一种GST蛋白抑制剂、其制备方法、药用组合物及其用途

By developing GST inhibitors with a quinazolinone structural backbone, the problems of insufficient selectivity and inhibitory activity in existing technologies have been solved, achieving effective inhibition of multidrug resistance in tumor cells and therapeutic effects with fewer side effects.

CN116693515BActive Publication Date: 2026-07-17SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
Filing Date
2022-02-25
Publication Date
2026-07-17

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Abstract

本发明涉及一种GST抑制剂、其制备方法、药用组合物及其用途。具体地，本发明提供了一类式I所示结构的化合物，其中各基团和取代基的定义如说明书中所述；本发明还公开了所述式I化合物的制备方法及其在预防和 / 或治疗GST异常活性相关疾病方面的用途。
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