Amino acid modified ionic liquid, its preparation method and application

Amino acid-modified ionic liquids improve drug delivery in the gastrointestinal tract, addressing the safety and absorption deficiencies of existing ionic liquids in drug delivery, and achieving higher drug bioavailability and safety.

CN116617403BActive Publication Date: 2026-05-19PEKING UNIV
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Patent Information

Application Number
CN202310602534.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-05-26
Publication Date
2026-05-19
Estimated Expiration
2043-05-26

AI Technical Summary

Technical Problem

Existing ionic liquids have shortcomings in drug delivery, including insufficient safety and absorption-enhancing effectiveness. In particular, they have low oral bioavailability for macromolecular drugs and are unable to overcome multiple barriers in the gastrointestinal tract, such as mucus and intestinal epithelial barriers, which affects the solubility, permeability, and stability of the drugs.

Method used

A novel anion was prepared by modifying geraniol with amino acid-modified ionic liquids by introducing natural amino acids or amino acid repeating segments. The anion was then paired with alkyl quaternary ammonium ions containing hydroxyl groups to adjust the structure of the ionic liquid, thereby enhancing its permeability and biocompatibility in intestinal mucus and intestinal epithelium and reducing its toxicity to cells.

Benefits of technology

It significantly improved the oral bioavailability of the drug, enhanced the drug's penetration into intestinal mucus and intestinal epithelium, reduced the impact on the gut microbiota, and improved safety and delivery efficiency.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides an amino acid modified ionic liquid and a preparation method and application thereof, the amino acid modified ionic liquid is an A-B structured compound comprising a cation A and an anion B; the cation A is a branched alkyl quaternary ammonium ion containing only one hydroxyl group; the anion B is a different amino acid modified geranic acid, and the different amino acid modified geranic acid is a monomer, a same and / or mixed amino acid dipeptide and / or polypeptide with a general formula B structure. The amino acid modified ionic liquid provided by the application not only has good oral safety, but also significantly enhances drug oral absorption, and can be used as a drug carrier, a dissolving agent, a penetration enhancer, a diluent and / or a dispersant, a surfactant in the drug field, is used for dispersing a drug active ingredient, enhances the solubility and / or permeability of the drug active ingredient, improves the stability of the drug in the gastrointestinal tract, and improves the transdermal absorption capacity of the active molecule.
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