containing pyrazole amide compounds is used to prevent or control powdery mildew caused by Erysiphegraminis (wheat powdery mildew), Uncinula necator (grape powdery mildew), Sphaerotheca fuligena (cucumber powdery mildew), and Podosphaera leucotricha (apple powdery mildew).

[0019] The composition containing pyrazole amide compounds can be used to protect seeds, plant roots and shoots from invasion by soil-borne pathogenic fungi.

[0020] A method for preventing or controlling the invasion of plants, plant parts, plant propagation material, and subsequently grown plant organs from plant pathogenic fungi, comprising applying the composition containing pyrazole amide compounds to the plant, plant parts, plant propagation material, or soil or cultivation medium in which the plant is growing or needs to grow, in an agronomically effective and substantially non-phytotoxic amount by seed treatment, foliar application, stem application, soaking, dripping, watering, spraying, misting, dusting, dispersing, or fumigation.

[0021] A method for preventing or controlling plant, plant parts, plant propagation material and subsequently grown plant organs from plant pathogenic fungi, comprising applying the composition of claim 1 containing a pyrazole amide compound to the plant, plant parts, plant propagation material or soil or cultivation medium in which the plant is growing or needs to grow, before or after the plant is infected by pathogenic fungi.

[0022] The compositions of the present invention containing pyrazole amide compounds exhibit excellent activity against a wide range of plant pathogenic fungi, such as Ascomycetes, Basidiomycetes, Oomycetes, and Deuteromycetes.

[0023] Ascomycetes include powdery mildew fungi such as those of the genus *Erysiphe* (including *Erysiphegraminis* for wheat, *Uncinula necator* for grape, *Sphaerotheca fuligena* for cucumber, and *Podosphaera leucotricha* for apple); diseases of the genus *Alternaria* such as *Alternaria solani* for tomato early blight and *Alternaria brassicae* for cabbage black spot; diseases of the genus *Guignardia* such as *Guignardia bidwelli* for grape black rot; diseases of the genus *Venturia* such as *Venturia inaequalis* for apple black spot; diseases of the genus *Septoria* such as *Septoria nodorum* and *Septoria tritici* for leaf blight; and *Pseudocercosporella herpotrichoides* for wheat basal rot. Diseases caused by species of the genus *Botrytis*, such as *Botrytis cinerea* (strawberry gray mold) and *Monilinia fructicola* (peach brown rot); diseases caused by species of the genus *Sclerotinia*, such as *Sclerotinia sclerotiorum* (rapeseed sclerotinia sclerotiorum), *Magnaporthe grisea* (rice blast fungus), and *Phomopsis viticola* (grape twig blight); diseases caused by species of the genus *Helminthosporium*, such as *Helminthosporium triticirepentis* (corn leaf spot fungus) and *Pyrenophorateres* (netting fungus); anthracnose diseases, such as *Glomerella* (black fruit rot) or diseases of the genus *Colletotrichum* (e.g., *Colletotrichum graminicola* (sorghum anthracnose) and *Colletotrichum orbiculare* (watermelon anthracnose); and *Gaeumannomyces graminis* (wheat take-all pathogen). The genera *Podosphaera*, *Monilinia*, *Uncinula*, and *Mycosphaerella* are all species of bacteria.

[0024] Basidiomycetes include rust fungal diseases caused by the genus *Puccinia* (e.g., *Puccinia recondita*, *Puccinia striiformis*, *Puccinia hordei*, *Puccinia graminis*, and *Puccinia arachidis*), coffee rust (*Hemileia vastatrix*), and soybean rust (*Phakopsorapachyrhizi*). The class Deuteromycetes includes genera such as *Botrytis*, *Cercospora*, *Alternaria*, *Helminthosporium*, *Fusarium*, *Septoria*, *Pyricularia*, species of *Rhizoctonia* (e.g., *Rhizoctonia solani* and *Rhizoctonia oryzae*), and diseases of the genus *Fusarium*, such as *Fusarium graminearum*, *Fusarium moniliforme*, *Fusarium oxysporum*, and *Fusarium proliferatum*. Fusarium solani; Verticillium dahliae; Sclerotium rolfsii; Rynchosporium secalis; Cercosporidium personatum, Cercospora aracchidicola, and Cercospor abeticola; Rutstroemia floccosum; Pseudocercospora.

[0025] The class Oomycetes includes the genera *Rhizoctonia*; *Llstilaginalcs*; *Phytophthora*, including diseases caused by fungi such as *Phytophthora festans*, *Phytophthora gigasperma*, *Phytophthora parasitica*, *Phytophthora cinnamomi*, and *Phytophthora capsici*; *Pythium*, including diseases caused by fungi such as *Pythium ahanidermatum*; and the family Downy mildew. Diseases of the Peronosporaceae genus include: grape downy mildew (Plasmoparaviticola); downy mildews (including tobacco downy mildew (Peronosporatabacina) and parasitic downy mildew (Peronosporaparasitica)); pseudo-downy mildews (including cucumber downy mildew (Pseudoperonosporacubensis) and bremialactucae); Pythium species such as Pythium aphaidermatum; and Plasmopara.

[0026] The compositions of the present invention containing pyrazole amide compounds are effective against, for example, the following classes of plant pathogenic fungi: Erysiphe, Puccinia, Botrytis, Pyricularia, Helminthosporium, Fusarium, Septoria, Cercospora, Alternaria, Rhizoctonia, and Hemileia.

[0027] The compositions of this invention containing pyrazole amide compounds exhibit significant activity against powdery mildew (Erysiphes pp.). They are particularly effective in controlling powdery mildew caused by Erysiphe graminis (wheat), Uncinula necator (grape), Sphaerotheca fuligena (cucumber), and Podosphaera leucotricha (apple).

[0028] The compounds of this invention containing pyrazole amides exhibit enhanced curative and residual control effects against fungal diseases such as powdery mildew in cereals, cucumbers, and grapes, and show improved systemic activity compared to traditional fungicides. Furthermore, the compositions of this invention possess high fungicidal activity over a wide concentration range and can be used in agriculture without causing harmful phytotoxicity.

[0029] Within the scope of this invention, the useful plants to be protected generally include the following categories of plants: cereals (wheat, barley, rye, oats, rice, corn, sorghum, and related species); sugar beets (sugar beets and forage beets); pome fruits, drupes, and berries (apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, and blackberries); legumes (beans, lentils, peas, soybeans); oilseed plants (rapeseed, mustard, poppies, olives, sunflowers, coconuts, castor oil plants, cocoa beans, and soybeans). Plants of the Cucumber genus (pumpkin, cucumber, melon); fiber plants (cotton, flax, hemp, jute); citrus fruits (orange, lemon, grapefruit, mandarin orange); vegetables (spinach, lettuce, asparagus, cabbage, carrot, onion, tomato, potato, pepper); plants of the Lauraceae family (avocado, cinnamon, camphor), such as tobacco, nuts, coffee, eggplant, sugarcane, tea, pepper, vines, hops, bananas and natural rubber plants, as well as ornamental plants.

[0030] The compositions of this invention containing pyrazole amide compounds are particularly important for the control of plant pathogenic fungi on a variety of plants. These include cereals such as wheat, barley, rye, rice, and sorghum; oil crops (such as rapeseed, mustard, olive, sunflower, coconut, castor oilseeds, cocoa beans, peanuts, or soybeans); fiber plants (such as cotton, flax, hemp, and jute); citrus fruits (such as oranges, lemons, grapes, and Chinese tangerines); legumes (such as kidney beans, lentils, peas, and soybeans); vegetables (such as lettuce, cabbage, bok choy, carrots, onions, tomatoes, potatoes, and bell peppers); fruits such as pome fruits, drupes, or berries, such as apples, pears, plums, peaches, apricots, cherries, strawberries, raspberries, blackberries, or gooseberries); corn; tobacco; nuts; coffee; sugarcane; tea; grapevines; bananas; and cucurbitaceous plants (such as pumpkins, cucumbers, and melons).

[0031] The compositions of the present invention containing pyrazole amide compounds can be used as foliar fungicides in crop protection, as well as as fungicides for seed dressing and as soil fungicides.

[0032] The compositions of the present invention containing pyrazole amide compounds can be applied to plant pathogens and / or their environment, or to plants, plant propagation material and subsequently grown plant organs, soil, material or space, before or after plant infection.

[0033] The composition of the present invention containing pyrazole amide compounds is applied to plant pathogens and / or their environment, or to plants, plant propagation material and subsequently grown plant organs, soil, material or space in an agronomically effective and substantially non-phytotoxic amount by means of seed treatment, foliar application, stem application, soaking, dripping, watering, spraying, misting, dusting, dispersing or fumigation.

[0034] The compositions of this invention containing pyrazole amide compounds can be used to protect seeds, the roots and shoots of the resulting plants from invasion by harmful soil pathogens. Protection of plant roots and shoots is preferred. Seeds can be contacted with an effective amount of the fungicidal composition of this invention before sowing and / or after germination. Seed treatment protects the seeds from plant pathogens and protects the roots and shoots of the resulting plants.

[0035] Application can be carried out before or during sowing. Methods for applying or treating the compositions containing pyrazole amide compounds described in this invention to plant propagation material, particularly seeds, are known in the art. Methods for seed dressing, coating, granulation, powdering, soaking, and furrow application of plant propagation material are also known.

[0036] Seeds treated with the compositions of the present invention containing pyrazole amide compounds are protected from pathogens not only by the seeds themselves but also by the plants that emerge from them after germination. Therefore, it is unnecessary to treat the plants directly at sowing time or shortly thereafter.

[0037] The seeds mentioned are selected from potato, sunflower, coffee, tobacco, canola, rapeseed, sugar beet, tomato, cucumber, green bean, Brassica, onion, soybean, wheat, barley, rye, oat, sorghum, peanut, sugarcane, rice, cabbage, cowpea, carrot, cotton, and corn seeds. Particularly important are the seeds of wheat, barley, rye, oat, corn, cotton, canola, rapeseed, soybean, and rice.

[0038] The composition containing pyrazole amide compounds described in this invention may be applied to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

[0039] The compositions of the present invention containing pyrazole amide compounds can also be applied by ordinary methods, such as watering, spraying, or spreading, with the application amount varying depending on weather conditions or crop condition.

[0040] Compared with the prior art, the present invention has the following beneficial effects: The composition containing pyrazole amide compounds of the present invention has good bactericidal effect and low application cost. Moreover, its activity and bactericidal effect are not a simple sum of the activities of each component, but have a significant synergistic effect. It is safe for crops and meets the safety requirements of pesticide formulations. Detailed Implementation Specific Implementation

[0042] Formulation Examples Example 1: 15% Fluopyram·Benzac-methyl wettable powder Weigh out 10% fluopyram, 5% benomyl, 5% sodium alkyl naphthalene sulfonate formaldehyde condensate, 6% sodium lignosulfonate, 7% silica, 0.2% sodium hexametaphosphate, and kaolin, and add to 100%. The mixture is then subjected to air jet milling to obtain 15% fluopyram·benomyl wettable powder.

[0043] Example 2: 12% Fluopyram·Benzac granules Weigh out 4% fluopyram, 8% benomyl, 7% diatomaceous earth, 5% calcium lignosulfonate, and clay to 100%, mix the mixture evenly, add an appropriate amount of water, knead, and dry to prepare granules.

[0044] Example 3: 20% Fluopyram·Benzac-methyl Water Dispersible Granules Weigh out 10% fluopyram, 10% benomyl, 6% lignin sulfonate, 7% naphthalene sulfonate condensate, 0.4% sodium hexametaphosphate, 3% sodium dodecyl sulfate, 0.3% EDTA, and corn starch to make up to 100%. Mix all components evenly, then use air jet milling, add water and knead, extrude and granulate, dry and sieve to obtain water-dispersible granules.

[0045] Example 4: 20% Fluopyram·Benzac Flocculin Suspension Weigh out 8% fluopyram, 12% benomyl, 4% polycarboxylate, 2% phenethylphenol polyoxyethylene ether phosphate, 0.5% xanthan gum, 0.1% preservative, 0.2% defoamer, 2% ethylene glycol, 0.5% sodium hexametaphosphate, and 0.2% EDTA, and add water to bring the total to 100%. After mixing all components evenly, subject the mixture to high-speed shearing and then grind the material into particles smaller than 5 micrometers using a sand mill to obtain the suspension.

[0046] Example 5 18% Fluopyram·Benzac-methyl emulsion Weigh out 9% fluopyram, 9% benomyl, 12% N-octylpyrrolidone, 3% alkylphenol formaldehyde resin polyoxyethylene ether (agricultural emulsion 700#), 3% ethylene glycol, and 0.8% sodium hexametaphosphate, and add water to make up to 100%. Mix all components evenly, and then shear at high speed at 2700 rpm to obtain the water emulsion.

[0047] Biological test cases Example 1: Combined virulence of benomyl and fluopyram in the treatment of cucumber powdery mildew. Experimental target: Cucumber powdery mildew (Erysiphe cucurbitacearum) occurred naturally in Dongfang Farm, Kunshan City, Jiangsu Province. It was propagated on potted cucumbers by the fungicide group of the Plant Protection Technology Department and preserved.

[0048] The cucumber variety selected is Shenqing No. 1. Seedlings are raised in seedling trays and transplanted into cultivation pots when the first true leaf appears. One plant is planted in each pot. The substrate is a 4:1 mixture of DFF farm soil and nutrient soil.

[0049] Preparation of conidial suspension: Brush off the spore powder from diseased leaves with a brush, transfer the spores to disease-free cucumber seedlings, and after conidia are produced again, wash off the fresh spores with distilled water, filter through double-layer gauze, and prepare a spore concentration of 1X10. 5 A suspension of spores per mL, the spore suspension should be prepared and used immediately.

[0050] Preparation of the reagents: Both benomyl and fluopyram were prepared into a stock solution of 10000 mg / L using methanol (analytical grade). This stock solution was then diluted with a 0.1% Tween 20 aqueous solution. Benomyl and fluopyram were mixed in five ratios: 4:1, 2:1, 1:1, 1:2, and 1:4. A blank control of 0.1% Tween 20 was also included.

[0051] Chemical treatment: Use a carbon dioxide sprayer at a pressure of 3 bar to evenly spray the solution onto both sides of the leaves, ensuring the leaf surface is uniformly moistened. Allow the solution to air dry naturally before use. Each treatment is repeated 4 times, with 2 pots per repeat, for a total of 8 pots, with 1 plant per pot.

[0052] Inoculation and cultivation: 24 hours after spraying, evenly inoculate the prepared fresh spore suspension onto the upper surface of the leaves, spraying approximately 12 mL of spore suspension onto each cucumber seedling at the 2-leaf stage. After the inoculated cucumber seedlings have dried, promptly move them into a greenhouse / plant growth chamber, maintaining a temperature of 20-24℃, RH 70%, and alternating light / dark cycles of 12 hours.

[0053] Investigation: Fourteen days after application of the pesticide, the disease incidence of each treatment was investigated by grade. All leaves of all plants in each treatment were investigated, and the grading was based on the following standards (by leaf). The diseased leaf rate of the blank control reached more than 80%.

[0054] Grade 0: No symptoms; Grade 1: The area of ​​lesions accounts for less than 5% of the total leaf area; Grade 3: Lesions cover 5% to 15% of the entire leaf area; Level 5: Lesions cover 15% to 25% of the entire leaf area; Level 7: Lesions cover 25% to 50% of the entire leaf area; Level 9: Lesions cover 50-75% of the entire leaf area; Level 11: The lesion area accounts for more than 75% of the total leaf area.

[0055] Based on the survey data, the disease index and prevention and control effects of each treatment were calculated.

[0056] Disease index Calculate according to formula (1), and keep the result to two decimal places.

[0057] In the formula: X —Disease index; N i —Number of diseased leaves at each level; i —Relative numerical values; N —Total number of leaves surveyed.

[0058] Prevention and control effect Calculate according to formula (2), and keep the result to two decimal places.

[0059] In the formula: P —Prevention and control effect, expressed as a percentage (%); CK—— Blank control of disease index; PT —Disease index of treatment drugs Statistical analysis Regression analysis was performed using DPS on the logarithmic concentrations of each single agent and different ratios of the mixture with corresponding inhibition rate probabilities to calculate EC. 50 and 95% confidence limit.

[0060] The synergistic effect of drug mixtures is evaluated by calculating the synergistic coefficient (SR) of the mixture using the Wadley method. SR < 0.5 indicates an antagonistic effect, 0.5 ≤ SR ≤ 1.5 indicates an additive effect, and SR > 1.5 indicates a synergistic effect. The synergistic coefficient (SR) is calculated according to equations (3) and (4): In the formula: X 1 EC of the mixture 50 Theoretical value, mg / L; P A —Percentage content of A in the mixture, % P B —Percentage content of B in the mixture, % A —EC of A in the mixture 50 Value, mg / L; B —EC of B in the mixture 50 Value, mg / L.

[0061] In the formula: SR – Synergistic effect coefficient of the mixture; X 1 EC of the mixture 50 Theoretical value, mg / L; X 2 EC of the mixture 50 Actual value, mg / L; Table 1. Toxicity tests of benomyl and fluopyram against cucumber powdery mildew. Table 1 shows that the combination of benomyl and fluopyram in a ratio of 1:4 to 4:1 exhibits a synergistic effect with a coefficient greater than 1.5 against cucumber powdery mildew, demonstrating a strong inhibitory effect on the disease. The synergistic effect is particularly pronounced when the ratios of benomyl and fluopyram are 1:4, 1:2, and 1:1, with synergistic coefficients exceeding 9.

[0062] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention can have various modifications and variations. Any modifications, substitutions, improvements, etc., are considered to be included within the protection scope of the present invention.

Claims

1. A composition containing a pyrazole amide compound, characterized in that, The active components consist of fluopyram and benomyl, wherein the weight ratio of fluopyram to benomyl is 20:1 to 1:

10.

2. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 20:1 to 1:

5.

3. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 15:1 to 1:

5.

4. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 10:1 to 1:

5.

5. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 5:1 to 1:

5.

6. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 4:1 to 1:

4.

7. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 4:1 to 1:

2.

8. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The weight ratio of fluopyram to benomyl is 4:1 to 1:

1.

9. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The composition also includes fillers and / or surfactants.

10. The composition containing a pyrazole amide compound according to claim 1, characterized in that, The composition is in the form of a suspension, water-dispersible granules, wettable powder, emulsion, or granules.

11. Use of the composition containing a pyrazole amide compound of claim 1 for the prevention or control of fungal diseases, said fungal diseases being fungal diseases of the genus Erysiphe.

12. Use of the composition containing a pyrazole amide compound as described in claim 1 for the prevention or control of fungal diseases caused by Erysiphe spp.

13. The composition containing pyrazole amide compounds according to claim 1 can be used to protect seeds, plant roots and shoots from invasion by soil-borne pathogenic fungi, said fungi being powdery mildew.

14. A method for preventing or controlling the invasion of plant, plant parts, plant propagation material, and subsequently grown plant organs from plant pathogenic fungi, characterized in that, This includes applying the composition of claim 1 containing a pyrazole amide compound to plants, plant parts, plant propagation material, or soil or cultivation medium in which the plant is growing or needs to grow, at an agronomically effective and substantially non-phytotoxic amount, by seed treatment, foliar application, stem application, soaking, dripping, watering, spraying, misting, dusting, dispersing, or fumigation, wherein the fungus is a powdery mildew fungus.

15. The method according to claim 14, characterized in that, This includes applying the composition of claim 1 containing a pyrazole amide compound to a plant, plant part, plant propagation material, or soil or cultivation medium in which the plant is growing or needs to grow, before or after the plant is infected by a pathogenic fungus, wherein the fungus is a powdery mildew.

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