Cosmetic composition comprising sucrose ester and solvent

Abstract

The present invention relates to a cosmetic composition comprising: (a) one or more esters of sucrose and a fatty acid, wherein the fatty acid is selected from those having from about 12 to about 24 carbon atoms, and wherein the sucrose ester is selected from the group consisting of monoesters, diesters, triesters, tetraesters, and mixtures thereof; and (b) one or more solvents selected from those having a Hildebrand solubility parameter of from about 23 to about 31.5 (J / cm 3 ) 1 / 2 and a polar component of the Hansen solubility parameter of from about 4.5 to about 10.5 (J / cm 3 ) 1 / 2 The cosmetic composition of the present invention solubilizes the sucrose ester in the cosmetic composition even when the sucrose ester is included in the composition at higher levels and / or even when the sucrose ester is included in the aqueous phase of the cosmetic composition.

Description

Technical Field

[0001] This invention relates to a cosmetic composition comprising: (a) one or more esters of sucrose and fatty acids, wherein the fatty acids are selected from those having about 12 to about 24 carbon atoms, and wherein the sucrose ester is selected from the group consisting of monoesters, diesters, triesters, tetraesters, and mixtures thereof; and (b) one or more solvents selected from those having a Hildebrand solubility parameter of about 23 to about 31.5 (J / cm³). 3 ) 1 / 2 Furthermore, the polar component of the Hansen solubility parameter is approximately 4.5 to approximately 10.5 (J / cm³). 3 ) 1 / 2 Those. The cosmetic compositions of the present invention dissolve sucrose esters even when sucrose esters are included in the composition at a higher concentration and / or even when sucrose esters are included in the aqueous phase of the cosmetic composition. Background Technology

[0002] Mammalian keratinocytes, especially human skin, are susceptible to damage from both external and internal factors. External factors include ultraviolet radiation, environmental pollution, wind, heat, infrared radiation, low humidity, irritating surfactants, and abrasives. Internal factors include aging and other biochemical changes within the skin. Both external and internal factors contribute to visible signs of skin damage. Typical skin damage in aging or damaged skin includes fine lines, wrinkles, hyperpigmentation, sallowness, sagging, dark circles, puffy eyes, enlarged pores, reduced skin turnover, and abnormal flaking or peeling. Additional damage caused by both external and internal factors includes visible dead skin, i.e., flaking, buildup, dryness, and roughness.

[0003] Currently, there are many consumer-available personal care products designed to improve the health and physical appearance of keratinized tissues such as skin, hair, and nails. Most of these products involve delaying, minimizing, or even eliminating wrinkles, blemishes, and other histological changes typically associated with skin aging or environmental damage. Consumers prefer topical products because they are not only effective but also safe and pleasant to use.

[0004] Multiple ingredients are used in such products to deliver the aforementioned beneficial effects. The inventors have discovered that one of these ingredients, sucrose esters, may be difficult to dissolve in the product composition, particularly when sucrose esters are contained in a higher concentration in the product composition and / or particularly when sucrose esters are contained in the aqueous phase of the product composition. It has also been found that, considering the provision of a fresh / refreshing sensation from the composition while simultaneously providing the beneficial effects from the sucrose esters, it may be preferable to dissolve the sucrose esters in the aqueous phase of the product composition rather than the oil phase.

[0005] Based on the foregoing, a cosmetic composition is needed that dissolves sucrose esters within the cosmetic composition, particularly when the sucrose esters are contained in a higher concentration in the composition and / or particularly when the sucrose esters are contained in the aqueous phase of the cosmetic composition. A cosmetic composition may also be needed that provides the beneficial effects from the sucrose esters while simultaneously providing a fresh / refreshing sensation from the composition. Summary of the Invention

[0006] This invention relates to a cosmetic composition comprising:

[0007] (a) an ester of one or more sucrose and fatty acids, comprising about 0.01% to about 50%, wherein the fatty acids are selected from those having about 12 to about 24 carbon atoms, and wherein the sucrose ester is selected from the group consisting of monoesters, diesters, triesters, tetraesters, and mixtures thereof; and

[0008] (b) about 0.01% to about 90% of one or more solvents selected from those with a Hildebrand solubility parameter of about 23 to about 31.5 (J / cm³). 3 ) 1 / 2 Furthermore, the polar component of the Hansen solubility parameter is approximately 4.5 to approximately 10.5 (J / cm³). 3 ) 1 / 2 Those;

[0009] The composition satisfies at least one of the following conditions:

[0010] The weight ratio of the sucrose ester to the solvent is about 2.5:1 to 1:10; and

[0011] The solvent is pentylene glycol.

[0012] It has now been surprisingly discovered that the cosmetic compositions of the present invention dissolve sucrose esters even when sucrose esters are included in the composition at a higher concentration and / or even when sucrose esters are included in the aqueous phase of the cosmetic composition.

[0013] Unrestricted by theory, it is believed that when a composition contains an aqueous carrier, most of the sucrose esters are contained in the aqueous phase of the composition. Unrestricted by theory, such compositions are believed to provide a refreshing, non-greasy, and / or invigorating sensory experience, while also providing the beneficial effects of sucrose esters. Detailed Implementation

[0014] References to "implementation" or similar methods in this specification mean that the specific materials, features, structures, and / or characteristics described in conjunction with that implementation are included in at least one implementation, or optionally multiple implementations, but do not imply that all implementations include the described materials, features, structures, and / or characteristics. Furthermore, materials, features, structures, and / or characteristics can be combined in any suitable manner in different implementations, and materials, features, structures, and / or characteristics can be omitted or replaced as described. Therefore, unless otherwise stated or declared as incompatible, although not expressly illustrated in the combination, the implementations and aspects described herein may include elements or components of other implementations and / or aspects, or may be combined with elements or components of other implementations and / or aspects.

[0015] In all embodiments, unless otherwise specified, all ingredient percentages are based on the weight of the cosmetic composition. Unless otherwise specified, all ratios are by weight. Significant figures do not express any limitation on the quantities shown or on the accuracy of the measurement. All values ​​should be understood to be modified by the word “about” unless otherwise specified. Unless otherwise specified, all measurements are understood to have been performed at approximately 25°C and ambient conditions, where “ambient conditions” means conditions at approximately 1 atmosphere and approximately 50% relative humidity. All numerical ranges are inclusive and can be combined to form narrower ranges not explicitly disclosed. For example, the upper and lower limits of the depicted ranges are interchangeable to form additional ranges.

[0016] The compositions of the present invention may comprise, consist of, or be composed of the basic components described herein, as well as optional ingredients. As used herein, “consistently consisting of” means that a composition or component may contain only additional ingredients that do not substantially alter the essential and novel features of the composition or method protected by the claims. As used in the specification and appended claims, unless the context clearly indicates otherwise, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well.

[0017] definition

[0018] The word “about” modifies a specific value by referring to a range equal to or less than 20 percent (+ / - 20%) of the specified value (e.g., less than 15%, 10%, or even less than 5%).

[0019] As used with reference to the composition, “apply” means applying or spreading the composition of the invention onto the surface of human skin, such as the epidermis.

[0020] In this article, “derivative” means an amide, ether, ester, amino, carboxyl, acetyl, and / or alcohol derivative of a given compound.

[0021] "Effective amount" means an amount of compound or composition sufficient to significantly induce a positive beneficial effect on keratinocytes during the treatment period. Positive beneficial effects can be health, appearance, and / or sensory benefits, including individual or combined beneficial effects disclosed herein.

[0022] "Cosmetic agent" means any substance and any of its components intended to be applied, poured, sprayed, atomized, introduced, or otherwise applied to the body of a mammal or any part thereof to provide a cosmetic effect. Cosmetic agents may contain substances generally recognized as safe (GRAS) by the U.S. Food and Drug Administration, food additives, and materials used in non-cosmetic consumer products (including over-the-counter drugs).

[0023] "Cosmetic composition" means a composition that contains cosmetic agents. Examples of cosmetic compositions include tinted cosmetics (such as foundation, lipstick, concealer, and mascara), skin care compositions (such as moisturizers and sunscreens), personal care compositions (such as rinse-off and leave-on bath products and soaps), and hair care compositions (such as shampoos and conditioners).

[0024] "Skincare" refers to conditioning and / or improving skin condition (e.g., skin health, appearance, or texture / feel). Some non-limiting examples of improving skin condition include improving skin appearance and / or feel by providing a smoother, more even appearance and / or feel; increasing the thickness of one or more layers of skin; improving skin elasticity or resilience; improving skin firmness; and reducing the oily, shiny, and / or dull appearance of skin; improving skin hydration or moisturization; improving the appearance of fine lines and / or wrinkles; improving skin peeling or flaking; plumping the skin; improving skin barrier properties; improving skin tone; reducing the appearance of redness or rashes; and / or improving skin radiance, luminosity, or translucency.

[0025] "Skincare active ingredients" refer to compounds or combinations of compounds that, when applied to the skin, provide immediate and / or long-lasting beneficial effects to the skin or the cell types typically present therein. Skincare active ingredients can modulate and / or improve the skin or its related cells (e.g., improve skin elasticity, hydration, skin barrier function, and / or improve cell metabolism).

[0026] "Skincare composition" means a composition that contains skincare active ingredients and regulates and / or improves skin condition.

[0027] "Synergy" and its variations refer to the effect provided by a combination of two or more materials that is greater than the expected sum of the effects of those materials.

[0028] As used herein, “treatment period” refers to the length of time and / or frequency of application of a material or composition to the target skin surface.

[0029] sucrose esters

[0030] The sucrose esters used herein are esters of sucrose and fatty acids, wherein the fatty acids are selected from those having about 12 to about 24 carbon atoms, preferably about 12 to about 22 carbon atoms, more preferably about 12 to about 18 carbon atoms, and wherein the sucrose esters are selected from the group consisting of monoesters, diesters, triesters, tetraesters, and mixtures thereof. Preferably, the fatty acids are selected from those having saturated alkyl groups containing the aforementioned number of carbon atoms.

[0031] Preferably, sucrose esters are included in the cosmetic composition in an amount of about 0.01% to about 50%, preferably about 0.1% to about 35%, more preferably about 0.5% to about 25%, and even more preferably about 1% to about 20%.

[0032] Preferably, the sucrose esters used herein contain about 10% to about 100%, preferably about 20% to about 100%, more preferably about 50% to about 90% of higher esters selected from the group consisting of diesters, triesters, tetraesters, and mixtures thereof.

[0033] In some cases, sucrose esters may be blends of two or more sucrose esters, wherein the two or more sucrose esters are present in any ratio of one sucrose ester to another of 1:10 to 1:1 (e.g., 1:7, 1:5, 1:3, or 1:2). In some cases, sucrose esters may be blends of sucrose laurate and sucrose dilaurate, wherein sucrose laurate is present at 50% to 80% by weight of the sucrose ester, and sucrose dilaurate is present at 20% to 45% by weight of the sucrose ester. Alternatively, sucrose esters may be blends of sucrose laurate, sucrose dilaurate, and sucrose trilaurate, wherein sucrose dilaurate is present at more than 35% by weight of the sucrose ester. A particularly suitable example of a sucrose ester used herein is sucrose dilaurate BC10034, available from BASF.

[0034] solvent

[0035] Considering the solubility of sucrose esters, the solvents suitable for use in this paper are selected from those with a Hildebrand solubility parameter of about 23 to about 31.5, preferably about 23 to about 29 (J / cm³). 3 ) 1 / 2 Furthermore, the polar component of the Hansen solubility parameter is approximately 4.5 to approximately 10.5, preferably approximately 5 to approximately 9, and more preferably approximately 5.5 to approximately 8 (J / cm³). 3 ) 1 / 2 Those.

[0036] One or a mixture of the solvents described above may be used, provided that each solvent meets the parameters described above. Such solvents include, for example, the materials listed in the table below:

[0037]

[0038]

[0039] Among these, pentylene glycol is highly preferred, considering the balance between improving the solubility of sucrose esters and minimizing the possibility of skin irritation. In one embodiment, the solvent is pentylene glycol.

[0040] The solvent is included in the cosmetic composition in an amount of about 0.01% to about 90%, preferably about 0.1% to about 50%, more preferably about 0.5% to about 30%.

[0041] In one embodiment, taking into account the dissolution of sucrose esters, the weight ratio between sucrose esters and solvents can be from about 1:1000 to about 1000:1, preferably from about 1:100 to about 100:1, more preferably from about 10:1 to about 1:10, even more preferably from about 5:1 to 1:10, even more preferably from about 2.5:1 to about 1:10, and even more preferably from about 2.5:1 to about 1:5.

[0042] In another embodiment, taking into account the dissolution of sucrose esters, the weight ratio between sucrose esters and solvents is about 2.5:1 to about 1:10, preferably about 2.5:1 to about 1:5.

[0043] The following are polar components for Hildebrand and Hansen solubility parameters for ingredients commonly used in cosmetic compositions but not as solvents as defined herein, for reference only:

[0044] <![CDATA[Hildebrand solubility parameter (J / cm 3 ) 1 / 2 > <![CDATA[Polar component of Hansen solubility parameter (J / cm 3 ) 1 / 2 > glycerin 34.90 12.2 water 47.80 42.3

[0045] Aqueous carrier

[0046] The aqueous carriers that can be used herein are those excluding the solvents defined above. Preferably, the aqueous carrier is substantially water. Deionized water is preferred. Depending on the desired characteristics of the product, water from natural sources containing mineral cations may also be used.

[0047] In one embodiment, the aqueous carrier may be present in an amount of about 50% to about 99%, preferably about 60% to about 98%, more preferably about 70% to about 98%, and even more preferably about 80% to about 95% by weight of the composition.

[0048] Cosmetic Composition

[0049] The cosmetic compositions described herein are intended for topical application to human skin and contain sucrose esters and solvents, and preferably also contain an aqueous carrier. The compositions herein may optionally contain one or more additional skin-active substances or other types of ingredients commonly included in topical cosmetic compositions.

[0050] The cosmetic compositions described herein may be cosmetic compositions, pharmaceutical compositions, or medicated cosmetic compositions, and may be provided in various product forms, including but not limited to solutions, suspensions, emulsions, creams, gels, toners, sticks, sprays, aerosols, ointments, cleansing liquids and solid sticks, pastes, foams, mousses, shaving creams, wipes, strips, patches, motorized patches, hydrogels, film-forming products, facial and skin masks (with and without insoluble sheets), cosmetics such as foundation, eyeliner, and eyeshadow. In some cases, the composition form may conform to a selected specific dermatologically acceptable carrier. For example, the composition (and carrier) may be provided in the form of an emulsion (e.g., water-in-oil, oil-in-water, or oil-in-water) or an aqueous dispersion. Preferably, the cosmetic compositions of the present invention are in the form of an oil-in-water emulsion.

[0051] Dermatologically acceptable carriers

[0052] The compositions disclosed herein may include dermatologically acceptable carriers (which may be referred to as "carriers"). The phrase "dermatologically acceptable carrier" means that the carrier is suitable for topical application to keratinocytes, has good aesthetic properties, is compatible with the active substance in the composition, and does not cause any unreasonable safety or toxicity issues. In one embodiment, the carrier is present at levels of about 50% to about 99% by weight, about 60% to about 98% by weight, about 70% to about 98% by weight, or alternatively about 80% to about 95% by weight.

[0053] The carrier can take many forms. In some cases, the solubility or dispersibility of the components (e.g., extracts, sunscreen active ingredients, additional components) determines the form and characteristics of the carrier. Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, sticks, flowable solids, or amorphous materials). In some cases, the dermatologically acceptable carrier is in the form of an emulsion. The emulsion may have a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water emulsions) or a continuous oil phase (e.g., water-in-oil or water-in-oil-in-oil emulsions). The oil phase of the present invention may comprise silicone oils, non-silicone oils (such as hydrocarbon oils, esters, ethers), and mixtures thereof. The aqueous phase typically comprises water and water-soluble components (e.g., water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other skin-care active ingredients). However, in some cases, the aqueous phase may contain components that are not water, including but not limited to water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other water-soluble skin-care active ingredients. In some cases, the non-aqueous components of the composition include wetting agents, such as glycerin and / or other polyols.

[0054] In some cases, the compositions described herein are in the form of an oil-in-water (“O / W”) emulsion that provides a mild and non-greasy sensory experience. Suitable O / W emulsions described herein may comprise a continuous aqueous phase of greater than 50% by weight of the composition, with the remainder being a dispersed oil phase. The aqueous phase may comprise 1% to 99% water by weight, along with any water-soluble and / or water-miscible components. In these cases, the dispersed oil phase will typically be present at less than 30% by weight of the composition (e.g., 1% to 20%, 2% to 15%, 3% to 12%, 4% to 10%, or even 5% to 8%) to help avoid some undesirable sensory effects of oily compositions. The oil phase may include one or more volatile and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils).

[0055] Skin conditioning agent

[0056] Optionally, the compositions of the present invention may further comprise skin conditioning agents. These agents may be selected from humectants and emollients. The amount of skin conditioning agent, based on the weight of the composition, may range from about 1% to about 50%, preferably from about 2% to about 40%, more preferably from about 5% to about 30%.

[0057] Humectants are polyols intended for moisturizing, reducing buildup, and promoting the removal of accumulated buildup from the skin. Typical polyols include polyalkylene glycols, and more preferably alkylene polyols and their derivatives. Examples include propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexanediol, 1,3-butanediol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol, and mixtures thereof. Glycerin is the most preferred humectant.

[0058] When a conditioning agent is a moisturizer, it can be selected from hydrocarbons, fatty acids, fatty alcohols, and esters.

[0059] fatty alcohols

[0060] The compositions described herein may contain fatty alcohols. Fatty alcohols refer to high molecular weight straight-chain primary alcohols having the following general formula:

[0061]

[0062] Where n = 8 to 32.

[0063] Fatty alcohols can be natural or synthetic, saturated or unsaturated, branched or linear. Some non-limiting examples of fatty alcohols commonly used in cosmetic compositions include octanol, decanol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol. Fatty alcohols as used herein are generally indicated by the number of carbon atoms in the molecule. For example, "C12 alcohol" refers to an alcohol having 12 carbon atoms in its chain (i.e., dodecyl alcohol).

[0064] Fatty alcohols may be included in the compositions herein in amounts of 0.0001% to 15% (e.g., 0.0002% to 10%, 0.001% to 15%, 0.025% to 10%, 0.05% to 7%, 0.05% to 5%, or even 0.1% to 3%) based on the weight of the composition.

[0065] Whitening agent

[0066] The compositions of this invention may contain skin-whitening agents. Skin-whitening agents used herein refer to active ingredients that not only alter the appearance of the skin but also further improve hyperpigmentation compared to pretreatment. Suitable skin-whitening agents include ascorbic acid compounds, vitamin B3 compounds, azelaic acid, butylated hydroxyanisole, gallic acid and its derivatives, quinoline, kojic acid, arbutin, mulberry extract, tetrahydrocurcumin, and mixtures thereof. It is also believed that the use of combinations of skin-whitening agents is advantageous because they can provide beneficial skin-whitening effects through different mechanisms.

[0067] When used, the composition preferably contains about 0.1% to about 10%, more preferably about 0.2% to about 5% of a whitening agent by weight of the composition.

[0068] Ascorbic acid compounds are available whitening agents, and ascorbate glucoside is a preferred derivative of ascorbic acid compounds.

[0069] Conditioner

[0070] The compositions described herein may contain 0.1% to 50% by weight of a conditioning agent (e.g., 0.5% to 30% by weight, 1% to 20% by weight, or even 2% to 15% by weight). Adding a conditioning agent can help provide the composition with desired sensory properties (e.g., a silky, lubricating feel upon application). Some non-limiting examples of conditioning agents include hydrocarbon oils and waxes, siloxanes, fatty acid derivatives, cholesterol, cholesterol derivatives, diglycerides, triglycerides, vegetable oils, vegetable oil derivatives, acetylglucosides, alkyl esters, alkenyl esters, lanolin, wax esters, beeswax derivatives, sterols and phospholipids, their salts, isomers and derivatives, and combinations thereof. Particularly suitable examples of conditioning agents include volatile or non-volatile silicone fluids, such as polydimethylsiloxane copolyols, dimethylpolysiloxanes, diethylpolysiloxanes, mixed C1-30 alkylpolysiloxanes, phenyl polydimethylsiloxanes, polydimethylsiloxane alcohols, polydimethylsiloxanes, polydimethylsiloxanes, silicone crosspolymers, and combinations thereof. Polydimethylsiloxanes may be particularly suitable because some consumers associate the sensory properties provided by certain polydimethylsiloxane fluids with good moisturizing properties. Other examples of silicone fluids suitable as conditioning agents are described in U.S. Patent 5,011,681.

[0071] Thickener

[0072] In some embodiments, the compositions of the present invention may further comprise one or more thickeners.

[0073] The non-limiting class of thickeners includes those selected from: carboxylic acid polymers, cross-linked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums.

[0074] When present, the composition preferably contains about 0.01% to about 5%, more preferably about 0.1% to about 4%, and even more preferably about 0.1% to about 3% by weight of the composition.

[0075] emulsifier

[0076] When the composition is in emulsion form, it may contain an emulsifier. The emulsifier may be nonionic, anionic, cationic, or zwitterionic. Some non-limiting examples of emulsifiers are disclosed in U.S. Patents 3,755,560 and 4,421,769, U.S. Publication 2006 / 0275237, and McCutcheon's "Detergents and Emulsifiers," North American Edition, pages 317-324 (1986).

[0077] Suitable examples of emulsifiers include nonionic emulsifiers such as polysorbate 20, polysorbate 80, polyglycerol-4-decanoate, and glycerol-25-pyrrolidone carboxylic acid isostearate. A particularly suitable example of an emulsifier used in the compositions described herein is polysorbate 20.

[0078] Other optional ingredients

[0079] The compositions described herein may contain one or more optional ingredients known for use in topical cosmetic compositions, provided that the optional components do not unacceptably alter the intended beneficial effects of the composition. In some cases, it may be desirable to select cosmetic active substances that act via different biological pathways so that the active substances do not interfere with each other. When the composition is in the form of an emulsion, the added ingredients should not introduce instability (e.g., dehydration shrinkage) into the emulsion. For example, it may be desirable to select optional ingredients that do not form complexes with other ingredients in the composition, especially pH-sensitive ingredients such as vitamin B3 compounds, salicylates, and peptides.

[0080] Additives should be suitable for contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, etc. When present, additives may be included in an amount of about 0.001% to 50% (e.g., 0.01% to 40%, 0.1% to 30%, 0.5% to 20%, or even 1% to 10%) by weight of the composition. Some non-limiting examples of additives include vitamins, minerals, peptides and peptide derivatives, glycosamines, sunscreens, oil-controlling agents, particles, flavonoids, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliating agents, skin brighteners, sunscreens, sun-free tanning agents, lubricants, anti-acne agents, degreasing agents, chelating agents, anti-wrinkle active ingredients, anti-atrophy active ingredients, phytosterols and / or phytohormones, N-acyl amino acid compounds, antimicrobial agents, and antifungal agents. Some particularly suitable examples of additives include one or more skincare active substances selected from the group consisting of: vitamin B3 compounds (e.g., niacinamide), n-acyl amino acids (e.g., undecenoyl phenylalanine), vitamin E compounds (e.g., tocopheryl acetate), palmitoylated dipeptides (e.g., palmitoyl-lysine-threonine), palmitoylated pentapeptides (e.g., palmitoyl-lysine-threonine-threonine-lysine-serine), vitamin A compounds (e.g., retinol and retinyl propionate), and combinations thereof. Other non-limiting examples of optional ingredients and / or skincare active substances that may be used herein are described in U.S. Patent Publications 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 0092408, 2008 / 0206373, 2010 / 0239510, 2010 / 0189669, and 20 US Patent Nos. 10 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146 and 2013 / 0022557, and US Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359 and 6,174,533.

[0081] Method of using cosmetic compositions

[0082] This method of use involves identifying the target skin area of ​​a person to be treated and applying the composition to that target skin area during the treatment period. The target skin area may be on the surface of facial skin (such as the forehead, perioral region, chin, periorbital region, nose, and / or cheeks) or another part of the body (e.g., hands, arms, legs, back, chest). The person to be treated is someone whose skin exhibits signs of oxidative stress (such as fine lines, wrinkles, hyperpigmentation, uneven skin tone, and / or other visible skin features commonly associated with aging). In some cases, the target skin area may not show visible signs of skin aging, but if the area is one that typically develops such problems as a person ages, the user (e.g., a relatively young user) may still wish to target such skin areas. In this way, this method can be used as a preventative measure to delay the onset of visible signs of skin aging.

[0083] The composition may be applied to the target skin area and, if necessary, to the surrounding skin at least once daily, twice daily, or more frequently daily during the treatment period. When applied twice daily, the first and second applications should be spaced at least 1 to 12 hours apart. Typically, the composition may be applied in the morning and / or at bedtime. The treatment period may last at least one week (e.g., about 2, 4, 8, or even 12 weeks). In some cases, the treatment period may be extended to several months (i.e., 3 to 12 months). In some cases, the composition may be applied for most of the week (e.g., at least 4, 5, or 6 days a week), at least once daily or even twice daily during a treatment period of at least 2, 4, 8, or 12 weeks.

[0084] The application of the composition can be achieved through topical application. Regarding the application of the composition, the terms "topical," "local," and "partially" refer to delivering the composition to a target area (e.g., wrinkles or fine lines) while minimizing delivery to skin surfaces that are not intended for treatment. The composition can be applied to and gently massaged into the skin area. The form of the composition or a dermatologically acceptable carrier should be chosen to facilitate topical application. While some embodiments herein envision topical application of the composition to a specific area, it should be understood that the compositions herein can be widely applied to one or more skin surfaces. In some embodiments, the compositions herein can be used as part of a multi-step cosmetic regimen, wherein the compositions of the present invention can be applied before and / or after one or more other compositions.

[0085] Manufacturing method

[0086] The cosmetic composition of the present invention is preferably prepared by a manufacturing method comprising the step of preparing a mixture of the following substances:

[0087] (a) sucrose esters; and

[0088] (b) Solvent.

[0089] In view of dissolving sucrose esters, the mixture preferably contains about 70% to about 100%, more preferably about 80% to about 100%, and even more preferably about 90% to about 100% of the total amount of sucrose esters and solvents by weight of the mixture.

[0090] In the mixture, taking into account the dissolution of sucrose esters, the weight ratio between sucrose esters and solvents is preferably from about 1:1000 to about 1000:1, more preferably from about 1:100 to about 100:1, even more preferably from about 10:1 to about 1:10, even more preferably from about 5:1 to 1:5, and even more preferably from about 2.5:1 to 1:2.5. In another embodiment, taking into account the dissolution of sucrose esters, the weight ratio between sucrose esters and solvents is from about 2.5:1 to about 1:10, preferably from about 2.5:1 to about 1:5.

[0091] The method preferably further includes the step of mixing the mixture and the aqueous carrier. The weight ratio between the aqueous carrier and the mixture is preferably from about 1000:1 to about 1:1000, more preferably from about 1:100 to about 100:1, even more preferably from about 1:10 to about 10:1, even more preferably from about 5:1 to about 1:5, and even more preferably from about 2:1 to about 1:5. Adding an aqueous carrier to the mixture can provide improved sucrose ester solubility. Too much aqueous carrier may result in reduced transparency / transparency and / or reduced sucrose ester solubility, while too little aqueous carrier may not result in any noticeable improvement in sucrose ester solubility.

[0092] The above-described steps of mixing the aqueous carrier and the mixture may include two sub-steps: a first dilution and a second dilution. The first dilution is the dilution of the mixture with the aqueous carrier. The second dilution is the dilution of the diluted mixture obtained from the first dilution to prepare the final product formulation of the cosmetic composition. In the second dilution, the diluent can be any substance contained in the cosmetic composition, including but not limited to the aqueous carrier. In the first dilution, the weight ratio between the aqueous carrier and the mixture is preferably in the range of about 1:10 to about 10:1, more preferably about 5:1 to about 1:5, and even more preferably about 2:1 to about 1:5. In the second dilution for preparing the final cosmetic composition, the diluent and any other ingredients are added to an appropriate amount up to 100% of the cosmetic composition. In the second dilution, if included, other ingredients, such as thickeners, humectants, surfactants, pigments, powders, and oils, are added simultaneously and sequentially.

[0093] combination

[0094] A. A cosmetic composition, said cosmetic composition comprising, by weight:

[0095] (a) about 0.01% to about 50%, preferably about 0.1% to about 35%, more preferably about 0.5% to about 25%, and even more preferably about 1% to about 20% of one or more sucrose and fatty acid esters, wherein the fatty acid is selected from those having about 12 to about 24 carbon atoms, preferably about 12 to about 22 carbon atoms, more preferably about 12 to about 18 carbon atoms, and wherein the sucrose ester is selected from the group consisting of monoesters, diesters, triesters, tetraesters, and mixtures thereof;

[0096] (b) about 0.01% to about 90%, preferably about 0.1% to about 50%, more preferably about 0.5% to about 30% of one or more solvents, said one or more solvents being selected from those with a Hildebrand solubility parameter of about 23 to about 31.5, preferably about 23 to about 29 (J / cm³). 3 ) 1 / 2 Furthermore, the polar component of the Hansen solubility parameter is approximately 4.5 to approximately 10.5, preferably approximately 5 to approximately 9, and more preferably approximately 5.5 to approximately 8 (J / cm³). 3 ) 1 / 2 Those;

[0097] The composition said composition satisfies at least one of the following conditions:

[0098] The weight ratio between the sucrose ester and the solvent is about 2.5:1 to 1:10; and the solvent is pentanediol.

[0099] B. The composition according to the foregoing characteristics, wherein the mixture comprises about 70% to about 100%, preferably about 80% to about 100%, more preferably about 90% to about 100% of the sum of the sucrose ester and the solvent.

[0100] C. The composition according to any one of the foregoing features, wherein the fatty acid is selected from those having a saturated alkyl group having about 12 to about 24 carbon atoms.

[0101] D. The composition according to any one of the foregoing features, wherein the weight ratio between the sucrose ester and the solvent is about 1:1000 to about 1000:1, preferably about 1:100 to about 100:1, more preferably about 10:1 to about 1:10, even more preferably about 5:1 to 1:10, and even more preferably about 2.5:1 to 1:5.

[0102] E. The composition according to any one of the foregoing features, wherein the composition further comprises an aqueous carrier.

[0103] F. The composition according to any one of the foregoing features, wherein the sucrose ester contains about 10% to about 100%, preferably about 20% to about 100%, more preferably about 50% to about 90% of a higher ester, said higher ester being selected from the group consisting of diesters, triesters, tetraesters, and mixtures thereof.

[0104] Example

[0105] Table 1 - Mixtures (wt%)

[0106]

[0107] **i) After mixing at 80°C for 60 minutes, observe visually 24 hours later.

[0108] Table 2 - First Dilution (wt%)

[0109]

[0110] **ii) Visually observe the mixture after mixing it with deionized water for 1 minute at room temperature.

[0111] Table 3 - Second Dilution (wt%)

[0112]

[0113] **iii) Visually observe the mixture after mixing as follows:

[0114] (a) Mix the aqueous phase components at room temperature until homogenized;

[0115] (b) Mix the homogenized aqueous phase components from (a) with the first dilution from Table 2 for 5 minutes; and

[0116] (c) Mix the mixed components from (b) and the oil phase components at 5000 rpm for 5 minutes at room temperature using a homogenizer.

[0117] Element

[0118] *1 Sepigel 305: Contains 40% polyacrylamide as the active ingredient. INCI: Polyacrylamide, water, C13-14 isoparaffins, and Laureth-7.

[0119] *2 Ultrez 20:INCI: Acrylate / C10-30 alkyl acrylate crosspolymer

[0120] *3 Sepimax Zen:INCI: Polyacrylate Crosspolymer-6

[0121] *4 Eldew PS-203INCI: Phytosterols / Ocyldodecyllauroylglutamate

[0122] The second dilutions, Examples 1 to 5, are skincare compositions of the present invention. The second dilution CEx.i is a skincare composition provided as a comparative example. As shown in the table above, the compositions of the present invention can dissolve sucrose esters in the skincare compositions, while the comparative examples cannot dissolve sucrose esters.

[0123] The dimensions and values ​​disclosed herein should not be construed as strictly limited to the precise numerical values ​​cited. Rather, unless otherwise specified, each such dimension is intended to represent the stated value and a range around which it is functionally equivalent. For example, a dimension disclosed as “40 mm” is intended to represent “approximately 40 mm”.

[0124] Unless expressly excluded or otherwise limited, every reference cited herein, including any cross-references or related patents or patent applications, and any patent application or patent claiming priority to or benefiting from it, is incorporated herein by reference in its entirety. Reference to any reference is not an endorsement of it as prior art to any disclosed or protected art herein, nor is it an endorsement of any such invention, either on its own or in combination with any one or more references. Furthermore, where any meaning or definition of a term in this invention conflicts with any meaning or definition of the same term in referenced documents, the meaning or definition given to that term in this invention shall prevail.

[0125] While specific embodiments of the invention have been illustrated and described by way of example, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications falling within the scope of the invention be covered by the appended claims.

Claims

1. A cosmetic composition comprising a sucrose ester, wherein the sucrose ester is dissolved in a continuous aqueous phase of the composition, the composition comprising: One or more esters of sucrose and lauric acid, comprising 0.5% to 25% by weight of the composition; and 0.5% to 30% solvent by weight of the composition; in: The sucrose ester comprises 20% to 100% higher esters by weight of the sucrose ester; The higher esters are selected from the group consisting of dilaurate, trilaurate, tetralaurate, and mixtures thereof; The sucrose dilaurate is present at a concentration of 35% or more based on the weight of the sucrose ester; the weight ratio between the sucrose ester and the solvent is 2.5:1 to 1:

10. The solvent is pentanediol; and The composition is an oil-in-water emulsion, wherein the dispersed oil phase is present in an amount of 1% to 8% by weight of the composition.

2. The composition according to claim 1, wherein the composition comprises, by weight of 1% to 20%, one or more esters of sucrose and lauric acid.

3. The composition according to claim 1, wherein the mixture comprises 70% to 100% of the sum of the sucrose ester and the solvent.

4. The composition according to claim 1, wherein the mixture comprises 80% to 100% of the sum of the sucrose ester and the solvent.

5. The composition according to claim 1, wherein the mixture comprises 90% to 100% of the sum of the sucrose ester and the solvent.

6. The composition according to claim 1, wherein the weight ratio between the sucrose ester and the solvent is 2.5:1 to 1:

5.

7. The composition according to claim 1, wherein the composition further comprises an aqueous carrier.

8. The composition according to claim 1, wherein the sucrose ester contains 50% to 90% of a higher ester selected from the group consisting of dilaurate, trilaurate, tetralaurate, and mixtures thereof.

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