Pesticidal compositions

Abstract

A pesticidal composition comprising: (i) from 25% to 35% by weight of pyridalyl; (ii) from 20% to 30% by weight of acetamiprid; and (iii) from 2.5% to 10% by weight of a buffer, based on the total weight of the composition, comprising: (a) from 2% to 7% by weight of an alkali metal or alkaline earth metal sulfate, and (b) from 0.1% to 5% by weight of an organic acid.

Description

[0001] This invention relates to compositions comprising a combination of insecticidal active ingredients, the preparation of such compositions, and methods of using such compositions to control harmful organisms in crops containing beneficial plants.

[0002] Insecticidal compositions comprising a combination of the insecticidal active ingredient methoxypiperidine ethyl ester and another active ingredient are known, for example, from WO 2013 / 107793. However, in some compositions used to control insects on crop plants, the chemical instability of the active ingredient (e.g., methoxypiperidine ethyl ester) can be a problem leading to a loss of insecticidal performance. Therefore, there remains a strong motivation to develop insecticidal compositions in which the active ingredient component maintains long-term chemical stability for practical purposes.

[0003] According to the present invention, a pest-killing composition is provided, comprising:

[0004] (i) 25% to 35% by weight of ethyl methoxypiperidine;

[0005] (ii) 20% to 30% by weight of acetamiprid; and

[0006] (iii) 2.5% to 10% by weight of a buffer, which, based on the total weight of the composition, comprises:

[0007] (a) 2% to 7% by weight of alkali metal sulfates and / or alkaline earth metal sulfates, and

[0008] (b) 0.1% to 5% organic acids by weight.

[0009] For practical purposes, the pest-killing compositions of the present invention exhibit highly advantageous levels of activity in controlling insect pests in crops with beneficial plants when applied foliar or in the soil, while maintaining acceptable crop safety (phytotoxicity) results. Activity means that the compositions of the present invention are able to kill or control insects, delay insect growth or reproduction, reduce insect populations, and / or reduce insect-induced damage to plants.

[0010] Furthermore, it has been unexpectedly discovered that the addition of organic acids (e.g., citric acid) to certain compositions containing methoxypiperidine ethyl ester and acetamiprid significantly improves the chemical stability of the methoxypiperidine ethyl ester active ingredient component and thus significantly improves the effective shelf life of compositions containing these two active ingredients.

[0011] Furthermore, according to the present invention, an aqueous composition is provided comprising the pest-killing composition according to the present invention, optionally further comprising one or more adjuvants or carriers.

[0012] Furthermore, according to the present invention, a (non-therapeutic) method for combating and controlling pests is provided, comprising applying the composition according to the present invention to the pest, to the site of the pest, or to a crop of useful plants susceptible to pest attack.

[0013] Ethyl methoxypiperidine ([3-(4-chloro-2,6-dimethyl-phenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl]ethyl carbonate. CAS No.: 1229023-00-0) is known particularly from WO 2010 / 066780, WO2018 / 114648 and WO 2018 / 114649. Acetamiprid ((1E)-N-[(6-chloro-3-pyridyl)methyl]-N'-cyano-N-methyl-acetamiprid. CAS No.: 135410-20-7) is known particularly from EP 0 456 826. Certain pesticide mixtures containing ethyl methoxypiperidine and acetamiprid as active ingredients are known from WO 2013 / 107793.

[0014] Preferably, the composition according to the invention comprises, as a bioactive ingredient, (i) 28% to 32% by weight of methoxypiperidine ethyl ester and (ii) 22% to 26% by weight of acetamiprid, more preferably (i) 29% to 31% by weight of methoxypiperidine ethyl ester and (ii) 23% to 25% by weight of acetamiprid.

[0015] The composition according to the invention comprises methoxypiperidine ethyl ester and acetamiprid as bioactive ingredients in a weight ratio of 5:6 to 7:4, and preferably in a weight ratio of 1:1 to 3:2.

[0016] Preferably, the composition according to the invention comprises 4.5% to 8% by weight of a buffer, and based on the total composition, it comprises 4% to 6% by weight of an alkali metal sulfate and 0.5% to 2.5% by weight of an organic acid. Most preferably, the composition according to the invention comprises 4.5% to 6.5% by weight of a buffer, and based on the total composition, it comprises 4% to 6% by weight of an alkali metal sulfate and 0.5% to 1.5% by weight of an organic acid.

[0017] More preferably, the composition according to the invention comprises 4.5% to 8% by weight of a buffer, and based on the total composition, it comprises 4% to 6% by weight of an alkali metal sulfate and 0.5% to 2.5% by weight of citric acid. Most preferably, the composition according to the invention comprises 4.5% to 6.5% by weight of a buffer, and based on the total composition, it comprises 4% to 6% by weight of an alkali metal sulfate and 0.5% to 1.5% by weight of citric acid.

[0018] The buffer component of the compositions of the present invention may include alkali metal sulfates or alkaline earth metal sulfates, or a combination of alkali metal sulfates and alkaline earth metal sulfates. Preferably, the alkali metal sulfate used in the compositions of the present invention is potassium sulfate or sodium sulfate, and most preferably sodium sulfate.

[0019] Preferably, the organic acid used according to the present invention is an organic acid containing one, two, or three carboxylic acid groups. More preferably, the organic acid is a tricarboxylic acid (i.e., containing three carboxylic acid groups). Even more preferably, the organic acid is citric acid or a salt thereof, such as a sodium or potassium salt of citric acid (sodium citrate or potassium citrate). Most preferably, the organic acid is citric acid.

[0020] In a preferred embodiment, based on the total weight of the composition (i.e., at most 100% by weight), the composition of the present invention further comprises:

[0021] (iv) 15% to 20% by weight of one or more dispersants;

[0022] (v) 1% to 5% by weight of defoamer; and

[0023] (vi) 15% to 30% by weight of filler, wherein optionally, based on the total weight of the composition, the filler comprises:

[0024] (c) 5% to 15% by weight of polymethylurea resin filler, and

[0025] (d) 10% to 15% by weight of lactose monohydrate filler.

[0026] In other preferred embodiments, the composition of the present invention may contain 1% to 3% by weight of a defoamer, and preferably 1.5% to 2.5% by weight of a defoamer.

[0027] In other preferred embodiments, the compositions of the present invention may contain 15% to 25% filler by weight, and preferably 18% to 22% filler by weight.

[0028] Preferably, the composition of the present invention is a water-dispersible particle (WG), which can be defined as a solid particulate formulation that, when added to water in a spray can, can be rapidly dispersed or dissolved, thereby providing a fine particulate suspension containing one or more harmful bioactive ingredients. The water-dispersible particles containing the composition according to the present invention can be prepared according to standard methods. The water-dispersible particles can be in the form of extruded particles or spray-agglomerated particles.

[0029] Preferably, in the aqueous composition according to the invention (e.g., a tank-mixed formulation for application to crops), the adjuvant is selected from mineral oil, vegetable oil, esterified vegetable oil, methylated vegetable oil, or alkyl phosphate adjuvant. A pest control adjuvant can be defined as a substance present in a pest control composition (e.g., a concentrated active ingredient formulation diluted in water in a tank for foliar spray application to crops) that, for example, improves the performance of the pest control active ingredient by promoting the spread of the active ingredient on the leaf surface or its penetration into the leaves of the crop plant.

[0030] Examples of adjuvant classes that can be used according to the present invention include mineral oils, vegetable oils, esterified vegetable oils, methylated vegetable oils, or alkyl phosphate ester adjuvants. Commercially available adjuvant products that can be barrel-mixed with the compositions of the present invention to produce aerosol formulations include HASTEN. TM (Victorian Chemical Co. Pty. Ltd. - Blends of esterified vegetable oils and nonionic surfactants) Syngenta - Alkyl Phosphate (EC Formulation) and LEDNA TM (Polaquimia - EC formulation containing soybean methyl ester) 463 (CRODA Europe Limited - 60% Paraffin Oil and Surfactant Blend) B (Bayer AG - rapeseed oil methyl ester (esterified vegetable oil)) HC (Winfield Solutions Ltd. - Methylated Soybean Oil) (HELENA Corporation - a blend of (methylated) vegetable oils and silicone-based nonionic surfactants), and FS Optique TM (GROWMARK Company - Methyl canola oil).

[0031] If the alkyl phosphate adjuvant is used in combination with the pest-killing composition according to the invention (i.e., in a barrel mix), the alkyl phosphate ester of the adjuvant is preferably tri-(2-ethylhexyl) phosphate, preferably used in combination with ethoxylated sorbitan hexaoleate, for example... Syngenta Corporation.

[0032] Dispersants are typically surfactants that, when added to a suspension of solid particles in a liquid, enhance particle separation to prevent sedimentation or agglomeration. Dispersants that can be used according to the present invention include, but are not limited to, ligninates (e.g., Ufoxane 3A, Borregard AS; Borresperse NA, Borregard AS; Polyfon). TM H, Ingevity, Inc.; Marasperse CBOS-4 powder, LignoTech, Inc.), naphthalene sulfonates (e.g., Dispergator B Gran, TFL Ledertechnik Ltd.), copolymers of 2,5-furandione and 2,4,4-trimethylpentene (e.g., Ta / 72, Solvay.

[0033] Defoamers are chemical additives that reduce and inhibit the formation of foam in compositions such as pesticides. Defoamers that can be used according to the present invention include, but are not limited to, polydimethylsiloxanes (e.g., XIAMETER). TM ACP-1500, Dow, Inc.; Antifoam MSA, Univar; Xiameter ACP-0001, Dow Brasil; Xiameter ACP-0100, Dow Chemical.

[0034] The fillers that can be used according to the present invention include, but are not limited to, polymethylurea resin ( M, Huber Engineering Materials, Inc.; Cropal UF100H, Yoo Sung Chemical Research & Development Co., Ltd.), Lactose Monohydrate ( 200M, DFE Pharmaceuticals; Lactose monohydrate, Foremost Farms, USA; Excipress TM Armor Pharmaceuticals; Excipure TM Armor Pharmaceuticals; anhydrous lactose, Kerry Pharmaceuticals.

[0035] Examples of pests that can be controlled by the compositions according to the present invention include:

[0036] From the order Acari, including species of the genera *Acalitus*, *Aculus*, *Acaricalus*, *Aceria*, *Acarussiro*, *Amblyomma*, *Argas*, *Boophilus*, *Brevipalpus*, *Bryobia*, *Calipitrimerus*, *Chorioptes*, *Dermanyssus gallinae*, *Dermatophagoides*, and *Eotetranychus*. Species of the genera *Eriophyes*, *Hemitarsonemus*, *Hyalomma*, *Ixodes*, *Olygonychus*, *Ornithodoros*, *Polyphagotarsone latus*, *Panonychus*, *Phyllocoptruta oleivora*, *Phytonemus*, *Polyphagotarsonemus*, *Psoroptes*, *Rhipicephalus*, and *Rhizoglyphus*. spp.), species of the genus Sarcoptes spp., species of the genus Steneotarsonemus spp., species of the genus Tarsonemus spp., and species of the genus Tetranychus spp.;

[0037] From the order Lobes, such as species of the genera *Haematopinus* spp., *Linognathus* spp., *Pediculus* spp., *Pemphigus* spp., and *Phylloxera* spp.;

[0038] From the order Coleoptera, such as species of the genera *Agriotes* spp., *Amphimallonmajale*, *Anomala orientalis*, *Anthonomus* spp., *Aphodius* spp., *Astylus atromaculatus*, *Ataenius* spp., *Atomaria linearis*, *Chaetocnema tibialis*, *Cerotoma* spp., *Conoderus* spp., *Cosmopolites* spp., *Cotinis nitida*, *Curculio* spp., *Cyclocephala* spp., and *Dermestes*. Species of the genera *Diabrotica* (spp.), *Diloboderus abderus*, *Epilachnas* (spp.), *Eremnus*, *Heteronychus arator*, *Hypothenemushampei*, *Lagria vilosa*, *Leptinotarsa ​​decemLineata*, *Lissorhoptrus* (spp.), *Liogenys*, *Maecolaspis*, *Maladeracastanea*, *Megascelis* (spp.), *Melighetes aeneus*, *Melolontha* (spp.), *Myochrous armatus*, *Orycaephilus* (spp.), and *Otiorhynchus* (spp.). spp.), species of the genera *Phyllophaga*, *Phlyctinus*, *Popillia*, *Psylliodes*, *Rhyssomatus aubtilis*, *Rhizopertha*, the family Scarabidae, and species of the genus *Sitophilus*.), species of the genera *Sitotroga*, *Somaticus*, *Sternechus subsignatus*, *Tenebrio*, *Tribolium*, and *Trogoderma*.

[0039] From the order Diptera, such as species of the genera *Aedes*, *Anopheles*, *Antherigona soccata*, *Bactrocea oleae*, *Bibiohortulanus*, *Bradysia*, *Calliphora erythrocephala*, *Ceratitis*, *Chrysomyia*, *Culex*, *Cuterebra*, *Dacus*, *Delia*, *Drosophila melanogaster*, *Fannias*, *Gastrophilus*, and *Geomyza*. *Tripunctata*, *Glossina* spp., *Hypoderma* spp., *Hyppobosca* spp., *Liriomyza* spp., *Lucilia* spp., *Melanagromyza* spp., *Musca* spp., *Oestrus* spp., *Orseolia* spp., *Oscinella frit*, *Pegomyia hyoscyami*, *Phorbia* spp., *Rhagoletis* spp., *Rivelia quadrifasciata*, *Scatella* species, *Sciara* spp., *Stomoxys* spp., *Tabanus* species spp.), species of the genus *Tannia* spp., and species of the genus *Tipula* spp.;

[0040] From the order Hemiptera, such as *Acanthocoris scabrator*, species of *Acrosternum*, *Adelphocoris lineolatus*, *Bathycoelia thalassina*, species of *Clavigralla tomentosicollis*, species of *Creontiades*, *Dichelops furcatus*, species of *Edessa*, species of *Euchistus*, *Eurydemapulchrum*, species of *Platystomum*, *Tea-winged*, and *Horcias*. Species of the genera *nobilellus*, *Rhizophora*, *Pterocarya*, *Tropical scale insects*, *Murgantia histrionic*, *Nesidiocoris tenuis*, *Nysius simulans*, *Island bugs*, *Dermacus*, *Cephalophora*, *Rhizophora*, *Coca brown mirid bugs*, *Scaptocoris castanea*, *Scotinophara*, *Thyanta*, *Triatophora*, and *Vatigailludens*.

[0041] From the order Hemiptera, such as the pea aphid (Acyrthosium pisum), species of the genus *Adalges*, *Agalliana ensigera*, *Talgilon psyllid*, species of the genus *Aleurodicus*, species of the genus *Aleurocanthus*, sugarcane whitefly, soft-haired whitefly (Aleurothrixus floccosus), cabbage whitefly (Aleyrodes brassicae), cotton leafhopper (Amarasca biguttula), lemon leafhopper, species of the genus *Aonidiella*, golden orange kidney scale (Aonidiella auranti), aphids, species of the genus *Aspidiotus*, *Acyrthosium pisum*, potato psyllid (Bactericera cockerelli), species of the genus *A.*, and species of the genus *Brachycaudus*. spp.), cabbage aphid, species of the genus *Cavariella* aegopodii Scop., species of the genus *Cavariella*, black-brown round shield scale, orange-brown round shield scale, species of the genus *Cofana*, species of the genus *Cofana*, species of the genus *Cryptospira*, species of the genus *C.*, brown soft scale, yellow-winged corn leafhopper, species of the genus *Nyctaginis*, citrus psyllid, wheat double-tailed aphid, species of the genus *C.*, species of the genus *C.*, woolly apple aphid, species of the genus *C.*, species of the genus *Gascardia*, *Glycaspis brimblecombei*, *Hyadaphis pseudobrassicae*, species of the genus *Hyalopterus*, and species of the genus *Hyperomyzus* *Pallidus*, *Idioscopusclypealis*, *African leafhopper*, *Grey planthopper* species, *Soil scale*, *Oyster scale* species, *Lopaphiserysimi*, *Lyogenys maidis*, *Long-tubed aphid* species, *Froghopper* species, *Metcalfa pruinosa*, *Wheat leafhopper*, *Wheat waxhopper*, *Gallus aphid* species, *Neotoxoptera sp.*, *Black-tailed leafhopper* species, *Nilaparvata spp.*, *Pear green aphid*, *Odonaspis ruthae*, *Sugarcane cotton aphid*, *Myrica rubescens*, *Psyllid* species, *Scale insect* species, *Gallus aphid* species, *Corn waxhopper*, *Flat-horned planthopper* species, *Hylloxera* species, *Phylloxera spp.*), species of the genera *Pseudatomoscelis*, *Pulvinaria aethiopica*, *Quesada gigas*, *Recilia dorsalis*, *Pseudococcus*, *Pulvinaria aethiopica*, *Quesada gigas*, *Recilia dorsalis*, *Sitobion*, *Spissistilus festinus*, *Tarophagus Proserpina*, *Tridiscus sporoboli*, *Trionymus*, *Pseudococcus africanus*, *Zyginidia scutellaris*;

[0042] From the order Hymenoptera, such as species of the genera *Acromyrmex*, *Arge* spp., *Atta* spp., *Cephus* spp., *Diprion* spp., *Diprionidae*, *Gilpinia polytoma*, *Hoplocampa* spp., *Lasius* spp., *Monomorium pharaonis*, *Neodiprion* spp., *Pogonomyrmex* spp., *Solenopsis* spp., and *Vespa* spp.;

[0043] From the order Isoptera, such as species of the genera *Coptotermes*, *Corniternes cumulans*, *Incisitermes*, *Macrotermes*, *Mastotermes*, *Microtermes*, and *Reticulitermes*; tropical fire ants (*Solenopsis* geminate);

[0044] From the order Lepidoptera, such as species of the genera *Longwinged Roller*, *Brown-banded Roller*, *Clearwing Moth*, *Gnaphalium*, cotton leafminer, *Amylois*, *Lysimachia*, *Yellow Roller*, *Argyresthia spp.*, *Betweenlea*, *Spodoptera*, cotton leafminer, corn leafminer, powdery mildew moth, peach fruit borer, *Grass borer*, *Leaf Roller*, *Chrysoteuchia topiaria*, grape fruit borer, *Leaf Roller*, *Cloud Roller*, *Striped Roller*, *Shellworm*, Lepidoptera butterflies, and *Cosmophila*. (flava), species of the genera *Pterocarya*, *Catharanthus*, *Ophiopogon*, *Epinotia* spp., *Etiella zinckinella*, species of *Epinotia*, *Epinotia jaculiferia*, species of *Grapholita*, *Epinotia spp. ... *Bifidalis*, species of the genera *Bombyx moth*, *Minter moth*, *Ephemeral leafminer*, *Cabbage moth*, *Tobacco hawk moth*, species of the genera *Mythimna*, *Minter moth*, *Geometrid moth*, *Orniodes indica*, European corn borer, species of the genera *Small leafroller*, *Brown leafroller*, *Small-eyed leafroller*, *Stem borer*, *Red bollworm*, *Coffee leafminer*, *One-spotted armyworm*, *Pot leafminer*, cabbage white butterfly, species of the genera *Butterfly*, *Petaling leafroller*, species of the genera *Geometrid moth*, *Peppermint leafroller*, *Richia albicosta*, species of the genera *Scirpophaga spp.*, species of the genera *Stem borer*, *Long-haired leafroller*, *Grey-winged leafroller*, cotton leafroller, species of the genera *Heteropterus*, species of the genera *Heteropterus*, *Leafroller*, *Powdered leafroller*, *Tomato leafminer*, and species of the genera *Ophiopogon*.

[0045] From the order Trichophagida, for example, species of the genera *Leptococcus* and *Leptococcus*;

[0046] From the order Orthoptera, such as the genera *Berberis*, *Berberis*, *Mole cricket*, *Madeira cockroach*, *Migratory locust*, *Neocurtilla hexadactyla*, *Berberis*, *Scapteriscus spp*, and *Desert locust*;

[0047] From the order Psittaciformes, such as species of the genus *Liposcelis*;

[0048] From the order Siphonaptera, such as species of the genera *Ctenopharynx*, *Ctenopharynx*, and *Xenopsyllacheopis*;

[0049] From the order Thysanoptera, such as *Calliothrips phaseoli*, species of the genera *Frankliniella*, *Heliothrips*, *Hercinothrips*, *Parthenothrips*, *Scirtothrips aurantii*, *Sericothrips variabilis*, species of the genera *Taeniothrips*, and species of the genera *Thrips*; and / or

[0050] From the order Thysanura, for example, silverfish (Lepisma saccharina).

[0051] Examples of soil-dwelling pests that can damage crops in the early stages of plant development include:

[0052] From the order Lepidoptera, such as species of the genera *Acleris*, *Aegeria*, *Agrotis*, *Alabama argillaceae*, *Amylois*, *Autographa*, *Busseola fusca*, *Cadra cautella*, *Chilo*, *Crocidolomiabinotalis*, *Diatraea*, *Diparopsis castanea*, *Elasmopalpus*, *Heliothis*, *Mamestra brassicae*, and *Phthorimaea*. operculella), diamondback moth (Plutellaxylostella), species of the genera *Scirpophaga*, species of the genera *Sesamia*, species of the genera *Spodoptera*, and species of the genera *Tortrix*;

[0053] From the order Coleoptera, such as species of the genera *Agriotes*, *Anthonomus*, *Atomaria linearis*, *Chaetocnema tibialis*, *Conotrachelus*, *Cosmopolites*, *Curculios*, *Dermestes*, *Diabrotica*, *Dilopoderus*, *Epilachna*, *Eremnus*, *Heteronychus*, *Lissorhoptrus*, *Melolonthas*, and *Orycaephilus*. spp.), species of the genera *Otiorhynchus*, *Phlyctinus*, *Popillia*, *Psylliodes*, *Rhizopertha*, *Scarabeidae*, *Sitotroga*, *Somaticus*, *Tanymecus*, *Tenebrio*, *Tribolium*, *Trogoderma*, and *Zabrus*;

[0054] From the order Orthoptera, such as species of the genus *Mole cricket*;

[0055] From the order Isoptera, such as species of the genus *Reticulitermes*;

[0056] From the order Psittaciformes, such as species of the genus *Liposcelis*;

[0057] From the order Lobes, such as species of the genera *Haematopinus* spp., *Linognathus* spp., *Pediculus* spp., *Pemphigus* spp., and *Phylloxera* spp.;

[0058] From the order Hemiptera, such as the apple cotton aphid;

[0059] From the order Hymenoptera, such as species of the genera *Acromyrmex*, *Atta*, *Cephus*, *Lasius*, *Monomorium pharaonis*, *Neodiprion*, *Solenopsis*, and *Vespaspp.*;

[0060] From the order Diptera, such as species of the genus Tipula spp.;

[0061] Cruciferous plants including flea beetles (species of the genus *Phyllotreta*), root maggots (species of the genus *Delia*), cabbage leaf weevils (species of the genus *Ceutorhynchus*), and aphids.

[0062] In particular, the compositions of the present invention can be applied to combat insects from the orders Hemiptera (especially whiteflies, aphids, psyllids, and armored and soft scales), Thysanoptera (thrips), Acari (mites), and Lepidoptera (butterflies and moths, and their larvae). Preferably, the compositions of the present invention can be applied to combat whiteflies, aphids, and thrips.

[0063] The compositions according to the invention can be used for crops containing useful plants, including perennial and annual crops such as berry plants, such as blackberries, blueberries, cranberries, raspberries, and strawberries; cereals such as barley, corn, millet, oats, rice, rye, sorghum, black wheat, and wheat; fiber plants such as cotton, flax, hemp, jute, and sisal; field crops such as sugar beets and forage beets, coffee beans, hops, mustard, rapeseed (canola), poppies, sugarcane, sunflowers, tea, and tobacco; fruit trees such as apples, apricots, avocados, bananas, cherries, citrus fruits, nectarines, peaches, pears, and plums; and grasses such as Bermuda grass, bluegrass, benjamin grass, centipede grass, yew grass, ryegrass, and St. Augustine grass. Including zoysia grass; herbs such as basil, borage, chives, coriander, lavender, angelica pubescens, mint, oregano, parsley, rosemary, sage, and thyme; legumes such as kidney beans, lentils, peas, and soybeans; nuts such as almonds, cashews, peanuts, hazelnuts, peanuts, pecans, pistachios, and walnuts; palm plants such as oil palms; ornamental plants such as flowers, shrubs, and trees; other trees such as cocoa trees, coconut trees, olive trees, and rubber trees; vegetables such as asparagus, eggplant, broccoli, cabbage, carrots, cucumbers, garlic, lettuce, zucchini, melons, watermelons, okra, onions, leeks, peppers, potatoes, squash, zucchini, rhubarb, spinach, and tomatoes; and grapevines such as grapes. The compositions of the present invention can also be applied to turf, lawns, and pastures.

[0064] Preferably, the compositions of the present invention can be applied to crops selected from useful plants:

[0065] - Solanaceae (including tomatoes, potatoes, eggplants, peppers, black peppers, and tobacco);

[0066] - Cucurbitales (including small pumpkin, large pumpkin, watermelon, cantaloupe, cucumber);

[0067] - Allium chinense (including onions, garlic, and leeks);

[0068] - Asparagales (including asparagus).

[0069] Preferably, the composition of the present invention can be applied to crops selected from the following useful plants: cucumber, squash, pepper, melon, watermelon, tomato, eggplant, zucchini or gourd.

[0070] The application rate of the agricultural chemical composition of the present invention depends on the specific type of insect to be controlled, the required level of control, and the timing and method of application, and can be readily determined by those skilled in the art. Generally, the composition of the present invention can be applied at a rate between 0.005 kg / ha and about 5.0 kg / ha, based on the total amount of active ingredient in the composition. An application rate between about 0.1 kg / ha and about 1.5 kg / ha is preferred, with an application rate between about 0.3 g / ha and 0.8 kg / ha being particularly preferred.

[0071] The pest control composition of the present invention can be used as an insecticide to control pests on cotton or soybean plants, particularly for controlling insects from the orders Hemiptera (especially whiteflies, aphids, psyllids and scale insects), Thysanoptera (thrips) and Acari (mites).

[0072] Specifically, transgenic cotton events expressing useful traits that can be used in combination with the compositions of the present invention include BXN10211, BXN10215, BXN10222, BXN10224, COT102, COT67B, GHB614, GHB119, LLCotton25, MON531, MON757, MON15985, MON1445, MON88913, MON1076, MON1698, MON88701, T304-40, 281-24-236, 3006-210-23, 31707, 31803, 31808, 42317, etc. Such combinations of the compositions of the present invention with cotton events expressing one or more useful traits can provide more durable yield protection, provide resistance management strategies for target pest control, and reduce farmer inputs, saving significant time and monetary costs.

[0073] Furthermore, transgenic soybean plants expressing toxins, such as insecticidal proteins like delta-endotoxins, such as Cry1Ac (Cry1Ac Bt protein), can be used in combination with the compositions of the present invention. Therefore, this can include transgenic soybean plants containing Event MON87701 (see U.S. Patent No. 8,049,071 and related applications and patents, and WO 2014 / 170327A1 (see, for example, regarding Intacta RR2 PRO) TM The paragraph on soybeans

[008] ), event MON87751 (U.S. Patent Application Publication No. 2014 / 0373191) or event DAS-81419 (U.S. Patent No. 8632978 and related applications and patents).

[0074] Other transgenic soybean plants may include the following: SYHT0H2-HPPD tolerance (US Patent Application Publication No. 2014 / 0201860 and related applications and patents), MON89788-glyphosate tolerance (US Patent No. 7,632,985 and related applications and patents), MON87708-dicamba tolerance (US Patent Application Publication No. US 2011 / 0067134 and related applications and patents), DP-356043-5-glyphosate and ALS tolerance (US Patent Application Publication No. US 2010 / 0184079 and related applications and patents), A2704-12-glufosinate tolerance (US Patent Application Publication No. US 2008 / 0320616 and related applications and patents), and DP-305423-1-ALS tolerance (US Patent Application Publication No. US 2011 / 0067134 and related applications and patents). The following events were involved: Event A5547-127-glufosinate tolerance (US Patent Application Publication No. US 2008 / 0312082 and related applications and patents); Event DAS-40278-9-tolerance to 2,4-dichlorophenoxyacetic acid and aryloxyphenoxypropionate (see WO 2011 / 022469, WO 2011 / 022470, WO 2011 / 022471 and related applications and patents); Event 127-ALS tolerance (WO 2010 / 080829 and related applications and patents); Event GTS. 40-3-2-glyphosate tolerance, event DAS-68416-4-2,4-dichlorophenoxyacetic acid and glufosinate tolerance, event FG72-glyphosate and isoxaflutole tolerance, event BPS-CV127-9-ALS tolerance and GU262-glufosinate tolerance or event SYHT04R-HPPD tolerance.

[0075] In an aqueous composition (e.g., a tank mix composition) containing the biocidal composition according to the invention, additional components comprising one or more of the following biocidal active ingredients may be added:

[0076] Avermectin, fenvalerate, acetamiprid, flufenoxuron, Acynonapyr, difenoconazole, afralan, fenvalerate, propyrin, cis-cypermethrin, lambda-cyhalothrin, sulfadiazine, methamidophos, triazophos, chlorfenapyr, benzopyrimoxan, β-cypermethrin, β-cypermethrin, bifenazate, bifenthrin, chlorfenapyr, bio-allethrin, bio-allethrin (S)-cyclopentyl isomer, bio-benzylfuran, diflubenzuron, broflanilide, broflufenoxuron, bromophos-ethyl, thiamethoxam, methyl ethyl ketone, thionyl phosphate, carbaryl, thionyl phosphate, carbaryl, thiamethoxam, carbaryl, thiamethoxam, carbaryl, batamethrin, CAS No.: 1472050-04-6, CAS No. CAS Nos: 1632218-00-8, 1808115-49-2, 2032403-97-5, 2044701-44-0, 2128706-05-6, 2249718-27-0, Chlorantraniliprole, Chlordane, Brofenoxam, Cyclobutrifluram, Cyfenoxam, Clenbuterol, Difenoconazole, Thiamethoxam, 2-Chlorophenyl N-methylcarbamate (CPMC), Benzofenphos, Brofenoxam, Cyclobutrifluram, Cyclobutrifluram, Cypermethrin, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram, Cyclobutrifluram Cypermethrin, cyhalodiamide, deltamethrin, cypermethrin, cypermethrin, cypermethrin, cyromazine, deltamethrin, difenoazone, dichlorvos, dichlorvos, diflubenzuron, diflubenzuron, dichlorvos ... mate), nematicides, fenthion, triphenyltin acetate, cypermethrin, fipronil, flumetoquinone, flupyridine, pyrimethanil, fluazaindolizine, fluzolon, flufenoxuron, flusilazole, flufenoxuron, flucypermethrin, flupyrazole, flupyrazole, flupyrazole, flupyramide, flupyriminin, fluralaner, flupentiofenox, flumetamide, thiazophos, γ-trifluorocypermethrin, Gossyplure TMImidacloprid, chlorfenapyr, halofenprox, heptafluthrin, thiamethoxam, flufenoxuron, imidacloprid, imidacloprid, cypermethrin, indoxacarb, iodomethacin, isocycloseram, isopyram, ivermectin, κ-bifenthrin, κ-heptafluthrin, lambda-cyhalothrin, rabidopin, chlorfenapyr, cyfluthrin, snailicide, methoxyfenozide, methoxybenzylfluthrin, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, methoxyfenozide, Momf luorothrin, nicofluprole, nicosulfuron, acetamiprid, nitrothion, omethoate, glufosinate, oxazosulfyl, parathion-ethyl, permethrin, fenpropathrin, phosmet, piperonyl butyl ether, pirimicarb, pyrimimiphos-ethyl, polyhedrovirus, propargite, propargite, fenpropathrin, propargite, propargite, propargite, profenofos Pyflubumide, pymetrozine, pyrafluprole, pyridaben, acetamiprid, pyrifluquinazon, pyrimostrobin, pyrazosulfuron, pyriproxyfen, pyrimethanil, cypermethrin, sarolaner, silachlor, flumethrin, spinosad, spinosad, spirodiclofen, spirotetramat, spirotetramat, flonicamid, tebufenozide, pyridaben, butylpyrimiphos s), heptamethrin, dithion, Tetrachloraniliprole, Tetradiphon, pyrethroid, tetrachlorfenapyr, acaricide, flufenoxuron, θ-cypermethrin, thiamethoxam, thiamethoxam, chlorpyrifos, thiamethoxam, thiamethoxam, acetamiprid, chlorpyrifos, tioxazafen, acetamiprid, cypermethrin, tetrabromopyr, pymetrozine, triazophos, trichlorfon, trichlorfon, trifluralin, tyclopyrazoflor, ζ-cypermethrin.

[0077] Example :

[0078] The following examples illustrate the invention and, in particular, demonstrate the remarkable effect of using a specific amount of the organic acid citric acid as a buffer component on the stability of methoxypiperidine ethyl ester in a heat storage test, thus demonstrating the feasibility of the composition for commercial pest control applications. The compositions according to the invention are prepared according to known formulation methods, for example, for water-dispersible (wettable) particles.

[0079] Referring to Table 1 below, composition A is a composition (without citric acid) that is not according to the invention as water-dispersible particles, and composition B is a composition (containing citric acid) that is water-dispersible particles according to the invention. Compositions A and B are identical, except that they contain citric acid and composition B has a slightly lower filler content to compensate for the presence of the citric acid component.

[0080] To test the strength of the chemical stability of the active ingredients (methoxypiperidine ethyl ester and acetamiprid), samples of composition A and composition B were prepared into a slurry in 50% water by weight and stored at 54°C for 2 weeks.

[0081] Table 1:

[0082]

[0083]

[0084] As can be seen from Table 2 below, after pulping, composition B according to the invention maintains 5% degradation of ethyl methoxypiperidine, which is considered acceptable, rather than composition A according to the invention showing unacceptable degradation of ethyl methoxypiperidine (greater than 20% loss).

[0085] Table 2:

[0086]

Claims

1. A composition for killing pests, comprising: (i) 25% to 35% by weight of ethyl methoxypiperidine; (ii) 20% to 30% by weight of acetamiprid; and (iii) 2.5% to 10% by weight of a buffer, which, based on the total weight of the composition, comprises: (a) 2% to 7% by weight of alkali metal sulfates and / or alkaline earth metal sulfates, and (b) 0.1% to 5% by weight of an organic acid, wherein the organic acid is citric acid.

2. The pest-killing composition according to claim 1, comprising: (i) 28% to 32% by weight of ethyl methoxypiperidine; and (ii) 22% to 26% acetamiprid by weight.

3. The pest-killing composition according to claim 1, comprising: (iii) 4.5% to 8% by weight of a buffer, which, based on the total weight of the composition, comprises: (a) 4% to 6% by weight of alkali metal sulfates, and (b) 0.5% to 2.5% organic acids by weight.

4. The pest-killing composition according to claim 1, wherein the alkali metal sulfate is potassium sulfate or sodium sulfate.

5. The pest-killing composition according to claim 1, wherein the alkali metal sulfate is sodium sulfate.

6. The pest-killing composition according to claim 1, further comprising: (iv) 15% to 20% by weight of one or more dispersants; (v) 1% to 5% by weight of defoamer; and (vi) 15% to 30% by weight of filler, wherein optionally, based on the total weight of the composition, the filler comprises: (c) 5% to 15% by weight of polymethylurea resin filler, and (d) 10% to 15% by weight of lactose monohydrate filler.

7. The composition according to claim 1, further comprising one or more additional components selected from wetting agents, biocides, stabilizers and pigments.

8. The pest-killing composition according to claim 1, wherein it is a water-dispersible particle.

9. An aqueous composition comprising the biocidal composition according to any one of claims 1 to 8, optionally further comprising one or more adjuvants or carriers.

10. The aqueous composition according to claim 9, wherein the adjuvant is selected from mineral oil, vegetable oil, esterified vegetable oil or alkyl phosphate adjuvant.

11. The aqueous composition according to claim 9, wherein the adjuvant is a methylated vegetable oil.

12. The aqueous composition according to claim 9, wherein the auxiliary agent is an alkyl phosphate ester auxiliary agent.

13. A method for combating and controlling pests, the method comprising applying to the pest, to the site of the pest, or to a crop of useful plants susceptible to pest attack the composition according to any one of claims 1 to 12.

14. The method of claim 13, wherein the pest is selected from the orders Hemiptera, Thysanoptera, Acari, or Lepidoptera.

15. The method of claim 14, wherein the pest is selected from whiteflies, aphids, and thrips.

16. The method according to any one of claims 13 to 15, wherein: (i) The plant is selected from soybeans and cotton; or (ii) Fruits and vegetables.

17. The method according to any one of claims 13 to 15, wherein the plant is selected from the genus Cucurbita or the family Solanaceae.

18. The method according to any one of claims 13 to 15, wherein the plant is selected from cucumber, melon, watermelon, citrus, onion, grape, tomato, pepper, chili, potato, and okra.

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