Compositions for enhancing the cooling effect

Abstract

The present disclosure relates generally to cooling intensity modifying compositions that enhance the cooling effect of cooling compounds such as menthol, verbenol, and the like. In some aspects, the present disclosure provides the use of such cooling intensity modifying compositions for the cooling effect of a cooling compound. In some other aspects, the present disclosure provides compositions (e.g., consumable compositions or oral care compositions) comprising a cooling compound (e.g., menthol, verbenol, and the like) and a cooling intensity modifying composition of the present disclosure. In some embodiments, such compositions are in the form of a food product, a beverage product, or an oral care product, such as a toothpaste, a mouthwash, a tooth whitening composition, a chewing gum, a dentifrice, and the like. In some other embodiments, such compositions are in the form of a body care product, such as a cosmetic product, a skin care product, or a hair care product.

Description

[0001] Cross-references to related applications

[0002] This application claims priority to U.S. Provisional Application No. 63 / 136,847, filed January 13, 2021, and U.S. Provisional Application No. 63 / 150,654, filed February 18, 2021, both of which are incorporated herein by reference as if they were set forth in their entirety. Technical Field

[0003] This disclosure generally relates to coolness-modifying compositions that enhance the cooling effect of cooling compounds such as menthol, lentinanol, etc. In some embodiments, this disclosure provides the use of such coolness-modifying compositions for the cooling effect of the cooling compounds. In other embodiments, this disclosure provides compositions (e.g., edible compositions or oral care compositions) comprising a cooling compound (e.g., menthol, lentinanol, etc.) and the coolness-modifying composition of this disclosure. In some embodiments, such compositions are in the form of food products, beverage products, or oral care products, such as toothpaste, mouthwash, teeth whitening compositions, chewing gum, dental floss, etc. Background Technology

[0004] Our sensory system is able to detect subtle changes in ambient temperature through the coordinated efforts of certain heat-sensing neurons. Temperature-sensitive proteins from the TRP channel family are typically found at sites where thermal stimuli translate into neuronal activity. Notably, these channels respond to a temperature range spanning the entire perceived temperature spectrum, from warm to unbearably hot, from pleasantly cool to unbearably cold. Furthermore, many of these channels are receptors for ligands that can elicit different psychophysical sensations, such as the heat associated with capsaicin and the cold associated with menthol.

[0005] Menthol modulates the TRPM8 receptor in a way that produces a cooling sensation in the mouth. This is why natural products containing menthol, such as peppermint extract, often produce a cooling effect in the mouth. For the same reason, menthol is frequently used as an ingredient in non-extractable flavorings for cavities that require a cooling effect. Even so, menthol can have a bitter or astringent taste, which some users may find unpleasant. Therefore, it may be necessary to develop strategies to enhance the cooling effect of menthol, allowing for lower concentrations of menthol while simultaneously reducing the undesirable astringency or bitterness.

[0006] Certain synthetic compounds can be used to enhance the cooling effect. These can be used alone or in combination with menthol. However, such compounds often impart certain unpleasant odors similar to menthol. Therefore, there is a ongoing need to discover new compositions that enhance the cooling effect of menthol in food, beverages, and oral care products without causing a bitter or astringent sensation. Summary of the Invention

[0007] This disclosure relates to the discovery that certain compositions exhibit unexpected effects in enhancing the cooling sensation (e.g., the cooling sensation of menthol) in food, beverages, or oral care products.

[0008] In a first embodiment, this disclosure provides a cooling effect modifying composition comprising a cooling effect enhancing compound selected from the group consisting of (E / Z)-2-methyl-2-butenal, (E / Z)-2-isopropyl-5-methyl-2-hexenal, and any combination thereof. In some embodiments, the cooling effect modifying composition further comprises a high-intensity sweetener. In some embodiments, the high-intensity sweetener is sucralose, sodium saccharin, or a combination thereof. In some embodiments, the composition comprises a flavoring agent, such as a mint flavoring.

[0009] In a second embodiment, this disclosure provides the use of (E / Z)-2-methyl-2-butenal for enhancing the cooling effect of flavored products. In some embodiments, the flavored product comprises a cooling compound, such as menthol or lentinanol. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0010] In a third embodiment, this disclosure provides the use of (E / Z)-2-isopropyl-5-methyl-2-hexenal for enhancing the cooling effect of flavored products. In some embodiments, the flavored product comprises a cooling compound, such as menthol or lentinanol. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0011] In a fourth embodiment, this disclosure provides a method for enhancing the cooling sensation of a cooling compound in a flavored product, comprising combining a cooling compound (e.g., menthol, lentinanol, or a combination thereof) with (E / Z)-2-methyl-2-butenal in the flavored product. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0012] In a fifth embodiment, this disclosure provides a method for enhancing the cooling sensation of a cooling compound in a flavored product, comprising combining a cooling compound (e.g., menthol, lentinanol, or a combination thereof) with (E / Z)-2-isopropyl-5-methyl-2-hexenal in the flavored product. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0013] In a sixth embodiment, this disclosure provides the use of the cooling effect modifying composition of the first embodiment for enhancing the cooling sensation of a flavored product. In some embodiments, the flavored product comprises a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0014] In a seventh embodiment, this disclosure provides a method for enhancing the cooling sensation of a flavored product, the method comprising combining a cooling-modifying composition of the first embodiment with a cooling compound (e.g., menthol, lentinanol, or a combination thereof) in the flavored product. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or teeth whitening product.

[0015] In an eighth embodiment, this disclosure provides a flavored product comprising the cooling-modifying composition of the first embodiment and a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or teeth whitening product.

[0016] In its ninth embodiment, this disclosure provides the use of (E / Z)-2-methyl-2-butenal for enhancing the cooling sensation of body care products. In some embodiments, the body care product contains a cooling compound, such as menthol or lentinanol. In some embodiments, the body care product is a shampoo, body wash, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, body oil, sunscreen, or bronzer.

[0017] In a tenth embodiment, this disclosure provides the use of (E / Z)-2-isopropyl-5-methyl-2-hexenal for enhancing the cooling sensation of body care products. In some embodiments, the body care product contains a cooling compound, such as menthol or lentinanol. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0018] In its eleventh form, this disclosure provides a method for enhancing the cooling sensation of a cooling compound in a body care product, comprising combining a cooling compound (e.g., menthol, lentinanol, or a combination thereof) with (E / Z)-2-methyl-2-butenal in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0019] In its twelfth embodiment, this disclosure provides a method for enhancing the cooling sensation of a cooling compound in a body care product, comprising combining a cooling compound (e.g., menthol, lentinanol, or a combination thereof) with (E / Z)-2-isopropyl-5-methyl-2-hexenal in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0020] In the thirteenth embodiment, this disclosure provides the use of the cooling-modifying composition of the first embodiment for enhancing the cooling sensation of body care products. In some embodiments, the body care product comprises a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0021] In the fourteenth embodiment, this disclosure provides a method for enhancing the cooling sensation of a body care product, the method comprising combining the cooling-modifying composition of the first embodiment with a cooling compound (e.g., menthol, lentinanol, or a combination thereof) in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0022] In the fifteenth embodiment, this disclosure provides a body care product comprising the cooling-modifying composition of the first embodiment and a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizing cream, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sun tanning agent.

[0023] Further forms and embodiments thereof are set forth in the following detailed description, figures, abstract and claims. Detailed Implementation

[0024] The following detailed description illustrates the various forms and implementations provided herein. This description is intended for reading by a person skilled in the art. Therefore, information familiar to such a person may not be included.

[0025] definition

[0026] Unless otherwise specified herein, the following terms and phrases have the meanings indicated below. This disclosure may employ other terms and phrases not expressly defined herein. Such other terms and phrases have the meanings that a person skilled in the art would have in the context of this disclosure. In some cases, a term or phrase may be defined in either a singular or plural form. In such cases, it should be understood that any term in its singular form may include its plural form, and vice versa, unless the contrary is explicitly stated.

[0027] In this article, “sweetener,” “sweetener,” “sweetener entity,” or “sweetener compound” means a compound that produces a detectable sweetness in a subject or an ingestible salt thereof, such as a compound that activates the T1R2 / T1R3 receptor in vitro.

[0028] "Cooling sensation" refers to the feeling of a decrease in ambient temperature produced by an ingestible substance within the body, which is usually regulated by the TRPM8 receptor.

[0029] "Cooling compound" refers to a compound that modulates the TRPM8 receptor. In some embodiments of any of the embodiments proposed herein, the cooling compound is menthol. Note that, as used herein, "menthol" refers to (-)-menthol. In some embodiments of any of the embodiments proposed herein, the cooling compound is penicillinol. Non-limiting examples of cooling compounds include N-ethyl-p-menthyl-3-carboxamide, isopreneol, 3-(L-menthyloxy)propane-1,2-diol, cis / trans-p-menthyl-3,8-diol, 3-(L-menthyloxy)-2-methylpropane-1,2-diol, 2-[2-(p-menthyloxy)ethoxy]ethanol, menthol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl)ethene, (1R,2R,5R)-N-ethyl-5-methyl-2-(propane- 1-En-2-yl)-cyclohexaneformamide, N-(3-hydroxy-4-methoxyphenyl)-2-isopropyl-5,5-dimethyl-cyclohexaneformamide, N-[4-(cyanomethyl)phenyl]-2-isopropyl-5,5-dimethyl-cyclohexaneformamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethyl-cyclohexane-1-carboxamide, L-menthol lactate, (-)-menthol glycol carbonate, (-)-menthol 1,2-glycerol ketal, D / L-menthol 1,2-glycerol ketal, (-) - Menthyl 1-propanediol carbonate, (-)-Menthyl 2-propanediol carbonate, D / L-Menthyl 1-propanediol carbonate, D / L-Menthyl 2-propanediol carbonate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexaneformamide, Menthyl acetamidooxalate, (E)-3-benzo[1,3]dioxacyclopenten-5-yl-N,N-diphenyl-2-acrylamide, 3,4-methylenedioxycinnamic acid, N,N-diphenylamide, N,N-dimethyl( -)-Menthyl succinimide, (1R,2S,5R)-N-(4-(carbamoylmethyl)phenyl)-menthyl formamide, (-)-menthyl pyrrolidone carboxylate, L-phenylephrine p-menthylcarboxamide, (1R,2S,5R)-N-(4-(cyanomethyl)-phenyl)menthyl formamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthyl formamide, 6-isopropyl-3,9-dimethyl-1,4-dioxane[4].5] Dec-2-one, (1R,2R,4S)-dihydrosansyl alcohol, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N,2,3-trimethyl-n-butyramide, ethyl 3-(p-menthane-3-carboxamido)acetate, N-ethyl-2,2-diisopropylbutyramide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-dimethylbutyramide, N-cyclohexane-2-one, (1R,2R,4S)-dihydrosansyl alcohol, N-ethyl-2,2-diisopropylbutyramide, (1R,2R,4S)-dihydrosansyl alcohol, N-cyclohexane-2-one, (1R,2R,4S)-dihydrosansyl alcohol, N-ethyl-2,2-diisopropylbutyramide, (1R,2R,4S)-dihydrosansyl alcohol, N-ethyl-2,2-diisopropylbutyramide, (1R,2R,4S)-dihydrosansyl alcohol, N-ethyl-2,2-diisopropylbutyramide, N-cyclohexane-2-one ... Propyl-5-methyl-2-isopropyl-cyclohexanecarboxamide, acetoacetic acid (-)-menthyl ester, succinic acid (-)-menthyl ester, (S)-3-hydroxybutyric acid (-)-menthyl ester, glutaric acid (-)-menthyl ester, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidin-2-one, di-(-)-menthyl glutaric acid, and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramide.

[0030] As used herein, the singular forms “an,” “a,” and “the” include plural indicators unless the context clearly indicates otherwise. For example, reference to “an substituent” covers a single substituent as well as two or more substituents, and so on.

[0031] As used herein, the words “for example,” “such as,” “like,” or “including” are intended to introduce examples that further illustrate a more general subject. Unless otherwise expressly stated, such examples are provided only to aid in understanding the embodiments shown in this disclosure and are not intended to be limiting in any way. These phrases also do not indicate any kind of preference for the disclosed embodiments.

[0032] As used herein, “include,” “contain,” “with,” and “comprised of” refer to an open group, meaning that the group may include other members besides those explicitly stated. For example, the phrase “includes A” means that A must be present, but other members may also be present. The terms “include,” “have,” and “composed of,” and their grammatical variations, have the same meaning. Conversely, “consist of,” “formed by,” or “constituting as” refer to a closed group. For example, the phrase “composed of A” means that only A exists.

[0033] As used herein, “E / Z” indicates that a compound having EZ stereochemistry may exist in E-configuration, Z-configuration, or any mixture of compounds in E-configuration and Z-configuration forms.

[0034] As used herein, "optionally" means that the events described below may or may not occur. In some embodiments, the optional event does not occur. In other embodiments, the optional event does occur one or more times.

[0035] As used herein, “or” will be given its broadest reasonable interpretation and is not limited to the “either / or” construction. Therefore, the phrase “containing A or B” means that A may exist while B does not, or B may exist while A does not, or both A and B may exist. Furthermore, for example, if A defines a class that can have multiple members (e.g., A1 and A2), then one or more members of that class may exist simultaneously.

[0036] Other terms are defined in other parts of this specification, even if not included in this subsection.

[0037] Cooling compounds

[0038] In some forms, this disclosure provides the use of (E / Z)-2-methyl-2-butenal for enhancing the cooling sensation of a flavored product. In some embodiments, the flavored product comprises a cooling compound, such as menthol or lentinanol. In related forms, this disclosure provides a method for enhancing the cooling sensation of a cooling compound (e.g., menthol or lentinanol) in a flavored product, comprising combining the cooling compound and (E / Z)-2-methyl-2-butenal in the flavored product. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0039] In some other forms, this disclosure provides the use of (E / Z)-2-methyl-2-butenal for enhancing the cooling sensation of body care products. In some embodiments, the body care product comprises a cooling compound, such as menthol or lentinanol. In related forms, this disclosure provides a method for enhancing the cooling sensation of a cooling compound (e.g., menthol or lentinanol) in a body care product, comprising combining the cooling compound with (E / Z)-2-methyl-2-butenal in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, body oil, sunscreen, or sunscreen enhancer.

[0040] As used herein, “(E / Z)-2-methyl-2-butenal” refers to the E- or Z-configuration of 2-methyl-2-butenal, or any mixture thereof. In some embodiments, (E / Z)-2-methyl-2-butenal is (E)-2-methyl-2-butenal. In some other embodiments, (E / Z)-2-methyl-2-butenal is (Z)-2-methyl-2-butenal. In some embodiments, (E / Z)-2-methyl-2-butenal is a mixture of (E)-2-methyl-2-butenal and (Z)-2-methyl-2-butenal. Suitable w / w ratios of E-configuration to Z-configuration range from 100:1 to 1:100, or 50:1 to 1:50, or 20:1 to 1:20, or 10:1 to 1:10, or 5:1 to 1:5, or 3:1 to 1:3, or 2:1 to 1:2. In some embodiments, such mixtures contain a larger amount of E-configuration relative to the Z-configuration. In some such embodiments, the w / w ratio of E-configuration to Z-configuration ranges from 3:2 to 100:1, or 3:2 to 50:1, or 3:2 to 25:1, or 3:2 to 10:1, or 3:2 to 5:1, or 3:2 to 4:1, or 3:2 to 3:1, or 3:2 to 2:1.

[0041] In terms of use or form incorporated into flavored products, flavored products can be any suitable food product, beverage product, or oral care product, each of which is described in further detail below. As explained in more detail below, flavored products may contain any other type of ingredient, including flavorings, natural and artificial sweeteners, etc.

[0042] In the context of intended use or inclusion in a body care product, the body care product can be any suitable product suitable for use on hair, skin, etc., which will be described in further detail below. As explained in more detail below, body care products may contain any other kind of ingredients, such as those commonly included in body care products.

[0043] (E / Z)-2-methyl-2-butenal can be present in flavored or body care products at any suitable concentration. In some embodiments, the concentration of (E / Z)-2-methyl-2-butenal in the flavored or body care product ranges from 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm, based on the total weight of the product.

[0044] In some embodiments, the flavored product also contains a high-intensity sweetener. In some such embodiments, the high-intensity sweetener is sodium saccharin or sucralose. In some embodiments, the high-intensity sweetener is sodium saccharin. Sodium saccharin can be present at any suitable concentration. In some embodiments, the concentration of sodium saccharin ranges from 10 ppm to 10,000 ppm, or from 50 ppm to 5,000 ppm, or from 100 ppm to 3,000 ppm, based on the total weight of the product.

[0045] In some embodiments, the flavored or body care product contains menthol, specifically (-)-menthol. Menthol may be present at any suitable concentration. In some embodiments, menthol is present at concentrations of 10 ppm to 20,000 ppm, or 50 ppm to 10,000 ppm, or 100 ppm to 7,000 ppm, or 500 ppm to 5,000 ppm, based on the total weight of the product.

[0046] In some embodiments, the flavored product or body care product contains menthol. Menthol may be present in the flavored product or body care product at any suitable ratio (w / w) to (E / Z)-2-methyl-2-butenal. In some embodiments, the w / w ratio of menthol to (E / Z)-2-methyl-2-butenal in the flavored product is from 1:1 to 200:1, or from 5:1 to 100:1.

[0047] In some embodiments, the flavored or body care product contains pennywort alcohol, also known as (3S,3aR,3bR,4S,7R,7aR)-octahydro-3,7-dimethyl-4-(1-methylethyl)-1H-cyclopentane[1.3]cyclopropane[1.2]benzene-3-ol. Pennywort alcohol may be present in the flavored or body care product at any suitable concentration. In some embodiments, the concentration of pennywort alcohol in the flavored or body care product ranges from 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm, based on the total weight of the product.

[0048] Other compounds and additives may be included in the flavored or body care product, as described in more detail below. For example, in some embodiments, the flavored or body care product contains one or two of (E / Z)-2-isopropyl-5-methyl-2-hexenal or any other cooling compound (such as any of those mentioned above).

[0049] In some forms, this disclosure provides the use of (E / Z)-2-isopropyl-5-methyl-2-hexenal for enhancing the cooling sensation of a flavored product. In some embodiments, the flavored product comprises a cooling compound, such as menthol or lentinanol. In related forms, this disclosure provides a method for enhancing the cooling sensation of a cooling compound (e.g., menthol or lentinanol) in a flavored product, comprising combining the cooling compound with (E / Z)-2-isopropyl-5-methyl-2-hexenal in the flavored product. In some embodiments, the flavored product is a food product or a beverage product. In some other embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, dental floss, chewing gum, or a teeth whitening composition.

[0050] In some other forms, this disclosure provides the use of (E / Z)-2-isopropyl-5-methyl-2-hexenal for enhancing the cooling sensation of body care products. In some embodiments, the body care product comprises a cooling compound, such as menthol or lentinanol. In related forms, this disclosure provides a method for enhancing the cooling sensation of a cooling compound (e.g., menthol or lentinanol) in a body care product, comprising combining the cooling compound with (E / Z)-2-isopropyl-5-methyl-2-hexenal in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, body oil, sunscreen, or sunscreen enhancer.

[0051] As used herein, “(E / Z)-2-isopropyl-5-methyl-2-hexenal” refers to the E- or Z-configuration of 2-isopropyl-5-methyl-2-hexenal, or any mixture thereof. In some embodiments, (E / Z)-2-isopropyl-5-methyl-2-hexenal is (E)-2-isopropyl-5-methyl-2-hexenal. In some other embodiments, (E / Z)-2-isopropyl-5-methyl-2-hexenal is (Z)-2-isopropyl-5-methyl-2-hexenal. In some embodiments, (E / Z)-2-isopropyl-5-methyl-2-hexenal is a mixture of (E)-2-isopropyl-5-methyl-2-hexenal and (Z)-2-isopropyl-5-methyl-2-hexenal. Suitable w / w ratios of E-configuration to Z-configuration range from 100:1 to 1:100, or 50:1 to 1:50, or 20:1 to 1:20, or 10:1 to 1:10, or 5:1 to 1:5, or 3:1 to 1:3, or 2:1 to 1:2. In some embodiments, such mixtures contain a larger amount of E-configuration relative to the Z-configuration. In some such embodiments, the w / w ratio of E-configuration to Z-configuration ranges from 3:2 to 100:1, or 3:2 to 50:1, or 3:2 to 25:1, or 3:2 to 10:1, or 3:2 to 5:1, or 3:2 to 4:1, or 3:2 to 3:1, or 3:2 to 2:1.

[0052] In terms of use or form incorporated into flavored products, flavored products can be any suitable food product, beverage product, or oral care product, each of which is described in further detail below. As explained in more detail below, flavored products may contain any other type of ingredient, including flavorings, natural and artificial sweeteners, etc.

[0053] In the context of intended use or inclusion in a body care product, the body care product can be any suitable product suitable for use on hair, skin, etc., which will be described in further detail below. As explained in more detail below, body care products may contain any other kind of ingredients, such as those commonly included in body care products.

[0054] (E / Z)-2-isopropyl-5-methyl-2-hexenal may be present in flavored or body care products at any suitable concentration. In some embodiments, the concentration of (E / Z)-2-isopropyl-5-methyl-2-hexenal in the flavored product ranges from 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm, based on the total weight of the product.

[0055] In some embodiments, the flavored product contains a high-intensity sweetener. In some such embodiments, the high-intensity sweetener is sodium saccharin or sucralose. In some embodiments, the high-intensity sweetener is sodium saccharin. Sodium saccharin can be present at any suitable concentration. In some embodiments, the concentration of sodium saccharin ranges from 10 ppm to 10,000 ppm, or from 50 ppm to 5,000 ppm, or from 100 ppm to 3,000 ppm, based on the total weight of the product.

[0056] In some embodiments, the flavored product contains menthol, specifically (-)-menthol. Menthol may be present at any suitable concentration. In some embodiments, menthol is present at concentrations of 10 ppm to 20,000 ppm, or 50 ppm to 10,000 ppm, or 100 ppm to 7,000 ppm, or 500 ppm to 5,000 ppm, based on the total weight of the product.

[0057] In some embodiments, the flavored product or body care product contains menthol. In such embodiments, menthol may be present in the flavored product or body care product at a relative concentration (w / w) of (E / Z)-2-isopropyl-5-methyl-2-hexenal in any suitable ratio. In some embodiments, the w / w ratio of menthol to (E / Z)-2-isopropyl-5-methyl-2-hexenal in the flavored product is from 1:1 to 200:1, or from 5:1 to 100:1.

[0058] In some embodiments, the flavored or body care product contains pennywort alcohol, also known as (3S,3aR,3bR,4S,7R,7aR)-octahydro-3,7-dimethyl-4-(1-methylethyl)-1H-cyclopentane[1.3]cyclopropane[1.2]benzene-3-ol. Pennywort alcohol may be present in the flavored product at any suitable concentration. In some embodiments, the concentration of pennywort alcohol in the flavored product ranges from 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm, based on the total weight of the product.

[0059] Other compounds and additives may be included in flavored or body care products, as described in more detail below. For example, in some embodiments, the flavored product contains one or two of (E / Z)-2-methyl-2-butenal or any other cooling compound (such as any of those mentioned above).

[0060] Cooling Modification Composition

[0061] For the purpose of delivery to or introduction into flavored or body care products, cooling-enhancing compounds (according to any of the above embodiments) may be included in any suitable composition.

[0062] In at least a first aspect, this disclosure provides a cooling-enhancing composition comprising a cooling-enhancing compound selected from the group consisting of (E / Z)-2-methyl-2-butenal, (E / Z)-2-isopropyl-5-methyl-2-hexenal, and any combination thereof.

[0063] The cooling effect modification composition may comprise any combination of cooling effect enhancing compounds. In some other embodiments of this type, the cooling effect enhancing composition comprises a combination of (E / Z)-2-methyl-2-butenal (according to any of the above embodiments) and (E / Z)-2-isopropyl-5-methyl-2-hexenal (according to any of the above embodiments).

[0064] The cooling effect modification composition may comprise any combination of cooling effect enhancing compounds. In some embodiments, the cooling effect enhancing composition comprises (E / Z)-2-methyl-2-butenal (according to any of the embodiments described above). In some other such embodiments, the cooling effect enhancing composition comprises a combination of (E / Z)-2-isopropyl-5-methyl-2-hexenal (according to any of the embodiments described above). In some other such embodiments, the cooling effect enhancing composition comprises a combination of (E / Z)-2-methyl-2-butenal (according to any of the embodiments described above) and (E / Z)-2-isopropyl-5-methyl-2-hexenal (according to any of the embodiments described above).

[0065] In the foregoing embodiments, when the cooling effect modifying composition comprises a combination of cooling effect enhancing compounds, the cooling effect enhancing compounds may be present in any suitable relative amount. In some embodiments, when the cooling effect modifying composition comprises a combination of cooling effect enhancing compounds, the ratio (w / w) of any two cooling effect enhancing compounds ranges from 1:20 to 20:1, or 1:10 to 10:1, or 1:5 to 5:1, or 1:3 to 3:1, or 1:2 to 2:1, or 2:3 to 3:2.

[0066] Furthermore, the cooling-enhancing compound may be present in the cooling-modifying composition at any suitable concentration. In embodiments where the cooling-modifying composition is a flavored product suitable for human consumption, the cooling-enhancing compound is present at a concentration of 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm.

[0067] Cooling-modifying compositions may contain any number of additional ingredients, such as those commonly used as additives and excipients in food products, beverage products, oral care products (e.g., toothpaste, mouthwash, and chewing gum), and body care products.

[0068] In some embodiments, the cooling effect modifying composition comprises menthol, specifically (-)-menthol. Menthol may be present at any suitable concentration. In some embodiments, when the cooling effect modifying composition is a flavored product suitable for human consumption, menthol is present at a concentration of 10 ppm to 20,000 ppm, or 50 ppm to 10,000 ppm, or 100 ppm to 7,000 ppm, or 500 ppm to 5,000 ppm based on the total weight of the composition. In some embodiments, when the cooling effect modifying composition is a body care product suitable for application to human skin or hair, menthol is present at a concentration of 10 ppm to 20,000 ppm, or 50 ppm to 10,000 ppm, or 100 ppm to 7,000 ppm, or 500 ppm to 5,000 ppm based on the total weight of the composition. Menthol may be present at a relative concentration (w / w) with any suitable proportion to the cooling effect enhancing compound. In some embodiments, the w / w ratio of menthol to cooling-enhancing compound in the cooling-modifying composition is 1:1 to 200:1, or 5:1 to 100:1.

[0069] In some embodiments, the cooling effect modifying composition comprises penicillin. Penicillin may be present in the flavored product or body care product at any suitable concentration. In some embodiments, the concentration of penicillin in the flavored product or body care product ranges from 1 ppm to 1000 ppm, or 5 ppm to 500 ppm, or 10 ppm to 300 ppm, or 20 ppm to 200 ppm, based on the total weight of the composition.

[0070] In some embodiments, the cooling effect modifying composition comprises other cooling agents, such as N-ethyl-p-menthyl-3-carboxamide. N-ethyl-p-menthyl-3-carboxamide may be present at any suitable concentration. In some embodiments, when the cooling effect modifying composition is a flavored product suitable for human consumption, N-ethyl-p-menthyl-3-carboxamide is present at a concentration of 1 ppm to 20,000 ppm, or 5 ppm to 10,000 ppm, or 10 ppm to 7,000 ppm, or 50 ppm to 5,000 ppm based on the total weight of the composition. In some embodiments, when the cooling effect modifying composition is a body care product suitable for application to human skin or hair, N-ethyl-p-menthyl-3-carboxamide is present at a concentration of 1 ppm to 20,000 ppm, or 5 ppm to 10,000 ppm, or 10 ppm to 7,000 ppm, or 50 ppm to 5,000 ppm based on the total weight of the composition. N-Ethyl-p-menthyl-3-carboxamide can be present at any suitable ratio (w / w) to the cooling-enhancing compound. In some embodiments, the w / w ratio of N-ethyl-p-menthyl-3-carboxamide to the cooling-enhancing compound in the cooling-modifying composition is from 1:1 to 200:1, or from 5:1 to 100:1.

[0071] In some embodiments, the cooling effect modifying composition comprises a cooling compound. In some embodiments, the cooling compound is menthol. In some embodiments, the cooling compound is lentinanol. In some embodiments, the cooling compound is N-ethyl-p-menthyl-3-carboxamide. In some embodiments, the cooling compound is: menthol, lentinanol, N-ethyl-p-menthyl-3-carboxamide, isopreneol, 3-(L-menthoxy)propane-1,2-diol, cis / trans-p-menthane-3,8-diol, 3-(L-menthoxy)-2-methylpropane-1,2-diol, 2-[2-(p-menthane-3-yloxy)ethoxy]ethanol, menthol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl)ethene, (1R,2R,5R)-N-ethyl N-(3-hydroxy-4-methoxyphenyl)-2-isopropyl-5,5-dimethyl-cyclohexaneformamide, N-[4-(cyanomethyl)phenyl]-2-isopropyl-5,5-dimethyl-cyclohexaneformamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethyl-cyclohexane-1-formamide, L-menthol lactate, (-)-menthol glycol carbonate, (-)-menthol 1,2-glycerol ketal, D / L-thiol lactate 1,2-Glyceryl Ketal, (-)-Menthol 1-Propanediol Carbonate, (-)-Menthyl 2-Propanediol Carbonate, D / L-Menthyl 1-Propanediol Carbonate, D / L-Menthyl 2-Propanediol Carbonate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(L-methylethyl)cyclohexaneformamide, Menthylacetamidooxalate, (E)-3-Benzo[1,3]dioxacyclopenten-5-yl-N,N-diphenyl-2-acrylamide, 3,4-Methylenedioxycinnamic acid, N, N-Diphenylamide, N,N-Dimethyl(-)-Menthylsuccinimide, (1R,2S,5R)-N-(4-(carbamoylmethyl)phenyl)-menthylformamide, (-)-menthylpyrrolidone carboxylate, L-Dephenylamine p-menthylformamide, (1R,2S,5R)-N-(4-(cyanomethyl)-phenyl)menthylformamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylformamide, 6-Isopropyl-3,9-Dimethyl-1,4-dioxane[4].5] Dec-2-one, (1R,2R,4S)-dihydrosansine, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N,2,3-trimethyl-n-butyramide, 3-(p-menthane-3-carboxamido)ethyl acetate, N-ethyl-2,2-diisopropylbutyramide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-dimethylbutyramide, N-cyclopropyl-5-methyl-2-isopropyl-cyclohexane Alkylcarbamate, acetoacetic acid (-)-menthyl ester, succinic acid (-)-menthyl ester, (S)-3-hydroxybutyric acid (-)-menthyl ester, glutaric acid (-)-menthyl ester, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidin-2-one, di-(-)-menthyl glutaric acid, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramide, or any combination thereof.

[0072] Cooling Modification Compositions Suitable for Flavored Products

[0073] In some embodiments of any of the foregoing embodiments, the cooling effect modifying composition comprises a sweetener, such as a low-calorie, zero-calorie, or high-intensity sweetener. The term "high-intensity sweetener" refers to a sweetener that is, for example, at least 10 times, or at least 20 times, or at least 50 times, or at least 100 times, or at least 250 times, or at least 500 times, or at least 750 times, or at least 1000 times, or at least 2500 times, or at least 5000 times, or at least 7500 times, or at least 10000 times sweeter than sucrose. In this document, saying that a sweetener is x times sweeter than sucrose means that a concentration of said sweetener in an aqueous solution relative to 1 / x the weight of sucrose produces a sweetness equivalent to that of sucrose. Examples of suitable sweeteners are described in more detail below. In some embodiments, the sweetener is sucralose, which refers to 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside. In some embodiments, the sweetener is sodium saccharin. Sodium saccharin may be present at any suitable concentration. In some embodiments, the concentration of sodium saccharin ranges from 10 ppm to 10,000 ppm, or 50 ppm to 5,000 ppm, or 100 ppm to 3,000 ppm. Sodium saccharin may have any suitable relative concentration to the cooling effect compound. In some embodiments, the ratio (w / w) of sodium saccharin to the cooling effect compound in the cooling effect modified composition ranges from 1:1 to 1,000:1, or 5:1 to 500:1.

[0074] In some embodiments, the cooling effect modifying composition comprises glucosylated natural steviol glycosides. As used herein, the term "natural steviol glycoside" refers to steviol glycosides naturally found in the plant species *Stevia rebaudiana*, *Stevia phlebophylla*, or *Rubus chingii*. Such compounds are glycosides of diterpenoid steviols. Some non-limiting examples include steviol glycosides, rebaudioside A, rebaudioside C, dulcoside A, etc. As used herein, the term "glucosylated natural steviol glycoside" refers to a compound obtained by enzymatically glucosylating a natural steviol glycoside to increase the degree of glucosylation. As used herein, the term "GSG" may be used interchangeably with "glucosylated natural steviol glycoside".

[0075] In embodiments where GSG is present, any suitable GSG can be used. Therefore, the GSG can have any suitable degree of additional glucosylation, and any suitable type of glucosylation. In some embodiments, the GSG used in the cooling effect modification composition has a glucosylation degree of at least 1.0, meaning that at least one mole of glucose has been enzymatically added to the natural steviol glycoside for every mole of natural steviol glycoside. In some other embodiments, the GSG used in the cooling effect modification composition has a glucosylation degree of at least 1.1, or at least 1.2, or at least 1.3, or at least 1.4, or at least 1.5, or at least 1.6, or at least 1.7, or at least 1.8, or at least 1.9, or at least 2.0, or at least 2.1, or at least 2.2, or at least 2.3, or at least 2.4, or at least 2.5. Glucosylation can be of any suitable type. For example, in some embodiments, the glucose enzymatically added to the natural steviol glycoside is α-glucose, β-glucose, or a combination thereof. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is α-glucose. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is β-glucose. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is a combination of α-glucose and β-glucose. The glucose added via enzymatic glucosylation can be incorporated through any suitable linkage. Typically, the added glucose unit is linked to other glucose units already present on the natural steviol glycoside. In some embodiments, the enzymatically added glucose unit is added via a 1,6 bond, meaning the glucose unit is added via the 1-position of the added glucose unit and the 6-position of a glucose unit already present on the natural steviol glycoside. In some other embodiments, the enzymatically added glucose unit is added via a 1,4 bond. In some other embodiments, the enzymatically added glucose unit is added via a 1,2 bond.

[0076] In embodiments where GSG is present, GSG may be present at any suitable concentration. In some embodiments, GSG is present in the cooling-modifying composition at concentrations ranging from 1 ppm to 100 ppm, or 1 ppm to 50 ppm, or 1 ppm to 30 ppm, or 1 ppm to 20 ppm, or 1 ppm to 10 ppm.

[0077] In some embodiments, the cooling effect modifying compositions that can be used comprise 4-amino-5,6-dimethylthiopheno[2,3-d]pyrimidine-2(1H)-one or any suitable salt thereof. In some embodiments, the cooling effect modifying compositions disclosed herein comprise the hydrochloride salt of 4-amino-5,6-dimethylthiopheno[2,3-d]pyrimidine-2(1H)-one.

[0078] In some embodiments of any of the foregoing embodiments, the cooling effect modifying composition further comprises a lactone. Any suitable lactone or a combination of lactones can be used. In some embodiments, the lactone comprises a lactone ring having 3 to 8 members, such as a 3-membered, 4-membered, 5-membered, 6-membered, 7-membered, or 8-membered lactone ring.

[0079] In some embodiments, the lactone comprises a 5-membered lactone ring having or not having unsaturated bonds (excluding the degree of unsaturation in the oxygen substituents on the ring), such as carbon-carbon double bonds. In some embodiments, the lactone comprises a 5-membered lactone ring having at least one unsaturated bond (e.g., one carbon-carbon double bond). Non-limiting examples of lactones comprising a 5-membered lactone ring having at least one unsaturated bond include angelicin α, angelicin β, menthol, 5,5-dimethyl-2(5H)-furanone, 5-ethyl-2(5H)-furanone, 5-pentyl-2(5H)-furanone, 5-hexyl-2(5H)-furanone, 5-pentyl-2(3H)-furanone, 4-methyl-3-pentyl-2(5H)-furanone, and 2(5H)-furanone. In some embodiments, the lactone comprises a 5-membered lactone ring without any unsaturated bonds. Non-limiting examples of such lactones include butyrolactoneγ, valproiconeγ, caprolactoneγ, heptanolactoneγ, octylolactoneγ, undecylolactoneγ, decylolactoneγ, dihydrojasmone lactone, and dihydromenthide lactone (3,6-dimethyl-hexahydro-2(3H)-benzofuranone). In some embodiments, the lactone is dihydromenthide lactone.

[0080] In some embodiments, the lactone comprises a 6-membered lactone ring with or without unsaturated bonds. In some embodiments, the lactone comprises a 6-membered lactone ring having at least one unsaturated bond. Non-limiting examples of lactones comprising a 6-membered lactone ring having at least one unsaturated bond include δ-2-decenolactone, coumarin, and 6-methylcoumarin. In some other embodiments, the lactone comprises a 6-membered lactone ring without any unsaturated bonds. Non-limiting examples of lactones comprising a 6-membered lactone ring without any unsaturated bonds include decanolide δ, dodecalide δ, and cyclohexyllactone.

[0081] For example, in some embodiments, the cooling effect modifying composition comprises caloric sugars such as sucrose, glucose, fructose (e.g., in the form of high-fructose corn syrup), or any combination thereof. In some embodiments, the cooling effect modifying composition comprises one or more rebaudiosides (e.g., rebaudioside A, rebaudioside D, rebaudioside E, rebaudioside M, or any combination thereof). Generally, the concentration of rebaudiosides (e.g., rebaudioside A) is about 20 to 50 times higher than the concentration of sucralose described above. In some embodiments, the cooling effect modifying composition comprises one or more high-intensity artificial sweeteners such as acesulfame potassium, aspartame, cyclamate, neotame, etc. When any such high-intensity artificial sweetener is present in the cooling effect modifying composition, their concentration will be approximately the same as the concentration described for sucralose described above. In some other embodiments, the cooling effect modifying composition comprises one or more low-caloric carbohydrates or sugar alcohols, such as allulose, xylitol, erythritol, etc. In some other embodiments, the cooling effect modifying composition comprises mogrosides, for example as monk fruit juice or extract, or as mogroside III, mogroside IV, mogroside V, symmonoside I, isomogroside V, or mogroside IV. E Isomogroside IV E Isomogroside IV and isomogroside III E One or more of the 1,6-α isomers of 1,1-oxomogroside V and symmenidine I, and any combination thereof. Other mogroside compounds that may be suitably included in cooling-modifying compositions are described in U.S. Patent Application Publication No. 2017 / 0119032.

[0082] Various other sweeteners may also be included in the cooling effect modified composition. Non-limiting examples include D-allulose, L-ribose, D-tagatose, L-glucose, L-fucose, L-arabinose, D-minobiose, D-leucobionic acid, isomaltitol, lactitol, mannitol, sorbitol, maltodextrin, saccharin, alitane, cyclamic acid, tagatose, maltose, galactose, mannose, lactose, D-tryptophan, glycine, maltitol, lactitol, isomaltitol, hydrogenated starch hydrolysate (HSH), chemically modified mogrosides (such as glucosylated mogroside), carrelame and other guanidine sweeteners, honey, Jerusalem artichoke syrup, licorice root, monk fruit (fruit, powder or extract), lucuma (fruit, powder or extract), maple sap (including, for example, from sugar maple). Sap from various trees including: saccharum, black maple (Acer nigrum), American red maple (Acer rubrum), silver maple (Acersaccharinum), Norway maple (Acer platanoides), ash-leaved maple (Acer negundo), large-leaved maple (Acer macrophyllum), coarse-toothed maple (Acer grandidentatum), Rocky Mountain maple (Acer glabrum), and maple (Acermono); maple syrup; maple sugar; walnut sap (including, for example, sap extracted from white walnut (Juglans cinerea), black walnut (Juglans nigra), ghost walnut (Juglans ailatifolia), and walnut (Juglans regia); and birch sap (including, for example, sap extracted from paper birch (Betula papyrifera), Canadian yellow birch (Betula alleghaniensis), mountain birch (Betula lenta), river birch (Betula nigra), grey birch (Betula populifolia), and weeping birch (Betula...). Resin extracted from *Pendula*, sycamore sap (e.g., sap extracted from *Platanus occidentalis*), ironwood sap (e.g., sap extracted from *Ostrya virginiana*), unrefined sucrose (mascobado), molasses (e.g., blackstrap molasses), molasses sugar, monalose, monellin, cane sugar (cane sugar)Sugar (also known as natural sugar, unrefined sucrose, or cane sugar), palm sugar, panocha, piloncillo, rapadura, raw sugar, rice syrup, sorghum, sorghum syrup, cassava syrup (also known as cassava starch syrup), thaumatin, yacon root, malt syrup, barley malt syrup, barley malt powder, beet sugar, cane sugar Sugar), crystallized fruit juice crystals, caramel, carob syrup, castor oil, hydrogenated starch hydrosol, hydrolyzed canned fruit juice, hydrolyzed starch, invert sugar, anethole, arabinogalactan, concentrated grape juice, syrup, P-4000, acesulfame potassium (also known as acetylsupan potassium or ace-K), aclame, advans, aspartame, baiyunosdie, neotame, benzamide derivatives, bernadame, aspartame alias (canderel), carrelame and other guanidine sweeteners, plant fiber, corn sugar, conjugated sugars, curculigosin, cyclamates, cyclocaryoside II) Demerara, dextran, dextrin, diastatic malt, dulcin, sucrol, valzin, dulcogenin A, dulcogenin B, emulin, enoxolone, maltodextrin, saccharin, estragole, ethyl maltol, glucin, gluconate, gluconolactone, glucosamine, glucuronic acid, glycerol, glycyphillin, glycyrrhizin, glycyrrhizin monoglucuronide, golden sugar, yellow sugar, golden syrup, granulated sugar, Gynostemma pentaphyllum, hernandulcin, isomerized liquid sugar, jallab, chicory root dietary fiber, kynurenine derivatives (including N) '-Formyl-kynurenine, N'-acetyl-kynurenine, 6-chloro-kynurenine), galactitol, litesse, ligicane, lycasin, N-(4-cyanophenyl)-N-(2,3-methylenedioxybenzyl)guanidinacetic acid, guanidine, farernum syrup, areca nut protein I, areca nut protein II, maltol, crystalline maltitol, maltodextrin, maltotriol, mannosamine, miraculin, mizuame, mogrosides (including, for example, mogroside IV, mogroside V and neomogroside), mukurozioside, nanosugars sugar), naringin dihydrochalcone, neohesperidin dihydrochalcone, raw sugar (nib sugar), black oligosaccharides, norbu, almond syrup, osladin, pekmez, pentadin, periandrin I, perillartine, petphyllum, phenylalanine, phloisosideside I, phlorodizin, phyllodulcin, polyglycitol syrup, polypodoside A, pterocaryoside A, pterocaryoside B, rebiana, refined syrup, rub syrup, rubusoside, selligueain A A) Shugr, ciprofloxacin I, and siraitiagrosvenorii), soybean oligosaccharides, Splenda, SRIoxime V, steviol glycosides, steviol disaccharides, steviol glycosides, strogins 1, 2 and 4, sucronic acid, sucrononate, sugars, sodium p-nitrophenylureapropionate (suosan), phloridzin, super aspartame, tetrasaccharides, threitol, treacle, trilobtain, tryptophan and its derivatives (6-trifluoromethyl-tryptophan, 6-chloro-D-tryptophan), vanilla sugar, heptenetropeol, beet syrup, aspartame-acesulfame potassium, assugrin, and any combination or blend of two or more of them.

[0083] In some embodiments, the cooling effect modifying composition may comprise any additional ingredients or combinations of ingredients commonly used in food and beverage products, including but not limited to:

[0084] Acids, including, for example, citric acid, phosphoric acid, ascorbic acid, sodium bisulfate, lactic acid, or tartaric acid;

[0085] Bitter components include, for example, caffeine, quinine, green tea, catechins, polyphenols, Robusta coffee bean extract, coffee bean extract, potassium chloride, menthol, or proteins (such as proteins and protein isolates derived from plants, algae, or fungi).

[0086] Coloring agents, including, for example, caramel color, red #40, yellow #5, yellow #6, blue #1, red #3, purple carrot, black carrot juice, purple sweet potato, vegetable juice, fruit juice, beta-carotene, curcumin, or titanium dioxide;

[0087] Preservatives, including, for example, sodium benzoate, potassium benzoate, potassium sorbate, sodium metabisulfite, sorbic acid, or benzoic acid;

[0088] Antioxidants, including, for example, ascorbic acid, calcium disodium EDTA, α-tocopherol, mixed tocopherols, rosemary extract, grape seed extract, resveratrol, or sodium hexametaphosphate;

[0089] Vitamins or functional ingredients, including, for example, resveratrol, Co-Q10, omega-3 fatty acids, theanine, choline chloride (citocoline), cellulose, inulin (chicory root), taurine, ginseng extract, guarana extract, ginger extract, L-phenylalanine, L-carnitine, L-tartrate, D-glucuronide, inositol, bioflavonoids, echinacea, ginkgo biloba, yerba mate, flaxseed oil, Garcinia cambogia peel extract, white tea extract, ribose, milk thistle (milk) Thistle extract, grape seed extract, pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12), nicotinamide (vitamin B3), biotin, calcium lactate, calcium pantothenate (pantothenic acid), calcium phosphate, calcium carbonate, chromium chloride, chromium polynicotinate, copper sulfate, folic acid, ferric pyrophosphate, iron, magnesium lactate, magnesium carbonate, magnesium sulfate, monopotassium phosphate, monosodium phosphate, phosphorus, potassium iodide, potassium phosphate, riboflavin, sodium sulfate, sodium gluconate, sodium polyphosphate, sodium bicarbonate, thiamine mononitrate, vitamin D3, vitamin A palmitate, zinc gluconate, zinc lactate or zinc sulfate;

[0090] Clouding agents, including, for example, ester gum, brominated vegetable oil (BVO) or sucrose isobutyrate acetate (SAIB);

[0091] Buffer solutions, including, for example, sodium citrate, potassium citrate, or salts;

[0092] Flavors include, for example, propylene glycol, ethanol, glycerin, gum arabic, maltodextrin, modified corn starch, dextrose, natural flavorings, natural flavorings with other natural flavorings (WONF), natural and artificial flavorings, artificial flavorings, silica, magnesium carbonate, or tricalcium phosphate; or

[0093] Starch and stabilizers, including, for example, pectin, xanthan gum, carboxymethyl cellulose (CMC), polysorbate 60, polysorbate 80, medium-chain triglycerides, cellulose gel, cellulose gum, sodium caseinate, modified food starch, gum arabic (acacia gum), inulin, or carrageenan.

[0094] When dissolved or suspended in an aqueous medium, the cooling-modifying composition can have any suitable pH value, such as from low pH to neutral pH. Low and neutral pH values ​​include, but are not limited to, 1.5 to 9.0, or 2.5 to 8.5; 3.0 to 8.0; 3.5 to 7.5, and 4.0 to 7 pH values.

[0095] In some embodiments, the cooling effect modifying composition according to any of the foregoing embodiments further includes one or more additional flavor modifying compounds, such as compounds that enhance sweetness (e.g., hesperidin, naringin, etc.), compounds that block bitterness, compounds that enhance umami, compounds that reduce sourness or licorice flavor, compounds that enhance saltiness, compounds that enhance cooling effect, or any combination of the foregoing compounds.

[0096] In some embodiments, the cooling-enhancing compositions disclosed herein comprise one or more sweetness-enhancing compounds. Such sweetness-enhancing compounds include, but are not limited to, naturally derived compounds such as hesperidin, naringenin, rhubarb glycoside, glucosylated steviol glycoside, glycyrrhizic acid derived from licorice, aromadendrin-3-O-acetate or other similar flavonols or flavonoids, or synthetic compounds such as those described in U.S. Patent Nos. 8,541,421; 8,815,956; 9,834,544; 8,592,592; 8,877,922; 9,000,054; and 9,000,051, and any compound described in U.S. Patent Application Publication No. 2017 / 0119032. Suitable examples include 3-((4-amino-2,2-dioxo-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propyl-propionamide, N-(1-((4-amino-2,2-dioxo-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methyl-prop-2-yl)isonicotinamide, or any combination thereof.

[0097] In some further embodiments, the cooling-modifying compositions disclosed herein comprise one or more other umami or rich-flavor-enhancing compounds. Such umami-enhancing compounds include, but are not limited to, naturally derived compounds, such as (E)-3-(3,4-dimethoxyphenyl)-N-(4-methoxyphenylethyl)acrylamide, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 8,735,081; 8,124,121; and 8,968,708.

[0098] In some further embodiments, the cooling-enhancing compositions disclosed herein comprise one or more cooling-enhancing compounds. Such cooling-enhancing compounds include, but are not limited to, naturally derived compounds, such as menthol or analogues thereof, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 9,394,287 and 10,421,727.

[0099] In some further embodiments, the cooling-modifying compositions disclosed herein comprise one or more bitterness-blocking compounds. Such bitterness-blocking compounds include, but are not limited to, naturally derived compounds, such as menthol or analogues thereof, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 8,076,491; 8,445,692; and 9,247,759. Examples include N-ethyl-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide; N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide; 2-(4-fluorophenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-( (2,3-Dihydro-1H-indene-5-yl)oxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-acetamide; 2-((2,3-Dihydro-1H-indene-5-yl)oxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-5-ylmethyl)-acetamide; 2-((5-methoxybenzofuran-2-yl)oxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-acetamide; and any combination thereof.

[0100] In some further embodiments, the flavor-modifying compositions disclosed herein comprise one or more flavor-modifying compounds. Such flavor-modifying compounds include, but are not limited to, tannins, cellulose materials, bamboo powder, etc.

[0101] In some further embodiments, the cooling effect modifying compositions disclosed herein comprise one or more flavor masking compounds. Such flavor masking compounds include, but are not limited to, cellulose materials, materials extracted from fungi, materials extracted from plants, citric acid, carbonic acid (or carbonates), etc.

[0102] In some embodiments, the cooling-modifying compositions disclosed herein may contain cyclosalt. When cyclosalt is present, its relative concentration is similar to that of the lactone.

[0103] The cooling effect modifying composition can be in any suitable form. For example, in some embodiments, the composition is in solid form, such as a solid powder. In some such embodiments, the composition also comprises a solid carrier, such as carbohydrates. In some other embodiments, the cooling effect modifying composition is in the form of a liquid solution or suspension. This liquid form can be aqueous or non-aqueous, or it can be an emulsion, such as an oil-in-water or water-in-oil emulsion. In some embodiments, the cooling effect modifying composition is incorporated into flavored products such as food or beverage products, or oral care products such as toothpaste or mouthwash.

[0104] In some embodiments, the cooling effect modifying composition comprises one or more flavorings, or any other additives described in H. Mitchell, *SWEETENERS AND SUGAR ALTERNATIVES IN FOOD TECHNOLOGY*, Backwell Publishing Ltd., 2006. As used herein, the term "flavoring" includes those flavorings known to those skilled in the art, such as natural and artificial flavorings. These flavorings may be selected from synthetic flavoring oils and flavoring aromatic substances or from oils, oleoresins and extracts derived from plants, leaves, flowers, fruits, etc., and combinations thereof. Representative flavoring oils, without limitation, include spearmint oil, cinnamon oil, deer hoof oil (methyl salicylate), peppermint oil, peppermint oil, clove oil, laurel oil, fennel oil, eucalyptus oil, thyme oil, cedarwood leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, and cassia seed oil. Useful flavorings also include artificial, natural, and synthetic fruit flavorings, such as vanilla and citrus oils, including lemon, orange, lime, grapefruit, yuzu, and sudachi, as well as fruit essences, including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, cantaloupe, plum, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya, etc. Other potential flavorings include milk flavorings, butter flavorings, cheese flavorings, cream flavorings, and yogurt flavorings; vanilla flavorings; tea or coffee flavorings, such as green tea flavorings, oolong tea flavorings, tea flavorings, cocoa flavorings, chocolate flavorings, and coffee flavorings; mint flavorings, such as peppermint flavorings, spearmint flavorings, and Japanese mint flavorings; and spice flavorings, such as asafoetida flavorings, Indian anise flavorings, star anise flavorings, angelica flavorings, fennel flavorings, allspice flavorings, cinnamon flavorings, chamomile flavorings, mustard flavorings, cardamom flavorings, coriander flavorings, fennel flavorings, clove flavorings, pepper flavorings, cilantro flavorings, and sassafras flavorings. Flavoring agents, including savory flavoring agents, Sichuan pepper flavoring agents, perilla flavoring agents, juniper berry flavoring agents, ginger flavoring agents, star anise flavoring agents, horseradish flavoring agents, thyme flavoring agents, tarragon flavoring agents, dill flavoring agents, bell pepper flavoring agents, nutmeg flavoring agents, basil flavoring agents, marjoram flavoring agents, rosemary flavoring agents, bay leaf flavoring agents, and mustard (Japanese horseradish) flavoring agents; alcoholic flavoring agents, such as red wine flavoring agents, whiskey flavoring agents, brandy flavoring agents, rum flavoring agents, gin flavoring agents, and liqueur flavoring agents; floral flavoring agents; and vegetable flavoring agents, such as onion flavoring agents, garlic flavoring agents, cabbage flavoring agents, carrot flavoring agents, celery flavoring agents, mushroom flavoring agents, and tomato flavoring agents.These flavorings can be used in liquid or solid form and can be used alone or in combination. Commonly used flavorings include peppermint, such as peppermint, menthol, spearmint, artificial vanilla, cinnamon derivatives, and various fruit flavorings, whether used alone or in combination. Flavorings can also provide a fresh breath property, especially peppermint flavorings when used in combination with cooling agents.

[0105] Flavoring agents can also provide a fresh breath characteristic, especially minty flavorings when used in combination with cooling agents. These flavoring agents can be used in liquid or solid form and can be used alone or in combination. Other useful flavoring agents include aldehydes and esters, such as cinnamyl acetate, cinnamaldehyde, citral diethyl acetal, dihydrocarboxyl acetate, eugenol formate, p-methyl anisole, etc. Generally, any flavoring agent or food additive can be used, such as those described by the National Academy of Sciences in Chemicals Used in Food Processing, publication 1274, pages 63-258.

[0106] Other examples of aldehyde flavoring agents include, but are not limited to, acetaldehyde (apple), benzaldehyde (cherry, almond), anisaldehyde (licorice, fennel), cinnamaldehyde (cinnamon), citral (α-citral, lemon, lime), neraldehyde (β-citral, lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, cream), jasmine aldehyde (piperaldehyde, vanilla, cream), vanillin (vanilla, cream), α-pentylcinnamaldehyde (spicy fruit flavoring agent), butyraldehyde (butter, cheese), pentanalaldehyde (butter, cheese), and lemongrass. Aldehydes (modified products, various types), decanal (citrus fruits), aldehyde C-8 (citrus fruits), aldehyde C-9 (citrus fruits), aldehyde C-12 (citrus fruits), 2-ethylbutanal (berries), hexenal, i.e., trans-2 (berries), tolueneformin (cherries, almonds), veratral (vanilla), 2,6-dimethyl-5-heptene, i.e., melon aldehyde (melon), 2,6-dimethyloctanal (green fruits), and 2-dodecenal (citrus, oranges), cherry, grape, strawberry shortbread, and mixtures thereof. This list of flavorings is merely exemplary and is not intended to limit the scope of the term "flavoring" or the generally disclosed information.

[0107] In some embodiments, peppermint flavoring agents, including menthol and related compounds, or other breath-freshening compounds, may be combined with cooling agents, such as those described in U.S. Patent Nos. 9,394,287 and 9,732,071. Other examples of cooling agents include 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxane ester, N-ethyl-p-menthaneformamide (WS-3, also known as menthane-3-carboxylic acid-N-acetamide), N-2,3-trimethyl-2-isopropylbutyramide (WS-23), menthyl lactate (Frescolat.RTM.ML), menthone glycerol acetal (Frescolat.RTM.MGA), menthyl succinate monomentholate (Physcool.RTM.), O-menthyl-glycerol, menthyl-N,N-dimethyl succinate, N-(4-cyanomethylphenyl)-p-menthaneformamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthaneformamide, menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, isomenthyl). Menthols, including menthols, neo-menthol, and menthol; menthyl ethers (e.g., (1-menthoxy)-1,2-propanediol, (1-menthoxy)-2-methyl-1,2-propanediol, 1-menthyl-methyl ether); menthyl esters (e.g., menthyl formate, menthyl acetate, menthyl isobutyrate, menthyl lactate, L-menthyl-L-lactate, L-menthyl-D-lactate, menthyl-(2-methoxy)acetate, menthyl-(2-methoxyethoxy)acetate, menthyl pyroglutamic acid ester); N-(4-cyanomethylphenyl)-p-menthanecarboxamide; N-(2-(pyridin-2)-yl)ethyl)-3-p-menthanecarboxamide; menthyl carbonates (e.g., menthyl propylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glyceryl carbonate, or mixtures thereof); and menthyl carboxylic amides (e.g., menthyl carboxylic acid-N-ethylamide [WS3], N-α).-(menthane-carbonyl)glycine ethyl ester [WS5], menthane carboxylic acid-N-(4-cyanophenyl)amide, menthane carboxylic acid-N-(alkoxyalkyl)amide), menthone and menthone derivatives (e.g., L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyric acid-N-methylamide [WS23]), isoprene alcohol or its esters (1-(-)-isomenthane alcohol, 1-(-)-isomenthane alcohol) Acetates), menthol derivatives (e.g., p-menthol-3,8-diol), N-(4-cyanomethylphenyl)-p-menthol formamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthol formamide, piperazine alcohol or synthetic or natural mixtures containing piperazine alcohol, pyrrolidone derivatives of cycloalkyl diones (e.g., 3-methyl-2-(1-pyrrolyl)-2-cyclopenten-1-one) or tetrahydropyrimidin-2-ones (e.g., icilin or related compounds, such as WO3). Menthol, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide, menthyl ethers (e.g., (1-menthoxy)-1,2-propanediol, (1-menthoxy)-2-methyl-1,2-propanediol), more polar menthyl esters (e.g., menthyl lactate, L-menthyl-L-lactate, L-menthyl-D-lactate, menthyl-(2-methoxy)acetate, menthyl-(2-methoxyethoxy)acetate, menthyl pyroglutamic acid ester), menthyl carbonates (e.g., menthyl propylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glycerol carbonate), and half-esters of menthol with dicarboxylic acids or their derivatives (e.g., succinic acid). Menthyl monomenthol, glutaric acid menthyl monomenthol, O-menthyl succinate-N,N-(dimethyl)amide, O-menthyl succinate amide), 3,4-methylenedioxycinnamic acid-N-cyclohexyl-N-2-pyridineamide, isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-amine, 3,4,6,7,11b,12-hexahydro-3,3-dimethyl-spiro[13H-dibenzo[a,f]quinazine-1-3,2'-[1,3]dithiacyclopentane]-1(2H)-one, 5,6,10b,11-tetrahydro-3-methyl-spiro[12H-benzo[a]furano[3,4-f]quinazine-1-2,2'-[1,3]dithiacyclopentane]-1(3H)-one. The most preferred cooling compounds are those selected from the group consisting of: 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxane ester, N-ethyl-p-menthaneformamide (WS-3, also known as menthane-3-carboxylic acid-N-ethylamide), menthyl lactate (Frescolat.RTM.ML), and menthone glycerol acetal (Frescolat.RTM).MGA), N-(4-cyanomethylphenyl)-p-menthaneformamide, and (1-menthoxy)-1,2-propanediol.

[0108] Cooling Modification Compositions for Body Care Products

[0109] In some embodiments of any of the foregoing embodiments, the cooling effect modifying composition comprises any compound, material, or combination thereof typically included in body care products (e.g., products suitable for application to human hair or skin).

[0110] In some embodiments, the composition comprises one or more fragrances. In some embodiments, at least a portion of the fragrance may be encapsulated. Suitable fragrances include complex mixtures of fragrance compounds selected to provide any desired odor. In the context of this disclosure, the term “fragrance” is used synonymously with “perfume.” Fragrance compounds commonly used in the fragrance industry and suitable for the purposes of this disclosure are described more fully in S. Arctander’s *Perfume Flavors and Chemicals*, Vols. I and II (1969) and *The Merck Index*, 8th edition, Merck & Co., Inc., Rahway, NJ. The term “fragrance compound” encompasses naturally occurring and synthetic materials known for use in fragrances, as well as animal oils. Fragrance compounds can also be any natural oil or extract, or chemical compound used in fragrance compositions. Natural oils and extracts are described in Guenther's *The Essential Oils 1949* and may include extracts, presses, collected exudates, and distillates from any of the following parts of a suitable plant: roots, rhizomes, bulbs, corms, stems, bark, heartwood, leaves, flowers, seeds, and fruits. Examples of such extracts and distillates include citrus fruit oils such as those of oranges, mandarins, grapefruits, limes, or lemons; tree oils such as those of pine or cedar; herbal oils such as those of peppermint, thyme, lavender, basil, rosemary, and cloves; or floral extracts such as those of roses, jasmine, lily of the valley, or geraniums.

[0111] In some embodiments, the body care composition may contain one or more ingredients that provide active beneficial effects for hair or skin care, such as compounds with antioxidant activity. For example, in some embodiments, the body care product contains ascorbic acid, also known as vitamin C, which is an essential nutrient with antioxidant activity. In some embodiments, the body care composition contains vitamin E, which refers to eight structure-related antioxidant compounds exhibiting free radical scavenging activity. These compounds include four tocopherol compounds and four tocotrienol compounds. In some embodiments, the body care composition contains resveratrol, an antioxidant compound naturally found in grape skins. In some embodiments, the body care composition contains certain oligopeptides, such as acetyl hexapeptide-8 (also known as acetyl hexapeptide-3), which are synthetic peptides that loosen wrinkles. A variety of other such compounds may also be included, such as retinol, niacinamide, coenzyme Q10, and various polyphenols, such as flavonoids like catechins. The amounts of these active ingredients may be the same as those typically found in other body care products.

[0112] The body care compositions disclosed herein may include or be incorporated into any suitable type of excipient or carrier. Generally, the excipient or carrier will be dermatologically acceptable. Non-limiting examples of excipients or carriers include water, glycerin, alcohols, oils, silicone-containing compounds, organosilicon compounds, and waxes. Variations and other suitable carriers will be apparent to those skilled in the art and are suitable for use in the body care compositions of this disclosure. In some embodiments, the concentrations and combinations of compounds, ingredients, and reagents may be selected such that these combinations are chemically compatible and do not form complexes that precipitate from the finished body care product.

[0113] The body care compositions disclosed herein can be constructed or formulated in a variety of different forms. Non-limiting examples include lotions (e.g., water-in-oil, water-in-oil, water-in-oil, water-in-silicone, silicone-in-water, oil-in-water, silicone-in-oil emulsions, etc.), creams, lotions, solutions (e.g., aqueous or hydroalcoholic), anhydrous bases (e.g., lipsticks and powders), gels, masks, scrubs, body butters, exfoliating creams, and ointments. Variations and other structures will be apparent to those skilled in the art and are suitable for use in the body care compositions of this disclosure.

[0114] A variety of other ingredients can be used, such as those commonly used in cosmetics, skin care products, or hair care products. The CTFA INTERNATIONAL COSMETIC INGREDIENT DICTIONARY ANDHANDBOOK (2004 and 2008) describes a variety of non-limiting ingredients that can be used in the compositions disclosed in this invention. Examples of these ingredient categories include: fragrances (artificial and natural; e.g., gluconic acid, phenoxyethanol, and triethanolamine), dyes and pigments (e.g., Blue 1, Blue 1 Lake, Red 40, titanium dioxide, D&C Blue 4, D&C Green 5, D&C Orange 4, D&C Red 17, D&C Red 33, D&C Violet 2, D&C Yellow 10, and D&C Yellow 11), flavorings or fragrances (e.g., stevia). Beef rebaudiana (sweet leaf) extract and menthol), adsorbents, lubricants, solvents, humectants (including emollients, humectants, film-forming agents, occlusive agents, and agents that affect the skin's natural moisturizing mechanisms), water-reppelants, UV absorbers (physical and chemical absorbers, such as para-aminobenzoic acid (“PABA” and corresponding PABA derivatives, titanium dioxide, zinc oxide, etc.), essential oils, vitamins (such as B, D, E, and K), trace metals (such as zinc, calcium, and selenium), anti-irritants (such as steroidal and non-steroidal anti-inflammatory drugs), plant extracts (such as aloe vera, ... Chamomile, cucumber extract, ginkgo biloba, ginseng, and rosemary; antimicrobial agents; antioxidants (e.g., BHT and tocopherol); chelating agents (e.g., disodium EDTA and tetrasodium EDTA); preservatives (e.g., methylparaben and propylparaben); pH adjusters (e.g., sodium hydroxide and citric acid); absorbents (e.g., aluminum octenyl succinate, kaolin, corn starch, oat starch, cyclodextrin, talc, and zeolite); skin bleaching and whitening agents (e.g., hydroquinone and nicotinamide lactate); moisturizers (e.g., sorbitol, urea, methylglucose ether 20, saccharide isomers). (isomerate and mannitol), exfoliants, waterproofing agents (e.g., magnesium hydroxide stearate / aluminum hydroxide), skin conditioning agents (e.g., aloe vera extract, allantoin, bisabolol, ceramides, dimethicone, hyaluronic acid, biosaccharide gum-1, ethylhexylglycerin, pentylene glycol, hydrogenated polydecene, octyl dodecyl oleate, and dipotassium glycyrrhizate). Further non-limiting examples of some of these ingredients are provided in the following subsections.

[0115] In some embodiments, the body care composition comprises one or more UV absorbers or reflectors. Suitable UV absorbers or reflectors include chemical and physical sunscreens. Non-limiting examples of chemical sunscreens include para-aminobenzoic acid (PABA), PABA esters (PABA glyceryl ester, PABA pentyl dimethyl ester and PABA octyl dimethyl ester), PABA butyl ester, PABA ethyl ester, PABA ethyl dihydroxypropyl ester, benzophenones (hydroxybenzophenone, sulfonisobenzophenone, benzophenone and benzophenone 1 to 12), cinnamates / esters (oxtinoxate, isoamyl p-methoxycinnamate, octyl methoxycinnamate, cinoxate, diisopropyl methyl cinnamate, DEA salt of methoxycinnamate, ethyl diisopropyl cinnamate, glyceryl caprylate dimethoxycinnamate and ethyl methoxycinnamate), cinnamates, salicylates / esters (methyl methacrylate, benzyl salicylate, ethylene glycol salicylate, isopropyl benzyl salicylate, etc.), and anthranilic acid. Salts / esters, ethyl urocarbamate, homosalate, octisalate, dibenzoylmethane derivatives (e.g., avobenzone), octocrylene, octyltriazinone, digalactotrioleate, glyceryl aminobenzoate, 2-hydroxy-1,4-naphthoquinone (lawsone) and dihydroxyacetone, ethylhexyltriazinone, dioctylbutyramide triazinone, benzylmalonate polysiloxane, terephthalimide dicamphor sulfonic acid, disodium phenyl dibenzimidazole tetrasulfonate, diethylaminohydroxybenzoyl benzoate, diethylaminohydroxybenzoyl benzoate, dibenzoxazolylphenylethylhexyliminotriazine, formyltrazol trisiloxane, methylene dibenzotriazolyl tetramethylbutylphenol, and diethylhexyloxyphenol methoxyphenyltriazine, 4-methylbenzimidyl camphor and isoamyl 4-methoxycinnamate. Non-limiting examples of physical sunscreens include kaolin, talc, petrolatum, and metal oxides (such as titanium dioxide and zinc oxide).

[0116] In some embodiments, the body care composition comprises one or more moisturizing agents. Non-limiting examples of moisturizing agents that may be used include amino acids, chondroitin sulfate, diglycerides, erythritol, fructose, glucose, glycerin, glycerol polymers, ethylene glycol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factors, PEG-15 butylene glycol, polyglycerol sorbitol, pyrrolidone carboxylic acid salts, potassium PCA, propylene glycol, sugar isomers, sodium glucuronide, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol. Other non-limiting examples include acetylated lanolin, acetylated lanolin alcohol, alanine, algae extracts, Aloe barbadensis, Aloe barbadensis extract, Aloe barbadensis gel, Althaea officinalis extract, Prunus armeniaca kernel oil, arginine, arginine aspartate salt / ester, Arnica montana extract, aspartic acid, Persea gratissima oil, barrier sphingolipids, butanol, beeswax, behenol, β-sitosterol, Betula alba bark extract, Borago officinalis extract, Ruscus aculeatus extract, butylene glycol, Calendula officinalis extract, calendula oil, and Euphorbia Cerifera wax, low-erucic acid rapeseed (canola) oil, caprylic / capric triglycerides, cardamom (Elettaria cardamomum) oil, coopernica cerifera wax, carrot (Daucus carota sativa) oil, castor (Ricinus communis) oil, ceramides, ceresin, cetearyl alcohol polyether-5, cetearyl alcohol polyether-12, cetearyl alcohol polyether-20, cetearyl caprylate, cetearyl alcohol polyether-20, cetearyl alcohol polyether-24, cetyl acetate, cetyl caprylate, cetyl palmitate, chamomile (Anthemis nobilis) oil, cholesterol, cholesterol esters, cholesterol hydroxystearate, citric acid, clary sage (Salvia sclarea) oil, cocoa (Theobroma cacao) butter, cocoa caprylate / capric acid ester, coconut (Coconut) Nucifera oil, collagen, collagen amino acids, corn (Zea)Mays oil, fatty acids, decyl oleate, polydimethylsiloxane copolyol, polydimethylsiloxane alcohol, dioctyl adipate, dioctyl succinate, dipentaerythritol hexacaprylate / hexacaprylate, DNA, erythritol, ethoxydiethylene glycol, ethyl linoleate, Eucalyptus globulus oil, Oenothera biennis oil, fatty acids, Geranium maculatum oil, glucosamine, glucosamine glutamate, glutamic acid, glyceryl polyether-26, glycerol, glyceryl glycerol, distearate, hydroxystearate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate, glyceryl stearate SE, glycine, ethylene glycol stearate, ethylene glycol stearate SE, glucosamine, grape seed oil, hazelnut (Corylus) Americana (American hazelnut) nut oil, Corylus avellana (European hazelnut) nut oil, hexanediol, hyaluronic acid, mixed safflower (Carthamus tinctorius) oil, hydrogenated castor oil, hydrogenated coconut oil glycerides, hydrogenated coconut oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm oil glycerides, hydrogenated palm kernel oil, hydrogenated soybean oil, hydrogenated tallow glycerides, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glucosamine, hydrolyzed keratin, hydrolyzed soybean protein, hydroxylated lanolin, hydroxyproline, isocetyl stearate, isocetyl stearoyl stearate, isodecanyl oleate, isopropyl isostearate, isopropyl lanolin, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearamide DEA, isostearic acid, isostearyl lactate, isostearyl neopentanoate, jasmine (Jasminum) Officinale oil, jojoba (Buxuschinensis) oil, giant kelp, kukui (Aleurites moluccana) nut oil, lactamide MEA, lanolin alcohol polyether-16, lanolin alcohol polyether-10 acetate, lanolin, lanolin acid, lanolin alcohol, lanolin oil, lanolin wax, lavender (Lavandula angustifolia) oil, lecithin, lemon (Citrus medica limonum) oil, linoleic acid, linolenic acid, macadamia nut (Macadamia) oilIngredients include: ternifolia oil, maltitol, chamomile (Chamomillarecutita) oil, methyl glucose sesquistearate, methylsilanol PCA, mineral oil, mink oil, sphaeromonas oil, myristyl lactate, myristate, myristyl propionate, neopentyl glycol dicaprylate / dicaprylate, octyl dodecyl alcohol, octyl myristate, octyl stearate, octyl hydroxystearate, octyl palmitate, octyl salicylate, octyl stearate, oleic acid, olive (Olea europaea) oil, orange (Citrus aurantiumdulcis) oil, palm (Elaeis guineensis) oil, palmitic acid, panthenyl thioethylamine, panthenol, panthenol ethyl ether, paraffin wax, PCA, peach (Prunus persica) kernel oil, and peanut (Arachis) oil. Hypogaea oil, PEG-8C12-18 ester, PEG-15 cocoylamine, PEG-150 distearate, PEG-60 isostearyl glycerol, PEG-5 stearyl glycerol, PEG-30 stearyl glycerol, PEG-7 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methylglucose sesquistearate, PEG-40 sorbitol oleate, PEG-5 soybean sterol, PEG-10 soybean sterol, PEG-2 stearate, PEG-8 stearate, PEG-20 stearate, PEG-32 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 stearate, pentadecyl lactone, peppermint (Mentha) Piperrita oil, Petrolatum, phospholipids, plankton extract, polyamino acid polysaccharide condensate, polyglycerol-3 diisostearate, polyquaternium-24, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, polysorbate 85, potassium myristate, potassium palmitate, propylene glycol, propylene glycol dicaprylate / dicaprylate, propylene glycol dicaprylate, propylene glycol dinonanoate, propylene glycol laurate, propylene glycol stearate, propylene glycol stearate SE, PVP, pyridoxine dipalmitate, retinol, retinol palmitate, rice bran oil, RNA, rosemary oil, rose oil, safflower oil, sage oil. Officinalis oil, sandalwood oil, serine, serum albumin, sesame oil, shea butter.(Parki) oil, silk powder, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium polyglutamate, soluble collagen, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean (Glycine soja) oil, sphingolipids, squalane, squalene, stearamide MEA-stearate, stearic acid, stearoxydimethylsiloxane, stearoxytrimethylsilane, stearyl alcohol, stearyl glycyrrhetinic acid stearate, stearyl heptanoate stearate, sunflower (Helianthus annuus) seed oil, sweet almond (Prunus amygdalus) Dulcis oil, synthetic beeswax, tocopheryl acetate, tocopheryl linoleate, tribehenin, tridecyl pentoate, tridecyl stearate, triethanolamine, tristearate, urea, vegetable oil, water, wax, wheat (Triticum vulgare) germ oil and ylang-ylang (Canangaodorata) oil.

[0117] In some embodiments, the body care compositions disclosed herein comprise one or more antioxidants, for example, in addition to or in combination with those antioxidants disclosed above. For example, in some embodiments, one or more of these additional antioxidants may be used in combination with ascorbic acid, vitamin E, or combinations thereof. Non-limiting examples of antioxidants that may be used include acetylcysteine, ascorbic acid derivatives such as ascorbic acid peptides, ascorbic acid dipalmitate, ascorbic acid methylsilanol pectate, ascorbic acid palmitate, ascorbic acid stearate, BHA, BHT, tert-butylhydroquinone, cysteine, cysteine ​​HCl, dipentylhydroquinone, ditert-butylhydroquinone, diceryl thiodipropionate, dioleotocopherol methylsilanol, disodium ascorbate sulfate, distearate thiodipropionate, di(tridecyl) thiodipropionate, dodecyl gallate, isoascorbic acid, ascorbate, ethyl ferulic acid, ferulic acid, gallate, hydroquinone, isooctyl thioglycolate, kojic acid, magnesium ascorbate, magnesium ascorbate phosphate, methylsilanol ascorbate, and natural plant antioxidants. Chemicals such as green tea or grape seed extract, nordihydroguaiac acid, octyl gallate, phenyl thioglycolic acid, potassium ascorbate tocopheryl phosphate, potassium sulfite, propyl gallate, quinone, rosmarinic acid, sodium ascorbate, sodium bisulfite, sodium isoascorbate, sodium metabisulfite, sodium sulfite, superoxide dismutase, sodium thioglycolate, sorbitol furfural, thiodiethylene glycol, thiodiethylene glycolamide, thiodiethylene glycol acid, thioglycolic acid, thiolactic acid, thiosalicylic acid, tocopherol polyether-5, tocopherol polyether-10, tocopherol polyether-12, tocopherol polyether-18, tocopherol polyether-50, tocophersolan, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, and tris(nonylphenyl) phosphite.

[0118] In some embodiments, the body care composition comprises one or more structuring agents. In some embodiments, the structuring agent helps to provide the composition with rheological properties that contribute to stability. In some embodiments, the structuring agent may also act as an emulsifier or surfactant. Non-limiting examples of structuring agents include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, polyethylene glycol ethers of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, polyethylene glycol ethers of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.

[0119] In some embodiments, the body care composition comprises one or more emulsifiers. Emulsifiers can reduce interfacial tension between phases and improve the formulation and stability of the emulsion. Emulsifiers can be nonionic, cationic, anionic, and zwitterionic. Non-limiting examples include esters of glycerol, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydride, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols, alkyl phosphate esters, polyoxyethylene fatty ether phosphate esters, fatty acid amides, acyl lactates, soaps, TEA stearate, DEA oleyl alcohol polyether-3 phosphate, polyethylene glycol 20 dehydrated sorbitol monolaurate (polysorbate 20), polyethylene glycol 5 soybean sterol, stearyl alcohol polyether-2, stearyl alcohol polyether-20, stearyl... Cetearyl alcohol polyether-21, cetearyl alcohol polyether-20, cetearyl glucoside, cetearyl alcohol, C12-13 alkanol polyether-3, PPG-2 methyl gluconate distearate, PPG-5-cetearyl alcohol polyether-20, bis-PEG / PPG-20 / 20 polydimethylsiloxane, cetearyl alcohol polyether-10, polysorbate 80, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate, PEG-100 stearate, arachidyl alcohol, arachidyl glucoside, and mixtures thereof.

[0120] In some embodiments, the body care composition comprises one or more silicone-containing compounds. Non-limiting examples of silicone-containing compounds include any member of the family of polymer products whose molecular backbone consists of alternating silicon and oxygen atoms and side groups attached to silicon atoms. By varying the -Si-O- chain length, side groups, and crosslinking, silicones can be synthesized into a variety of materials. Their consistency can vary from liquid to gel to solid. Silicone-containing compounds suitable for use in the body care compositions disclosed herein include, but are not limited to, those commonly known to those skilled in the art. Non-limiting examples include silicone oils (e.g., volatile and non-volatile oils), gels, and solids. In some embodiments, the silicone-containing compound includes silicone oils, such as polysiloxanes. Non-limiting examples of polyorganosiloxanes include polydimethylsiloxane, cyclodimethylsiloxane, polyorganosiloxane-11, phenyl polytrimethylsiloxane, trimethylsilylamino polydimethylsiloxane, stearoxytrimethylsilane, or mixtures of these materials with other organosiloxane materials in any given proportion to achieve the desired consistency and application properties for the intended application (e.g., for a specific area such as skin, hair, or eyes). "Volatile silicone oil" includes silicone oils with low heat of vaporization, such as silicone oils with less than about 50 calories per gram. Non-limiting examples of volatile silicone oils include cyclodimethylsiloxane; low-viscosity polydimethylsiloxanes, such as polydimethylsiloxanes with a viscosity of about 50 cst or less. Other non-limiting volatile silicone oils that may be used in the context of this invention include those available from manufacturers such as Dow Corning, General Electric, and SWS Silicones.

[0121] In some embodiments, the body care composition comprises one or more exfoliating agents. Exfoliating agents contain ingredients that remove dead skin cells from the outer surface of the skin. These agents can act mechanically, chemically, or otherwise. Non-limiting examples of mechanical exfoliating agents include abrasives such as pumice, silica, cloth, paper, seashells, beads, solid crystals, solid polymers, etc. Non-limiting examples of chemical exfoliating agents include acid and enzyme exfoliating agents. Acids that can be used as exfoliating agents include, but are not limited to, glycolic acid, lactic acid, citric acid, alpha-hydroxy acids, beta-hydroxy acids, etc. Other exfoliating agents known to those skilled in the art may also be considered for use in the context of the body care compositions disclosed herein.

[0122] In some embodiments, the body care composition comprises one or more essential oils. Essential oils include oils extracted from herbs, flowers, trees, and other plants. These oils typically exist as tiny droplets between plant cells and can be extracted by several methods known to those skilled in the art, such as steam distillation, enfleurage (e.g., by using fat extraction), maceration, solvent extraction, or mechanical pressing. When these types of oils are exposed to air, they tend to evaporate (e.g., volatile oils). Essential oils are generally insoluble in water but soluble in ethanol, ether, fixed oils (plants), and other organic solvents. Essential oils are usually named after the plant from which they are extracted. Non-limiting examples of essential oils that can be used in the body care compositions disclosed herein include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento oil, rose oil, anise oil, balsam oil, bergamot oil, rosewood oil, cedarwood oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper berry oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin orange oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, and rose tartare. Otto oil, rosemary oil, sandalwood oil, spearmint oil, spikenard oil, vetiver oil, wintergreen oil, and ylang-ylang. Other essential oils known to those skilled in the art are also considered suitable for use in the context of this invention.

[0123] In some embodiments, the body care composition comprises one or more thickening agents. Thickening agents, including thickeners or gelling agents, include substances that increase the viscosity of the composition. Thickeners include those that increase the viscosity of the composition without substantially modifying the efficacy of the active ingredients within the composition. Thickeners can also increase the stability of the composition. Commonly used thickeners include hydrogenated polyisobutylene, glyceryl trihydroxystearate, ammonium acryloyldimethyl taurate / vp copolymer, or combinations thereof. Other non-limiting examples of additional thickeners that may be used include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include crosslinked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acid, and salts and esters of such acrylic and substituted acrylic acids, wherein the crosslinker contains two or more carbon-carbon double bonds and is derived from polyols. Examples of commercially available carboxylic acid polymers include carbomer, which is an acrylic homopolymer crosslinked with an allyl ether of sucrose or pentaerythritol. Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers. Non-limiting examples are described in U.S. Patent Nos. 5,100,660; 4,849,484; 4,835,206; 4,628,078; and 4,599,379. Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers, including substituted branched or unbranched polymers) include polyacrylamide, isoparaffins and lauryl ether-7, acrylamide and substituted acrylamides with acrylic acid and substituted acrylic acid in multi-block copolymers. Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is alkyl-substituted cellulose, wherein the hydroxyl groups of the cellulose polymer are hydroxyalkylated (e.g., hydroxyethylated or hydroxypropylated) to form hydroxyalkylated cellulose, and then C 10 -C 30 Straight-chain or branched alkyl groups are further modified via ether bonds. Typically, these polymers are C16-264 ... 10 -C 30Ethers of linear or branched alcohols with hydroxyalkyl cellulose. Other useful polysaccharides include sclerosanans, which consist of a linear chain of (1–3) linked glucose units, with (1–6) linked glucose units per three units. Non-limiting examples of gums that may be used include acacia gum, agar, alginate, alginic acid, ammonium alginate, branched starch, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimethylammonium chloride, lithium montmorillonite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar gum, ark tar gum, giant kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotinia gum, sodium carboxymethyl dextran, sodium carrageenan, astragalus gum, xanthan gum, and mixtures thereof.

[0124] In some embodiments, the body care composition comprises one or more preservatives. Non-limiting examples of preservatives that may be used in the context of this invention include quaternary ammonium preservatives, such as polyquaternium-1 and benzyl alkyl ammonium halides (e.g., benzalkonium chloride and benzalkonium bromide), parabens (e.g., methylparaben and propylparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, or combinations thereof.

[0125] In some embodiments, the body care composition comprises one or more emollients. Non-limiting examples of suitable emollients include: (a) silicone oils and their modifications, such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils; (b) fats and oils, including natural fats and oils such as jojoba oil, soybean oil, sunflower oil, rice bran oil, avocado oil, almond oil, olive oil, sesame oil, persic oil, castor oil, coconut oil, mink oil; cocoa butter; tallow, lard; hardened oils obtained by hydrogenation of the above oils; and synthetic monoglycerides, diglycerides, and triglycerides, such as glyceryl myristate and glyceryl 2-ethylhexanoate; (c) (d) Waxes, such as carnauba wax, cetearyl wax, beeswax, lanolin and their derivatives; (e) Hydrophobic plant extracts; (f) Hydrocarbons, such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristan and mineral oil; (g) Higher fatty acids, such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid, arachidonic acid and polyunsaturated fatty acids (PUFAs); (h) Higher alcohols, such as lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cholesterol and 2-hexyldecyl alcohol; (h) Esters, such as cetyl caprylate, Myristyl lactate, cetyl lactate, isopropyl myristate, myristyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, alkyl lactate, alkyl citrate, and alkyl tartrate; (i) essential oils and their extracts, such as peppermint oil, jasmine oil, camphor oil, white cedar oil, bitter orange peel oil, rye oil, turpentine oil, cinnamon oil, bergamot oil, Satsuma mandarin oil, calamus oil, pine oil, lavender oil, laurel oil, clove oil, cypress oil, eucalyptus oil, lemon... Lemon oil, borage oil, thyme oil, peppermint oil, rose oil, sage oil, sesame oil, ginger oil, basil oil, juniper oil, lemongrass oil, rosemary oil, rosewood oil, avocado oil, grape oil, grapeseed oil, myrrh oil, cucumber oil, watercress oil, calendula oil, elderberry oil, geranium oil, linden flower oil, amaranth oil, seaweed oil, ginkgo oil, ginseng oil, carrot oil, guarana oil, tea tree oil, jojoba oil, comfrey oil, oatmeal oil, cocoa butter, neroli oil, vanilla oil, green tea oil, pennywort oil. Royal oil, aloe vera oil, menthol, eucalyptol, eugenol, citral, citronellol oil, borneol, linalool, geraniol, evening primrose oil, camphor oil, thymol, spirantol oil, penene oil, limonene oil and terpene oils; (j) lipids, such as cholesterol, ceramides, sucrose esters and pseudoceramides;(k) Vitamins, minerals, and skin nutrients, such as vitamins A, E, and K; vitamin alkyl esters, including vitamin C alkyl esters; magnesium, calcium, and milk; (l) sunscreens, such as octyl methoxycinnamate and butyl methoxybenzoylmethane; (l) phospholipids; (m) polyols, such as glycerin, propylene glycol, etc.; and polyols, such as polyethylene glycol; (n) anti-aging compounds, such as α-hydroxy acids and β-hydroxy acids; and (o) mixtures of any of the foregoing components, etc.

[0126] In some embodiments, the body care composition comprises one or more tackifiers. Non-limiting examples of suitable tackifiers include aliphatic hydrocarbon resins, aromatic-modified aliphatic hydrocarbon resins, hydrogenated polycyclopentadiene resins, polycyclopentadiene resins, rosin, rosin esters, wood rosin, wood rosin esters, tall oil rosin, tall oil rosin esters, polyterpenes, aromatic-modified polyterpenes, terpene phenolic resins, aromatic-modified hydrogenated polycyclopentadiene resins, hydrogenated aliphatic resins, hydrogenated aliphatic aromatic resins, hydrogenated terpenes and modified terpenes, hydrogenated rosin acid, hydrogenated rosin esters, polyisoprene, partially or fully hydrogenated polyisoprene, polybutene, partially or fully hydrogenated polybutene, etc. The tackifier may be fully or partially hydrogenated. The tackifier may also be nonpolar, meaning that the tackifier substantially does not contain monomers with polar groups. In some embodiments, no polar groups are present. In some embodiments, the polar group is present in an amount of up to about 5% by weight, preferably up to about 2% by weight, and more preferably up to about 0.5% by weight.

[0127] In some embodiments, the body care composition comprises one or more colorants, such as pigments or dyes. Examples of suitable pigments include, but are not limited to, inorganic pigments, organic pigments, lakes, pearlescent pigments, iridescent or optically variable pigments, and mixtures thereof. The term "pigment" should be understood to refer to inorganic or organic, white or colored particles. Within the scope of this invention, the pigments may be surface-treated as appropriate, but are not limited to treatments such as those with silicones, perfluorinated compounds, lecithin, and amino acids.

[0128] In some embodiments, the body care composition comprises one or more surfactants. Surfactants that can be used as surfactant components in the compositions disclosed herein include nonionic, anionic, cationic, and amphoteric (ampholy) surfactants and can be used in combination with each other.

[0129] In some embodiments, the body care composition comprises one or more pH adjusters. pH adjusters include inorganic and organic acids and bases, particularly ammonia, citric acid, phosphoric acid, acetic acid, sodium hydroxide, lactic acid, levulinic acid, glycolic acid, tartaric acid, malic acid, pyrrolidone carboxylic acid (PCA), succinic acid, citric acid, glutamic acid, 2-amino-2-methyl-1-propanol (AMP), and triethanolamine (TEA).

[0130] In some embodiments, the body care composition comprises one or more reducing agents. Suitable reducing agents include, but are not limited to, salts of thiourea, thiosulfates, sulfites, bisulfites, metabisulfites, borosides, and hypophosphites (e.g., sodium salts), ascorbic acid and its salts, esters, and derivatives (e.g., ascorbate palmitate and ascorbate polypeptides), and tocopherol and its salts, esters, and derivatives (e.g., tocopheryl acetate). Other well-known reducing agents may also be used, such as those listed in the INCI manual.

[0131] In some embodiments, the body care composition comprises one or more fragrances. Non-limiting examples of suitable fragrances include natural oils or naturally derived materials, as well as synthetic fragrances such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, ethers, nitriles, and polyfunctional compounds. Non-limiting examples of natural oils include the following: basil (Ocimum basilicum) oil, bay leaf (Pimento acris) oil, lemon balm (Monarda didyma, American peppermint) oil, bergamot (Citrus aurantium bergamia) oil, cardamom (Elettaria cardamomum) oil, cedarwood (Cedrus atlantica) oil, chamomile (Anthemis nobilis) oil, cinnamon (Cinnamomum cassia) oil, lemongrass (Cymbopogon nardus) oil, clary sage (Salvia sclarea) oil, clove (Eugenia caryophyllus) oil, clove leaf (Eufenia caryophyllus) oil, sedge (Cyperus esculentus) oil, cypress (Cupressus sempervirens, Mediterranean cypress) oil, lemon eucalyptus (Eucalyptus citriodora) oil, and spotted geranium (Geranium) oil. maculatum oil, ginger oil, grapefruit oil, hazelnut oil, jasmine oil, juniper oil, cypress tar, juniper tar, jujube oil, kiwifruit water, lavandin oil, lavender oil, lavender water, lemon oil, lemongrass oil, lime oil, linden oil, lime oil. Cordata (European linden) oil, linden (Tilia cordata) water, citrus (Citrus nobilis)The ingredients include: Guangxi sand orange oil, nutmeg (Myristica fragrans) oil, orange (Citrus aurantium dulcis) flower oil, orange (Citrus aurantium dulcis) oil, orange (Citrus aurantium dulcis) water, patchouli (Pogostemon cablin) oil, peppermint (Menthe piperita) oil, peppermint (Menthe peperita) water, rosemary (Rosmarinus officinalis) oil, rose oil, rose (Rosadamascena, Damask rose) extract, rose (Rosa multiflora, rosehip) extract, rosewood (Anibarosaeodora) extract, sage (Salvia officinalis) oil, sandalwood (Santalum album) oil, spearmint (Menthe viridis) oil, tea tree (Melaleuca alternifolia) oil, and ylang-ylang (Cananga odorata) oil. Some non-limiting examples of synthetic hydrocarbon fragrances include caryophyllene, β-farnesene, limonene, α-pinene, and β-pinene. Some non-limiting examples of synthetic alcohol fragrances include bacdanol, citronellol, linalool, phenethyl alcohol, and α-terpineol (R.dbd.H). Some non-limiting examples of synthetic aldehyde fragrances include 2-methylundecaldehyde, citral, hexylcinnamaldehyde, ifocyclic citral, lily aldehyde, and 10-undecenal. Some non-limiting examples of synthetic ketone fragrances include cashmeran, α-ionone, isocyclemone E, koavone, muscone, and tunamus. Some non-limiting examples of synthetic ester fragrances include benzyl acetate, 4-tert-butylcyclohexyl acetate (cis and trans), cypress acetate, tricyclodecenyl acetate (cyclacet), isoborneol acetate, and α-terpineol acetate (R = acetyl). Some non-limiting examples of synthetic lactone fragrances include coumarin, jasmine lactone, muscone lactone, and peach aldehyde. Some non-limiting examples of synthetic ether fragrances include ambroxan, anther (carvone), and galacmus. Some non-limiting examples of synthetic nitrile fragrances include cinnamonitrile and geraniol. Finally, some non-limiting examples of synthetic polyfunctional fragrances include amyl salicylate, isoeugenol, hedione, heliotropine, lyral, and vanillin.

[0132] In some embodiments, the body care composition comprises one or more foaming agents. Foaming agents include, for example, sodium lauryl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglyceride sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerol fatty acid esters, fatty acid diethanolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters. These foaming agents can be used alone or in combination of two or more.

[0133] In some embodiments, the body care composition comprises one or more tanning agents. Suitable tanning agents include, but are not limited to, α-hydroxy aldehydes and ketones, glyceraldehyde and related alcohol aldehydes, various indoles, imidazoles and their derivatives, and various approved pigmenting agents. Other suitable tanning agents include, but are not limited to, methylglyoxal, glyceraldehyde, erythritol, alloxan, 2,3-dihydroxysuccinaldehyde, 2,3-dimethoxysuccinaldehyde, 2-amino-3-hydroxysuccinaldehyde, and 2-benzylamino-3-hydroxysuccinaldehyde.

[0134] In some embodiments, the body care composition comprises one or more astringents. Suitable astringents include, but are not limited to, aluminum citrate, aluminum lactate, birch extract, coffee extract, evening primrose extract, grape extract, henna extract, ivy extract, lemon extract, witch hazel extract, ammonium alum and potassium alum, aluminum triphosphate, aluminum glycinate and aluminum phenol sulfate, aluminum cloxa, aluminum allantoin, aluminum stearate, aluminum sulfate and aluminum citrate, sodium aluminum phosphate, sodium alum, sodium aluminum chlorohydroxylactate, calcium lactate, calcium chloride, calcium sulfate hydrate, sodium aluminum lactate, zinc acetate, zinc chloride, zinc sulfate, zinc lactate, zinc zeolite, zinc phenolsulfonate, and combinations thereof.

[0135] In some embodiments, the body care composition comprises one or more antiseptics. Suitable antiseptics include, but are not limited to, methyl, ethyl, propyl, or butyl parabens; phenoxyethanol; o-phenylphenol; dehydroacetic acid or its salts; p-cresol; m-cresol; o-chloro-m-xylenol; peppermint oil; echinacea; bloodroot; cayenne pepper; tea tree oil; wild bergamot; chaparral; stinging metal; laurel; myrrh; gamboge bark; toothache tree; calendula; chamomile; mupirocin; neomycin sulfate; bacitracin; polymyxin B; 1-ofloxacin; tetracyclines (chlortetracycline hydrochloride, oxytetracycline hydrochloride, and tetracycline hydrochloride). hydrochoride), clindamycin phosphate, gentamicin sulfate, benzalkonium chloride, benzyl chloride, hexylresorcinol, methylbenzyl chloride, phenol, quaternary ammonium compounds, triclocarban, triclosan, and tea tree oil.

[0136] In some embodiments, the body care composition comprises one or more deodorants or antiperspirants. Suitable antiperspirants and deodorants include, but are not limited to, zinc salts such as zinc sulfate and zinc chloride, glycine salts such as zirconium aluminum glycinate, aluminum chloride hydrate, zirconium aluminum tetrachloride hydrate, zinc carbonate, o-phenylphenol, and quaternary ammonium compounds such as dimethyl benzyl ammonium chloride and hexamethyl diammonium chloride.

[0137] In some embodiments, the body care composition comprises one or more lightening agents. Examples of lightening agents include, but are not limited to, hydroquinone, kojic acid, licorice or derivatives thereof, ascorbic acid or derivatives thereof, arbutin, bearberry extract, Glycyrrhiza glabra and derivatives thereof, Chlorella vulgaris extract, perilla extract, coconut extract and / or other decolorizing agents.

[0138] In some embodiments, the body care composition comprises one or more biocides. Examples of biocides include, but are not limited to, triclosan, 3,4,4'-triclocarban; 3,4,4'-trifluoromethyl-4,4'-diclocarban; 5-chloro-2-methyl-4-isothiazolin-3-one; iodopropynyl butylcarbamate; 8-hydroxyquinoline; 8-hydroxyquinoline citrate; 8-hydroxyquinoline sulfate; 4-chloro-3,5-dimethylphenol; 2-bromo-2-nitropropane-1,3-diol; diazolidinyl urea; butoconazole; nystatin; terconazole; nitrofurantoin; phenazopyridine; acyclovir; clotrimazole. imazole); chloroxylenol; chlorhexidine; miconazole; terconazole; butyl paraben; ethyl paraben; methyl paraben; methyl chloroisothiazoline; methylisothiazoline; a mixture of 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin and 3-iodo-2-propynyl butylcarbamate; hydroxyquinoline; EDTA (ethylenediaminetetraacetic acid); tetrasodium EDTA; parabens; alkylpyridine compounds; cocophosphatidyl PG-dimethylammonium chloride; chlorhexidine gluconate; chlorhexidine digluconate; chlorhexidine acetate; chlorhexidine hydroxyethylsulfonic acid; chlorhexidine hydrochloride; benzalkonium chloride; benzyl chloride; polyhexamethylene biguanide; and mixtures thereof.

[0139] It may also include other ingredients commonly used in body care compositions such as skin care or hair care products.

[0140] Flavored products and related uses

[0141] In at least another form, this disclosure provides the use of the cooling-modifying compositions of the foregoing forms and embodiments thereof to enhance the cooling sensation of flavored products, for example, by enhancing the cooling sensation of cooling compounds (e.g., menthol, lentinanol, or other cooling compounds mentioned above) in the flavored product. In a related form, this disclosure provides a method for enhancing the cooling sensation of a flavored product, the method comprising introducing the cooling-modifying compositions of the foregoing forms and embodiments thereof into the flavored product.

[0142] In connection with these aspects, the flavored product can be any flavored product according to the forms and embodiments described below. In some embodiments, the flavored product is a beverage product, such as enhanced sparkling beverages, cola, lemon-lime sparkling beverages, orange sparkling beverages, grape sparkling beverages, strawberry sparkling beverages, pineapple sparkling beverages, ginger ale, root beer, fruit juice, fruit-flavored fruit juice, fruit juice beverages, honey beverages, vegetable juice, vegetable-flavored juice, sports drinks, energy drinks, fortified water beverages, vitamin-fortified water, near-water beverages, coconut water, tea beverages, coffee, cocoa beverages, beverages containing milk ingredients, beverages containing cereal extracts, and smoothies. In some other embodiments, the flavored product is a food product, such as packaged foods, canned foods, meal replacement products, etc. In some embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, or teeth whitening compositions, such as those disclosed in U.S. Patent Application Publication No. 2019 / 0167545, which is incorporated herein by reference.

[0143] Flavored products can be in any suitable physical form. For example, in some embodiments, the flavoring composition can be in solid form, such as a powder. In a further such embodiment, the flavoring product is tooth powder, such as tooth powder used for whitening teeth, removing stains (e.g., tobacco stains), etc. In some other embodiments, the flavoring product can be a paste or slurry, such as toothpaste. In some other embodiments, the flavoring product can be in the form of a cream or gel, such as tooth gel, skin cream, or tooth cream. In some other embodiments, the flavoring product can be, for example, a liquid suspension or solution having an aqueous carrier. In some embodiments, the flavoring product can be in the form of an emulsion, such as a microemulsion or nanoemulsion, in which surfactants, emulsifiers, etc., may be present. In some embodiments, the flavoring product is a personal care product, such as a product for application to the skin, face, lips, gums, mouth, etc. Such personal products can be used for any suitable purpose, such as skin whitening, teeth whitening, etc.

[0144] In some forms, this disclosure provides flavored products comprising any composition of the foregoing forms or embodiments thereof. In some embodiments, the flavored product is a beverage product, such as soda water, flavored water, tea, etc. In some other embodiments, the flavored product is a food product, such as yogurt.

[0145] In embodiments where the flavored product is a beverage, the beverage may be selected from enhanced sparkling beverages, cola, lemon-lime sparkling beverages, orange sparkling beverages, grape sparkling beverages, strawberry sparkling beverages, pineapple sparkling beverages, ginger ale, root beer, fruit juice, fruit-flavored fruit juice, fruit juice beverages, honey beverages, vegetable juice, vegetable-flavored juice, sports drinks, energy drinks, fortified water beverages, vitamin-fortified water, near-water beverages, coconut water, tea beverages, coffee, cocoa beverages, beverages containing milk ingredients, beverages containing cereal extracts, and smoothies. In some embodiments, the beverage may be a soft drink.

[0146] In some implementations, the flavored product is an oral care product. "Oral care product" refers to a personal care product or other product that, during normal use, is not intentionally swallowed for the purpose of systemic application of a specific therapeutic agent, but rather remains in the mouth for a sufficient duration to contact substantially all tooth surfaces and / or oral tissues for oral activities. Oral care compositions can take many forms, including toothpaste, dental floss, teething gel, subgingival gel, mouthwash, mousse, foam, oral spray, lozenges, chewing tablets, chewing gum, or denture products. Oral care compositions may also be incorporated into strips or films for direct application or adhesion to oral surfaces.

[0147] In some implementations, the flavored product is a pharmaceutical product, such as a product designed to carry or deliver certain active pharmaceutical ingredients (APIs). Such APIs can be over-the-counter (OTC) medications, such as acetaminophen and other OTC cough and cold medications. In some implementations, the API is a prescription-based medication.

[0148] In some embodiments of any form and implementation of flavored products described herein, the flavored product is a non-naturally occurring product, such as a packaged food or beverage product.

[0149] Other non-limiting examples of food and beverage products or preparations include sweet coatings, frostings or icings of such products, or any entity comprising: soups, dry processed foods, beverages, ready-to-eat foods, canned or pickled foods, frozen processed foods, chilled processed foods, snack foods, baked goods, confectionery, dairy products, ice cream, meal replacements, pasta and noodles, and sauces, seasonings, condiments, baby food and / or spreads.

[0150] Generally, soups refer to canned / marinated, dehydrated, instant, refrigerated, UHT, and frozen soups. For the purposes of this definition, soup is a food made from meat, poultry, fish, vegetables, grains, fruits, and other ingredients, cooked in a liquid that may contain some or all of these ingredients in visible pieces. It may be clear (as broth) or thick (as chowder), smooth, mushy, or chunky, ready-to-eat, semi-concentrated, or concentrated, and can be served hot or cold as a first course or main course, or as a snack (sip) between meals. Soup can be used as an ingredient in the preparation of other dietary components, ranging from broth (consommé) to sauces (cream- or cheese-based soups).

[0151] Dehydrated and cooked food products generally refer to: (i) cooking aids, such as powdered, granular, paste-like, concentrated liquid products, including bouillon, broth, and broth-like products in compressed blocks, tablets, or powder or granules, sold separately as finished products or as ingredients in products, seasonings, and formulation mixtures (regardless of technology); (ii) dietary solution products, such as dehydrated soups and freeze-dried soups, including dehydrated soup mixtures, dehydrated instant soups, dehydrated ready-to-eat soups, dehydrated or self-heating preparations of ready-made dishes, meals, and single-serving main courses, including pasta, potatoes, and rice; and (iii) dietary garnish products, such as seasonings, marinades, salad dressings, salad toppings, dips, mixes, batter mixtures, storage-stable sauces, barbecue sauces, liquid formulation mixtures, concentrates, sauces or gravy mixtures, including salad formulation mixtures, sold as finished products or as ingredients in products, whether dehydrated, liquid, or frozen.

[0152] The beverage category generally refers to beverages, beverage mixtures, and concentrates, including but not limited to carbonated and non-carbonated beverages, alcoholic and non-alcoholic beverages, ready-to-drink beverages, liquid concentrates used to prepare beverages (such as soda water), and dry powder beverage precursor mixtures. The beverage category also includes alcoholic beverages, soft drinks, sports drinks, isotonic beverages, and hot beverages. Alcoholic beverages include, but are not limited to, beer, cider / pear liqueur, FABs, wine, and spirits. Soft drinks include, but are not limited to, carbonated beverages, such as cola and non-cola carbonated beverages; fruit juices, such as fruit juice, honey drinks, fruit juice beverages, and fruit-flavored beverages; bottled water, including soda water, spring water, and purified / catering water; functional beverages, which can be carbonated or non-carbonated, including sports drinks, energy drinks, or elixir beverages; and concentrates, such as ready-to-drink liquid and powder concentrates. Whether hot or cold, beverages include, but are not limited to, coffee or iced coffee, such as fresh, instant and blended coffee; tea or iced tea, such as black tea, green tea, white tea, oolong tea and flavored tea; and other beverages, including flavored, malt-based or plant-based powders, granules, blocks or tablets mixed with milk or water.

[0153] Snacks generally refer to any food consumed as a simple, informal meal, including but not limited to sweet and savory (salty, spicy, or other non-sweet) snacks and snack bars. Examples of snacks include, but are not limited to, fruit desserts, potato chips / crisps, extruded snacks, tortillas / cornflakes, popcorn, pretzels, nuts, and other sweet and savory snacks. Examples of snack bars include, but are not limited to, granola / cereal bars, breakfast bars, energy bars, fruit bars, and other snack bars.

[0154] Baked goods generally refer to any edible product whose preparation involves exposure to heat or excessive sunlight. Examples of baked goods include, but are not limited to, bread, buns, biscuits, muffins, cereals, toaster pastries, cakes, waffles, tortillas, soft biscuits, pies, bagels, egg tarts, quiche, cakes, any baked goods, and any combination thereof.

[0155] Ice cream generally refers to frozen desserts containing cream, sugar, and flavorings. Examples of ice cream include, but are not limited to: instant ice cream; family-sized ice cream; frozen yogurt and artisanal ice cream; and ice cream based on soy, oats, legumes (such as red beans and mung beans), and rice.

[0156] Confectionery generally refers to sweet-tasting edible products. Examples of confectionery include, but are not limited to, hard candy, gelatin, chocolate, sugar candy, chewing gum, and any combination of these products.

[0157] Meal replacement foods generally refer to any food designed to replace a regular diet, especially for those concerned about health or fitness. Examples of meal replacements include, but are not limited to, weight loss products and recovery products.

[0158] Ready-to-eat foods generally refer to any food that can be consumed as a meal without extensive preparation or processing. Ready-to-eat foods include products for which manufacturers have added recipe "skills," thus offering high levels of convenience, completeness, and readiness. Examples of ready-to-eat foods include, but are not limited to, canned / marinated, frozen, dried, and refrigerated ready-to-eat foods; dinner mixes; frozen pizzas; refrigerated pizzas; and pre-made salads.

[0159] Pasta and noodles include any pasta and / or noodles, including but not limited to canned, dried, and chilled / fresh pasta; as well as plain, instant, chilled, frozen, and snack noodles.

[0160] Canned / pickled foods include, but are not limited to, canned / pickled meat and meat products, fish / seafood, vegetables, tomatoes, beans, fruits, ready-to-eat foods, soups, pasta and other canned / pickled foods.

[0161] Frozen processed foods include, but are not limited to, frozen processed red meat, processed poultry, processed fish / seafood, processed vegetables, meat substitutes, processed potatoes, baked goods, desserts, ready-to-eat foods, pizzas, soups, noodles and other frozen foods.

[0162] Dry processed foods include, but are not limited to, rice, dessert mixes, dry ready-to-eat foods, dehydrated soups, instant soups, dried pasta, plain pasta, and instant noodles. Refrigerated processed foods include, but are not limited to, refrigerated processed meats, processed fish / seafood products, lunch boxes, fresh-cut fruit, ready-to-eat foods, pizzas, pre-made salads, soups, fresh pasta, and noodles.

[0163] Sauces, condiments and seasonings include, but are not limited to, tomato sauce and puree, broth / soup cubes, herbs and spices, monosodium glutamate (MSG), table sauces, soy sauces, pasta sauces, wet / cooking sauces, dry / powder mixtures, ketchup, mayonnaise, mustard, salad dressings, balsamic vinegar, dips, marinades, and other sauces, condiments and seasonings.

[0164] Infant food includes, but is not limited to, milk- or soy-based formula foods; as well as prepared, dried, and other infant foods.

[0165] Spreads include, but are not limited to, jams and preserves, honey, chocolate sauce, nut spreads, and yeast spreads.

[0166] Dairy products generally refer to edible products derived from the milk of mammals. Examples of dairy products include, but are not limited to, dairy drinks, cheese, yogurt and fermented milk beverages, and other dairy products.

[0167] The following are further examples of flavored products, particularly food and beverage products or formulations. Exemplary ingestible compositions include one or more confections, chocolates, chocolate chips, countlines, selflines / softlines, boxed varieties, standard boxed varieties, twist-wrapped miniature chocolates, flavored chocolates, toy-shaped chocolates, sandwich cookies, other chocolate confections, mints, standard mints, strong mints, hard candy, soft lozenges, gums, jellies and chewables, toffee, caramel and nougat, medicated candies, lollipops, licorice, other confections, bread, packaged / industrial bread, bulk / artificial bread, pastries, cakes, packaged / industrial cakes, bulk / artificial cakes, biscuits, and chocolate coatings. Cookies, sandwich cookies, biscuits, savory biscuits and crackers, bread substitutes, breakfast cereals, instant cereals, family breakfast cereals, flakes, cereals, other cereals, children's breakfast cereals, hot cereals, ice cream, ready-to-eat ice cream, single-serving dairy ice cream, single-serving water ice cream, multi-pack dairy ice cream, multi-pack water ice cream, family-sized ice cream, family-sized dairy ice cream, ice cream desserts, bulk ice cream, family-sized water ice cream, frozen yogurt, artisanal ice cream, dairy products, milk, fresh / pasteurized milk, whole milk fresh / pasteurized milk, semi-skimmed fresh / pasteurized milk, extended shelf life / UHT milk, whole milk extended shelf life / UHT milk, semi-skimmed milk extended shelf life / UHT milk, fat-free milk Long shelf life / UHT milk, goat milk, condensed milk / unsalted condensed milk, plain condensed milk / unsalted condensed milk, flavored, functional and other condensed milk, flavored milk beverages, dairy-only flavored milk beverages, flavored milk beverages with fruit juice, soy milk, yogurt beverages, fermented milk beverages, coffee creamer, milk powder, flavored milk powder beverages, cream, cheese, processed cheese, spreadable cheese, processed cheese that is difficult to spread, unprocessed cheese, spreadable unprocessed cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, yogurt, plain / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinking yogurt, regular drinking yogurt, probiotic drinking yogurt, frozen and shelf-stable desserts, dairy-based desserts, soy-based desserts, frozen desserts, fresh cheese and quark cheese. Plain fresh cheese and quark cheese, flavored fresh cheese and quark cheese, savory fresh cheese and quark cheese, sweet and savory snacks, fruit snacks, potato chips / fries, puffed snacks, tortilla chips / corn chips, popcorn, pretzels, nuts, other sweet and delicious snacks, snack bars, granola, breakfast bars, energy bars, fruit bars, other snack bars, meal replacements, weight loss products, recovery drinks, ready-to-eat foods, canned ready-to-eat foods, frozen ready-to-eat foods, dried ready-to-eat foods, frozen ready-to-eat meals, dinner mixes, frozen pizza, chilled pizza, soup, canned soup, dehydrated soup, instant soup, cold soup, hot soup, frozen soup, pasta, canned pasta, dried pasta, frozen / fresh pasta, noodles, plain pastaInstant noodles, cup / bowl instant noodles, bagged instant noodles, frozen noodles, snack noodles, canned foods, canned meat and meat products, canned fish / seafood, canned vegetables, canned tomatoes, canned beans, canned fruits, canned ready-to-eat foods, canned soups, canned pasta, other canned foods, frozen foods, frozen processed red meat, frozen processed poultry, frozen processed fish / seafood, frozen processed vegetables, frozen meat substitutes, frozen potatoes, oven-baked potato chips, other oven-baked potato products, non-oven frozen potatoes, frozen baked foods, frozen desserts, frozen ready-to-eat foods, frozen pizzas, frozen soups, frozen noodles, other frozen foods, dried foods, dessert mixtures, dried ready-to-eat foods, dehydrated soups, instant soups, dried pasta, plain noodles, instant noodles, cup / bowl instant noodles, bagged instant noodles, refrigerated foods, refrigerated processed meats, refrigerated fish / seafood products, refrigerated processed fish, refrigerated coated fish, refrigerated smoked fish, refrigerated lunches Bread rolls, chilled ready-to-eat foods, chilled pizzas, chilled soups, chilled / fresh pasta, chilled noodles, oils and fats, olive oil, vegetable and seed oils, cooking fats, butter, margarine, spread oils and fats, functional spread oils and fats, sauces, seasonings and condiments, tomato paste and puree, broth / soup cubes, soup cubes, gravy granules, liquid soup bases and ingredients, herbs and spices, fermented sauces, soy sauces, pasta sauces, wet sauces, dry sauces / powder mixtures, tomato sauce, mayonnaise, regular mayonnaise, mustard, salad dressing, regular salad dressing, low-fat salad dressing, balsamic vinegar sauce, dips, marinades, other sauces, seasonings and condiments, baby food, formula milk powder, standard formula milk powder, growing-up formula milk powder, toddler formula milk powder, hypoallergenic formula, prepared baby food, dried baby food, other baby food, spreads, jams and preserves, honey, chocolate spread, nut spreads and yeast spreads. Exemplary ingestible compositions also include confectionery, baked goods, ice cream, dairy products, sweet and delicious snacks, snack bars, meal replacement products, ready-to-eat foods, soups, pasta, noodles, canned foods, frozen foods, dried foods, refrigerated foods, oils and fats, baby foods, or spreads, or mixtures thereof. Exemplary ingestible compositions also include breakfast cereals, sweetened beverages, or solid or liquid concentrate compositions for preparing beverages, ideally enabling the reduction of the concentration of previously known sugar sweeteners or artificial sweeteners.

[0168] Some embodiments provide chewable compositions that can be swallowed or not. In some embodiments, the chewable composition may be gum, chewing gum, saccharified gum, sugar-free gum, functional gum, bubble gum, which individually or in combination comprises compounds disclosed and described herein.

[0169] In some embodiments, the cooling-modifying compositions disclosed and described herein may be provided, alone or in combination, as flavoring concentrate formulations, for example, suitable for subsequent processing to produce ready-to-use (i.e., ready-to-eat) products. A “flavoring concentrate formulation” refers to a formulation that should be reconstituted with one or more diluents to become a ready-to-use composition. The term “ready-to-use composition” is used herein interchangeably with “ingestible composition,” which means any substance that can be ingested orally, whether alone or in combination with another substance, whether intended for consumption or not. In one embodiment, a ready-to-use composition includes compositions that can be directly consumed by humans or animals. Flavoring concentrate formulations are typically used by mixing with or diluting with one or more diluents, such as any edible or ingestible ingredient or product, to impart or alter one or more flavorings to the diluent. Such a process of use is generally referred to as reconstitution. Reconstitution can be carried out in a domestic or industrial setting. For example, a consumer may reconstitute frozen fruit juice concentrate in the kitchen with water or other aqueous media to obtain a ready-to-use fruit juice beverage. In another example, soft drink syrup concentrates can be reconstituted by manufacturers on a large industrial scale using water or other aqueous media to produce ready-to-use soft drinks. Because flavor concentrate formulations have a higher concentration of flavorings or seasonings than ready-to-use compositions, they are generally not suitable for direct consumption without reconstitution. There are many advantages to using and producing flavor concentrate formulations. For example, one advantage is reduced weight and volume during transportation, as flavor concentrate formulations can be reconstituted at the time of use by adding a suitable solvent, solid or liquid.

[0170] The flavored product according to any one of the foregoing embodiments may further include, in some embodiments, one or more additional flavor-modifying compounds, such as compounds that enhance sweetness (e.g., hesperidin, naringin, glucosylated steviol glycosides, etc.), compounds that block bitterness, compounds that enhance umami, compounds that enhance richness, compounds that reduce acidity, compounds that enhance saltiness, compounds that enhance cooling effects, or any combination thereof.

[0171] In some embodiments of any form and implementation of a sweetener or flavoring concentrate described herein, the sweetener or flavoring concentrate is a non-naturally occurring product, such as a composition specifically manufactured for the production of flavored products, such as food or beverage products.

[0172] In one embodiment, the flavor concentrate formulation comprises i) compounds disclosed and described herein, alone or in combination; ii) a carrier; and iii) optionally at least one adjuvant. The term "carrier" refers to a generally inert auxiliary substance, such as a solvent, binder, or other inert medium, used in combination with the compounds of the present invention and one or more optional adjuvants to form a formulation. For example, water or starch can be a carrier for the flavor concentrate formulation. In some embodiments, the carrier is the same as the dilution medium used to reconstitute the flavor concentrate formulation; in other embodiments, the carrier is different from the dilution medium. As used herein, the term "carrier" includes, but is not limited to, an ingestibility-acceptable carrier.

[0173] The term "adjuvant" refers to an additive that complements, stabilizes, maintains, or enhances the intended function or efficacy of an active ingredient, such as the compounds of the present invention. In one embodiment, at least one adjuvant comprises one or more flavoring agents. Flavoring agents may have any flavor known to those skilled in the art or to consumers, such as chocolate, coffee, tea, mocha, French vanilla, peanut butter, chai, or combinations thereof. In another embodiment, at least one adjuvant comprises one or more sweeteners. The one or more sweeteners may be any sweetener described in this application. In yet another embodiment, the at least one adjuvant comprises one or more ingredients selected from the group consisting of: emulsifiers, stabilizers, antimicrobial preservatives, antioxidants, vitamins, minerals, fats, starches, protein concentrates and isolates, salts, and combinations thereof. Examples of emulsifiers, stabilizers, antimicrobial preservatives, antioxidants, vitamins, minerals, fats, starches, protein concentrates and isolates, and salts are described in U.S. Patent No. 6,468,576, the entire contents of which are incorporated herein by reference for all purposes.

[0174] In one embodiment, the flavor concentrate formulation of the present invention may be in the form of liquids, solids, foam materials, pastes, gels, emulsions, and combinations thereof, including solutions and suspensions, such as liquids containing a certain amount of solid contents. In one embodiment, the flavor concentrate formulation is in the form of a liquid, including both water-based and non-water-based formulations. In some embodiments, the flavor concentrate formulation of the present invention may be carbonized or non-carbonated.

[0175] Flavor concentrate formulations may further include a freezing point depressant, a nucleating agent, or both as at least one adjuvant. A freezing point depressant is an intake-acceptable compound or reagent that lowers the freezing point of a liquid or solvent to which the compound or reagent is added. That is, the freezing point of a liquid or solution containing a freezing point depressant is lower than the freezing point of a liquid or solvent without a freezing point depressant. In addition to lowering the initial freezing point, freezing point depressants can also lower the water activity of the flavor concentrate formulation. Examples of freezing point depressants include, but are not limited to, carbohydrates, oils, ethanol, polyols such as glycerol, and combinations thereof. A nucleating agent refers to an intake-acceptable compound or reagent capable of promoting nucleation. The presence of a nucleating agent in a flavor concentrate formulation can improve the texture of slush and help maintain the physical properties and performance of slush at freezing temperatures by increasing the number of desired ice crystal centers. Examples of nucleating agents include, but are not limited to, calcium silicate, calcium carbonate, titanium dioxide, and combinations thereof.

[0176] In one embodiment, the flavor concentrate formulation is formulated to have a low water activity to extend shelf life. Water activity is the ratio of the vapor pressure of water in the formulation to the vapor pressure of pure water at the same temperature. In one embodiment, the water activity of the flavor concentrate formulation is less than about 0.85. In another embodiment, the water activity of the flavor concentrate formulation is less than about 0.80. In yet another embodiment, the water activity of the flavor concentrate formulation is less than about 0.75.

[0177] Body care products and related uses

[0178] In at least another form, this disclosure provides the use of the above-described cooling-modifying compositions for enhancing the cooling sensation of body care products. In some embodiments, the body care product comprises a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0179] In at least another form, this disclosure provides a method for enhancing the cooling sensation of a body care product, the method comprising combining the above-described cooling-modifying composition with a cooling compound (e.g., menthol, lentinanol, or a combination thereof) in the body care product. In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sunscreen enhancer.

[0180] In at least another form, this disclosure provides a body care product comprising the above-described cooling-modifying composition and a cooling compound (e.g., menthol, lentinanol, or a combination thereof). In some embodiments, the body care product is a shampoo, shower gel, soap, exfoliating scrub, moisturizing cream, facial serum, antiperspirant, deodorant, lotion, oil, sunscreen, or sun tanning agent.

[0181] In some implementations, the body care product is a personal care or beauty product. Personal care and beauty products include products that can be applied to the skin, hair, and nails, and can be either leave-on or wash-off products. In the context of this disclosure, "wash-off" means that the intended use of the product involves applying it to the skin and / or hair and then rinsing or wiping it off from the skin or hair within seconds to minutes of the application step. Personal care and beauty products include powders, creams, emulsions, lotions, gels, and oils for application to the skin (face, hands, feet, etc.), color bases (liquids and pastes), and liquid-soaked tissues; products for applying and removing makeup to the face and eyes; hair care products, including hair tints and hair bleaches; products for perming, straightening, styling, and fixing hair; shaving products, including creams, mousses, and hair removal products; tanning products and products that allow tanning without sunlight; deodorants and antiperspirants.

[0182] In some implementations, personal care or beauty products are selected from the group consisting of: shaving aids, shampoos, hair care products, leave-in skin care products, skin cleansing or washing products (e.g., wash-off skin cleansing or washing products), wipes, and body sprays, deodorants, or antiperspirants. Shaving aids specifically include foams, gels, creams, and soap bars (see, for example, U.S. Patent Nos. 7,069,658, 6,944,952, 6,594,904, 6,182,365, 6,185,822, 6,298,558, and 5,113,585). Shampoos and hair care products specifically include 2-in-1 shampoos and shampoos formulated for dry or oily hair, or shampoos containing additives such as anti-dandruff agents. Hair care products can be either shampoo-free or leave-in, and also include hair tonics, bleaching agents, colorants, setting products, and styling products. See, for example, U.S. Patent Nos. 6,162,423, 5,968,286, 5,935,561, 5,932,203, 5,837,661, 5,776,443, 5,756,436, 5,661,118, and 5,618,523. Leave-in skincare products include eau de toilette, perfume, cologne, wipes, body sprays, deodorants, and antiperspirants. Skin cleansing products specifically include beauty and hygiene soap bars, shower gels, liquid soaps, body washes, exfoliating gels, and creams (see, for example, U.S. Patent Nos. 3,697,644; 4,065,398; and 4,387,040). Wipes specifically include skin cleansing wipes, baby wipes, makeup remover wipes, and skin refreshing wipes (see, for example, U.S. Patent Nos. 4,775,582; WO 02 / 07701; WO 2007 / 069214 and WO 95 / 16474). Body sprays, deodorants, and antiperspirants specifically include sticks, liquid roll-on applicators, and pressurized sprays.

[0183] Example

[0184] To further illustrate the invention, the following embodiments are included. These embodiments should not be construed as specifically limiting the invention. Variations of these embodiments within the scope of the claims are within the capabilities of those skilled in the art and are considered to fall within the scope of the invention described and claimed herein. The reader will recognize that those skilled in the art, upon mastering this disclosure, can prepare and use the invention without exhaustive examples.

[0185] Example 1 – Toothpaste Formulation

[0186] The toothpaste compositions were prepared according to certain embodiments of this disclosure. Table 1 below lists the ingredients (wt%) contained in two control compositions and two test compositions using cooling-enhancing compounds.

[0187] Table 1

[0188] Opaque toothpaste base 98.50％ 98.50％ 98.50％ 98.50％ Sodium saccharin 0.20％ 0.20％ 0.20％ 0.20％ Menthol 0.30％ 0.40％ 0.30％ 0.30％ trans-2-methyl-2-butenal 0.00％ 0.00％ 0.01％ 0.00％ 2-Isopropyl-5-methyl-2-hexenal 0.00％ 0.00％ 0.00％ 0.01％ water 1.00％ 0.90％ 0.99％ 0.99％

[0189] Example 2 – Sensory Testing

[0190] Sensory testers (a panel of four oral care flavorists) were asked to perform the following tests: (1) brushing their teeth with a control sample for 1 minute; (2) rating three key indicators (coolness, bitterness, burning, and any other perceived tone) at different time intervals as described below; and (3) using a scale of 0 to 5 as shown below, where 0 indicates no impact (initial potency) / intensity and 5 indicates very high impact / intensity. The results are shown in Table 2.

[0191] Table 2

[0192]

[0193] Example 3 – Toothpaste Composite Base

[0194] Table 3 below shows sample ingredients of toothpaste formulations according to certain embodiments disclosed herein. Amounts are given as a weight percentage.

[0195] Table 3

[0196] Polyethylene glycol 400 2.00％ 2.00％ Xanthan Gum 0.60％ 0.60％ Sorbitol 70% solution 50.00％ 50.00％ Sodium fluoride 0.22％ 0.22％ Sodium benzoate 0.20％ 0.20％ water 15.02％ 15.02％ Hydrated silica (Tixosil 73) 22.00％ 22.00％ Hydrated silica (Tixosil 43) 7.00％ 7.00％ Titanium dioxide Ci77891 0.50％ 0.50％ Sodium lauryl sulfate 1.25％ 1.25％ Mint flavoring 1.00％ 1.00％ trans-2-methyl-2-butenal 0.01％ 0.00％ 2-Isopropyl-5-methyl-2-hexenal 0.00％ 0.01％ Sodium saccharin 0.20％ 0.20％

[0197] Example 4 – Mouthwash Composite Base

[0198] Tables 4 and 5 below show sample ingredients of mouthwash formulations for certain embodiments disclosed herein. Amounts are given as a weight percentage.

[0199] Table 4

[0200] Dissolvant PG 10.00％ 10.00％ Sodium fluoride 0.02％ 0.02％ Deionized water / purified water 76.36％ 76.36％ Poloxamer 407NF 0.25％ 0.25％ Sorbitol 70% solution 8.00％ 8.00％ Sodium saccharin 0.02％ 0.02％ Sodium benzoate 0.06％ 0.06％ Mint flavoring 0.20％ 0.20％ trans-2-methyl-2-butenal 0.01％ 0.00％ 2-Isopropyl-5-methyl-2-hexenal 0.00％ 0.01％ Glycerin NAT 5.00％ 5.00％ Sucralose 0.01％ 0.01％ benzoic acid 0.07％ 0.07％

[0201] Table 5

[0202] 190 Proof of Ethanol 15.00％ 15.00％ Mint flavoring 0.20％ 0.20％ trans-2-methyl-2-butenal 0.01％ 0.00％ 2-Isopropyl-5-methyl-2-hexenal 0.00％ 0.01％ Deionized water / purified water 71.31％ 71.31％ Poloxamer 407NF 0.24％ 0.24％ Sodium lauryl sulfate 0.04％ 0.04％ Sorbitol 70% solution 10.00％ 10.00％ Sodium saccharin 0.03％ 0.03％ glycerin 3.00％ 3.00％ Sodium benzoate 0.10％ 0.10％ Sucralose 0.02％ 0.02％ benzoic acid 0.05％ 0.05％

[0203] Example 5 – Piper cubebazol toothpaste formulation

[0204] The toothpaste compositions were prepared according to certain embodiments of this disclosure. Table 6 below lists the ingredients (wt%) contained in two control compositions and two test compositions using cooling-enhancing compounds.

[0205] Table 6

[0206] Opaque toothpaste base 98.50％ 98.50％ 98.50％ Sodium saccharin 0.20％ 0.20％ 0.20％ Piper cubebazol 0.01％ 0.01％ 0.01％ trans-2-methyl-2-butenal 0.00％ 0.01％ 0.00％ 2-Isopropyl-5-methyl-2-hexenal 0.00％ 0.00％ 0.01％ water 1.29％ 1.28％ 1.28％

[0207] Example 6 – Sensory Testing

[0208] Sensory testers (a panel of four oral care flavorists) were asked to perform the following tests: (1) brush their teeth for 1 minute with a control sample; (2) rate three key indicators (coolness, bitterness, burning, and any other perceived tone) at different time intervals as described below; and (3) use a scale of 0 to 5 as shown below, where 0 indicates no impact (initial potency) / intensity and 5 indicates very high impact / intensity. The results are shown in Table 7.

[0209] Table 7

[0210]

[0211] Example 7 - Shower Gel

[0212] The components and amounts of the shower gel base are shown in Table 8 (wt%).

[0213] Table 8

[0214] Deionized water 52.4 <![CDATA[EDTA tetrasodium (1) > 0.1 Sodium benzoate 0.5 Propylene glycol 2.0 <![CDATA[Sodium C12-C15 pareth sulfate 2) > 35.0 <![CDATA[cocamidopropyl betaine 3) > 8.0 <![CDATA[Polyquaternium-7 4) > 0.2 40% aqueous solution of citric acid qs Sodium chloride qs total 100.0

[0215] 1) Edeta B powder, BASF

[0216] 2)Zetesol AO 328U, Zschimmer&Schwarz

[0217] 3) Tego-Betain F50, Evonik

[0218] 4) Merquat 550, Lubrizol

[0219] Add the components of the shower gel base (as above) one by one in the given order, mix and dissolve separately. Adjust the final pH of the shower gel base with citric acid solution until the pH is in the range of 4.3 to 4.8. Adjust the final viscosity of the composition to 3000 cPs (+ / - 1500 cPs) by adding sodium chloride. Brookfield RV / Rod #4 / Speed ​​#20 rpm.

[0220] The shower gel base was mixed with menthol and 2-isopropyl-5-methyl-2-hexenal in the relative amounts (in weight %) shown in Table 9.

[0221] Table 9

[0222]

[0223] Example 8 – Sensory Evaluation of Shower Gel

[0224] Sensory evaluations were performed on the shower gels of Examples 7A and 7B. Each of the 22 sample panel members entered the shower and wet their entire bodies with running water. They then applied the shower gel to their wet hands and then to their bodies, massaging in circular motions to create good lather. The water flow was then turned off. The cooling intensity during lathering was assessed at this point. The panel members then rinsed their bodies thoroughly, exited the shower, and dried themselves. The cooling intensity was assessed at designated evaluation points. Panel members were asked to rate the cooling intensity on a scale of 1 to 10 at five different time points: during showering, and at time intervals of 5, 15, 30, and 45 minutes after showering. Table 10 shows the average assessments from the 22 panel members at these time points.

[0225] Table 10

[0226]

[0227] Example 9 – Shampoo

[0228] The shampoo base was prepared, and its components and amounts are shown in Table 11. To prepare phase A, polymer JR-400 was dispersed in water. The remaining components of phase A were added one by one, mixing thoroughly after each addition. This premix was added to the polyquaternium-10 dispersion and mixed for another 5 minutes. Then, while stirring, premixed phases B and C (Monomuls 90L-12 was heated to melt in Texapon NSO IS) were added. Phases D and E were added while stirring. The pH was adjusted with citric acid solution to a range of 5.5 to 6.0.

[0229] Table 11

[0230]

[0231] 1) Ucare Polymer JR-400, Noveon

[0232] 2) Schweizerhall

[0233] 3) Glydant, Lonza

[0234] 4) Texapon NSO IS, Cognis

[0235] 5) Tego Betain F 50, Evonik

[0236] 6)Amphotensid GB 2009,Zschimmer&

[0237] Schwarz

[0238] 7) Monomuls 90L-12, Gruenau

[0239] 8) Sodium Niparaben, NIPA

[0240] The shampoo base was mixed with menthol and 2-isopropyl-5-methyl-2-hexenal in the relative amounts shown in Table 12.

[0241] Table 12

[0242]

[0243] Example 10 – Sensory Evaluation of Shampoo

[0244] Sensory evaluations were performed on the shampoos of Examples 9A, 9B, and 9C. Seventeen sample panel members each wet their hair and used the normal amount of shampoo provided, lathering and thoroughly washing for at least 2 minutes. Each panel member then thoroughly rinsed their hair, exited the shower, and towel-dried their body and hair. Cooling intensity was assessed at designated evaluation points. Panel members were asked to rate the cooling intensity on a scale of 1 to 7 at five different time points: during lathering, and at time intervals of 15 minutes, 30 minutes, 1 hour, and 2 hours after showering. Table 13 shows the average evaluations from the 17 panel members at these time points.

[0245] Table 13

[0246]

Claims

1. Use of a cooling-enhancing compound in the preparation of a flavored product or a body care product that enhances the cooling sensation, wherein the flavored product or the body care product contains a cooling substance, the cooling substance being menthol or lentinanol, wherein the cooling-enhancing compound is selected from the group consisting of (E / Z)-2-methyl-2-butenal, (E / Z)-2-isopropyl-5-methyl-2-hexenal, and any combination thereof.

2. The use according to claim 1, wherein the cooling-enhancing compound is (E / Z)-2-methyl-2-butenal.

3. The use according to claim 1, wherein the cooling-enhancing compound is (E / Z)-2-isopropyl-5-methyl-2-hexenal.

4. The use according to claim 1, wherein the cooling-enhancing compound is used in a flavored product, and the flavored product comprises a high-intensity sweetener.

5. The use according to claim 4, wherein the high-intensity sweetener is sodium saccharin, sucralose, or any combination thereof.

6. The use according to claim 1, wherein the flavored product further comprises a mint flavoring agent.

7. The use according to claim 1, wherein the flavored product is a food product, an oral care product, or a pharmaceutical product.

8. The use according to claim 1, wherein the flavored product is a beverage product.

9. The use according to claim 1, wherein the body care product is a skin care product or a hair care product.

10. The use according to claim 1, wherein the body care product is a beauty product.

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