一种芽孢杆菌及其发酵方法和应用

By screening and optimizing Bacillus fermentation conditions, the yield of triptolide was increased, solving the problem of low triptolide production, providing a new source of raw materials, reducing resource waste, and supporting medical and pharmaceutical research.

CN116716200BActive Publication Date: 2026-07-17GUILIN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUILIN UNIVERSITY OF TECHNOLOGY
Filing Date
2022-09-09
Publication Date
2026-07-17

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Abstract

本发明公开了一种芽孢杆菌及其发酵方法和应用，属于天然产物提取领域。所述芽孢杆菌(Bacillus sp.)保藏编号为CGMCC No.25391。本发明还公开一种利用所述的芽孢杆菌发酵雷公藤甲素的方法，包括以下步骤：将所述芽孢杆菌按照接种量3‑7％接种于发酵培养基，调整pH值为7.4，再于22‑34℃摇瓶发酵培养20‑36h，得到发酵液；利用高效液相色谱仪分离并测定所述发酵液中的雷公藤甲素。本发明通过雷公藤不同组织筛选出一种高产雷公藤甲素的内生细菌，为雷公藤甲素的生产提供了新的原料和生物发酵方法。
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