An animal live vaccine intradermal continuous inoculation immunizer

Abstract

The application discloses an intradermal continuous vaccination immunizer for animal live vaccine, which comprises a pipette gun cover, a volume adjusting mechanism is arranged at the top of the pipette gun cover, a vaccine storage tube is arranged at the bottom of the volume adjusting mechanism and located in the pipette gun cover, a vaccine storage mechanism is connected to the outside of the vaccine storage tube, an injection mechanism is connected to the bottom of the pipette gun cover, the injection mechanism comprises an injection needle plate connected to the pipette gun cover, and a plurality of injection needles are connected to the injection needle plate. The application can continuously take out the vaccine, continuously vaccinate, replace the vaccine storage mechanism and the injection mechanism, and is flexible and convenient. When vaccinating the animals, the application can not only ensure that the vaccine with the full dose is accurately injected into the intradermal without loss, but also can avoid cross infection, improve vaccination efficiency and reduce labor intensity.

Description

Technical Field

[0001] This invention belongs to the field of vaccine injection technology, and in particular relates to an intradermal continuous immunization device for live animal vaccines. Background Technology

[0002] Lumpy skin disease (LSD) is a pox-like disease in cattle caused by the bovine lumpyskin disease virus (LSDV), belonging to the genus *Capepoxvirus* of the subfamily Vertebraviirinae in the family Poxviridae. Clinical features include fever, nodules on the skin, mucous membranes, and internal organs, swollen lymph nodes, and skin edema; some cases are fatal. The disease can also cause decreased milk production in dairy cows, temporary or permanent infertility in bulls, hide damage, and even death due to secondary infections, thus severely impacting the economy. The morbidity rate ranges from 5% to 45%, with a mortality rate reaching 10%. This disease is listed as a notifiable disease by the World Organisation for Animal Health (OIE) (OIE 2014 Class List) and is classified as a Class A infectious disease in my country's *List of Quarantine Diseases for Imported Animals of the People's Republic of China*.

[0003] Sheep pox is an acute, contagious disease caused by the sheep pox virus. It is listed as one of the 93 notifiable animal diseases by the World Organisation for Animal Health (FAO / OIE), and is classified as a Class A infectious disease in my country. Its morbidity rate can reach over 75%, and its mortality rate can exceed 50%, with lamb mortality reaching 100%. It can also cause abortions in ewes. Outbreaks and epidemics of this disease reduce livestock productivity, halt trade in live animals and livestock products, and cause significant economic losses to the sheep farming industry.

[0004] Sheep pox is widespread in sheep-raising countries worldwide, and is highly contagious with a high morbidity rate, often occurring in outbreaks. Reports indicate a morbidity rate of 60% and a mortality rate of 24.7% in adult sheep, and a mortality rate of 93% in lambs. Infected sheep often exhibit emaciation and stunted growth after recovery, affecting their production performance and the quality of meat, milk, and other livestock products. The resulting trade restrictions and sanitation costs are difficult to estimate.

[0005] In recent years, outbreaks of sheep pox and orthopnea have occurred frequently both domestically and internationally. Since there are currently no effective treatments for these diseases, vaccination is the only effective measure to prevent bovine nodular skin disease, sheep pox, and orthopnea. Currently, my country widely uses goat pox vaccine to prevent goat pox and sheep pox, and uses a 5-fold dose of attenuated goat pox vaccine to immunize cattle to prevent bovine nodular skin disease. Attenuated live sheep pox and orthopnea vaccines are characterized by low dosage and long-lasting immunity, and are widely used in veterinary clinical practice (especially since sheep pox has become one of the essential vaccines for sheep farming). Attenuated live sheep pox and orthopnea vaccines are generally administered via intradermal injection into the oral mucosa (commonly used for orthopnea vaccines), the inner side of the tail, or the inner thigh (commonly used for sheep pox vaccines). This method of administration produces rapid immunity and is reliable; however, the disadvantage is that intradermal injection is difficult to perform, and grassroots veterinarians often inject subcutaneously or intramuscularly, which can lead to uncertain immunization effects or immunization failure. This is because, according to the sheep pox vaccine instructions, 0.5 ml should be injected into the inner thigh or the inner side of the tail root of each sheep. However, this is actually quite difficult. Sheepskin is very thin; the thickest sheepskin is only 0.5 to 1 mm, and lambs' skin is even less than 0.5 mm. It is extremely difficult to administer 0.5 ml of vaccine, and even if the injection is completed, it cannot be guaranteed that it will be injected into the skin. Summary of the Invention

[0006] The purpose of this invention is to provide an intradermal continuous immunization device for live animal vaccines to solve the problems existing in the prior art.

[0007] To achieve the above objectives, the present invention provides the following solution: The present invention provides an intradermal continuous immunization device for live animal vaccines, comprising a pipette jacket, a volume adjustment mechanism at the top of the inner side of the pipette jacket, a vaccine reservoir tube at the bottom of the volume adjustment mechanism, the vaccine reservoir tube being located inside the pipette jacket, a vaccine storage mechanism being connected to the outside of the vaccine reservoir tube, the vaccine storage mechanism being located outside the pipette jacket, and an injection mechanism being connected to the bottom of the pipette jacket, the injection mechanism including an injection needle plate communicating with the pipette jacket, and a plurality of injection needles being connected inside the injection needle plate.

[0008] Preferably, the volume adjustment mechanism includes a volume adjustment shaft rotatably connected to the top of the pipette sleeve, an injection handle fixedly connected to the outer side of the volume adjustment shaft, a volume adjustment knob fixedly connected to the top of the volume adjustment shaft extending to the outer side of the pipette sleeve, a spring-loaded upper plug rotatably connected inside the volume adjustment shaft, the spring-loaded upper plug being located at the top of the inner side of the pipette sleeve, a volume adjustment spring fixedly connected to the bottom surface of the spring-loaded upper plug, a volume adjustment lower nut fixedly connected to the bottom surface of the volume adjustment spring, the volume adjustment lower nut being threadedly connected to the volume adjustment shaft, the volume adjustment spring being sleeved on the outer side of the volume adjustment shaft, a connecting mechanism fixedly connected to the bottom surface of the volume adjustment shaft, the connecting mechanism communicating with the vaccine reservoir tube, and a volume display window provided on one side of the top of the pipette sleeve.

[0009] Preferably, the connecting mechanism includes a piston connecting rod fixedly connected to the volume adjusting shaft, the piston connecting rod being located on the bottom surface of the volume adjusting lower nut, a piston being fixedly connected to the bottom surface of the piston connection, and the piston being located inside the vaccine reservoir tube.

[0010] Preferably, the bottom surface of the vaccine reservoir tube is provided with a vaccine reservoir tube outlet, and a sealing mechanism is provided between the vaccine reservoir tube outlet and the bottom surface of the pipette sleeve.

[0011] Preferably, the sealing mechanism includes a vaccine reservoir outlet plug slidably connected to the bottom of the vaccine reservoir outlet, the vaccine reservoir outlet plug being slidably connected to the inner wall of the pipette sleeve, and a spring fixing head being fixedly connected between the bottom surface of the vaccine reservoir outlet plug and the bottom surface of the pipette sleeve, respectively, and an outlet plug spring being fixedly connected between the two spring fixing heads.

[0012] Preferably, the bottom surface of the pipette sleeve is provided with a pipette vaccine outlet, and the pipette vaccine outlet is connected to the injection needle plate through a vaccine outlet connecting tube.

[0013] Preferably, the injection needle plate is provided with a connecting sleeve, the top surface of the connecting sleeve is connected to the vaccine outlet connecting tube, the bottom surface of the connecting sleeve is connected to the injection needle dispensing tube, and the bottom surface of the injection needle dispensing tube is connected to a plurality of injection needles.

[0014] Preferably, the vaccine storage mechanism includes a vaccine conduit that is connected to both the pipette sleeve and the vaccine reservoir tube, and a vaccine storage bottle is connected to the side of the vaccine conduit away from the pipette sleeve.

[0015] Preferably, a pipette handle is fixed to the top of the pipette sleeve on the side away from the volume display window.

[0016] The present invention discloses the following technical effects: The present invention can continuously transfer vaccines and achieve continuous immunization. At the same time, the vaccine storage mechanism and injection mechanism can be separated from the pipette jacket, and new vaccine storage mechanism and injection mechanism can be replaced, which is flexible and convenient. When immunizing animals, it can not only ensure that the vaccine of the required dosage is accurately and without loss to the skin, but also avoid cross-infection, improve vaccination efficiency, and reduce labor intensity. Attached Figure Description

[0017] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments and descriptions of this application are used to explain this application and do not constitute an undue limitation of this application. In the drawings:

[0018] Figure 1 This is a schematic diagram of the structure of the intradermal continuous immunization device for the animal live vaccine of the present invention;

[0019] Figure 2 This is a bottom view of the present invention.

[0020] In the diagram: 1. Pipette sleeve; 2. Pipette handle; 3. Injection handle; 4. Volume adjustment knob; 5. Spring-loaded upper plug; 6. Volume adjustment shaft; 7. Volume adjustment spring; 8. Volume adjustment lower nut; 9. Volume display window; 10. Piston connecting rod; 11. Vaccine storage bottle; 12. Vaccine tubing; 13. Piston; 14. Vaccine reservoir tube; 15. Vaccine reservoir tube outlet; 16. Vaccine reservoir tube outlet plug; 17. Outlet plug spring; 18. Pipette vaccine outlet; 19. Vaccine outlet connecting tube; 20. Connecting sleeve; 21. Injection needle plate; 22. Injection needle dispensing tube; 23. Injection needle; 24. Spring retainer. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0023] Reference Figure 1-2As shown, the present invention provides an intradermal continuous immunization device for live animal vaccines, including a pipette jacket 1. The top of the pipette jacket 1 is provided with a volume adjustment mechanism, and the bottom of the volume adjustment mechanism is provided with a vaccine reservoir tube 14. The vaccine reservoir tube 14 is located inside the pipette jacket 1. A vaccine storage mechanism is connected to the outside of the vaccine reservoir tube 1. The vaccine storage mechanism is located outside the pipette jacket 1. An injection mechanism is connected to the bottom of the pipette jacket 1. The injection mechanism includes an injection needle plate 21 connected to the pipette jacket 1. A plurality of injection needles 23 are connected inside the injection needle plate 21.

[0024] This invention provides an intradermal continuous immunization device for viral and attenuated live vaccines such as sheep pox, sheep oral thrush, and bovine nodular dermatitis. It can continuously transfer vaccines and simultaneously perform continuous immunization. Furthermore, the vaccine storage and injection mechanisms are detachable from the pipette housing 1, allowing for replacement with new ones, offering flexibility and convenience. When immunizing animals, it not only ensures that the required dose of vaccine is accurately and without loss to the intradermal layer, but also avoids cross-infection, improves immunization efficiency, and reduces labor intensity.

[0025] Further optimization of the design: The volume adjustment mechanism includes a volume adjustment shaft 6 rotatably connected to the top of the pipette sleeve 1; an injection handle 3 is fixedly connected to the outside of the volume adjustment shaft 6; the top of the volume adjustment shaft 6 extends to the outside of the pipette sleeve 1 and is fixedly connected to a volume adjustment knob 4; a spring-loaded upper plug 5 is rotatably connected inside the volume adjustment shaft 6; the spring-loaded upper plug 5 is located at the top inside the pipette sleeve 1; a volume adjustment spring 7 is fixedly connected to the bottom surface of the spring-loaded upper plug 5; a volume adjustment lower nut 8 is fixedly connected to the bottom surface of the volume adjustment spring 7; the volume adjustment lower nut 8 is threadedly connected to the volume adjustment shaft 6; the volume adjustment spring 7 is sleeved on the outside of the volume adjustment shaft 6; a connecting mechanism is fixedly connected to the bottom surface of the volume adjustment shaft 6; the connecting mechanism is connected to the vaccine reservoir tube 14; and a volume display window 9 is provided on one side of the top of the pipette sleeve 1.

[0026] The design of the accurate vaccine dispensing section is based on Hooke's Law: within certain limits, the force exerted by a spring is proportional to its elastic force. In other words, the volume of liquid inside the pipette sleeve 1 is proportional to the elastic force of the spring within the pipette sleeve 1. This section consists of a volume adjustment knob 4, a volume adjustment shaft 6, a spring cap 5, a volume adjustment spring 7, a volume adjustment lower nut 8, and a volume display window 9 that displays the volume calculated by the number of turns of the spring when the volume adjustment knob 4 is tightened and loosened. The main working principle of the accurate vaccine dispensing section is as follows: according to the required injection dosage, the volume adjustment knob 4 is turned clockwise (decreasing the dosage) or counterclockwise (increasing the dosage). At this time, because the spring cap 5 remains stationary, the volume adjustment lower nut 8 moves up and down along the thread of the volume adjustment shaft 6 as the volume adjustment knob 4 and volume adjustment shaft 6 rotate, compressing or loosening the volume adjustment spring 7 on the volume adjustment shaft 6. The volume adjustment lower nut 8 is partially fixed within the pipette body and can move up and down, but cannot rotate left and right.

[0027] The scheme is further optimized. The connecting mechanism includes a piston rod 10 fixedly connected to the volume adjustment shaft 6. The piston rod 10 is located on the bottom surface of the volume adjustment lower nut 8. The bottom surface of the piston 13 is fixedly connected to the piston 13, and the piston 13 is located inside the vaccine reservoir tube 14.

[0028] To further optimize the design, a vaccine reservoir tube outlet 15 is provided on the bottom surface of the vaccine reservoir tube 14, and a sealing mechanism is provided between the vaccine reservoir tube outlet 15 and the bottom surface of the pipette outer sleeve 1.

[0029] The solution is further optimized. The sealing mechanism includes a vaccine reservoir outlet plug 16 that is slidably connected to the bottom of the vaccine reservoir outlet 15. The vaccine reservoir outlet plug 16 is slidably connected to the inner wall of the pipette outer sleeve 1. A spring fixing head 24 is fixedly connected between the bottom surface of the vaccine reservoir outlet plug 16 and the bottom surface of the pipette outer sleeve 1, respectively. An outlet plug spring 17 is fixedly connected between the two spring fixing heads 24.

[0030] Piston rod 10 is connected to volume adjustment shaft 6, and it is connected to piston 13 inside vaccine storage tube through a hole. Vaccine storage tube has vaccine inlet and outlet, and vaccine reservoir outlet 15 is located at its bottom center. Directly below vaccine reservoir outlet 15 is vaccine reservoir outlet plug 16, with a central protrusion made of silicone (a soft material). Like piston 13, the reservoir tube consists of a connecting rod and a spring. When continuously immunizing animals, first adjust volume adjustment knob 4 to its maximum range, then continuously press injection handle 3 to move piston 13 up and down to expel air from the reservoir tube, creating a negative pressure chamber. This negative pressure allows the vaccine in the vaccine reservoir to enter the vaccine storage container until the vaccine completely fills the vaccine storage tube and all connected pipes. Then, set the immunization dose. Each press of the vaccine injection handle 3 to the bottom of the spring and then completely releasing it constitutes one injection and inhalation of the vaccine.

[0031] To further optimize the design, the bottom surface of the pipette sleeve 1 is provided with a pipette vaccine outlet 18, which is connected to the injection needle plate 21 through a vaccine outlet connecting tube 19.

[0032] In a further optimized design, a connecting sleeve 20 is provided inside the injection needle plate 21. The top surface of the connecting sleeve 20 is connected to the vaccine outlet connecting tube 19, and the bottom surface of the connecting sleeve 20 is connected to the injection needle dispensing tube 22. The bottom surface of the injection needle 23 dispensing tube is connected to several injection needles 23.

[0033] The injection needle plate 21 is 3-5cm long and 2-3cm wide. One end of the connecting sleeve 20 is connected to four injection needles 23 through a connecting tube. The tip of each injection needle 23 enters the interior of the injection needle plate 21 from the outside, and the tip of each injection needle 23 faces the long side of the injection needle plate 21.

[0034] The injection needle plate 21 has each injection needle 23 inserted through the center line of the injection needle plate 21. The injection needles 23 are parallel to each other and on the same plane. The angle between the plane and the injection needle plate 21 where the inoculation device is located is 30°.

[0035] The dispensing tube 22 of the injection needle is made of PVC tubing. The dispensing tube 22 of the injection needle is connected to each injection needle 23 by a PVC tubing connector.

[0036] The vaccine storage mechanism is further optimized by including a vaccine conduit 12 that is connected to both the pipette sleeve 1 and the vaccine reservoir tube 14. The side of the vaccine conduit 12 away from the pipette sleeve 1 is connected to a vaccine storage bottle 11.

[0037] To further optimize the design, a pipette handle 2 is fixedly attached to the top of the pipette sleeve 1 on the side away from the volume display window 9.

[0038] When administering continuous immunizations to animals, first adjust the volume adjustment knob 4 to its maximum range. Hold the pipette handle 2 and continuously press the injection handle 3 with your thumb. This causes the piston 13 of the vaccine reservoir 14 to move up and down, expelling the air from the reservoir and creating a negative pressure chamber. This negative pressure allows the vaccine from the storage bottle 11 to enter the reservoir 14 until it completely fills the reservoir and all connected tubing. Set the immunization dose (0.5 ml), fix the sheep in place, align the needle tip of the injection needle plate 21 with the wider part of the sheep's tail root, and then press the front edge of the injection needle plate 21 firmly against the inside of the tail root and push it horizontally forward. This allows the needle tip 23 to pierce the inner epidermis of the tail root. Press the injection handle 3 with your thumb, and the vaccine will be administered at four points on the inside of the sheep's tail root. Releasing the injection handle 3 automatically completes another round of vaccine aspiration, thus achieving continuous immunization. This ensures accurate intradermal administration of the vaccine without loss and guarantees the correct dosage.

[0039] Then set the dose to be administered. Each time you press the vaccine injection handle 3 times until the spring is fully released, that is one injection and inhalation of the vaccine.

[0040] Both the injection needle plate 21 and the vaccine storage bottle 11 are detachable. The vaccine storage bottle 11 can be made into a sterile, disposable plastic bottle, which prevents contamination of the vaccine before immunization. When immunizing animals, one injection needle plate 21 can be used per animal. As long as the immunization equipment is properly prepared beforehand, the problem of cross-infection caused by using a single set of immunization equipment can be avoided. When administering intradermal immunization, as long as the injection needle plate 21 is inserted parallel to the inner side of the tail root, the vaccine can be injected intradermally without loss. Multiple animals can be immunized consecutively, improving vaccination efficiency and reducing labor intensity. In addition, when using this immunization device to vaccinate pregnant animals, the animals experience less pain, and immunization personnel do not need to excessively restrain the animals, thus effectively avoiding mechanical abortion caused by vaccination.

[0041] Example 1: Immunization with goat pox live vaccine

[0042] First, dilute the goat pox live vaccine with physiological saline (Harbin Weike Biotechnology Development Co., Ltd.) to 25ml / bottle. Pour the diluted vaccine into the vaccine storage bottle 11. Adjust the volume control knob 4 to its maximum range. Holding the pipette handle 2, continuously press the injection handle 3 with your thumb to move the piston 13 of the vaccine reservoir tube 14 up and down, expelling the air from the reservoir tube 14 and creating a negative pressure chamber. Use this negative pressure to allow the vaccine from the storage bottle 11 to enter the reservoir tube 14 until it is completely filled with vaccine and all connected tubing. Then, set the immunization dose to 0.5ml, fix the goat to be immunized, align the needle tip of the injection needle plate 21 with the wider part of the inner side of the goat's tail root, and then press the front edge of the injection needle plate 21 firmly against the inner side of the tail root and push it horizontally forward. This allows the needle tip 23 to pierce the inner epidermis of the tail root. Press the injection handle 3 with your thumb, and the vaccine will be administered at four points on the inner side of the goat's tail root. Release the pipette handle; the vaccine will be automatically drawn in, and the immunization will continue for the next sheep to be immunized.

[0043] When vaccinating cattle against bovine nodular dermatitis with sheep pox vaccine, the principle and method are the same, except that the immunization dose is 5 times that of sheep.

[0044] Example 2: Immunization with attenuated live attenuated ovine infectious pustular virus vaccine

[0045] First, dilute the ovine infectious pustular virus (IPV) attenuated live vaccine with physiological saline to 2 ml / bottle. Pour the diluted vaccine into the vaccine storage bottle 11. Adjust the volume control knob 4 to its maximum range. Holding the pipette handle 2, continuously press the injection handle 3 with your thumb to move the piston 13 of the vaccine reservoir tube 14 up and down, expelling air from the reservoir tube 14 and creating a negative pressure chamber. Use this negative pressure to allow the vaccine from the storage bottle 11 to enter the reservoir tube 14 until it is completely filled with vaccine and all connected tubing. Set the immunization dose to 0.2 ml. Fix the sheep to be immunized. Align the needle tip of the injection needle plate 21 with the wider part of the lower lip mucosa. Then, press the front edge of the injection needle plate 21 against the wider inner side of the sheep's lower lip mucosa and push it horizontally forward. This allows the needle tip 23 to pierce the lip mucosa epidermis. Press the injection handle 3 with your thumb; the vaccine will then be administered at four points on the sheep's lip mucosa. Release the pipette handle 2; the vaccine will be automatically drawn in. Continue immunizing the next sheep.

[0046] In the description of this invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0047] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. An intradermal continuous immunization device for live animal vaccines, characterized in that: The device includes a pipette sleeve (1), with a volume adjustment mechanism at the top inside the pipette sleeve (1) and a vaccine reservoir tube (14) at the bottom of the volume adjustment mechanism. The vaccine reservoir tube (14) is located inside the pipette sleeve (1), and a vaccine storage mechanism is connected to the outside of the vaccine reservoir tube (14). The vaccine storage mechanism is located outside the pipette sleeve (1), and an injection mechanism is connected to the bottom of the pipette sleeve (1). The injection mechanism includes an injection needle plate (21) connected to the pipette sleeve (1), and a plurality of injection needles (23) are connected inside the injection needle plate (21). The volume adjustment mechanism includes a volume adjustment shaft (6) rotatably connected to the top of the pipette sleeve (1). An injection handle (3) is fixed to the outside of the volume adjustment shaft (6). The top of the volume adjustment shaft (6) extends to the outside of the pipette sleeve (1) and is fixed to a volume adjustment knob (4). A spring upper plug (5) is rotatably connected inside the volume adjustment shaft (6). The spring upper plug (5) is located at the top inside the pipette sleeve (1). A volume adjustment spring (7) is fixed to the bottom surface of the spring upper plug (5). A volume adjustment lower nut (8) is fixed to the bottom surface of the volume adjustment spring (7). The volume adjustment lower nut (8) is threadedly connected to the volume adjustment shaft (6). The volume adjustment spring (7) is sleeved on the outside of the volume adjustment shaft (6). A connecting mechanism is fixed to the bottom surface of the volume adjustment shaft (6). The connecting mechanism is connected to the vaccine reservoir tube (14). A volume display window (9) is provided on one side of the top of the pipette sleeve (1).

2. The animal live vaccine intradermal continuous immunization device according to claim 1, characterized in that: The connecting mechanism includes a piston rod (10) fixedly connected to the volume adjustment shaft (6). The piston rod (10) is located on the bottom surface of the volume adjustment lower nut (8). The piston (13) is fixedly connected to the bottom surface of the piston (13). The piston (13) is located inside the vaccine reservoir tube (14).

3. The animal live vaccine intradermal continuous immunization device according to claim 1, characterized in that: The bottom surface of the vaccine reservoir tube (14) is provided with a vaccine reservoir tube outlet (15), and a sealing mechanism is provided between the vaccine reservoir tube outlet (15) and the bottom surface of the pipette sleeve (1).

4. The animal live vaccine intradermal continuous immunization device according to claim 3, characterized in that: The sealing mechanism includes a vaccine reservoir outlet plug (16) slidably connected to the bottom of the vaccine reservoir outlet (15). The vaccine reservoir outlet plug (16) is slidably connected to the inner wall of the pipette sleeve (1). A spring fixing head (24) is fixed between the bottom surface of the vaccine reservoir outlet plug (16) and the bottom surface of the pipette sleeve (1). An outlet plug spring (17) is fixed between the two spring fixing heads (24).

5. The animal live vaccine intradermal continuous immunization device according to claim 1, characterized in that: The bottom surface of the pipette sleeve (1) is provided with a pipette vaccine outlet (18), which is connected to the injection needle plate (21) through a vaccine outlet connecting tube (19).

6. The animal live vaccine intradermal continuous immunization device according to claim 5, characterized in that: The injection needle plate (21) is provided with a connecting sleeve (20). The top surface of the connecting sleeve (20) is connected to the vaccine outlet connecting tube (19). The bottom surface of the connecting sleeve (20) is connected to the injection needle dispensing tube (22). The bottom surface of the injection needle (23) is connected to a plurality of injection needles (23).

7. The animal live vaccine intradermal continuous immunization device according to claim 1, characterized in that: The vaccine storage mechanism includes a vaccine conduit (12) that is connected to the pipette sleeve (1) and the vaccine reservoir tube (14) respectively, and a vaccine storage bottle (11) is connected to the side of the vaccine conduit (12) away from the pipette sleeve (1).

8. The animal live vaccine intradermal continuous immunization device according to claim 1, characterized in that: The pipette sleeve (1) has a pipette handle (2) fixed to the top side away from the volume display window (9).

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