Iron-nickel foam-based mimetic enzyme, and preparation method and application thereof

By preparing a mimic enzyme based on iron-nickel foam and combining it with polydopamine nanoparticles, along with natural enzymes, the problems of operational complexity and long time in the colorimetric detection of hydrogen peroxide and glucose using iron-based nanomaterials were solved, achieving simplified and efficient detection.

CN116637622BActive Publication Date: 2026-05-29CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
Filing Date
2023-05-30
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing iron-based nanomaterials are complex to operate in the colorimetric detection of hydrogen peroxide and glucose. Nanoparticle aggregation leads to reduced enzyme-like activity, and reliance on large detection instruments results in long detection times.

Method used

An enzyme-simulated method based on iron-nickel foam is used. The morphology is calcined to form a wrinkled shape to increase the specific surface area. This is then combined with polydopamine nanoparticles and natural enzymes for detection. The detection is performed using a smartphone and a matching light source device.

Benefits of technology

The detection process is simplified, the simulated enzyme and reaction solution are easily separated, the detection time is short, the overall detection time is less than 10 minutes, and the detection results are accurate.

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Abstract

The application provides an iron-nickel foam-based artificial enzyme and a preparation method thereof. The artificial enzyme is obtained by calcining iron-nickel foam, and the artificial enzyme is folded in morphology due to calcination and is convenient to separate from a reaction solution. The artificial enzyme is compounded with polydopamine nanoparticles to obtain a composite material, which can be used for detecting hydrogen peroxide. The composite material is further condensed with a natural enzyme to obtain an integrated enzyme, which can be used for detecting glucose. In the process of colorimetric detection of hydrogen peroxide or glucose, a smart phone and a matching light source device are used for detection, and the overall detection time is less than 10 min.
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