一种含有大鲵皮肤分泌物的非对称纳米纤维膜及其制备方法和应用
By preparing asymmetric nanofiber membranes containing secretions from the skin of giant salamanders, the problems of pain and secondary damage during wound dressing changes have been solved, enabling painless dressing changes and tissue regeneration, and exhibiting good biocompatibility and antibacterial properties.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- UNIV OF SCI & TECH BEIJING
- Filing Date
- 2023-05-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing wound dressings are prone to causing pain and secondary injury when changed, and it is difficult to achieve painless changes during wound healing. They also lack effective adhesion and biocompatibility.
Asymmetric nanofiber membranes were prepared by configuring polylactic acid electrospinning solution and gelatin-salamander mixed spinning solution. The polylactic acid outer layer isolates moisture and bacteria, while the gelatin inner layer adheres strongly to the wound. Combined with thermopressing technology, a self-adhesive dressing is formed. The gelatin layer can be decomposed after repair, enabling painless replacement.
It achieves self-adhesion and painless replacement of wound dressings, promotes tissue regeneration, has good biocompatibility and antibacterial properties, avoids secondary damage and pain, and is suitable for dynamic wound management.
Smart Images
Figure CN116607266B_ABST