千层纸素A在治疗肺动脉高压药物中的应用
Thousand-layer paper pigment A is used to treat pulmonary hypertension. By improving pulmonary arteriolar remodeling and reducing pulmonary hypertension, it overcomes the shortcomings of existing drugs in preventing and reversing vascular remodeling, and achieves better therapeutic effects.
CN116672333BActive Publication Date: 2026-07-17ZUNYI MEDICAL UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZUNYI MEDICAL UNIVERSITY
- Filing Date
- 2023-07-13
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing drug treatments for pulmonary arterial hypertension (PAH) have limited effectiveness in preventing and reversing vascular remodeling, and there is a lack of drugs that can effectively improve pulmonary artery remodeling.
Method used
Oroxylin A (OA) was used as a novel drug component and administered via gavage to treat pulmonary hypertension induced by lily alkaloids, and its ameliorative effect on pulmonary hypertension was studied.
Benefits of technology
Thousand-layer paper pigment A significantly reduced pulmonary hypertension in rats, improved pulmonary arteriolar remodeling, reduced pulmonary vascular stenosis and fibrosis, and enhanced the therapeutic effect on pulmonary hypertension.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN116672333B_ABST
Abstract
本方案公开了化合物应用技术领域的千层纸素A在治疗肺动脉高压药物中的应用。本发明发现千层纸素A对肺动脉高压具有良好的治疗和改善作用，在扩大千层纸素A的应用范围的同时，为PAH的治疗提供新的选择。
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