一种新型高载药量微针制造方法
By preparing excipient solutions and API suspensions, combined with photosensitive adhesives and ultraviolet light irradiation, high drug-load microneedles were prepared, solving the problem of low drug loading in existing microneedles and improving efficient drug delivery and puncture capabilities.
CN116690871BActive Publication Date: 2026-07-17NANTONG WEIZHEN PHARM TECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANTONG WEIZHEN PHARM TECH CO LTD
- Filing Date
- 2023-06-21
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing microneedles have low drug loading capacity, which limits their application range and mechanical properties, making it difficult to deliver high doses of drugs. Furthermore, their porous structure reduces their puncture capability.
Method used
High-drug-load microneedles were prepared by using excipient solution preparation and API suspension preparation, and by vacuum concentration of API in microneedle mold, combined with photosensitive adhesive and ultraviolet light irradiation. The drug content in the microneedles was detected by high-performance liquid chromatography.
Benefits of technology
This improved the drug loading capacity of microneedles, enhanced their puncture ability, expanded their application range, and achieved efficient drug delivery.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN116690871B_ABST
Abstract
本发明的目的是提供一种新型高载药量微针制造方法，包括辅料溶液配置、API悬浮液的配置、微针制备和微针检测，所述辅料溶液配置为在NVP溶液中加入光引发剂，光引发剂的浓度范围为0‑5％，光敏胶的浓度为1.5％，所述API悬浮液的配置为在辅料溶液中加入API，形成API悬浮液，提供可提高微针载药量的通用方法。
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