Fundus imaging device based on line-scan confocal

Abstract

The application discloses an eye fundus imaging device based on line scanning confocal, and belongs to the field of optical imaging and biomedical diagnosis equipment. The shell comprises a bottom plate, a focusing structure is installed on the shell, a mounting plate is located in the shell and cooperates with the focusing structure, a light source, a shaping structure, a reflecting structure, a galvanometer, a scanning structure imaging structure and a second detector are installed on the mounting plate, an objective lens structure is installed on the bottom plate, the focusing structure drives the mounting plate to move relative to the objective lens structure to adjust the distance between the light source, the shaping structure, the reflecting structure, the galvanometer, the scanning structure imaging structure and the second detector relative to the objective lens structure, so that the device can adjust the focal length according to the condition of the human eye; the shaping structure comprises a first cylindrical lens, a second cylindrical lens and a third cylindrical lens, the shaping structure is located between the light source and the reflecting structure on the light path, and the three cylindrical lenses modulate the light emitted by the light source into a line light source with uniform illuminance, so that an eye fundus image with uniform illuminance is obtained.

Description

Technical Field

[0001] This invention relates to the field of optical imaging and biomedical diagnostic equipment, and in particular to a fundus imaging device based on line scanning confocal imaging. Background Technology

[0002] Currently, there are various fundus retinal imaging techniques available in clinical practice, including fundus cameras, optical coherence tomography (OCT), and confocal scanning, which play an important role in biological research and disease diagnosis.

[0003] Existing line-scan confocal fundus imaging devices cannot adjust the focal length according to the condition of the human eye. Furthermore, the line beam modulated by a single cylindrical lens in existing line-scan confocal fundus imaging devices is a Gaussian line beam, which has uneven illumination. This results in uneven brightness in the fundus image, with the central part being brighter and the upper and lower parts being darker, thus affecting the image quality. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, one of the objectives of the present invention is to provide a fundus imaging device based on line scanning confocal imaging, which has a compact structure and can adjust the focal length according to the condition of the human eye and provide uniform illumination.

[0005] One of the objectives of this invention is achieved through the following technical solution:

[0006] A fundus imaging device based on line-scan confocal microscopy includes a housing and an objective lens structure. The housing includes a base plate. The fundus imaging device based on line-scan confocal microscopy further includes a focusing structure, a mounting plate, a light source, a shaping structure, a reflecting structure, a galvanometer, a scanning imaging structure, and a second detector. The focusing structure is mounted on the housing. The mounting plate is located inside the housing and cooperates with the focusing structure. The light source, shaping structure, reflecting structure, galvanometer, scanning imaging structure, and second detector are mounted on the mounting plate. The objective lens structure is mounted on the base plate. The focusing structure drives the mounting plate to move relative to the objective lens structure to adjust the distances of the light source, shaping structure, reflecting structure, galvanometer, scanning imaging structure, and second detector relative to the objective lens structure. The shaping structure includes a first cylindrical mirror, a second cylindrical mirror, and a third cylindrical mirror. The shaping structure is located between the light source and the reflecting structure in the optical path.

[0007] Furthermore, the shaping structure also includes a first reflector, a second reflector, and a third reflector. The first reflector and the second reflector are arranged opposite to each other, the second reflector and the third reflector are arranged parallel to each other, and the line connecting the first reflector and the second reflector is perpendicular to the line connecting the second reflector and the third reflector.

[0008] Furthermore, the first cylindrical mirror is located between the light source and the first reflector, and the second and third cylindrical mirrors are located between the third reflector and the reflective structure.

[0009] Furthermore, the imaging structure includes an aperture stop and a second imaging mirror group, the imaging structure being located between the second detector and the galvanometer structure, and the aperture stop being located between the second imaging mirror group and the galvanometer structure.

[0010] Furthermore, the aperture is provided with a circular light-transmitting hole and includes a central elongated obstruction.

[0011] Furthermore, the second detector includes a mounting bracket and a detector body. The detector body is fixed to the mounting bracket. The mounting bracket has mounting holes, which can be multiple or elongated. The mounting holes allow the mounting bracket to be installed at different positions on the mounting plate.

[0012] Furthermore, the focusing structure can be any one of a screw nut, a linear module, or a cylinder.

[0013] Furthermore, the scanning structure includes a fifth reflecting mirror and a scanning objective lens. The objective lens structure includes a first beam splitter and a flat objective lens. The fifth reflecting mirror, the scanning objective lens, the first beam splitter, and the flat objective lens are arranged sequentially and located on the same straight line.

[0014] Furthermore, the objective lens structure also includes a target, a target objective lens, a second beam splitter, a first imaging lens group, and a first detector, wherein the target, target objective lens, second beam splitter, first imaging lens group, and first detector are located on one side of the first beam splitter.

[0015] Furthermore, the second beam splitter is positioned opposite to and parallel to the first beam splitter, the target and the target objective are located on one side of the second beam splitter, and the first imaging lens group and the first detector are located on the other side of the second beam splitter.

[0016] Compared to existing technologies, the focusing structure of the fundus imaging device based on line scanning confocal imaging in this invention moves the mounting plate relative to the objective lens structure to adjust the distances of the light source, shaping structure, reflection structure, galvanometer, scanning imaging structure, and second detector relative to the objective lens structure. This allows the fundus imaging device based on line scanning confocal imaging to adjust the focal length according to the condition of the human eye. The shaping structure includes a first cylindrical mirror, a second cylindrical mirror, and a third cylindrical mirror. The shaping structure is located between the light source and the reflection structure in the optical path. The first cylindrical mirror, the second cylindrical mirror, and the third cylindrical mirror modulate the light emitted by the light source into a line light source with uniform illumination, thereby obtaining a fundus image with uniform illumination. Attached Figure Description

[0017] Figure 1 This is a perspective view of the fundus imaging device based on line scanning confocal imaging according to the present invention;

[0018] Figure 2 for Figure 1 A cross-sectional view of a fundus imaging device based on line scanning confocal imaging;

[0019] Figure 3 for Figure 1 A three-dimensional view of the internal structure of a fundus imaging device based on line scanning confocal imaging;

[0020] Figure 4 for Figure 1 Another three-dimensional view of the internal structure of a fundus imaging device based on line scanning confocal imaging;

[0021] Figure 5 for Figure 1 A top view of the internal structure of a line-scan confocal fundus imaging device;

[0022] Figure 6 for Figure 1 A cross-sectional view of the aperture of a line-scan confocal fundus imaging device;

[0023] Figure 7 for Figure 1 Optical path diagram of a fundus imaging device based on line scanning confocal scanning.

[0024] In the diagram: 10. Outer shell; 11. Base plate; 12. Top cover; 20. Focusing structure; 30. Mounting plate; 40. Light source; 50. Shaping structure; 51. First shell; 52. First cylindrical mirror; 53. First reflecting mirror; 54. Second reflecting mirror; 55. Third reflecting mirror; 56. Second cylindrical mirror; 57. Third cylindrical mirror; 60. Reflecting structure; 61. Mounting post; 62. Fourth reflecting mirror; 70. Galvanometer structure; 71. Clip-on component; 72. Galvanometer; 80. Scanning structure; 81. Second shell; 82. Fifth reflecting mirror. 83. Scanning objective lens; 90. Objective lens structure; 91. Mounting block; 92. Third housing; 93. First beam splitter; 94. Plan objective lens; 95. Target; 96. Target objective lens; 97. Second beam splitter; 98. First imaging lens group; 99. First detector; 100. Imaging structure; 101. Aperture; 1011. Light aperture; 1012. Light shield; 102. Second imaging lens group; 110. Second detector; 111. Detector body; 112. Mounting bracket; 1120. Mounting hole; 200. Human eye. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] It should be noted that when a structure is said to be "fixed to" another structure, it can be directly on the other structure or it can be fixed through another intermediate structure. When a structure is said to be "connected to" another structure, it can be directly connected to the other structure or it may be fixed through another intermediate structure. When a structure is said to be "set on" another structure, it can be set directly on the other structure or it may be set through another intermediate structure. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this article are for illustrative purposes only.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0028] like Figures 1 to 7 As shown, the present invention provides a fundus imaging device based on line scanning confocal imaging for achieving rapid imaging of the human eye 200°.

[0029] The present invention provides a fundus imaging device based on line scanning confocal imaging, comprising a housing 10, a focusing structure 20, a mounting plate 30, a light source 40, a shaping structure 50, a reflection structure 60, a galvanometer structure 70, a scanning structure 80, an objective lens structure 90, an imaging structure 100, and a second detector 110.

[0030] The outer casing 10 includes a base plate 11 and a top cover 12. The top cover 12 is mounted on the base plate 11, and a receiving space is formed between the top cover 12 and the base plate 11.

[0031] The focusing structure 20 is mounted on the base plate 11. The focusing structure 20 can be any one of a screw nut, a linear module, or a cylinder. The focusing structure 20 is used to drive the mounting plate 30, causing the mounting plate 30 to move within the receiving space to adjust the focal length, so that the fundus imaging device based on line scanning confocal imaging can adjust the focal length according to the condition of the human eye 200.

[0032] Mounting plate 30 is a flat plate, which is fixed to the output end of focusing structure 20. The length of mounting plate 30 is less than the length of base plate 11, so that mounting plate 30 can move relative to base plate 11 in the length direction.

[0033] The light source 40 is fixed to the mounting plate 30. Specifically, to save space, the light source 40 is fixed to the bottom of the mounting plate 30.

[0034] The shaping structure 50 is fixed to the upper surface of the mounting plate 30. The shaping structure 50 includes a first housing 51, a first cylindrical mirror 52, a first reflecting mirror 53, a second reflecting mirror 54, a third reflecting mirror 55, a second cylindrical mirror 56, and a third cylindrical mirror 57. The first housing 51 is mounted on the mounting plate 30, and the first cylindrical mirror 52, the first reflecting mirror 53, the second reflecting mirror 54, the third reflecting mirror 55, the second cylindrical mirror 56, and the third cylindrical mirror 57 are mounted on the first housing 51.

[0035] The first reflector 53 and the second reflector 54 are arranged opposite to each other, and the second reflector 54 and the third reflector 55 are arranged parallel to each other. The line connecting the first reflector 53 and the second reflector 54 is perpendicular to the line connecting the second reflector 54 and the third reflector 55. The first cylindrical mirror 52 is located between the light source 40 and the first reflector 53, and the second cylindrical mirror 56 and the third cylindrical mirror 57 are located between the third reflector 55 and the reflecting structure 60.

[0036] The first reflecting mirror 53, the second reflecting mirror 54, and the third reflecting mirror 55 deflect the light path, reducing the size of the shaping structure 50 and enabling a smaller size of the fundus imaging device based on line scanning confocal imaging. The first cylindrical mirror 52, the second cylindrical mirror 56, and the third cylindrical mirror 57 modulate the light emitted from the light source 40 into a uniformly illuminated line light source, thereby obtaining a uniformly illuminated fundus image.

[0037] The reflective structure 60 includes a mounting post 61 and a fourth reflector 62. The mounting post 61 is fixed to the mounting plate 30, and the fourth reflector 62 is mounted on the top of the mounting post 61.

[0038] The galvanometer structure 70 includes a snap-fit ​​member 71 and a galvanometer 72, with the galvanometer 72 mounted on the snap-fit ​​member 71.

[0039] The scanning structure 80 includes a second housing 81, a fifth reflecting mirror 82, and a scanning objective lens 83. The second housing 81 is fixed to the upper surface of the mounting plate 30. The fifth reflecting mirror 82 and the scanning objective lens 83 are mounted on the second housing 81. The fifth reflecting mirror 82 is disposed opposite to the galvanometer 72.

[0040] The objective structure 90 includes a mounting block 91, a third housing 92, a first beam splitter 93, a plan objective 94, a target 95, a target objective 96, a second beam splitter 97, a first imaging lens group 98, and a first detector 99.

[0041] Mounting block 91 is fixed to base plate 11, and third housing 92 is mounted on mounting block 91. First beam splitter 93, plan objective lens 94, target 95, target objective lens 96, second beam splitter 97, first imaging lens group 98, and first detector 99 are mounted on third housing 92. Fifth reflecting mirror 82, scanning objective lens 83, first beam splitter 93, and plan objective lens 94 are arranged sequentially and on the same straight line. Target 95, target objective lens 96, second beam splitter 97, first imaging lens group 98, and first detector 99 are located on one side of first beam splitter 93. Second beam splitter 97 is arranged opposite to and parallel to first beam splitter 93; target 95 and target objective lens 95 are located on one side of second beam splitter 97, and first imaging lens group 98 and first detector 99 are located on the other side of second beam splitter 97.

[0042] The imaging structure 100 includes an aperture 101 and a second imaging mirror group 102. The imaging structure 100 is located between the second detector 110 and the galvanometer structure 70, and the aperture 101 is located between the second imaging mirror group 102 and the galvanometer structure 70. Specifically, the aperture 101 has a light-transmitting aperture 1011 and a light-shielding strip 1012. The light-transmitting aperture 1011 is circular, and the light-shielding strip 1012 is elongated and located at the center of the light-transmitting aperture 1011. The aperture 101 blocks stray light from the light returning from the plan objective lens 94.

[0043] The second detector 110 includes a mounting bracket 112 and a detector body 111. The detector body 111 is fixed to the mounting bracket 112. The mounting bracket 112 is provided with mounting holes 1120. The number of mounting holes 1120 is multiple or the mounting holes 1120 are elongated. The mounting holes 1120 enable the mounting bracket 112 to be installed at different positions on the mounting plate 30.

[0044] When using a fundus imaging device based on line scanning confocal imaging, the light emitted from the light source 40 is transmitted to the fourth mirror 62 via the first cylindrical mirror 52, first reflecting mirror 53, second reflecting mirror 54, third reflecting mirror 55, second cylindrical mirror 56, and third cylindrical mirror 57 of the shaping structure 50. The first cylindrical mirror 52, second cylindrical mirror 56, and third cylindrical mirror 57 modulate the light emitted from the light source 40 into a line light source with uniform illumination. The first reflecting mirror 53, second reflecting mirror 54, and third reflecting mirror 55 reflect the light, changing the optical path and reducing the size of the device. The light reflected by the fourth reflecting mirror 62 is incident on the human eye 200 via the galvanometer 72, fifth reflecting mirror 82, scanning objective lens 83, first beam splitter 93, and plan objective lens 94. The reflected light from the fundus of the human eye 200 is received by the detector body 111 via the plan objective lens 94, first beam splitter 93, scanning objective lens 83, fifth reflecting mirror 82, galvanometer 72, aperture 101, and second imaging mirror group 102. Aperture 101 blocks stray light from the light returning from the plan objective lens 94.

[0045] The target 95 has a light source. The light from the target 95 passes through the target objective lens 96, the second beam splitter 97, the first beam splitter 93, and the plan objective lens 94 and enters the human eye 200. The human eye 200 is aligned with the target 95. The reflected light from the human eye 200 passes through the plan objective lens 94, the first beam splitter 93, the second beam splitter 97, and the first imaging lens group 98 and is received by the first detector 99.

[0046] The focusing structure 20 of this application, based on a line-scan confocal fundus imaging device, moves the mounting plate 30 relative to the objective lens structure 90 to adjust the distances of the light source 40, shaping structure 50, reflecting structure 60, galvanometer 72, scanning structure 80, imaging structure 100, and second detector 110 relative to the objective lens structure 90. This allows the line-scan confocal fundus imaging device to compensate for the refractive power of the human eye 200. This line-scan confocal fundus imaging device can match different light sources 40 to achieve line confocal imaging of the fundus, and has the advantages of good imaging quality and compact structure.

[0047] The above embodiments merely illustrate several implementation methods of the present invention, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the invention patent. It should be noted that, for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention. These are all equivalent modifications and improvements made to the above embodiments based on the essential technology of the present invention, and all of these fall within the protection scope of the present invention.

Claims

1. A fundus imaging device based on line-scan confocal microscopy, comprising a housing and an objective lens structure, wherein the housing includes a base plate, characterized in that: The fundus imaging device based on line scanning confocal imaging further includes a focusing structure, a mounting plate, a light source, a shaping structure, a reflecting structure, a galvanometer, a scanning structure, an imaging structure, and a second detector. The focusing structure is mounted on the housing, and the mounting plate is located inside the housing and cooperates with the focusing structure. The light source, shaping structure, reflecting structure, galvanometer, scanning structure, imaging structure, and second detector are mounted on the mounting plate, and the objective lens structure is mounted on the base plate. The focusing structure drives the mounting plate to move relative to the objective lens structure to adjust the distance of the light source, shaping structure, reflecting structure, galvanometer, scanning structure, imaging structure, and second detector relative to the objective lens structure. The shaping structure includes a first cylindrical mirror, a second cylindrical mirror, and a third cylindrical mirror. The shaping structure is located between the light source and the reflecting structure in the optical path to modulate the light emitted by the light source into a line light source with uniform illumination. The shaping structure further includes a first reflector, a second reflector, and a third reflector. The first reflector and the second reflector are arranged opposite to each other, and the second reflector and the third reflector are arranged parallel to each other. The line connecting the first reflector and the second reflector is perpendicular to the line connecting the second reflector and the third reflector.

2. The fundus imaging device based on line scanning confocal imaging according to claim 1, characterized in that: The first cylindrical mirror is located between the light source and the first reflector, and the second and third cylindrical mirrors are located between the third reflector and the reflective structure.

3. The fundus imaging device based on line scanning confocal imaging according to claim 1, characterized in that: The imaging structure includes an aperture and a second imaging mirror group. The imaging structure is located between the second detector and the galvanometer, and the aperture is located between the second imaging mirror group and the galvanometer.

4. The fundus imaging device based on line scanning confocal imaging according to claim 3, characterized in that: The aperture has a circular light-transmitting hole and includes a central elongated obstruction.

5. The fundus imaging device based on line scanning confocal imaging according to claim 1, characterized in that: The second detector includes a mounting bracket and a detector body. The detector body is fixed to the mounting bracket. The mounting bracket has mounting holes, which can be multiple or elongated. The mounting holes allow the mounting bracket to be installed at different positions on the mounting plate.

6. The fundus imaging device based on line scanning confocal imaging according to claim 1, characterized in that: The focusing structure can be any one of a screw nut, a linear module, or a cylinder.

7. The fundus imaging device based on line scanning confocal imaging according to claim 1, characterized in that: The scanning structure includes a fifth reflecting mirror and a scanning objective lens. The objective lens structure includes a first beam splitter and a flat objective lens. The fifth reflecting mirror, the scanning objective lens, the first beam splitter, and the flat objective lens are arranged sequentially and located on the same straight line.

8. The fundus imaging device based on line scanning confocal imaging according to claim 7, characterized in that: The objective lens structure also includes a target, a target objective lens, a second beam splitter, a first imaging lens group, and a first detector, wherein the target, target objective lens, second beam splitter, first imaging lens group, and first detector are located on one side of the first beam splitter.

9. The fundus imaging device based on line scanning confocal imaging according to claim 8, characterized in that: The second beam splitter is positioned opposite to and parallel to the first beam splitter. The target and the target objective are located on one side of the second beam splitter, and the first imaging lens group and the first detector are located on the other side of the second beam splitter.

Images