一种On-DNA芳基乙烯化合物与胺反应构建C-N键的方法

By constructing CN bonds between on-DNA arylethylene compounds and amines in the presence of palladium catalyst and base, the problem of lack of diversity and efficient screening in DNA-encoded compound libraries was solved, and high-yield compound library synthesis and multi-well plate operation were achieved.

CN116732617BActive Publication Date: 2026-07-17HITGEN INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HITGEN INC
Filing Date
2022-03-04
Publication Date
2026-07-17

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Abstract

本发明涉及一种On‑DNA芳基乙烯化合物与胺反应构建C‑N键的方法。该方法以On‑DNA芳基乙烯化合物为原料，在钯催化剂、碱存在下通过共轭加成构建C‑N键。本发明提供的On‑DNA芳基乙烯化合物与胺反应的方法能够在有机溶剂 / 水相的混合水相中进行，后处理简单，条件温和，能够在较短时间内高收率得到高多样性的DNA编码化合物库，并且适用于多孔板进行的DNA编码化合物的合成。
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