一种甘草酸稳定的Pickering中低内相凝胶乳液及其制备方法和应用

By combining glycyrrhizic acid with plant essential oils to form nanofiber particles, a glycyrrhizic acid-stabilized Pickering medium-low internal phase gel emulsion was prepared, which solved the problems of insufficient stability and antibacterial properties of traditional dressings in the wound healing of diabetic patients, and achieved effective repair of wounds in diabetic patients.

CN116606452BActive Publication Date: 2026-07-17WENZHOU INST UNIV OF CHINESE ACAD OF SCI

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
Filing Date
2023-05-18
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In the existing technology, traditional wound dressings are not effective in healing chronic wounds of diabetic patients, synthetic dressings are expensive and have poor stability, and hydrogel dressings are prone to damaging the skin and have limited application range, making it difficult to meet the high requirements of diabetic patients.

Method used

By using a glycyrrhizic acid-stabilized Pickering low-internal-phase gel emulsion, glycyrrhizic acid small molecules are self-assembled to form nanofiber particles, which are then combined with plant essential oils to prepare a stable gel emulsion that can be formed without a high internal phase. This emulsion has antibacterial, anti-inflammatory, and healing-promoting properties.

Benefits of technology

This gel emulsion exhibits good stability and antibacterial properties in wound healing in diabetic patients. It can slowly release oil phase solvents, providing effective wound repair and is suitable for the treatment of chronic wounds in diabetic patients.

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Abstract

本发明涉及生物医用技术领域,尤其涉及一种甘草酸稳定的Pickering中低内相凝胶乳液及其制备方法和应用,所述甘草酸稳定的Pickering中低内相凝胶乳液的形成过程包括:以甘草酸小分子在降温过程中自组装形成纳米纤维粒子,以纳纤维米粒子为固体粒子稳定Pickering乳液,通过纳米纤维粒子的桥联作用诱导Pickering乳液参与超分子凝胶的网络构建,从而无需高内相就能形成中低内相的Pickering凝胶乳液。本发明中的甘草酸稳定的Pickering中低内相凝胶乳液对大肠杆菌和金黄色葡萄球菌都具有良好的抗菌性能,同时该凝胶乳液对糖尿病患者伤口愈合具有良好的修复作用,是一种兼具抗菌、消炎、修复作用的生物医用材料,具有良好的应用前景。
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