一种生物墨水及其应用以及阴茎海绵体假体及其制备方法

The use of bio-ink 3D printing technology to fabricate penile corpora cavernosa prostheses solves the problems of poor biocompatibility and customization of existing prosthesis materials, and realizes high-precision, low-cost personalized penile prostheses with good biocompatibility and safety.

CN116617461BActive Publication Date: 2026-07-17SOUTH CHINA UNIV OF TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Filing Date
2023-06-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing penile prosthesis materials suffer from poor biocompatibility, inadequate stiffness, poor customizability, and high cost, which affect patient comfort and functionality.

Method used

Penile cavernous body prostheses are fabricated using bio-ink through 3D printing technology. A hydrogel matrix is ​​formed using polymer-based materials, initiators, crosslinking agents, and light absorbers. This matrix is ​​combined with biomimetic vascular sinus cavities and biomimetic white membrane structures. The prosthesis structure is formed through photocuring and crosslinking, and then coated with an anticoagulant layer.

Benefits of technology

A biocompatible penile cavernous body prosthesis has been developed, which can simulate erection and flaccidity, meet personalized customization needs, reduce the risk of thrombosis, and is low in cost and quick to form.

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Abstract

本发明属于生物医用材料技术领域,提供了一种生物墨水及其应用以及阴茎海绵体假体及其制备方法,本发明提供的生物墨水,包含高分子基材料、引发剂、交联剂、光吸收剂和水,本发明提供的生物墨水在紫外光照射下可发生凝胶化反应,得到的水凝胶基体材料的断裂伸长率可达200~600%,从而应用到3D打印中。本发明还提供了一种阴茎海绵体假体,本发明提供的阴茎海绵体假体以生物相容性水凝胶作为基体材料,经过涂覆得到的抗凝血层,可有效的降低血栓形成的风险,安全稳定性好。本发明的阴茎海绵体假体具有仿生血管窦腔和仿生白膜结构,注水膨胀对应勃起状态,泄压恢复对应疲软状态,使得阴茎保持更为正常的外观形态。
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