Spatial light modulation targeting of therapeutic laser for treatment of ocular disorders

Abstract

A therapeutic laser for treating an ocular condition can be modulated by a spatial light modulating device in order to simultaneously focus the therapeutic laser on a plurality of target locations.

Description

[0001] Related applications

[0002] This application claims priority to Canadian Patent Application 3,100,460, filed on November 24, 2020, entitled “Spatial Light Modulation Targeting for Therapeutic Lasers for Treating Eye Conditions,” the entire contents of which are incorporated herein by reference. Technical Field

[0003] This disclosure relates to a laser delivery system for ophthalmology, and more particularly, to targeting for delivering laser to one or more target locations. Background Technology

[0004] Eye conditions such as diabetic retinopathy, age-related macular degeneration, vitreoretinal traction, tears, retinal detachment, retinal tears, glaucoma, venous occlusion, choroidal detachment, diabetic macular edema, posterior vitreous detachment, cataracts, and floaters may include treatment options that focus a laser at one or more locations. The delivered / focused laser is absorbed by the tissues of the eye, leading to changes in the eye such as photocoagulation, incision, ablation, etc. While laser treatment can be used to treat a wide variety of eye conditions, the procedure often requires laser treatment at multiple different locations.

[0005] Delivering / focusing the treatment laser to each treatment site can be time-consuming and may require precise eye tracking to ensure any eye movement is accounted for during laser delivery. Furthermore, laser treatment at one site can alter or affect other treatment sites, which may require replanning. Additionally, laser treatment can be uncomfortable for the patient, and therefore treating each target site individually may not be desirable.

[0006] Masking techniques have been used to filter treatment lasers and target multiple treatment sites simultaneously. However, masking can present problems with focusing at each individual target location. Furthermore, it can be difficult to position and align the mask relative to the patient.

[0007] Additional, novel, and / or improved systems and methods for targeting therapeutic lasers used to treat eye conditions are desired. Summary of the Invention

[0008] According to this disclosure, a therapeutic laser delivery system for ophthalmology is provided, comprising: a therapeutic laser delivery optical path including at least one input port for receiving a therapeutic laser and an output port for delivering at least a portion of the therapeutic laser to an ophthalmic target; a spatial light modulator (SLM) device arranged to modulate the therapeutic laser delivered to the ophthalmic target in order to control the target position on the ophthalmic target to which the therapeutic laser is delivered / focused; and at least one processor configured to determine the target position and control the SLM device to modulate the therapeutic laser to be delivered / focused at the determined target position.

[0009] In another embodiment of the system, the system further includes a targeted laser delivery optical path for delivering a targeted laser to an ophthalmic target, wherein the SLM device is further arranged to modulate the targeted laser for delivery / focusing at a target location on the ophthalmic target.

[0010] In another embodiment of the system, the laser delivery optical path includes an alignment optical path for aligning the target laser and inputting it to at least one input port of the treatment laser delivery optical path.

[0011] In another embodiment of the system, the system further includes an imaging system that captures images of ophthalmic targets.

[0012] In another embodiment of the system, the image captured by the imaging system captures the targeted laser focused by the SLM device.

[0013] In another embodiment of the system, the captured images are processed to compare the captured targeted laser, focused by the SLM device, with the target location.

[0014] In another embodiment of the system, the comparison between the target laser captured in the image and the target location is used as feedback for controlling the SLM device.

[0015] In another embodiment of the system, the imaging system includes one or more of the following: a fundus camera system; a scanning laser ophthalmoscopy (SLO) imaging system; and an optical coherence tomography (OCT) system.

[0016] In a further embodiment of the system, the imaging system includes a tracking system for tracking eye movement.

[0017] In another embodiment of the system, the determined target locations include multiple simultaneous treatment locations for the therapeutic laser.

[0018] In another embodiment of the system, the SLM device is controlled to simultaneously deliver / focus a portion of the therapeutic laser at each of a plurality of simultaneous treatment locations.

[0019] In another embodiment of the system, the delivery / focusing of the therapeutic laser at each of the simultaneously treated locations has a corresponding power.

[0020] In another embodiment of the system, the power of the portion of the therapeutic laser delivered / focused at at least one of the simultaneous treatment positions is different from the power of the portion at at least another of the simultaneous treatment positions.

[0021] In another embodiment of the system, the at least one processor is further configured to control the SLM device to pulse-shape the therapeutic laser.

[0022] In another embodiment of the system, the SLM device includes one or more of the following: a liquid crystal-based SLM device; a microelectromechanical micromirror-based SLM device; a film mirror-based SLM device; and an active or passive elemental surface.

[0023] In another embodiment of the system, the target location of the ophthalmic target is located at one or more of the following: the sclera of the ophthalmic target; the iris of the ophthalmic target; the pupil of the ophthalmic target; the cornea of ​​the ophthalmic target; the retina of the ophthalmic target; and the vitreous fluid of the ophthalmic target.

[0024] In another embodiment of the system, the delivery / focusing of the therapeutic laser at the target location is used to treat one or more of the following: diabetic retinopathy; age-related macular degeneration; vitreomacular traction; tear; retinal detachment; retinal hole; glaucoma; venous occlusion; choroidal detachment; diabetic macular edema; posterior vitreous detachment; cataract; floaters; and dry eye.

[0025] According to this disclosure, a method for targeting a therapeutic laser to an ophthalmic target is provided, comprising: determining a plurality of target locations of an ophthalmic device; controlling a spatial light modulation (SLM) device to focus a targeting laser at each of the determined plurality of target locations; capturing an image of the targeting laser focused at the determined plurality of target locations; comparing the position of the focused targeting laser captured in the image with the determined target location; and controlling the SLM device based on feedback from the comparison of the position of the focused targeting laser captured in the image with the determined target location.

[0026] In another embodiment of the method, determining multiple target locations includes: capturing one or more images of ophthalmic targets; and processing one or more images to determine multiple target locations. Attached Figure Description

[0027] Further features and advantages of this disclosure will become apparent from the following detailed description taken in conjunction with the accompanying drawings, in which:

[0028] Figure 1 An ophthalmic system for using focused therapeutic lasers is shown;

[0029] Figure 2 Another ophthalmic system for focused therapeutic lasers is shown;

[0030] Figure 3 This demonstrates a method for targeting therapeutic lasers to ophthalmic targets; and

[0031] Figure 4 This demonstrates another method for targeting therapeutic lasers to ophthalmic targets. Detailed Implementation

[0032] Treatment lasers used in ophthalmology can be delivered and / or focused by spatial light modulation (SLM) devices, which allow the treatment laser to be delivered and / or focused simultaneously at multiple locations. For example, a treatment laser can be delivered or focused at many different locations to ablate, cut, and / or photocoagulate tissue. The laser does not need to be focused but can be delivered directly to the eye, such as for transscleral light-mediated biostimulation of the trabecular meshwork of a patient's eye, which can be used to treat glaucoma or high intraocular pressure. SLM devices allow for simultaneous treatment of multiple locations. Laser treatment can be painful for an individual, and therefore reducing the number of treatments required can be beneficial. Simultaneous delivery and / or focusing of the treatment laser at multiple locations allows for immediate treatment without the need for multiple laser sessions. Previous techniques treated individual locations sequentially, requiring tracking of eye movement between treatments. Simultaneous treatment of multiple locations reduces the amount of eye tracking required and thus reduces potential errors during treatment. Furthermore, laser treatment at individual locations can affect other locations, and therefore may necessitate reassessment of the treated locations after a single treatment. Conversely, simultaneous treatment of multiple locations allows all locations to be treated without requiring further reassessment. In addition to delivering / focusing therapeutic lasers at multiple locations, SLM devices can control shape, phase, polarization, wavefront tilt, diffraction, wavefront helicity, orbital angular momentum order, and generate non-diffractive beams (e.g., Bessel and self-healing beams) of delivered and / or focused therapeutic lasers.

[0033] Figure 1An ophthalmic system for delivering / focusing therapeutic lasers is illustrated. System 100 includes a therapeutic laser source 102 that provides a source of laser for use in ocular treatment. The therapeutic laser source 102 may be provided by a series of different laser sources, including, for example, femtosecond lasers. The therapeutic laser may be coupled to an optical path that may include one or more optical components schematically depicted by lens 104. The optical components may include, for example, optical lenses, mirrors, filters, beam splitters, gratings, polarizers, etc. System 100 further includes an electronically addressable SLM device 106 that controllably modulates the light from the therapeutic source. SLM device 106 may be, for example, a liquid crystal-based SLM device, such as a liquid crystal on silicon (LCoS) device capable of pixel-by-pixel, controllably modulating the phase of the laser. For example, an LCoS SLM may include a panel of pixel elements, such as 1920x1080, 3840x2160, although other sizes are also possible, each size being controllable to modulate the phase of the incident light. The SLM device may be controlled in various ways. For example, an SLM device can be driven by an electrical signal similar to that used to drive an LCD panel. Although a liquid crystal-based SLM device has been described above, other SLM devices can also be used. For example, an SLM device can be provided by a micromirror-based SLM device. SLM devices allow for pixel-by-pixel modulation of the phase of the incident laser, which allows for control of the pattern of the delivered / focused laser at the ophthalmic target. SLM devices are digitally controllable to impart some form of spatially varying phase modulation to the beam reflected from or transmitted through them.

[0034] System 100 may further include additional optical components for delivering modulated laser light to an optical target. The additional optical components are schematically depicted as a mirror 108, but may include, for example, lenses, filters, polarizers, etc. The optical target is the patient's eye 110. The SLM device allows laser delivery / focusing at multiple target locations, one of which is designated as location 112. The target location 112 where the laser is delivered / focused is a location already determined for treatment. For example, in treating age-related macular degeneration, the target location could be the site of a subretinal drusen. Treatments for other eye conditions may have different targets; however, regardless of the specific target, the SLM device is capable of modulating the laser so that it is simultaneously delivered / focused at multiple target locations.

[0035] Although shown and described as a single location, the target location does not need to be limited to a single point. SLM devices can utilize a shape-defined laser delivery / focusing method. For example, in treating vitreous-macular traction, the shape of the delivery / focusing laser can be a cupped surface or other similar shape that cuts the line causing traction. Another example is in the treatment of glaucoma, where the laser is delivered to the limbal region of the eye. Here, the delivered laser point is spatially configured into a specific shape to illuminate the trabecular meshwork of the eye.

[0036] System 100 further includes one or more controllers, schematically depicted as a computer 114 controlling system components including SLM devices and possibly therapeutic laser sources. The one or more controllers may be configured to provide system control functions 116. The one or more controllers may be configured, for example, by executing instructions stored in memory. System control functions 116 may include planning functions 118 that allow for the planning of treatments. Planning functions 118 may be provided in various ways, such as a manual process allowing a user to load an image of a patient's eye and specify a target location on the image. Additionally or alternatively, the planning function may process the image to automatically or semi-automatically identify the target location. This processing may be based on a specific eye condition to be treated, or may identify an eye condition present in one or more images and determine the treatment location for treating that condition. In addition to planning treatment locations, the planning function may also determine or specify parameters for treatment at each location, such as laser power, duration, number of repetitions, pulse shape, wavelength, wavefront, and other relevant parameters.

[0037] SLM treatment function 120 can use information from planning function 118 (and specifically, treatment location and treatment parameters) to control the SLM device and, possibly, the treatment laser source. For example, the SLM planning function can generate control signals to drive the SLM device, which will enable the delivery / focusing of the laser according to the treatment plan.

[0038] Figure 2Another ophthalmic system for delivering / focusing therapeutic lasers is shown. System 200 is similar to system 100, and similar components will not be described in further detail. In addition to the optics for the therapeutic laser and SLM device, system 200 is depicted as having an additional targeting laser source 250 and an imaging system 260. Although system 200 is described as including both a targeting laser source and an imaging system, it is possible that the system includes only one of these components. Furthermore, although depicted as a single imaging system, the system may include multiple different imaging systems and targeting systems. Canadian Patent Application 3,096,285, filed October 16, 2020, entitled “Ophthalmic Imaging and Laser Delivery Device, System, and Method,” describes a device capable of delivering therapeutic lasers and including multiple imaging systems and targeting lasers. The entire contents of Canadian Patent Application 3,096,285 are incorporated herein by reference in their entirety for all purposes. The device described in Canadian Patent Application 3,096,285 uses scanning optics to allow the therapeutic laser to be delivered / focused at different locations. While the device described in Canadian patent application 3,096,285 can deliver / focus a therapeutic laser at any desired treatment location, it cannot deliver / focus the therapeutic laser at multiple target locations simultaneously. By incorporating an SLM device for therapeutic laser delivery, it is possible to adjust the phase of the therapeutic laser to deliver / focus the laser at multiple locations simultaneously.

[0039] As depicted, in addition to the therapeutic laser 102 and the SLM device 106, system 200 includes a targeted laser source 250 traversing an optical path comprising various optical components 252 and a beam splitter / combiner 254 for combining the targeted laser with the therapeutic laser. The optical components 252 may include, for example, optical components and sensors for aligning the targeted laser, such that once combination is performed by the beam combiner 254, the path of the targeted laser is aligned with the path of the therapeutic laser. The targeted laser is modulated by the SLM device in the same manner as the therapeutic light; however, the targeted laser does not affect biological ocular tissue. The targeted laser may have the same or different wavelengths as the therapeutic laser. If the wavelengths of the targeted laser and the therapeutic laser are different, the phase modulation can be digitally corrected. The targeted laser can serve as a preview of where the therapeutic laser will actually target, and thus can be used to validate the treatment plan before actual treatment is performed by the therapeutic laser.

[0040] The imaging system may include one or more systems for imaging a patient's eye 110, and may include a corresponding light source 262, which may include a laser and corresponding optical components 264, which may include lenses, scanning optics, beam splitters, beam combiners, etc. The imaging system may include, for example, a fundus imaging camera system, a scanning laser ophthalmoscopy (SLO) system, an optical coherence tomography (OCT) system, or other imaging systems. One or more beam splitters / combiners 266 may be used to direct imaging light from each corresponding system of the imaging light source to the eye and back to the imaging sensor of the specific imaging system. Individual imaging systems may share one or more optical components.

[0041] Despite Figure 2 Not shown, but system 200 includes one or more controllers configured to provide the system control functions described above. The control functions can control the targeting laser and the imaging system. The control functions can control the system, including, for example, the SLM device 106, based on information from one or more imaging systems. For example, the imaging system can capture the location of the targeting laser delivered / focused by the SLM device. The actual location of the delivered / focused targeting laser can be compared with the desired treatment location (such as those provided by the planning function), and the comparison result is used as feedback to control the SLM device and more precisely target the desired location.

[0042] Furthermore, one or more components of the imaging system can be used as an eye-tracking system to track eye movement and update the target position based on that movement. Control of the SLM device can be performed in real time to, for example, adjust the delivery / focusing position of the target laser and / or therapeutic laser at certain frequencies f to account for eye movement.

[0043] Figure 3A method for targeting a therapeutic laser to an ophthalmic target is illustrated. Method 300 begins with determining the target location (302). The target location can be determined in various ways, including, for example, by displaying one or more images of the patient's eye and allowing the individual to specify the target location on the images. Alternatively or alternatively, the target location can be determined automatically by processing images of the patient's eye, for example using artificial intelligence (AI) or machine learning (ML) algorithms or engines. Automatic or semi-automatic determination of the target location may include capturing images (318), such as fundus images, SLO images, and / or OCT images, and processing the images by an AI engine trained to recognize the target location (320). The target location may include the specific spatial location of the target and treatment parameters for that specific location, such as laser power, number of treatment repetitions, wavelength, pulse shape, etc. Regardless of how the target location is determined, once the target location is determined, the SLM device is controlled to deliver / focus the targeted laser to the determined location (304). The SLM device may deliver / focus the targeted laser on the determined treatment location; however, the targeted laser will not have the same parameters as the therapeutic laser, such as power. One or more images (306) including the delivery / focusing location of the target laser are captured. The captured images are processed to identify the actual target location of the target laser and compared with the determined treatment location (308). Any difference between the target location and the determined treatment location can be used as feedback for controlling the SLM to more accurately target the treatment location (310). While adjusting the SLM device, additional images (312) of the target laser are captured and used to determine whether the target location is in an acceptable position relative to the desired treatment location (314). If the target location of the target laser is unacceptable (No at 314), the control of the SLM is adjusted again (310), and the targeting process continues. If the target location is acceptable (Yes at 314), the treatment laser can be controlled (316) to treat at these locations according to the treatment plan.

[0044] Figure 4 Another method for targeting a therapeutic laser to an ophthalmic target is illustrated. Method 400 captures an image of the patient's eye (402). Various imaging techniques can be used to capture the image, including fundus cameras, SLO imaging systems, OCT imaging systems, or other imaging techniques. Figure 4Two illustrative images 402a and 402b of a patient's eye are shown. The patient in image 402a has several microaneurysms, and the patient in image 402b has glaucoma. Once the images are captured, they are processed to identify treatment locations (404). Images 402a and 404b can be processed to identify the locations requiring treatment highlighted in Figures 404a and 404b. Treatment locations are highlighted with arrows in the figures. Identification of treatment locations can be done manually, automatically, or semi-automatically (requiring manual confirmation of the treatment location). The treatment location can be used to control the SLM device to shape the treatment laser beam delivered simultaneously to the target location.

[0045] The SLM device can be controlled to deliver lasers simultaneously to treatment sites (406). The treatment site can be verified by first irradiating it with a targeted laser, the shape of which is adjusted by the SLM device. The location where the targeted laser is delivered can be captured by an imaging system and compared to the desired treatment site. If the targeted site is acceptable (yes at 408), i.e., the targeted laser is delivered to the site where treatment is required, the treatment site can be irradiated with a therapeutic laser (410), wherein the shape of the therapeutic laser is adjusted by the SLM device to deliver it simultaneously to all treatment sites. If the targeted site is unacceptable, the SLM device can be controlled to adjust the treatment site (412), and the adjusted treatment site (406) can be irradiated again with the targeted laser.

[0046] The systems and methods for using SLM devices to simultaneously deliver / focus laser light to one or more locations within a patient's eye have been described above. The SLM device is digitally controllable to impart some form of spatial phase modulation to light passing through or reflected from the SLM device. Spatial phase modulation provided by the SLM device allows control over the shape of the laser to simultaneously deliver / focus it to multiple locations within the eye. SLM devices can be provided by different types of devices, including, for example, translucent or transmissive SLM devices or reflective SLM devices. Liquid crystal display (LCD) technology can be used to provide translucent or transmissive SLM devices, while liquid crystal on silicon (LCoS) technology can be used to provide reflective SLM devices. Other technologies can be used to provide SLM devices capable of controllably imparting some form of spatial modulation to light, including, for example, microelectromechanical micromirror-based SLM devices, membrane-mirror-based SLM devices, and active or passive metasurfaces. Regardless of the type of SLM device, the laser can be delivered / focused to different areas of the eye, including the sclera, iris, pupil, cornea, retina, vitreous humor, or other areas. Laser delivery / focusing can be used to treat a variety of eye conditions, including diabetic retinopathy, age-related macular degeneration, vitreous-macular traction, tears, retinal detachment, retinal tears, glaucoma, venous occlusion, choroidal detachment, diabetic macular edema, posterior vitreous detachment, cataracts, floaters, and dry eye.

[0047] Those skilled in the art will understand that Figures 1 to 4 The systems and components shown may include components not shown in the figures. For the sake of simplicity and clarity, the elements in the figures are not necessarily drawn to scale, are merely schematic, and are not intended to limit the structure of the elements. It will be apparent to those skilled in the art that many variations and modifications may be made without departing from the scope of the invention as defined in the claims.

[0048] While certain components and steps have been described, it is contemplated that the individually described components and steps may be combined together to form fewer components or steps, or that these steps may be performed sequentially, non-sequentially, or simultaneously. Furthermore, although the above description assumes a specific order, those skilled in the art will understand, in consideration of the present teachings, that the specific order of some steps relative to others may be changed. Similarly, individual components or steps may be provided by multiple components or steps. Those skilled in the art will understand, in consideration of the present teachings, that the components and processes described herein, apart from the specific implementations described herein as illustrative examples, may be provided by various combinations of software, firmware, and / or hardware.

[0049] The techniques of various implementations can be implemented using software, hardware, and / or a combination of software and hardware. Various implementations are directed to apparatuses, such as nodes that can be used in communication systems or data storage systems. Various implementations are also directed to non-volatile machine-readable media (e.g., ROM, RAM, CD, hard disk, etc.) that include machine-readable instructions for controlling a machine (e.g., a processor) to implement one, more, or all of the steps of one or more of the described methods.

[0050] Some embodiments are directed to computer program products comprising a computer-readable medium including code for causing a computer or multiple computers to perform various functions, steps, actions, and / or operations, such as one or more of the steps described above. According to embodiments, the computer program product may (and sometimes does) include different code for each step to be executed. Therefore, the computer program product may (and sometimes does) include code for each individual step of a method (e.g., a method for operating a communication device such as a wireless terminal or node). The code may be in the form of machine-executable instructions stored on a computer-readable medium such as RAM (random access memory), ROM (read-only memory), or other types of storage devices. In addition to embodiments directed to computer program products, some embodiments are directed to processors configured to implement one or more of the various functions, steps, actions, and / or operations of one or more of the methods described above. Thus, some embodiments are directed to processors (e.g., CPUs) configured to implement some or all of the steps of the methods described herein. The processor may be used, for example, in a communication device or other devices described in this application.

[0051] In view of the above description, many additional variations of the methods and apparatus of the various embodiments described above will be apparent to those skilled in the art. These variations are considered to be within the scope.

Claims

1. A therapeutic laser delivery system for ophthalmic use, comprising: A scanning laser ophthalmoscope SLO system, configured to generate SLO light for SLO imaging; Optical coherence tomography (OCT) system, configured to generate OCT light for OCT imaging; A therapeutic laser configured to generate a therapeutic laser to pass through a therapeutic laser delivery optical path for delivering at least a portion of the therapeutic laser to an ophthalmic target; A spatial light modulator (SLM) device is arranged in the therapeutic laser delivery optical path to modulate the therapeutic laser, wherein the SLM device is configured to split the therapeutic laser into multiple therapeutic laser beams to simultaneously deliver the multiple therapeutic laser beams to multiple target locations. as well as At least one processor is configured to determine the plurality of target locations and control the spatial light modulator (SLM) device to modulate the therapeutic laser for treating a floater in vitreous fluid of the ophthalmic target. The spatial light modulator (SLM) device is configured to control one or more characteristics of the therapeutic laser, including one or more of the following: shape, phase, polarization, wavefront tilt, diffraction, wavefront helicity, and orbital angular momentum order.

2. The system according to claim 1, further comprising: A targeted laser is configured to generate a targeted laser beam through a targeted laser delivery optical path for delivering the targeted laser beam to the ophthalmic target, wherein the spatial light modulator (SLM) device is further arranged to modulate the targeted laser beam and split the targeted laser beam into multiple targeted laser beams to simultaneously deliver the multiple targeted laser beams to multiple target locations.

3. The system according to claim 2, wherein, The laser delivery optical path includes an alignment optical path, which is used to align the target laser and input it into the therapeutic laser delivery optical path.

4. The system according to claim 2 or 3, further comprising: An imaging system that captures images of the ophthalmic target.

5. The system according to claim 4, wherein, The image captured by the imaging system captures the plurality of targeted laser beams delivered by the spatial light modulator (SLM) device.

6. The system according to claim 5, wherein, The captured images are processed to compare the plurality of targeted laser beams delivered by the spatial light modulator (SLM) device with the target location.

7. The system according to claim 6, wherein, The comparison of the plurality of targeted laser beams captured in the image with the target location is used as feedback for controlling the spatial light modulator (SLM) device.

8. The system according to claim 4, further comprising: Fundus camera system.

9. The system according to claim 4, wherein, The imaging system includes a tracking system for tracking eye movement.

10. The system according to any one of claims 1 to 3, wherein, The identified multiple target locations include multiple simultaneous treatment locations for the therapeutic laser.

11. The system according to claim 10, wherein, The spatial light modulator (SLM) device is controlled to simultaneously deliver a portion of the therapeutic laser to each of the plurality of simultaneous treatment locations.

12. The system according to claim 11, wherein, The portion of the therapeutic laser delivered to each of the simultaneous treatment locations has a corresponding power.

13. The system according to claim 12, wherein, The power of the portion of the therapeutic laser delivered to at least one of the simultaneous treatment positions is different from the power of the portion at at least another of the simultaneous treatment positions.

14. The system according to any one of claims 1 to 3, wherein, The at least one processor is further configured to control the spatial light modulator (SLM) device to pulse-shape the therapeutic laser.

15. The system according to any one of claims 1 to 3, wherein, The spatial light modulator (SLM) device includes one or more of the following: LCD-based SLM devices; SLM equipment based on microelectromechanical micromirrors; SLM device based on membrane mirror; Active element surface; and Passive element surface.

16. The system according to any one of claims 1 to 3, wherein, The target location of the ophthalmic target is located in one or more of the following: The sclera of the ophthalmic target; The iris of the ophthalmic target; The pupil of the ophthalmic target; The cornea of ​​the ophthalmic target; The retina of the ophthalmic target; as well as The vitreous fluid of the ophthalmic target.

17. The system according to any one of claims 1 to 3, wherein, The delivery / focusing of the therapeutic laser at the target location is used to treat one or more of the following: Diabetic retinopathy; Age-related macular degeneration; Vitreous macular traction; Tearing; Retinal detachment; Cracks; glaucoma; Venous occlusion; Choroidal detachment; Diabetic macular edema; Posterior vitreous detachment; cataract; floating body; and Dry eyes.

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