Laser ablation and imaging monitoring integrated system and control method thereof

Abstract

The application discloses a kind of laser ablation and imaging monitoring integrated system and its control method, it is related to medical equipment technical field.The system, continuous laser is connected with first laser channel, pulsed laser is connected with second laser channel, and the second laser channel is provided with light splitting prism;The first end of third laser channel in probe is connected to first laser channel and second laser channel respectively, the second end of third laser channel in probe is communicated with focusing lens therein, and the first end of transducer lead in probe is connected with ultrasonic transducer therein;The second end of transducer lead is connected to ultrasonic transceiver, photoelectric sensor receives optical signal from light splitting prism, photoelectric sensor is connected to processor and ultrasonic transceiver respectively, and ultrasonic transceiver is connected to processor.The present application can carry out imaging monitoring to effect while carrying out laser ablation, reduce time and economic cost and imaging precision is high.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an integrated system for laser ablation and imaging monitoring and its control method. Background Technology

[0002] Atherosclerotic plaques are a significant cause of cardiovascular events; therefore, their detection and treatment are crucial for the diagnosis and prevention of cardiovascular diseases. Laser ablation is currently the most commonly used clinical treatment for plaques. It utilizes photochemical, photothermal, and photomechanical effects to ablate plaques within the coronary arteries, breaking them down into fragments <25 μm in diameter that are directly absorbed by the circulatory system, demonstrating high safety and effectiveness. However, current laser ablation catheters can only ablate plaques; they cannot directly monitor the condition of the ablated plaques. Monitoring the ablation process often requires third-party imaging techniques, such as intravascular ultrasound (IVUS), intravascular optical coherence tomography (IVOCT), and digital subtraction angiography (DSA), increasing both time and financial costs. Summary of the Invention

[0003] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes an integrated laser ablation and imaging monitoring system and its control method, which can perform imaging monitoring of the effect while performing laser ablation, reducing time and economic costs while achieving high imaging accuracy.

[0004] On one hand, embodiments of the present invention provide an integrated laser ablation and imaging monitoring system, including a laser subsystem, a probe, and an imaging subsystem; The laser subsystem includes a first laser channel, a second laser channel, a continuous laser, and a pulsed laser. The continuous laser is connected to the first laser channel, and the pulsed laser is connected to the second laser channel. A beam splitter is provided on the second laser channel. The probe includes a third laser channel, a focusing lens, an ultrasonic transducer, and a transducer lead wire. The first end of the third laser channel is connected to the first laser channel and the second laser channel, respectively. The second end of the third laser channel is connected to the focusing lens. The first end of the transducer lead wire is connected to the ultrasonic transducer. The imaging subsystem includes a photoelectric sensor, an ultrasonic transceiver, and a processor. The second end of the transducer lead is connected to the ultrasonic transceiver. The photoelectric sensor receives optical signals from the beam splitter. The photoelectric sensor is connected to both the processor and the ultrasonic transceiver. The ultrasonic transceiver is connected to the processor.

[0005] According to some embodiments of the present invention, the laser subsystem further includes a wavelength division multiplexer, wherein the first laser channel is connected to the input end of the wavelength division multiplexer via a first fiber coupler, the second laser channel is connected to the input end of the wavelength division multiplexer via a second fiber coupler, and the output end of the wavelength division multiplexer is connected to the first end of the third laser channel.

[0006] According to some embodiments of the present invention, both the first laser channel and the second laser channel are provided with a beam shaping module, the beam shaping module including a first lens, a through-hole plate and a second lens, the through-hole plate being disposed between the first lens and the second lens; For the beam shaping module disposed on the first laser channel, the beam shaping module is disposed between the continuous laser and the first fiber coupler; The beam shaping module is disposed on the second laser channel, between the beam splitter and the second fiber coupler.

[0007] According to some embodiments of the present invention, the imaging subsystem further includes a time delay unit, and the photoelectric sensor is connected to the ultrasonic transceiver through the time delay unit.

[0008] According to some embodiments of the present invention, the imaging subsystem further includes a data acquisition card and an amplifier, and the ultrasonic transceiver is connected to the processor in sequence through the amplifier and the data acquisition card.

[0009] According to some embodiments of the present invention, the ultrasonic transducer is a hollow focusing ultrasonic transducer, the focusing lens is disposed in the middle of the hollow focusing ultrasonic transducer, and the focal point of the beam formed by the focusing lens is located at the same position as the focal point of the sound beam formed by the hollow focusing ultrasonic transducer.

[0010] According to some embodiments of the present invention, the third laser channel includes an optical fiber and a collimating lens, the first end of the optical fiber is connected to the first laser channel and the second laser channel respectively, the second end of the optical fiber is connected to the collimating lens, and the collimating lens is connected to the focusing lens.

[0011] According to some embodiments of the present invention, the hollow focusing ultrasonic transducer and the focusing lens are disposed on the side of the probe; The third laser channel also includes a coated reflector, and the collimating lens is connected to the focusing lens through the coated reflector.

[0012] On the other hand, embodiments of the present invention also provide a control method for an integrated laser ablation and imaging monitoring system, applied to the integrated laser ablation and imaging monitoring system described in the preceding embodiments, the control method comprising: The continuous laser is activated to emit a first laser beam, which is converged by the first laser channel and the third laser channel in the probe onto the focusing lens to emit the laser. The pulsed laser is activated to emit a second laser beam, which is split by the beam splitter. A portion of the second laser beam is focused by the focusing lens through the second laser channel and the third laser channel in the probe for photoacoustic detection, while the other portion is received by the photoelectric sensor. The photoelectric sensor converts the optical signal into a trigger electrical signal, and transmits the trigger electrical signal to the processor and the ultrasonic transceiver; The ultrasonic transceiver transmits an ultrasonic electrical signal based on the trigger electrical signal, and the ultrasonic electrical signal is converted into ultrasonic waves by the ultrasonic transducer for sound wave detection. The processor receives a photoacoustic signal and a first ultrasonic signal within the same pulse period based on the trigger electrical signal, and obtains a monitoring image based on the photoacoustic signal and the first ultrasonic signal, wherein the photoacoustic signal is a second ultrasonic signal generated by a pulsed laser, and the first ultrasonic signal is an echo excited by a sound wave.

[0013] According to some embodiments of the present invention, the monitoring image includes a photoacoustic image and an ultrasonic image, wherein the photoacoustic image is obtained by processing the photoacoustic signal, and the ultrasonic image is obtained by processing the first ultrasonic signal.

[0014] The technical solution described above has at least one of the following advantages or beneficial effects: A laser beam emitted by a continuous laser is converged by a focusing lens through a first laser channel and a third laser channel in the probe to achieve laser ablation. Simultaneously, a laser beam emitted by a pulsed laser is split by a beam splitter, with one portion converged by a second laser channel and a third laser channel in the probe to a focusing lens for photoacoustic detection, and the other portion received by a photoelectric sensor. The photoelectric sensor converts the optical signal into a trigger electrical signal. An ultrasonic transceiver transmits an ultrasonic electrical signal based on the trigger electrical signal. The ultrasonic electrical signal is converted into ultrasonic waves by an ultrasonic transducer in the probe to achieve acoustic wave detection. The processor receives the photoacoustic signal based on photoacoustic detection and the first ultrasonic signal based on acoustic wave detection within the same pulse period based on the trigger electrical signal, and obtains a monitoring image based on the photoacoustic signal and the first ultrasonic signal. This application can simultaneously achieve laser ablation and imaging monitoring, with imaging monitoring including photoacoustic imaging and ultrasonic imaging, thus improving imaging accuracy. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the integrated laser ablation and imaging monitoring system provided in an embodiment of the present invention; Figure 2 This is a schematic diagram of the overall structure of the probe provided in an embodiment of the present invention; Figure 3 This is a cross-sectional view of the probe provided in an embodiment of the present invention. Detailed Implementation

[0016] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar originals or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0017] In the description of this invention, it should be understood that the orientation descriptions, such as up, down, left, right, etc., are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention.

[0018] In the description of this invention, the use of terms such as "first," "second," etc., is merely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of technical features indicated, or implicitly indicating the order of the technical features indicated.

[0019] Before providing a further detailed description of the embodiments of this application, the nouns and terms involved in the embodiments of this application will be explained, and the nouns and terms involved in the embodiments of this application shall be interpreted as follows.

[0020] Excimer laser ablation technology utilizes the energy generated by the laser absorbed by relevant tissues within blood vessels (such as thrombi and plaques) to ablate them. Due to its shallow ablation depth, low heat release, and minimal unnecessary tissue damage, its safety is ensured, making its application in coronary arteries more promising. Laser plaque ablation exerts its therapeutic effect primarily through three mechanisms: First, photochemical action, where the excimer laser pulse is absorbed by the tissues within the coronary arteries, causing the carbon-carbon double bonds to break and disrupting the cell's molecular structure; second, photothermal action, where the energy generated by the laser can raise the intracellular temperature, thereby producing water vapor that promotes cell rupture and generates steam bubbles at the catheter tip; and third, photomechanical action, where the expansion and contraction of these bubbles further destroy the atherosclerotic tissue within the blood vessel. Through these three mechanisms, plaque tissue is broken into fragments with a diameter <25μm, which are then absorbed by the reticuloendothelial system, thus avoiding complications such as no-reflow.

[0021] Photoacoustic imaging (PAI) is a bio-imaging technique based on differences in light absorption, using photoacoustic waves (i.e., ultrasound) as the information carrier. When biological tissue is irradiated by a short-pulse laser, the tissue absorbs light energy and generates heat, causing a temperature change at the laser irradiation point, resulting in instantaneous thermal expansion and the emission of ultrasound waves. This phenomenon of ultrasound generation by light excitation is called the photoacoustic effect, and the generated ultrasound signal is the photoacoustic signal. After the photoacoustic signal is received by an ultrasound detector, algorithms are used to reconstruct the light absorption distribution within the tissue, which is photoacoustic imaging. Photoacoustic imaging is a non-invasive, non-destructive imaging technique. When a pulsed laser excites biological tissue, ultrasound waves are generated as the information carrier. By receiving the ultrasound signals, an image of the light absorption distribution of the biological tissue can be reconstructed, making it a non-ionizing, non-invasive, and non-destructive imaging method. Utilizing the spectral selective absorption differences of biological tissues, multiple wavelengths can be used for excitation imaging. The obtained differentiated photoacoustic signals can reflect multi-dimensional information such as tissue structure, function, and blood oxygen saturation. Intravascular photoacoustic imaging utilizes the differences in light absorption characteristics among different tissues within a plaque, and by selecting different wavelengths, it is possible to analyze the components within the plaque.

[0022] Ultrasound imaging utilizes the differences in acoustic impedance between different tissues. In intravascular ultrasound imaging, there is a difference in acoustic impedance between atherosclerotic plaques and normal blood vessel walls. Therefore, ultrasound imaging can be used to locate plaques, determine their position and distribution within blood vessels, and assess the degree of stenosis at their location.

[0023] This invention provides an integrated laser ablation and imaging monitoring system, referring to... Figure 1 The integrated laser ablation and imaging monitoring system includes a laser subsystem, a probe 300, and an imaging subsystem.

[0024] The laser subsystem includes a first laser channel 100, a second laser channel 200, a continuous laser and a pulsed laser. The continuous laser is connected to the first laser channel, and the pulsed laser is connected to the second laser channel. A beam splitter 210 is provided on the second laser channel.

[0025] Reference Figure 2 and Figure 3 The probe 300 includes a third laser channel 310, a focusing lens 320, an ultrasonic transducer 330, and a transducer lead 340. The first end of the third laser channel is connected to the first laser channel and the second laser channel respectively, the second end of the third laser channel is connected to the focusing lens, and the first end of the transducer lead is connected to the ultrasonic transducer.

[0026] The imaging subsystem includes a photoelectric sensor, an ultrasonic transceiver, and a processor. The second end of the transducer lead is connected to the ultrasonic transceiver. The photoelectric sensor receives the optical signal from the beam splitter. The photoelectric sensor is connected to the processor and the ultrasonic transceiver, respectively. The ultrasonic transceiver is connected to the processor.

[0027] In this embodiment, the laser beam emitted by the continuous laser is converged by a focusing lens through a first laser channel and a third laser channel in the probe to achieve laser ablation. Simultaneously, the laser beam emitted by the pulsed laser is split by a beam splitter; a portion of this beam is converged by a focusing lens through a second laser channel and a third laser channel in the probe to achieve photoacoustic detection, while the other portion is received by a photoelectric sensor. The photoelectric sensor converts the optical signal into a trigger electrical signal. An ultrasonic transceiver transmits an ultrasonic electrical signal based on the trigger electrical signal. This ultrasonic electrical signal is converted into ultrasonic waves by an ultrasonic transducer in the probe to achieve acoustic wave detection. The processor receives the photoacoustic signal based on photoacoustic detection and the first ultrasonic signal based on acoustic wave detection within the same pulse period based on the trigger electrical signal, and obtains a monitoring image based on the photoacoustic signal and the first ultrasonic signal. This embodiment of the invention can achieve laser ablation and imaging monitoring based on the same probe. The imaging monitoring includes photoacoustic imaging and ultrasonic imaging, improving imaging accuracy.

[0028] In this embodiment, when using the integrated laser ablation and imaging monitoring system, the ablation function or monitoring function can be achieved by separately controlling the on / off state of components such as the continuous laser, pulsed laser, and imaging subsystem. For example, when monitoring the laser ablation effect is required, the continuous laser, pulsed laser, and imaging subsystem can be turned on to ablate the tissue through the probe while simultaneously monitoring the ablation site. When it is necessary to monitor the lesion site before treating it, the pulsed laser and imaging subsystem can be turned on first to locate the lesion tissue through photoacoustic imaging and ultrasound imaging, and then the continuous laser can be turned on to treat the lesion site.

[0029] In some embodiments, the photoelectric sensor may be a component such as a photodiode that can convert optical signals into electrical signals.

[0030] In some embodiments, please continue with the parameters. Figure 1 The laser subsystem also includes a wavelength division multiplexer 400. The first laser channel is connected to the input of the wavelength division multiplexer through a first fiber coupler 410, the second laser channel is connected to the input of the wavelength division multiplexer through a second fiber coupler 420, and the output of the wavelength division multiplexer is connected to the first end of the third laser channel.

[0031] In some embodiments, please continue to refer to Figure 1Both the first and second laser channels are equipped with beam shaping modules 500. Each beam shaping module includes a first lens 510, a through-hole plate 530, and a second lens 520, with the through-hole plate positioned between the first and second lenses. For the beam shaping module in the first laser channel, it is positioned between the continuous laser and the first fiber coupler. For the beam shaping module in the second laser channel, it is positioned between the beam splitter and the second fiber coupler.

[0032] In some embodiments, please continue to refer to Figure 1 The imaging subsystem also includes a timer, through which the photoelectric sensor is connected to the ultrasonic transceiver.

[0033] In this embodiment, a beam splitter separates the laser beam from the pulsed laser. Most of the laser beam is used for photoacoustic detection in the probe, while a smaller portion is transmitted to a photoelectric sensor for timing control of photoacoustic and ultrasonic imaging. The photoelectric sensor converts the optical signal into a trigger signal and sends it to both the processor and a delay unit. The delay unit receives the trigger signal and waits for a preset time (less than the pulse period) before forwarding the trigger signal to control the ultrasonic transceiver to generate an ultrasonic signal for acoustic detection. By setting the delay unit to perform photoacoustic and acoustic detection sequentially within the same pulse period, interference between signals received by the processor later is reduced, improving the accuracy of photoacoustic and ultrasonic imaging.

[0034] In some embodiments, please continue to refer to Figure 1 The imaging subsystem also includes a data acquisition card and an amplifier. The ultrasonic transceiver is connected to the processor via the amplifier and the data acquisition card. After receiving the echo, the ultrasonic transceiver transmits the signal to the ultrasonic transceiver for reception via the transceiver leads. The signal received by the ultrasonic transceiver passes through the amplifier and the data acquisition card in sequence, and is finally received by the processor.

[0035] In some embodiments, please continue to refer to Figure 3 The ultrasonic transducer is a hollow focusing ultrasonic transducer, with the focusing lens set in the middle of the hollow focusing ultrasonic transducer. By selecting a focusing lens and a hollow ultrasonic transducer with appropriate parameters, the focal point of the beam formed by the focusing lens and the focal point of the acoustic beam formed by the hollow focusing ultrasonic transducer can be located at the same position, realizing synchronous monitoring of the laser ablation position using photoacoustic imaging and ultrasonic imaging.

[0036] In some embodiments, please continue to refer to Figure 3The third laser channel includes an optical fiber 311 and a collimating lens 312. The first end of the optical fiber is connected to the first laser channel and the second laser channel respectively, and the second end of the optical fiber is connected to the collimating lens. The collimating lens is connected to the focusing lens, and the collimating lens is used to collimate the beam output from the optical fiber.

[0037] In some embodiments, please continue to refer to Figure 3 The hollow focusing ultrasonic transducer and focusing lens are located on the side of the probe housing 350. The third laser channel also includes a coated reflector 313. The collimating lens is connected to the focusing lens through the coated reflector. After the laser beam is reflected by the coated reflector to a certain angle through the collimating lens, the lateral laser beam can pass through the central through hole of the ultrasonic transducer, and the focusing lens adapted to the through hole can focus the beam.

[0038] In some embodiments, the processor processes the obtained photoacoustic signal to obtain corresponding photoacoustic and ultrasonic images through algorithms, and uses these images to evaluate the laser ablation effect. The processor can be hardware such as an FPGA to achieve collaborative operation.

[0039] According to some specific embodiments of the present invention, the integrated laser ablation and imaging monitoring system of the present invention can be functionally divided into a laser ablation system, a photoacoustic imaging system and an ultrasonic imaging system, and the acoustic / optical signal transmission paths of each system are as follows.

[0040] In a laser ablation system, a continuous pulse laser emits a laser beam, which passes through a beam shaping module, then through a first fiber optic coupler to a wavelength division multiplexer, and finally into the probe's optical fiber for transmission and laser ablation. The laser path within the probe is as follows: the laser beam is output from the end of the optical fiber, collimated by a collimating lens, reflected by a coated mirror, and then reflected again by a focusing lens onto the tissue for ablation.

[0041] In a photoacoustic imaging system, a pulsed laser emits a portion of the laser beam. This beam is split by a beam splitter and then enters a photodiode to trigger a data acquisition card. The majority of the laser beam, after passing through the beam splitter, sequentially passes through a beam shaping module, a second fiber coupler, and a wavelength division multiplexer before entering the probe for tissue photoacoustic detection. The photoacoustic signal output from the probe is received by an ultrasonic transceiver, amplified, and then sent to the data acquisition card. The data acquisition card performs analog-to-digital conversion on the photoacoustic signal before sending it to a processor for image processing. The laser path in the probe is as follows: the laser beam originates from the end of the optical fiber, is collimated by a collimating lens, then emitted by a coated mirror, and finally emitted through a focusing lens to the tissue for photoacoustic signal excitation. The second ultrasonic signal generated by the excited tissue, i.e., the photoacoustic signal, is received by a hollow focusing ultrasonic transducer, then transmitted through the transducer leads to the ultrasonic transceiver, amplified, and sent to the processor for image reconstruction.

[0042] In an ultrasound imaging system, after the processor receives a trigger electrical signal, it waits for a preset time via a delay before triggering the ultrasound transceiver to generate an ultrasonic electrical signal. This signal excites the hollow focused ultrasound transceiver through the transducer leads to generate ultrasonic waves to excite plaques and blood vessel walls. The hollow focused ultrasound transceiver receives the ultrasonic waves returned from the tissue and converts them into electrical signals. These signals are then transmitted outward through the ultrasound transceiver leads and received by the ultrasound transceiver. After being amplified by an amplifier, the signals are sent to a data acquisition card for analog-to-digital conversion and then processed by the processor for image processing.

[0043] In some other embodiments, the hollow focusing ultrasonic transducer and the focusing lens can also be located at the end of the probe, and the laser beam is directly focused by the focusing lens at the end after passing through the collimating lens.

[0044] This invention also provides a control method for an integrated laser ablation and imaging monitoring system, applied to the integrated laser ablation and imaging monitoring system described in the preceding embodiments. The control method includes: A continuous laser is activated to emit a first laser beam, which is then focused onto a focusing lens through a first laser channel and a third laser channel in the probe to emit the laser beam. A pulsed laser is activated to emit a second laser beam, which is then split by a beam splitter. One part of the second laser beam is focused by a focusing lens through a second laser channel and a third laser channel in the probe for photoacoustic detection, while the other part is received by a photoelectric sensor. The photoelectric sensor converts the optical signal into a trigger electrical signal, and then transmits the trigger electrical signal to the processor and the ultrasonic transceiver; An ultrasonic transceiver transmits ultrasonic electrical signals based on a trigger electrical signal. The ultrasonic electrical signals are then converted into ultrasonic waves by an ultrasonic transducer for sound wave detection. The processor receives a photoacoustic signal and a first ultrasonic signal within the same pulse period based on the trigger electrical signal, and obtains a monitoring image based on the photoacoustic signal and the first ultrasonic signal, wherein the photoacoustic signal is a second ultrasonic signal generated by a pulsed laser, and the first ultrasonic signal is an echo excited by a sound wave.

[0045] In some embodiments, the monitoring images include photoacoustic images and ultrasonic images, wherein the photoacoustic images are obtained by processing photoacoustic signals and the ultrasonic images are obtained by processing a first ultrasonic signal.

[0046] The connection of the aforementioned components refers to the physical connection between the components, including wired connections such as wires and circuits, as well as wireless connections such as wireless communication, in order to enable the components to work together.

[0047] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0048] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

[0049] The above is a detailed description of the preferred embodiments of the present invention, but the present invention is not limited to the embodiments described. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and these equivalent modifications or substitutions are all included within the scope defined by the claims of this application.

Claims

1. An integrated system for laser ablation and imaging monitoring, characterized in that, Includes a laser subsystem, a probe, and an imaging subsystem; The laser subsystem includes a first laser channel, a second laser channel, a continuous laser, and a pulsed laser. The continuous laser is connected to the first laser channel, and the pulsed laser is connected to the second laser channel. A beam splitter is provided on the second laser channel. The laser subsystem further includes a wavelength division multiplexer, wherein the first laser channel is connected to the input end of the wavelength division multiplexer via a first fiber coupler, the second laser channel is connected to the input end of the wavelength division multiplexer via a second fiber coupler, and the output end of the wavelength division multiplexer is connected to the first end of the third laser channel; The probe includes a third laser channel, a focusing lens, an ultrasonic transducer, and a transducer lead wire. The first end of the third laser channel is connected to the first laser channel and the second laser channel, respectively. The second end of the third laser channel is connected to the focusing lens. The first end of the transducer lead wire is connected to the ultrasonic transducer. The ultrasonic transducer is a hollow focusing ultrasonic transducer, and the focusing lens is disposed in the middle of the hollow focusing ultrasonic transducer. The focal point of the beam formed by the focusing lens is located at the same position as the focal point of the sound beam formed by the hollow focusing ultrasonic transducer. The imaging subsystem includes a photoelectric sensor, an ultrasonic transceiver, and a processor. The second end of the transducer lead is connected to the ultrasonic transceiver. The photoelectric sensor receives optical signals from the beam splitter. The photoelectric sensor is connected to both the processor and the ultrasonic transceiver. The ultrasonic transceiver is connected to the processor.

2. The integrated laser ablation and imaging monitoring system according to claim 1, characterized in that, Both the first laser channel and the second laser channel are provided with a beam shaping module. The beam shaping module includes a first lens, a through-hole plate, and a second lens. The through-hole plate is disposed between the first lens and the second lens. For the beam shaping module disposed on the first laser channel, the beam shaping module is disposed between the continuous laser and the first fiber coupler; The beam shaping module is disposed on the second laser channel, between the beam splitter and the second fiber coupler.

3. The integrated laser ablation and imaging monitoring system according to claim 1, characterized in that, The imaging subsystem also includes a time delay unit, through which the photoelectric sensor is connected to the ultrasonic transceiver.

4. The integrated laser ablation and imaging monitoring system according to claim 1, characterized in that, The imaging subsystem also includes a data acquisition card and an amplifier, and the ultrasonic transceiver is connected to the processor in sequence through the amplifier and the data acquisition card.

5. The integrated laser ablation and imaging monitoring system according to claim 1, characterized in that, The third laser channel includes an optical fiber and a collimating lens. The first end of the optical fiber is connected to the first laser channel and the second laser channel, respectively, and the second end of the optical fiber is connected to the collimating lens. The collimating lens is connected to the focusing lens.

6. The integrated laser ablation and imaging monitoring system according to claim 5, characterized in that, The hollow focused ultrasonic transducer and the focusing lens are disposed on the side of the probe; The third laser channel also includes a coated reflector, and the collimating lens is connected to the focusing lens through the coated reflector.

Images