一种3-叔丁基-5-硼酸酯基吡啶的合成方法
By using a combined reaction system of 3-bromo-5-iodopyridine with tert-butylmagnesium chloride, zinc salt, and copper salt, tert-butyl is introduced into the pyridine ring, solving the problems of lengthy steps, low safety performance, and low yield in the prior art, and realizing the efficient and safe synthesis of 3-tert-butyl-5-boronate pyridine.
CN116768928BActive Publication Date: 2026-07-17SHANGHAI BICHEN BIOCHEMICAL TECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI BICHEN BIOCHEMICAL TECH CO LTD
- Filing Date
- 2023-06-15
- Publication Date
- 2026-07-17
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Figure CN116768928B_ABST
Abstract
一种3‑叔丁基‑5‑硼酸酯基吡啶的合成方法，采用价廉易得的3‑溴‑5‑碘吡啶为原料，采用叔丁基氯化镁，卤化锌及氰化亚铜联合使用的反应体系，将叔丁基引入吡啶环，简化了反应步骤，且反应收率较高。同时，本发明所用的的原料和试剂均市售可得、反应条件温和，后处理及纯化操作简便，成本低廉，适于放大化生产。
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