Thawing device for thawing a substrate and method for thawing a substrate

Abstract

This invention relates to a thawing apparatus and a method for thawing a substrate (1) in a frozen aggregated state. The thawing apparatus includes: a. a receiving unit (3) for arranging the container (2) containing the substrate (1), the receiving unit (3) having a heating device for providing the thermal energy required to thaw the substrate (1); b. a first motion device (21) configured to transmit a first motion to the receiving unit (3) and the container (2) therein together with the substrate (1), wherein the first motion is a motion performed substantially in a plane, particularly a linear motion; c. a second motion device (22) configured to transmit a second motion to the receiving unit (3) and the container (2) therein together with the substrate (1), wherein the second motion is a full-speed motion. The method for thawing the substrate (1) is contained in the container (2). The thawing apparatus proposed in this invention can shorten the thawing time while providing a gentle thawing process.

Description

Technical Field

[0001] This invention relates to a thawing device for thawing a substrate in a frozen aggregate state, particularly plasma, wherein the substrate is contained in a container, particularly a bag. The thawing device includes a receiving unit for arranging the container containing the substrate, the receiving unit having a heating device for providing the thermal energy required to thaw the substrate. Furthermore, the thawing device includes a first movement device configured to transmit a first movement to the receiving unit and the container placed therein with the substrate, wherein the first movement is a substantially planar movement, particularly a linear movement.

[0002] Furthermore, the present invention relates to a method for thawing a frozen aggregated matrix (particularly plasma), wherein the matrix is ​​contained in a container, particularly a bag. Background Technology

[0003] Thawing devices for thawing medical substrates are well known in the prior art. For example, reference should first be made to publication DE 195 48 826 A1, which discloses a universal thawing device. The problems described therein can be—at least in part—transferred to the present invention, which is why the problems already described in DE 195 48 826 A1 will be mentioned below.

[0004] As mentioned earlier, in clinical practice, industrially supplied active pharmaceutical ingredients are typically diluted to patient-specific concentrations using carrier solutions at standard concentrations and volumes before administration. Because these individually prepared formulations are often used for long-term treatment, correspondingly large total volumes are used when preparing patient-specific active ingredient mixtures. Therefore, a portion of the total volume intended for individual administration must be filled into syringes or other containers and then frozen. Only in this way can the typically heat-labile active ingredient be preserved for the required extended period.

[0005] One problem with this established and widely used traditional preservation method is that each individual sample requires a relatively long thawing time. Furthermore, this is particularly inconvenient because the timing of the next batch of active ingredient administration cannot be accurately predicted. Although the administration protocol for the active ingredient volume is tailored to each patient, a blood sample is typically taken from the patient first so that the decision on whether to administer the active ingredient and, if so, the exact time when the next partial volume can be administered can only be made after blood analysis. Therefore, this process often leads to schedule shifts and ultimately results in the loss of previously thawed active ingredient.

[0006] This problem can be solved using the rapid defrosting device described above.

[0007] Similarly, a problem addressed in DE 195 48 826 A1 is that frozen liquids can be thawed using microwave thawing devices that heat the liquid via microwave radiation at frequencies of 2.425 to 2.475 GHz. However, a drawback of this approach is that, in most cases, due to radiation focusing, the frozen liquid is heated intensely in a specific area, resulting in uneven heating. Heating the frozen liquid only in a particular area can damage the liquid's components or active ingredients, thus predictably leading to chemical modification of these components or active ingredients. In addition to chemical modification of the (thawed) drug, depending on the matrix type, microwave radiation can also cause denaturation of vaccines, proteins, or serums in the injection solution.

[0008] Under warm tap water, the substrate in a container can become contaminated with microorganisms through openings, cracks, or other means of external thawing. Even heating with the user's hand cannot eliminate the possibility of such contamination. Furthermore, thawing in the user's hand takes a relatively long time. However, the ability to rapidly thaw and apply medical substrates is urgently needed and crucial, especially in routine hospital operations, emergency rooms, or in the event of an accident.

[0009] To avoid these problems, DE 195 48 826 A1 proposes using a shaking mechanism to additionally set the substrate for motion thawing during heating (via a heating element, not a microwave device). While this technique allows for a more gentler thawing process on the substrate than microwave-based thawing and is faster than the manual thawing process described above, the thawing time is insufficient for certain medical substrates or applications. A common example of this is medical substrates (i.e., plasma) stored in a cryo-aggregate state and requiring rapid thawing. Plasma is typically stored (preserved) at -30 to -40°C but can only be administered in a liquid aggregate state (i.e., after thawing).

[0010] In large, complex surgeries, especially in emergency situations, plasma must be rapidly available and applied to address significant blood loss in patients (e.g., accidental injuries). Such high blood loss can also occur during transplantation, necessitating rapid plasma access.

[0011] Because the approximately 30-minute thawing time can be achieved using conventional equipment and methods (as known, for example, from DE 195 48826 A1), plasma is typically thawed to provide a "storage" for upcoming surgeries, so that it can be readily available when needed. Unused plasma is disposed of post-operatively, which has a certain adverse effect on the already scarce plasma reserves.

[0012] Therefore, providing shorter thawing times for frozen plasma is crucial for ensuring effective and life-saving patient care. At the same time, ensuring the plasma is properly thawed is also essential. Summary of the Invention

[0013] Therefore, the objective of this invention is to provide a thawing device and a method for thawing a matrix, particularly plasma in a frozen aggregated state, thereby achieving a shorter thawing time compared to the prior art, while simultaneously enabling a soothing thawing process.

[0014] The above problem is solved by the following thawing device and method.

[0015] A thawing device for thawing a frozen aggregated substrate (1), the substrate (1) being contained in a container (2), the thawing device comprising: a. A receiving unit (3) for arranging the container (2) containing the substrate (1), the receiving unit (3) having a heating device for providing the heat energy required to thaw the substrate (1); b. A first motion device (21) configured to transmit a first motion to the receiving unit (3) and the container (2) therein together with the substrate (1), wherein the first motion is a motion performed substantially on a plane; Its characteristics are c. A second motion device (22) configured to transmit a second motion to the receiving unit (3) and the container (2) therein together with the substrate (1), wherein the second motion is a full-speed motion, the second motion device (22) comprising at least one second motion unit (36) configured to apply a lifting motion to the receiving unit (3), wherein, when the lifting motion is applied, a portion of the receiving unit (3) deforms to a degree corresponding to the thawed portion of the substrate (1); characterized in that: The first motion device (21) includes a linear drive device (25) which is mechanically connected to at least one movable mounting guide device (27) via a mechanical coupling device (26), the at least one guide device (27) being mechanically connected to the receiving unit (3) for transmitting the first motion; The mechanical coupling device (26) is a universal spring joint disposed between the linear drive device (25) and the at least one guide device (27), and connected to the linear drive device (25) and the at least one guide device (27) or to a component operatively connected thereto by a connecting device (28).

[0016] A thawing device for thawing a frozen aggregated matrix (1), the matrix (1) being contained in a container (2), the thawing device comprising: a. A receiving unit (3) for arranging the container (2) containing the substrate (1), the receiving unit (3) having a heating device for providing the heat energy required to thaw the substrate (1); b. A first motion device (21) configured to transmit a first motion to the receiving unit (3) and the container (2) placed therein together with the substrate (1), wherein the first motion is a motion performed substantially in a plane, particularly a linear motion; Its characteristics are A further motion device (80) is configured to transmit further motion to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the further motion operating in a direction different from the first motion, particularly perpendicular to the plane in which the first motion is performed; characterized in that: The first motion device (21) includes a linear drive device (25) which is mechanically connected to at least one movable mounting guide device (27) via a mechanical coupling device (26), the at least one guide device (27) being mechanically connected to the receiving unit (3) for transmitting the first motion; The mechanical coupling device (26) is a universal spring joint disposed between the linear drive device (25) and the at least one guide device (27), and connected to the linear drive device (25) and the at least one guide device (27) or to a component operatively connected thereto by a connecting device (28).

[0017] It should be noted that the features listed individually in this invention can be combined with each other in any technically useful manner and illustrate further embodiments of the invention. This description further characterizes and specifies the invention, particularly in relation to the accompanying drawings. Furthermore, the features described in connection with the defrosting apparatus of the invention may be advantageous embodiments of the method of the invention, and vice versa.

[0018] It should also be noted that the conjunction “and / or” used herein to indicate the relationship between and connect two features should always be interpreted as meaning that, in the first embodiment of the subject matter of the invention, only the first feature may exist, in the second embodiment, only the second feature may exist, and in the third embodiment, both the first and second features may exist.

[0019] As previously stated, the present invention primarily relates to a thawing device for thawing a matrix, particularly plasma in a frozen aggregated state, said matrix being contained in a container, particularly a bag, the thawing device comprising: A receiving unit is used to arrange a container containing the substrate, the receiving unit including a heating device for providing the heat energy required to thaw the substrate; b. A first motion device configured to transmit a first motion to a receiving unit and a container disposed therein together with a substrate, wherein the first motion is a motion performed substantially in a plane, particularly a linear motion.

[0020] According to the present invention, the defrosting device is characterized by c, namely, a second movement device, which is configured to transmit a second movement to the receiving unit and the container placed therein together with the substrate, wherein the second movement is a full-speed movement. The first and second movement devices are assembled on one or more stable (position-fixed) substrates.

[0021] This thawing device can be configured to simultaneously thaw multiple matrices, particularly plasma, contained in various containers. For simplicity, the following notes refer to a description of the design features required for thawing matrices contained in a single bag. In a thawing device, these features can easily be found in multiple devices; that is, the thawing device can include multiple thawing units, each capable of thawing the matrices in a single container. Therefore, the following explanation refers to a single thawing unit.

[0022] For the purposes of this invention, "matrix" can be specifically understood as referring to a medical matrix. A "medical" matrix is ​​primarily used in the medical field, for example, for intravenous injection or injection therapy in patients. In order to use a medical matrix (e.g., to administer medication to a patient), it must be in liquid form. In a proper (chemical) sense, it is not necessarily a (pure) liquid composed of a single chemical compound. For example, a matrix can be a homogeneous or non-homogeneous mixture of various substances. An example of a homogeneous mixture of substances is a solution. Non-homogeneous mixtures can be emulsions, suspensions, or foams. Furthermore, fine particles (such as nanoparticles, proteins, etc.) can be distributed in solid form within a liquid or a mixture of several liquids. In this case, "liquid" can also be understood as a paste-like or viscous substance, for example, with significantly reduced fluidity compared to water. As previously mentioned, the matrix is ​​in a frozen-focused state prior to the thawing process. To complete the thawing process in the inventive thawing device, the matrix can be completely or partially frozen. For example, it is conceivable that the matrix undergoes a pre-thawing process, such as thawing at room temperature, before actual thawing in the thawing device, so that the matrix is ​​already partially thawed before actual thawing in the thawing device. In particular, a “matrix” can be understood to refer to a blood preparation, such as plasma.

[0023] Nevertheless, a “matrix” can also be some other kind of matrix, such as food, feed, chemicals, medical analytes, or something similar.

[0024] The matrix is ​​placed or stored in a container. The container can be sealed, even vacuum-sealed. In addition to the matrix, an inert gas (e.g., N2) may be present in the container. The container may have an opening device that allows it to be opened once or several times before being closed again. The container can be, in particular, a bag, preferably a medical bag. These are typically disposable medical plastic bags.

[0025] The unique advantages of the thawing device of the present invention will be described below using the thawing process of plasma as the thawing matrix as an example. In known thawing devices (without microwave heating), for example, in the device described in DE 195 48 826 A1, the uppermost layer of frozen plasma is initially heated relatively quickly during thawing. This forms a thin liquid film on the plasma surface and remains in this liquefied state. As a result, the initial temperature difference between the liquid film and the heating element is greatly reduced. Therefore, starting from the heating element, the heat can only be insufficiently tracked in the direction of the inner (still frozen) plasma, thus also providing sufficient heat to the inner plasma layer and causing it to thaw rapidly. This is because, through the temperature sensor present in the thawing device and associated with the heating control system, essentially only the temperature of the outer (already melted) liquid film is detected. However, since the heating is controlled based on the measured temperature difference between the molten plasma (measured by the temperature sensor) and the heating element, the temperature difference between the plasma interior and the heating element is not considered. Therefore, the heat provided to the system is too little, making it impossible for the plasma to thaw sufficiently quickly.

[0026] On the other hand, when thawing plasma (or other matrices) using the thawing device of the present invention, the motion applied to the plasma (the first motion and the second or further motion applied by the first and second or further motion devices, respectively) ensures that the liquefied (thawed) plasma continues to cool and stabilize at a temperature of 0°C to 5°C. These motions continue until all the plasma is liquefied (thawed). A particular advantage of this method is the generation of a (significantly larger) temperature difference between the plasma and the heating element of the thawing device. Therefore, heat transfer can be replenished more effectively into the matrix (e.g., plasma) and distributed more uniformly relative to the total volume of matrix contained in the container. This further reduces the thawing time compared to thawing devices known in the prior art. A thawing time of 5-8 minutes can be achieved using the thawing device of the present invention relative to 300 ml of plasma as the matrix (placed in a plasma bag used as a container), but more particularly, the thawing time is 6-8 minutes.

[0027] The aforementioned receiving unit is designed for temporarily arranging and / or securing a container (together with the substrate contained therein). The receiving unit can partially or completely enclose the container depending on the usage conditions. The receiving unit can be formed as one or more parts. As described above, the receiving unit includes a heating device for providing the thermal energy required to thaw the substrate. In particular, this heating device is for emitting thermal radiation, but preferably not microwave radiation. Advantageously, the heating device can be designed or arranged to uniformly surround the container placed within the receiving unit. Uniform heat transfer helps ensure a gentle yet rapid thawing process. The heating device is connected to a control and regulation device. Furthermore, at least one temperature sensor, preferably several temperature sensors, is associated with the control and regulation device, through which the temperature of the substrate to be thawed (at least the temperature in the surface area) can be detected. Based on the measured temperature, the heat source can be adjusted. Control and regulation can be automated.

[0028] A collection tray can be provided below the receiving unit to collect moisture, spilled substrate, etc. This prevents impurities or moisture from accumulating in the defrosting unit. The collection tray can be removed from the defrosting device for emptying.

[0029] The first motion transmitted from the first motion device to the receiving unit and the container and substrate placed therein is preferably a rocking motion, i.e., a reciprocating motion on a plane. The rocking motion occurs at a frequency of about 20 Hz and preferably includes a motion of about 10 mm. The rocking motion can be a linear motion or a motion guided within a circle. It is also conceivable to perform more complex motion sequences (motion patterns) on the plane. The plane can be a horizontal plane or a plane arranged elsewhere in space (e.g., inclined). As mentioned above, the motion is "substantially" performed on a plane. This means that the main direction of the motion is within a plane, but there are still slight deviations. For example, such deviations may be caused by factors such as imbalance, weight distribution, etc.

[0030] As previously described, the second motion applied by the second motion device to the receiving unit and the container and substrate placed therein is a full-speed motion. During this "full-speed motion" (also referred to as "full speed"), the container and the substrate placed therein will at least partially deform. The "full-speed" process can also be understood as kneading or pressing. According to the invention, the first and second motions (full-speed motion) are applied in parallel and transferred to the receiving unit and the container and substrate placed therein. This allows for better mixing of the substrate during thawing and more uniform heat transfer to the substrate, which is a decisive factor in reducing thawing time.

[0031] Further advantageous embodiments of the thawing apparatus of the present invention arise from the features described below. It should be emphasized that the features described below are undoubtedly also advantageous design features of the method of the present invention. To avoid repetition, the features are described below only in relation to the thawing apparatus of the present invention.

[0032] According to a first advantageous embodiment of the invention, in the defrosting apparatus of the invention, the receiving unit can be formed in the shape of a shell, wherein the shell comprises a first half-shell and a second half-shell, wherein the first half-shell is the lower half-shell and the second half-shell is the upper half-shell, and wherein the first half-shell and the second half-shell are detachably connected to each other. The advantage of this shell shape is that it reliably secures the container within the receiving unit without the risk of the container shifting out of the receiving unit during motion transmission. The shape of the receiving unit is not limited to a shell shape. These half-shells may have at least partially different plasticity and / or deformability. "Deformability" specifically refers to reversible (elastic) deformability. Therefore, it is advantageous if the lower half-shell has at least partially greater plasticity and / or deformability than the upper half-shell. This is because the full-speed motion applied to the receiving unit, i.e., the shell, is primarily applied to the lower half-shell. This deformability (the flexibility of the material) is necessary to allow for flexible changes in the shape of the container during full-speed motion. This is because the shape of the container permanently changes during the defrosting process.

[0033] According to another advantageous embodiment of the invention, the defrosting apparatus of the invention can provide first and second half-shells adapted to the shape of a container, wherein the first and second half-shells at least partially surround the container when the container is arranged inside the shell. The shapes of the first and second half-shells match the shape of the container, ensuring a reliable fit of the container in the receiving unit. The shape, size, and material structure of the first and second half-shells can be configured to compensate for the expansion of the container during matrix defrosting. Preferably, the expansion of the first and second half-shells corresponds to the volume expansion of the matrix, if any. Alternatively, the receiving volume of the receiving unit can be provided to be slightly larger than the volume of the container so that the container can be placed in the receiving unit with a certain gap. For example, the half-shell can have a rectangular half-shell base, wherein the shell shape has sidewall portions adjacent to the side portions of the half-shell base and extending along the longitudinal half-shell axis. Preferably, the sidewall portions of these lower half-shells are formed to be flexible, while the sidewall portions of the upper half-shell are formed to be dimensionally stable, i.e., rigid.

[0034] According to another advantageous embodiment of the invention, a fixing device can be provided in the thawing apparatus of the invention, disposed on the first and second half-shells, thereby securing the container. For example, the fixing device can be implemented in the form of tabs or fixing clips formed or arranged on the respective half-shells, which mate with their corresponding fixing devices and are arranged or formed on their respective opposing half-shells. The fixing device mates with the tabs or fixing clips can be a fastening opening, a Velcro fastener, a clamping member, etc. Alternatively, securing can also be achieved by snap-fit.

[0035] According to another advantageous embodiment of the invention, in the defrosting device of the invention, the first and second half-shells each have a multi-layered structure, and in each case, a heating element is provided in one layer of the layered structure of the respective half-shell. The heating element of the respective half-shell provides a heating device. The heating element can be signal-connected to the aforementioned control and adjustment device. Furthermore, the heating element has a power supply line. The heating element can extend along the half-shell (particularly on the surface of the half-shell base) in a meandering or spiral manner, for example, wherein the heating element can be formed of stainless steel. Preferably, the thickness of the heating element is 50µm. Using a stainless steel heating element allows for an increase in the width and maximum heating capacity compared to conventional copper elements. The individual heating elements can also be in the form of heating foil.

[0036] The multi-layered structure of the semi-shell preferably comprises the following: Facing the container arranged in the receiving unit, the semi-shell has an outer shell or support layer for supporting the container. This is preferably made of stainless steel and has a thickness of 100µm to 150µm. Next is an electrically insulating layer, preferably 50µm thick, which, for example, can be made of a polyimide film. Following the insulating layer is a layer comprising heating elements, such that this layer has a thickness of 50µm. The layer comprising heating elements can be in the form of stainless steel foil, but can also be made of an electrically insulating material in which one or more stainless steel heating elements are integrated. Next is a support layer or insulating layer, which is preferably formed of glass fiber reinforced plastic and has a thickness of 0.3 mm. Next is a mounting bracket for the heating shell, which can be made of aluminum and has a thickness of 0.5 to 1.0 mm.

[0037] According to another advantageous embodiment of the invention, the defrosting apparatus of the invention may include a first motion device comprising a linear drive mechanism mechanically connected via a mechanical coupling to at least one movable guide mechanism mechanically connected to a receiving unit to transmit the first motion. The mechanical coupling mechanism may be of any type, provided it is suitable for transmitting the first motion generated by the linear drive to the receiving unit. It can also be conceivable to be an electrically driven coupling. "Mechanical active connection" can be understood as any form of connection through which motion transmission between two components is realized or regulated. The mechanical active connection may be provided by a direct mechanical connection between the two components or by connecting one or more intermediate components arranged between the two components to form a motion transmission mode. The linear drive mechanism generates a translational motion that is transmitted to the receiving unit. In this case, the motion may be a linear motion or another motion with a predetermined path. The linear drive may be a threaded rod drive (ball screw drive), a roller screw drive, a hydraulic drive, a pneumatic drive, or an electromechanical linear drive (e.g., a linear motor).

[0038] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, the provided mechanical connection device is a cross-spring joint, which is arranged between the linear drive and at least one guide device, and connected to the linear drive and at least one guide device, or operatively connected thereto via a connecting device, such as a stainless steel strip. Instead of a stainless steel strip, the connecting device can also be another force transmission device, such as a tension belt, chain, spring, etc. The cross-spring joint is characterized by the absence of friction, lubrication, and maintenance.

[0039] According to another advantageous embodiment of the invention, in the defrosting device according to the invention, a linear drive connection can be provided to a mechanical or electric spring system configured to adjust the operating characteristics and efficiency of the linear drive. The aforementioned mechanical connection between the linear drive and the at least one guiding device (using a mechanical coupling device) provides a mechanical oscillating circuit. This is supported by the aforementioned mechanical or electric spring system, which in particular can improve the efficiency and smooth operation of the oscillating circuit. The mechanical spring system may include an adjustable leaf spring. The electric spring system may include a transformer with a movable yoke, preferably coupled in conjunction with the linear drive designed as a reluctance motor.

[0040] According to another advantageous embodiment of the invention, in the defrosting apparatus according to the invention, the provided linear drive is an electromechanical linear drive with at least one stator assembly and one rotor assembly, the rotor assembly being connected to a mechanical coupling via a connecting device, particularly a stainless steel strip. The electromechanical linear drive is preferably a linear motor capable of generating translatory feed movement. A linear motor is a linear design of a rotating machine, which can be imagined as a rotating electric motor unwound and cut towards the center. It consists of a current-carrying primary section (similar to the stator of a rotating electric machine, referred to herein as the stator assembly) and a reaction or secondary section (similar to the rotor of a rotating electric machine, referred to herein as the rotor assembly). The linear motor can be a synchronous linear motor, an asynchronous linear motor, a stepper linear motor, or a DC linear motor. Although the stator arrangement in an asynchronous design is equipped with shorting bars, it consists of permanent magnets as in a synchronous motor. The linear drive can also be a reluctance motor, which includes a stator assembly and a rotor assembly.

[0041] According to another advantageous embodiment of the invention, in the defrosting apparatus according to the invention, at least one guide device and a rotor device are each movably mounted on a guide rod, which is preferably arranged on a common surface. Preferably, the bearings of the at least one guide rod device and the rotor devices on the respective guide rods are sliding bearings. The movement of the rotor devices and at least one guide device is preferably counter-rotating. Furthermore, it must be ensured that the rotor devices and guide devices (together with the components connected thereto) have approximately the same weight, because otherwise undesirable imbalances may occur in the sequence of movements. The aforementioned counter-rotating movement requires a pivot point, which is provided here by a coupling device, particularly a universal joint. Cross spring joints are frictionally connected to the rotor devices and at least one guide device or component, all of which are operatively connected by a connecting device (e.g., a stainless steel band). In a preferred embodiment, the guide rods can run horizontally and be aligned with each other. Instead of the individual guide rods guiding the rotor devices and at least one guide device, a common guide rod can also be provided to guide the rotor devices and at least one guide device.

[0042] According to another advantageous embodiment of the invention, the thawing apparatus according to the invention provides a second motion device comprising at least one second motion unit configured to apply a lifting motion to the receiving unit, particularly the lower half-shell, wherein, when the lifting motion is applied, a portion of the receiving unit, particularly the lower half-shell, deforms to a degree corresponding to the thawing portion of the matrix. This is because the matrix can only deform in a at least partially thawed state. The greater the proportion of thawed matrix, the greater the lifting motion that can be transmitted to the matrix. When the lifting motion is applied to the lower half-shell, it is lifted to the degree to which the matrix has liquefied during the thawing process. Physically, frozen plasma (as an example of a thawable matrix in the thawing apparatus of the invention) is in a crystalline state. As the plasma gradually heats up during the thawing process, initially at the surface, the plasma gradually becomes amorphous near the surface. As a result, the deformability of the plasma increases. The second motion device may include multiple second motion units that apply lifting motion to the receiving unit, particularly the lower half-shell, at different spatial positions, thereby generating a full-speed motion from multiple lifting motions. The lifting motion applied to the lower half-shell by the second motion units at various different positions can be performed simultaneously or continuously at all positions. Additionally, lifting movements can be performed simultaneously at a predetermined number of locations. Preferably, the lifting movements are performed in a manner that continuously changes the position of the lower shell (and container). The second movement unit can be controlled by control electronics (e.g., a microcontroller) in a predetermined scheme so that the second movement unit can perform lifting movements in a desired sequence in the direction of the receiving unit and the container and matrix placed therein. Stroke movements apply pressure to the plasma at continuously changing positions, causing the amorphous portion of the plasma to liquefy or further thaw faster than if no full-speed movement were applied.

[0043] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, a force-transmitting member can be provided, disposed between a receiving unit, particularly the lower half-shell, and at least one second motion unit. The force-transmitting member is connected to the receiving unit, particularly the lower half-shell, and at least one second motion unit to transmit lifting motion to the receiving unit, particularly the lower half-shell. If several second motion units are provided, it is advantageous to provide force-transmitting members corresponding to the number of second motion units, and in each case, arrange these members between the receiving unit and each of the second motion units, connecting them to the two components. The force-transmitting member can be connected to a component belonging to each of the second motion units, such as the housing.

[0044] In another embodiment, the force transmission member can also be used to transmit a first motion in addition to the lifting motion. This is because the first motion (rocking motion) is transmitted to the container (including the substrate) arranged within the receiving unit via a mechanical connection / link between the guide device and the receiving unit. If the guide device is connected to the force transmission member, the first motion (rocking motion) can also be transmitted to the receiving unit via the force transmission member. In this case, a force transmission member can therefore be provided for transmitting both the first and second motions. Furthermore, in another alternative embodiment, several guide devices can be provided, movably mounted on a common guide rod or on individual (particularly parallel) guide rods. For synchronous motion transmission starting from the linear drive, the guide devices can be mechanically connected to each other. Additionally, the linear drive can also be mechanically connected to its respective movably mounted guide devices via multiple mechanical couplings. The mechanical couplings can all be universal joints, arranged between the linear drive and the guide devices, and can all be operatively connected to the linear drive and the respective guide devices or components via connecting devices. If multiple guide devices are provided, each guide device can be connected to the force transmission member.

[0045] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, the provided force transmission component includes a ball bearing, and the force transmission component is connected to the receiving unit, particularly the lower shell, via a welded joint. The ball bearing (particularly via a ball joint) is advantageous because the triangular conditions (due to the matrix always changing shape during defrosting) always change with the transmission of force. With the ball bearing, the force transmission path can adapt to changes in the shape of the matrix contained in the container. Alternatively, another type of fastener, such as a temperature-stable adhesive connection or a mechanical connection (e.g., a riveted connection), can also be considered instead of a welded connection.

[0046] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, at least one second motion unit is provided, which includes at least one lifting magnet configured to transmit stroke action (particularly lifting stroke) to a force transmission member and a container disposed therein, together with the substrate therein, by performing a lifting motion. If the second motion device includes multiple second motion units, each second motion unit may include a lifting magnet. When a lifting motion is performed, the stroke may first be transmitted from the lifting magnet to a linkage associated with each second motion unit. This linkage may be connected to a movably mounted bracket, which is connected to the force transmission member. The bracket is movably mounted and also tracks the first motion (rocking motion) triggered by a linear drive. The movable mounting of the bracket serves to decouple the second motion unit (for generating full-speed motion) from the first motion or associated oscillation. Therefore, the second motion unit preferably does not track the first motion. The bracket is movably mounted on a guide rod, which is mounted in a housing associated with the respective second motion unit.

[0047] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, at least one second motion unit includes at least one mechanical lifting device configured to transmit the stroke (particularly the lifting stroke) to a force transmission pin by performing a lifting motion, the force transmission pin being movably arranged transversely to (particularly perpendicular to) the stroke axis.

[0048] The force transmission pin can move laterally (particularly perpendicularly) to the stroke axis between first and second positions. In its second position, it is used to transmit the lifting motion performed by at least one mechanical lifting device to the force transmission member, the receiving unit connected to the force transmission member, and the container disposed within the receiving unit along with the substrate therein. Specifically, the force transmission pin in its second position can be configured to transmit the lifting motion performed by at least one mechanical lifting device to a component directly or indirectly connected to the force transmission member. In particular, the force transmission pin in its second position transmits the lifting motion to a housing portion in which a bracket connected to the force transmission member is movably mounted. The bracket is movably mounted on a guide rod disposed within the housing portion. The function of the movable mounting of the bracket, in this embodiment, is to separate the second motion unit (for generating full-speed motion) from the first motion.

[0049] In the first position of the force transmission pin, no stroke motion is transmitted along the direction of the force transmission member. The force transmission pin can be controlled by a control unit and moved back and forth transversely (particularly perpendicular to) the stroke axis by a motion mechanism. The force transmission pin can be movably guided in a guide device (e.g., a guide groove). This implementation requires less power than the embodiment based on a lifting magnet. According to this implementation, the stroke motion is generated by a geared motor, driving the camshaft at approximately 60 revolutions per minute. The motion is first transmitted to a plunger connected to the camshaft and arranged along the stroke axis for linear motion, whereby the plunger can engage the (lower) end of the power transmission pin in the second position and transmit the stroke motion to it.

[0050] A further motion device may be provided. This further motion device may be configured to transmit further motion to the receiving unit and the container and substrate placed therein. Preferably, the further motion travels in a direction different from the first motion. Preferably, the further motion is perpendicular to the plane in which the first motion of the first motion device is executed.

[0051] If the first motion is linear, then the subsequent motion is preferably perpendicular to that linear motion. The subsequent motion can be perpendicular.

[0052] The further motion may be a full-speed motion. The further motion device may be included within or form the second motion device.

[0053] In another advantageous embodiment of the invention, the further movement is not a full-speed movement.

[0054] The receiving unit, particularly the lower half-shell, can be flexible or deformable. Alternatively, the container unit or one or two half-shells, particularly the lower half-shell, can be dimensionally stable, i.e., rigid.

[0055] For example, one or both of the receiving unit or half-shell form are dimensionally stable and / or the force transmission members have planar force transmission regions, and in such embodiments, further movement is preferably not full-speed movement.

[0056] In addition to the second motion device, further motion devices may be provided.

[0057] The further motion device can be configured to directly transmit the further motion to the receiving unit. Alternatively, the further motion device can be configured to indirectly transmit the further motion to the receiving unit, particularly via a second motion device.

[0058] As previously stated, the present invention also relates to a thawing apparatus for a thawing matrix, particularly plasma in a frozen aggregated state, said matrix being contained in a container, particularly a bag, the thawing apparatus comprising: a. A receiving unit for arranging a container containing a substrate, the receiving unit including a heating device for providing the heat energy required to thaw the substrate; b. A first motion device configured to transmit a first motion to a receiving unit and a container therein containing a substrate, wherein the first motion is a motion performed substantially in a plane, particularly a linear motion.

[0059] According to the invention, the defrosting device is characterized by a further motion device configured to deliver further motion to the receiving unit and the container therein together with the substrate, the further motion running in a direction different from the first motion, in particular perpendicular to the plane in which the first motion takes place.

[0060] A further motion device can be provided to replace the second motion device. This simplifies the defrosting device. The further motion device can be simpler than the second motion device.

[0061] Further movement can also be a linear motion.

[0062] This further motion device enables rapid distribution of heated molecules in the matrix. This is achieved through a rapid and concentrated energy input, achievable via the further motion device. This faster molecular distribution simultaneously allows for rapid cooling of the molecules heated by the heat input. This, in turn, makes the thawing process extremely rapid, thus significantly reducing thawing time.

[0063] The further motion, conveyed by the further motion device to the receiving unit and the container placed therein along with the substrate, is preferably a further rocking motion, i.e., a back-and-forth motion performed on a plane. The first motion and / or the further motion can be performed at a frequency between 0.5 and 50 Hz. The first motion and / or the further motion can be performed at a frequency between 5 and 50 Hz, preferably including a motion of 1 to 20 mm or 5 to 15 mm. The further rocking motion is preferably performed at a frequency of about 20 Hz, preferably including a motion of about 10 mm. The further motion can be a linear motion or a motion guided within a circle. It is also conceivable to perform more complex motion sequences (motion patterns) on a plane. The plane can be a vertical plane or a plane arranged elsewhere in space (e.g., inclined).

[0064] Preferably, the defrosting device thus transmits two preferably superimposed shaking motions in different directions to the receiving unit and the container and substrate therein, preferably to the entire container and substrate. XY motion of the receiving unit and container can be achieved, preferably XY motion of the entire container.

[0065] A tuning device can be provided, configured to tune the frequency and / or phase position of the further motion to the frequency and / or phase position of the first motion. This allows for optimization of the superposition of the first motion and the further motion.

[0066] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, the further motion device includes at least one motion unit. The further motion device may include multiple motion units. The further motion device may include two motion units.

[0067] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, at least one motion unit of the further motion device includes a linear drive device that can be mechanically connected to the receiving unit to transmit further motion. Preferably, the linear drive device generates a translational motion that can be transmitted to the receiving unit. In this case, the motion can be a linear motion or another motion having a predetermined path. The linear drive device can be a threaded rod drive (ball screw drive), roller screw drive, hydraulic drive, pneumatic drive, or electromechanical linear drive (e.g., a linear motor).

[0068] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, the linear drive of the further motion device is an electromechanical linear drive with at least one stator and one rotor, the rotor being operatively connected to the receiving unit. The electromechanical linear drive is preferably a linear motor capable of generating translational feed motion. Preferably, the linear motor is largely based on the Lorentz force. As previously described, a linear motor is a linear version of a rotating machine; it can be conceived as a rotating motor unwound and cut towards the center. It consists of a current-carrying primary section (corresponding to the stator of a rotating motor, referred to herein as the stator assembly) and a reactive or secondary section (corresponding to the rotor of a rotating motor, referred herein as the rotor assembly). The linear motor can be a synchronous linear motor, an asynchronous linear motor, a stepper linear motor, or a DC linear motor. Although the stator assembly in an asynchronous design is equipped with a shorting bar, it consists of permanent magnets as in a synchronous motor. Furthermore, the linear drive of the further motion device can be a reluctance motor, which includes a stator assembly and a rotor assembly. In this way, cost savings can be achieved compared to a linear motor that is essentially based on the Lorentz force. However, linear motors, which are essentially based on Lorentz force, can be controlled more precisely than reluctance motors, thus achieving higher peak values. The rotor mechanism of the linear drive for the further motion device preferably rotates in tandem with the further motion, rather than in opposite directions.

[0069] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, a force-transmitting member is disposed between the receiving unit, particularly the lower half-shell, and at least one moving unit of the further moving device. This force-transmitting member can be connected to the receiving unit, particularly the lower half-shell, and at least one moving unit of the further moving device to transmit further movement to the receiving unit, particularly the lower half-shell. If multiple moving units of the further moving device are provided, it is advantageous to provide force-transmitting members corresponding to the number of moving units, and in each case, these members are arranged between the receiving unit and each moving unit and connected to the two components. The force-transmitting member can be connected to a component belonging to each moving unit of the further moving device, such as the shell.

[0070] In addition to further motion, force transmission components can also be provided to transmit the initial motion.

[0071] According to another advantageous embodiment of the invention, in the defrosting apparatus of the invention, the force-transmitting member has a flat force-transmitting region for transmitting force to the receiving unit. Thus, deformation of the receiving unit, particularly the lower shell, can be avoided or reduced during force transmission.

[0072] Preferably, the linear drive of the further motion device is an electromechanical linear drive in the form of a linear motor, which is largely based on Lorentz force rather than, for example, a reluctance motor. Preferably, the linear actuator of the further motion device has a stator assembly including a stator and / or control windings and / or a base. Preferably, these stators are iron stators. Preferably, the stator and / or control windings are spaced apart from the housing (e.g., housing base) via the base.

[0073] Preferably, a recess in the stator assembly is exposed, preferably between the control winding and the stator. Preferably, the recess is surrounded by the control winding and the stator. Preferably, the linear actuator of the further motion device includes a rotor arrangement. Preferably, the rotor assembly includes at least one rotor. The rotor may include sheet metal or permanent magnets. The permanent magnet may be a neodymium permanent magnet (NdFeB permanent magnet). Preferably, the rotor assembly includes a force transmission member, which further preferably transmits force between the rotor and the receiving unit. Preferably, the force transmission member has a planar force transmission area that can be connected to the receiving unit, for example, in a force-locking and / or form-locking manner. The rotor may be connected to the force transmission member, for example, in a force-locking and / or form-locking manner. The force transmission member may also be referred to as a fastening component. Preferably, the force transmission member includes plastic, such as fiber-reinforced plastic, and / or metal, such as aluminum. The force transmission member may be plate-shaped, preferably with a thickened end including the force transmission area. The force transmission member may be arranged in a recess in the stator assembly, and it may move within the recess in the direction of the first movement and / or further movement. Preferably, current is applied to the control winding to cause the rotor and force transmission components to move back and forth in the direction of further motion, thereby preferably transmitting the further motion to the receiving unit.

[0074] In order to superimpose the first motion with the further motion, the linear drive device of the first motion device (e.g.) can be connected to the receiving unit through a force transmission member.

[0075] A guiding device may be provided for guiding the force-transmitting member in the slot, preferably along a first and / or further direction of movement. Preferably, the guiding device includes a guide frame that preferably moves along the first direction of movement. Preferably, the guide frame includes guide wheels. Preferably, the guide wheels mate with guide rails. The guide rails can be aligned along the first direction of movement. The guide rails can be mounted to a housing via a base, preferably a housing base. Preferably, the guiding device includes a connecting device between the guide frame and the force-transmitting member. This connecting device can be connected to the force-transmitting member and the guide frame. Preferably, the connecting device allows relative movement between the force-transmitting member and the guide frame along a further direction of movement and / or guides the force-transmitting member along the first and / or further direction of movement. The connecting device preferably includes a steel spring plate. The steel spring plate can have a planar design. The shape of the steel spring plate can be at least generally square. The steel spring plate is about 100 mm long, about 80 mm wide, and about 0.3 mm thick. The steel spring plate can be connected to the force-transmitting member with one edge and to the guide frame with the opposite edge. The guiding device for each force-transmitting component may include two connecting devices attached to the force-transmitting component, preferably on both sides of the force-transmitting component. In the case where two motion units of the further motion device are arranged adjacently and perpendicular to the first motion, the guiding device may also include only one connecting device for each force-transmitting component. The connecting devices may be arranged on both sides of the transmission element, back to back.

[0076] As described above, the aforementioned task is also accomplished by thawing a frozen, aggregated matrix, particularly plasma. In this case, the matrix is ​​contained in a container, particularly in a bag. This method is carried out using a thawing apparatus according to the invention and includes the following steps: a. Arrange containers containing the substrate in the receiving unit. b. Heating the matrix contained in the container using a heating device, wherein during the heating process... i. A first motion is transmitted by a first motion device to a receiving unit and a container placed therein together with the substrate, wherein the first motion is a motion that occurs substantially in a plane, particularly a linear motion, and ii. The second motion is transmitted by the second motion device to the receiving unit and the container placed therein together with the substrate, and the second motion is a full-speed motion.

[0077] This task is also addressed by thawing a frozen aggregated matrix, particularly plasma, placed in a container, particularly a bag, using the thawing apparatus of the present invention, comprising the following steps: a. Arrange a container containing the substrate in the receiving unit. b. Heating the matrix contained in the container using a heating device, wherein during the heating process... i. A first motion is transmitted by a first motion device to a receiving unit and a container placed therein together with the substrate, wherein the first motion is a motion that occurs substantially in a plane, particularly a linear motion, and ii. A further motion device is employed, wherein the further motion is transmitted to the receiving unit and the container therein together with the substrate, the further motion running in a direction different from the first motion, in particular running perpendicular to the plane in which the first motion is performed.

[0078] Further features and advantages of the present invention will become apparent from the following description of non-limiting embodiments of the invention, which will be described in more detail below with reference to the accompanying drawings. The drawings are as follows: Brief description of the attached figures Figure 1 is a schematic diagram of the thawing device and its main components of the present invention; Figure 2 is a schematic diagram of the defrosting device of the present invention, shown in a longitudinal section. The figure specifically shows the components related to the first motion device. Figure 3. Perspective view of the receiving unit and container related to the defrosting device of the present invention; Figure 4 shows the layered structure of the half-shell related to the receiving unit in Figure 3; Figure 5 is a schematic diagram of the second motion unit related to the second motion device, showing the first embodiment; Figure 6 is a schematic diagram of the second motion unit related to the second motion device, showing the second embodiment; Figure 7 shows a possible spatial arrangement of multiple second motion units according to Figure 5; Figure 8 is a schematic diagram of the possible spatial arrangement of multiple second motion units according to Figure 6; Figure 9. Schematic diagram of the electromechanical linear actuator and electric spring system; Figure 10 is a schematic diagram of the design of a reluctance motor as a linear drive device, including an electric spring system; Figure 11 is a partially exploded perspective view of a further embodiment; Figure 12 is a side view of the embodiment shown in Figure 11 in the direction of arrow 120. Detailed Implementation

[0079] Figure 1 is a schematic diagram of the thawing device structure of the present invention, which is used to thaw a matrix 1 in a frozen aggregated state. In particular, the matrix 1 can be plasma. The frozen matrix 1 is contained in a container 2, particularly a bag.

[0080] The thawing device has a housing 4 that can be opened via an opening flap 5. The opening flap 5 is hinged to or pivotally mounted on the housing 4 via a hinge 6. Inside the housing 5, a receiving unit 3 is provided, into which a container 2 (together with the substrate 1) can be placed or inserted. In the following description, it is assumed that the container 2 is a flexible plasma bag. The receiving unit 3 includes a heating device (not shown in Figure 1) for providing the heat required to thaw the substrate. The receiving unit 3 is tray-shaped, comprising a first half-shell 8 and a second half-shell 9, the first half-shell 8 being the lower half-shell and the second half-shell 9 being the upper half-shell. The half-shells 8 and 9 are detachably connected to each other. The first half-shell 8 and the second half-shell 9 are adapted to the shape of the container 2, wherein, when the container is placed inside the housing, the first and second half-shells 8 and 9 at least partially surround the container 2 (see Figure 1). As shown in detail in Figure 3, a clamp-shaped fixing device 10 is arranged on the first and second half-shells 8 and 9, through which the container 2 can be fixed in the shell formed by the half-shells 8 and 9. Furthermore, the half-shells 8 and 9 are interconnected by the fixing device 10. The half-shells 8 and 9 have a rectangular half-shell base 11 and 12. The shell shape is preferably determined by the sidewall portions; these sidewall portions 13 of the lower half-shell 8 are designed to be flexible, while the sidewall portions 14 of the upper half-shell 9 are designed to be dimensionally stable, i.e., rigid. The clamp-shaped fixing device 10 can be fixed to the two opposing half-shells 8 and 9 by suitable fastening devices.

[0081] The first and second half-shells 8 and 9 each have a multi-layer structure 15 (FIG. 4), with heating elements 16 arranged in one layer of the multi-layer structure 15 of each half-shell 8 and 9. The heating elements 16 of each half-shell 8 and 9 provide a heating device. The heating elements 16 may extend along the half-shells 8 and 9 in a meandering or spiral manner (particularly on the surfaces of the half-shell bases 11 and 12), wherein the heating elements 16 are formed of stainless steel. Preferably, the thickness of the heating elements 16 is 50 µm. Each heating element 16 may also be in the form of a heating foil.

[0082] The multi-layer structure 15 of the half-shells 8 and 9 is configured as follows (see Figure 4). Facing the container 2 inside the receiving unit 3, the half-shells 8 and 9 have an outer layer 17 or support layer supporting the container 2. This layer is preferably made of stainless steel and has a thickness of 100µm to 150µm. Next is an electrical insulation layer 18, preferably 50µm thick, which can be made of polyimide film, for example. The layer containing the heating element 16 is adjacent to the insulation layer 18 and has a thickness of 50µm. The layer containing the heating element 16 can also be in the form of stainless steel foil, but can also be made of an electrical insulating material, in which one or more heating elements 16 made of stainless steel are integrated. Following this is a support layer or insulation layer 19, which is preferably formed of glass fiber reinforced plastic and has a thickness of 0.3 mm. Next is the mounting bracket 20 of each half-shell 8 and 9, which is made of aluminum and has a thickness of 0.5 to 1.0 mm.

[0083] As shown in Figure 1, another component of the defrosting device is a collection tray 7 located in the housing 4 below the receiving unit 3. This tray prevents moisture or other impurities generated during defrosting (e.g., leakage of matrix 1 through cracks in container 2) from reaching various parts of the defrosting device, such as areas that might damage electrical components. Preferably, the collection tray 7 is designed and arranged in such a way that it can be removed from the housing 4 for emptying.

[0084] A first motion device 21 is disposed within a housing 4, which is configured to transmit the first motion (indicated by motion arrow 24) to a receiving unit 3 and a container 2 placed therein together with a substrate 1. The first motion is a substantially planar motion, particularly a linear motion. The first motion device 21 includes a linear drive device 25, which is mechanically operatively connected via a mechanical coupling device 26 to at least one movably mounted guide device 27 (FIG. 2), which is mechanically operatively connected to the receiving unit 3 for transmitting the first motion.

[0085] The mechanical coupling device 26 is a universal joint disposed between the linear drive device 25 and at least one guide device 27, and connected to the linear drive device 25 and at least one guide device 27, or to a component operably connected thereto via a connecting device 28 (e.g., a stainless steel strip). The linear drive device 25 is an electromechanical linear drive device with at least one stator device 29 and a rotor device 30, the rotor device 30 being connected to the mechanical coupling device 26 via the connecting device 28 (particularly a stainless steel strip). At least one guide device 27 and the rotor device 30 are movably mounted on guide rods 31, 32, which are arranged on a common surface E. When the rotor device 30 begins to move (see movement arrow 23), this movement is transmitted to the guide device 27 via the mechanical coupling device 26. The guide device 27 also moves (see movement arrow 24), but in the opposite direction to the slider device 30.

[0086] Furthermore, the thawing device includes a second motion device 22, which is configured to transmit a second motion to the receiving unit 3 and the container 2 placed therein along with the substrate 1. This second motion is a full-speed motion. In Figure 1, the second motion device 22 is shown to have multiple second motion units 36, which transmit motion to the receiving unit 3 at multiple locations. The same applies to Figures 7 and 8.

[0087] For this purpose, the second motion device 22 includes at least one (preferably several) second motion units 36, wherein the at least one second motion unit 36 ​​is configured to apply a lifting motion to the receiving unit 3 (in particular the lower shell 8) (e.g., see the motion arrow 37 in FIG. 5 and the motion arrow 38 in FIG. 6, all of which have the characteristics of vertical lifting motion), wherein, during the lifting motion, the receiving unit 3 (in particular the lower shell 8) will be partially deformed, the degree of deformation corresponding to the thawed range of the substrate 1.

[0088] The second motion unit 36 ​​is arranged in different spatial positions so as to apply lifting motion to the receiving unit 3 (especially the lower shell 8), thereby generating full-speed motion by multiple lifting motions.

[0089] Figures 5 and 6 show different designs for the second motion unit 36. However, both designs include a force transmission member 39 arranged between the receiving unit 3 (i.e., the lower shell 8) and at least one second motion unit 36. This force transmission member 39 is connected to the receiving unit 3 (i.e., the lower shell 8) and at least one second motion unit 36 ​​to transmit lifting motion to the receiving unit 3, i.e., the lower shell 8. The force transmission member 39 has ball bearings 40 and is connected to the lower shell 8 via a welded joint 41.

[0090] According to the embodiment shown in FIG5, at least one second motion unit 36 ​​includes at least one lifting magnet 42, which is configured to transmit a stroke (particularly a lifting stroke) to a force transmission member 39, a receiving unit 3 connected to the force transmission member 39, and a container 2 arranged together with the substrate 1 within the receiving unit 3 by performing a lifting motion (see motion arrow 37). If the second motion device 22 includes a plurality of second motion units 36, each second motion unit 36 ​​may include one lifting magnet.

[0091] When the lifting motion is performed (Figure 5), the stroke is first transmitted from the lifting magnet 42 to the linkage 43 (or housing portion) associated with the second motion unit 36. The linkage 43 (or housing portion) is connected to a movably mounted bracket 44, which in turn is connected to the force transmission member 39. The bracket 44 is movably mounted on the guide rod 45, thereby tracking the first motion (rocking motion) triggered by the linear actuator 25 (see motion arrow 46). The movable mounting of the bracket 44 serves to separate the second motion unit 36 ​​(for generating full-speed motion) from the first motion or associated oscillation. Therefore, the second motion unit 36 ​​does not move with the first motion.

[0092] According to the embodiment shown in FIG6, at least one second motion unit 36 ​​includes at least one mechanical lifting device 47, which is configured to transmit stroke (particularly lifting stroke) to a force transmission pin 48 by performing a lifting motion, the latter being arranged to be movable laterally (particularly perpendicular to) the stroke axis H.

[0093] In this configuration, the force transmission pin 48 can move laterally (particularly perpendicularly) to the stroke axis H between a first position 101 and a second position 102. In its second position 102, the force transmission pin 48 transmits the lifting motion generated by the mechanical lifting device 47 to the force transmission member 39, the receiving unit 3 connected to the force transmission member 39, and the container 2 arranged within the receiving unit 3 together with the substrate 1. Specifically, the force transmission pin 48 is configured in its second position 102 to transmit the lifting motion generated by the mechanical lifting device 47 to the housing portion 49, where a bracket 50 connected to the force transmission member 39 is movably mounted. The bracket 50 is movably mounted on a guide rod 51 located within the housing portion 49. The movable mounting of the bracket 50 serves to separate the second motion unit 36 ​​from the first motion device 21 and the resulting first motion.

[0094] At the first position 101 of the force transmission pin 48, no stroke motion is transmitted along the direction of the force transmission member 39. The force transmission pin 48 is controlled by the control unit 52 and moves back and forth transversely (particularly perpendicular to) the stroke axis via the motion mechanism 53. According to this embodiment, the stroke motion is generated by the geared motor 54, driving the camshaft 55 at approximately 60 revolutions per minute. First, the motion is transmitted to the plunger 56, which is connected to the camshaft 55 and arranged along the stroke axis H for linear motion. The plunger 56 engages the (lower) end of the force transmission pin 48 at the second position 102 of the force transmission pin 48 and transmits the stroke motion thereto. Simultaneously, a groove 57 is formed at the lower end of the housing portion 49 to correspond to the upper end of the force transmission pin 48 and provide a positive fit. A plunger plate 58 can be provided to accommodate multiple plungers 56.

[0095] Figure 7 illustrates the distribution or arrangement of the second motion units 36 (including lifting magnets 42 according to the design shown in Figure 5) in the width and length of the receiving unit 3 (shown on the left). In this embodiment, a total of 6 second motion units 36 and a total of 6 lifting magnets 42 are provided.

[0096] Similar to Figure 7, Figure 8 also shows the distribution of the second motion units 36, but according to the embodiment shown in Figure 6 (mechanical lifting device 47). The left-hand view reproduces the distribution of the second motion units 36 along the width of the receiving unit 3, while the right-hand view shows the distribution of the second motion units 36 along the length of the receiving unit 3. As shown, six plungers 56 are arranged on a common plunger plate 58. The plunger plate 58 and the plungers 56 reciprocate using a geared motor 54 and a camshaft 55. As described in the embodiment of Figure 6, each plunger 56 is associated with a force transmission pin 48, and each pin can have a first position 101 and a second position 102. Therefore, each of the six force transmission pins 48 has a control unit 52 and a motion mechanism 53.

[0097] The linear actuator 25 is connected to a mechanical or electric spring system 33, which is used to adjust the operating characteristics and efficiency of the linear actuator 25. In particular, the spring system 33 is used to improve the vibration circuit of the vibrator drive (first motion device) while providing smooth operation.

[0098] Figure 9 illustrates an electric spring system combined with an electromechanical linear actuator 25, particularly a permanent magnet linear motor as the linear actuator 25. This linear actuator 25 includes the following components: a neodymium permanent magnet 59, a copper flat coil 60, a laminated iron stator circuit 61, a laminated iron rotor circuit 62, and a rotor bearing 63 with a sliding bearing. The electric spring system 33 is connected to or operatively coupled to the permanent magnet linear motor via the rotor bearing 63.

[0099] Figure 10 shows the electric spring system 33 and the reluctance motor, which replaces the permanent magnet linear motor shown in Figure 9. Reluctance motors are known in the art and involve a special design of the motor in which torque is generated solely by magnetic resistance and not to a large extent by Lorentz force; this is often the case with magnetically excited motors.

[0100] The electric spring system 33 is similar to a reluctance motor. The transformer 64 shown on the left in Figure 10 is magnetically neutral and remains without current. The lead yoke 67 is connected to the left transformer 64. The right transformer 65 is supplied with current at a certain point, simultaneously generating a force proportional to the applied current, acting on the right transformer, while the left transformer 64 remains without current. When the yoke 66 of the right transformer 65 is now in the neutral position, the above steps are repeated, but in the opposite direction. The electric spring system 33 (transformer 68) is slightly larger than the reluctance transformers 64 and 65. The transformer 68 of the spring system 33 is continuously energized, resulting in it remaining in the neutral position (despite current flow) and exerting no force (see the yoke position of the lead yoke 71). If the reluctance motor now moves the slider 69 (see movement arrow 70), the force generated by the spring system 33 counteracts the force of the reluctance motor. The decisive factor here is setting the current in the spring system so that the entire drive system is supported by spring force, achieving maximum mechanical deflection with the minimum current flow of the reluctance motor.

[0101] As shown in Figure 1, the other components of the defrosting device are power electronics 34 and electronic devices 35.

[0102] Figures 11 and 12 illustrate another embodiment in which a further motion device 80 is provided instead of a second motion device. This further motion device is configured to deliver further motion (indicated by motion arrow 82) to the receiving unit 3 and the container 2, in which the container 2 is placed together with the substrate. This further motion is a vertical linear motion and a linear action perpendicular to the first motion. In the embodiment shown in Figures 11 and 12, this further motion is not a full-speed motion.

[0103] The receiving unit 3 is flexible or deformable. Alternatively, one or both of the receiving unit 3 or the half-shells 8 and 9 can be dimensionally stable, i.e. rigid.

[0104] This further movement is another shaking motion. Therefore, the defrosting device transmits two superimposed shaking motions in different directions to the receiving unit 3 and the entire container 2 placed therein, including the entire substrate. XY motion of the receiving unit 3 and the entire container 2 can be achieved.

[0105] The further motion device 80 includes two motion units 84. Each of these motion units 84 includes a linear actuator 86.

[0106] In each case, the linear drive 86 is mechanically connected to the receiving unit 3 to transmit the further motion.

[0107] Force transmission member 88 is disposed between the lower half shell 8 and each of the two motion units 84, and is connected to the lower half shell 8 and each of the two further motion units 84 in order to transmit further motion to the lower half shell 8.

[0108] The force transmission member 88 has a flat force transmission region 90 for transmitting force to the receiving unit 3. This at least largely prevents deformation of the receiving unit 3.

[0109] The linear actuator 86 of the further motion unit 84 is an electromechanical linear actuator that is largely based on Lorentz force in the form of a linear motor, rather than (for example) a reluctance motor.

[0110] The linear actuator 86 has a stator assembly 92, which includes a stator 94, a control winding 96, and a base 98. The stator 94 is an iron stator and, together with the control winding 96, is separated from the housing 4 (i.e., the housing base) by the base 98.

[0111] The stator assembly 92 exposes the slot 100, which is surrounded by the control winding 96 and the stator 94.

[0112] The movement of the rotor assembly 102 of the linear actuator 86 of the motion unit 84 is in the same direction as the further movement.

[0113] Rotor assembly 102 includes one rotor 104 at a time. The rotor is an iron sheet or a permanent magnet.

[0114] The slider assembly 102 includes a force transmitter 88 that transmits force between the slider 104 and the receiving unit 3.

[0115] The force transmission region 90 of the force transmission member 88 is positively and non-positively connected to the receiving unit 3. The slider 104 is connected to the force transmission member 88. The force transmission member 88 is plate-shaped, with its thickened end including the force transmission regions 90 and 106. The force transmission member 88 is disposed in a groove 100 of the stator assembly 92 and can move therein along the first and further movement directions. Applying current to the control winding 96 causes the rotor 104 and the force transmission member 88 to move back and forth along the further movement direction, thereby transmitting the further movement to the receiving unit 3.

[0116] In order to superimpose the first motion on the further motion, for example, the linear drive device 25 of the first motion device 21 can be connected to the receiving unit 3 via the force transmission member 88 (not shown in Figures 11 and 12).

[0117] Two guide devices 108 are provided for guiding two force-transmitting members 88 within a groove 100 in the directions of a first movement and a further movement. Each guide device 108 includes a guide frame 110 movable in the first movement direction and equipped with guide wheels 112. The guide wheels 112 engage with guide rails 114 oriented in the first movement direction. The guide rails 114 are mounted to the housing 4, i.e., the housing base, via bases 116. Each guide device 108 includes a connecting device 118 located between the guide frame 110 and the force-transmitting member 88, which is movable relative to the force-transmitting member 88 in the direction of further movement, or guides the force-transmitting member 88 in the directions of the first and further movements. The connecting device 118 is configured as a planar steel spring sheet. The steel spring sheet is connected to the force-transmitting member 88 with one edge and to the guide frame 110 with the opposite edge.

[0118] Two motion units 84 are arranged side by side, perpendicular to the first motion. The guide device 108 must include a connecting device 118 for each force transmission member 88. The connecting devices 118 are located on both sides of the force transmission member 88, back to back.

[0119] Attached Figure Reference Symbol Definitions 1. Matrix 2 containers 3 Receiving Unit 4. Shell 5. Sealing cap 6. Hinges 7. Collect trays 8 First Half Shell 9 Second half-shell 10 Fixing devices 11 Half-shell base 12 Half-shell base 13. Sidewall section 14. Sidewall section 15-layer structure 16 Heating elements 17. Outer shell 18 Electrical insulation layer 19. Supporting layer or insulating layer 20 Install bracket 21 First motion device 22 Second motion device 23 Moving arrows 24 moving arrows 25 Linear Actuator 26 Mechanical linkage device 27. Guiding device 28 Connecting device 29 Stator assembly 30 Rotor assembly 31 Guide rod 32 Guide rods 33 Spring System 34 Power Electronic Equipment 35 Electronic Components 36 Second Motion Unit 37. Movement arrows 38 moving arrows 39 Force Transmission Components 40 ball bearing 41 Welded joints 42 magnets 43. Linkage device 44 brackets 45 Guide rod 46 moving arrows 47 Mechanical lifting device 48 Force transmission pins 49. Shell section 50 brackets 51 Guide rod 52 Control device 53 Sports Organizations 54 Gear Motor 55 Camshaft 56 plunger 57 Groove 58 plunger plate 59 Neodymium permanent magnets 60 Copper Flat Coil 61. Laminated stator, reverse direction 62. Add lead-iron rotor, reverse direction. 63 Rotor bearings 64 Transformers 65 Transformer 66 Magnetic yoke 67 Magnetic yoke 68 Transformers 69 brackets 70 Movement Arrows 80 Further motion device 82 moving arrows 84 further motor units 86 linear drive unit 88 force transmission components 90 Force Transmission Area 92 stator assembly 94 stator 96 control winding 98 base 100 grooves 102 Rotor Unit 104 sliders 106 thickened end 108 guide device 110 guide frame 112 guide wheels 114 guide rail 116 base 118 Fastener 120 arrows E plane H lifting axis L-shaped semi-shell longitudinal axis

Claims

1. A thawing device for thawing a frozen aggregated substrate (1), the substrate (1) being contained in a container (2), the thawing device comprising: a. A receiving unit (3) for arranging the container (2) containing the substrate (1), the receiving unit (3) having a heating device for providing the heat energy required to thaw the substrate (1); b. A first motion device (21) configured to transmit a first motion to the receiving unit (3) and the container (2) therein together with the substrate (1), wherein the first motion is a motion performed substantially on a plane; c. a second movement device (22) arranged to impart a second movement to the receiving unit (3) and the container (2) in which the substrate (1) is placed together with, wherein the second movement is a full-scale movement, the second movement device (22) comprising at least one second movement unit (36) arranged to exert a lifting movement on the receiving unit (3), wherein, When the lifting motion is applied, the partial deformation of the receiving unit (3) reaches a degree corresponding to the thawed portion of the matrix (1); characterized in that: The first motion device (21) includes a linear drive device (25) which is mechanically connected to at least one movable mounting guide device (27) via a mechanical coupling device (26), the at least one guide device (27) being mechanically connected to the receiving unit (3) for transmitting the first motion; The mechanical coupling device (26) is a universal spring joint disposed between the linear drive device (25) and the at least one guide device (27), and connected to the linear drive device (25) and the at least one guide device (27) or to a component operatively connected thereto by a connecting device (28).

2. The defrosting device according to claim 1, characterized in that, The frozen aggregated matrix (1) is plasma, the container (2) is a bag; the motion performed on the plane is linear motion; the receiving unit (3) is a first half-shell (8).

3. The defrosting device according to claim 1, characterized in that, The receiving unit (3) is formed in the shape of a shell, wherein the shell includes a first half shell (8) and a second half shell (9), wherein the first half shell (8) is the lower half shell and the second half shell (9) is the upper half shell, and wherein the first half shell (8) and the second half shell (9) are detachably connected together.

4. The defrosting device according to claim 2, characterized in that, The first half-shell (8) and the second half-shell (9) are adapted to the shape of the container (2) and when the container is placed in the shell, the first half-shell (8) and the second half-shell (9) at least partially surround the container (2).

5. The defrosting device according to claim 2, characterized in that, Fixing devices (10) are provided on the first half-shell (8) and the second half-shell (9), which can be used to fix the container (2).

6. The defrosting device according to claim 2, characterized in that, The first half-shell (8) and the second half-shell (9) each have a multi-layer structure (15), and in each case, a heating element (16) is provided in one layer of the layer structure (15) of the first half-shell (8) and the second half-shell (9).

7. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, The linear drive (25) is connected to a mechanical or electric spring system (33) adapted to adjust the working characteristics and efficiency of the linear drive (25).

8. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, The linear drive device (25) is an electromechanical linear drive device having at least one stator device (29) and a rotor device (30), the rotor device (30) being connected to the mechanical coupling device (26) via the connecting device (28), the connecting device (28) being a stainless steel strip.

9. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, The at least one guide device (27) and the rotor device (30) are each movably mounted on guide rods (31, 32), which are disposed on a common surface (E).

10. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, A force transmission member (39) is provided between the receiving unit (3) and the at least one second motion unit (36), the force transmission member (39) being connected to the receiving unit (3) and the at least one second motion unit (36) so as to transmit the lifting motion to the receiving unit (3).

11. The defrosting apparatus according to claim 10, characterized in that, The force transmission component (39) includes a ball bearing (40), and is further characterized in that the force transmission component (39) is fixed to the receiving unit (3) by a welded joint (41).

12. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, The at least one second motion unit (36) includes at least one lifting magnet (42) configured to transmit a stroke to a force transmission member (39), the receiving unit (3) connected to the force transmission member (39), and the container (2) arranged together with the substrate (1) within the receiving unit (3).

13. The defrosting apparatus according to claim 12, characterized in that, The at least one second motion unit (36) includes at least one mechanical lifting device (47) configured to transmit stroke to a force transmission pin (48) by performing a lifting motion, the latter being movably arranged transverse to the stroke axis (H), i.e., perpendicular to the stroke axis (H).

14. The defrosting apparatus according to claim 13, characterized in that, The force transmission pin (48) moves laterally along the stroke axis (H) between a first position (101) and a second position (102), the force transmission pin (48) being positioned at its second position (102) to transmit the lifting motion performed by the at least one mechanical lifting device (47) to the force transmission member (39), the receiving unit (3) connected to the force transmission member (39), and the container (2) placed in the receiving device together with the substrate (1).

15. The defrosting apparatus according to any one of claims 1 to 6, characterized in that, A further motion device (80) is provided, which is configured to transmit further motion to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the further motion running in a different direction from the first motion, that is, running perpendicular to the plane in which the first motion is performed.

16. A thawing device for thawing a frozen aggregated substrate (1), the substrate (1) being contained in a container (2), the thawing device comprising: a. A receiving unit (3) for arranging the container (2) containing the substrate (1), the receiving unit (3) having a heating device for providing the heat energy required to thaw the substrate (1); b. A first motion device (21) configured to transmit a first motion to the receiving unit (3) and the container (2) placed therein together with the substrate (1), wherein, The first motion is a motion performed substantially on a plane; A further motion device (80) is configured to transmit further motion to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the further motion running in a direction different from the first motion and perpendicular to the plane in which the first motion is performed; characterized in that: The first motion device (21) includes a linear drive device (25) which is mechanically connected to at least one movable mounting guide device (27) via a mechanical coupling device (26), the at least one guide device (27) being mechanically connected to the receiving unit (3) for transmitting the first motion; The mechanical coupling device (26) is a universal spring joint disposed between the linear drive device (25) and the at least one guide device (27), and connected to the linear drive device (25) and the at least one guide device (27) or to a component operatively connected thereto by a connecting device (28).

17. The defrosting apparatus according to claim 16, characterized in that: The matrix (1) in the frozen aggregated state is plasma, and the container (2) is a bag.

18. The defrosting apparatus according to claim 16 or 17, wherein, The motion performed on the plane is a linear motion.

19. A method for thawing a frozen aggregated matrix (1) using the thawing apparatus of claim 1, wherein the matrix (1) is contained in a container (2), comprising the following steps: a. The arrangement of the container (2) containing the substrate (1) in the receiving unit (3), b. Heating the substrate (1) contained in the container (2) using the heating device, wherein, during the heating process i. A first motion is transmitted via the first motion device (21) to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the first motion being a motion performed substantially on a plane, and ii. The second motion is transmitted through the second motion device (22) to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the second motion being a full-speed motion.

20. The method according to claim 19, wherein, The motion performed on the plane is a linear motion.

21. The method according to claim 19, characterized in that, The method is performed using the thawing apparatus as described in any one of claims 2 to 6.

22. A method for thawing a frozen aggregated matrix (1) using the thawing apparatus of claim 16, wherein, The substrate (1) is contained in a container (2), and the following steps are included: a. The arrangement of the container (2) containing the substrate (1) in the receiving unit (3), b. The substrate (1) contained in the container (2) is heated by the heating device, wherein, during heating... i. A first motion is transmitted via the first motion device (21) to the receiving unit (3) and the container (2) placed therein together with the substrate (1), the first motion being a motion performed substantially on a plane, and ii. The further motion is transmitted to the receiving unit (3) and the container (2) placed therein together with the substrate (1) by the further motion device (80), the further motion running in a different direction from the first motion, perpendicular to the running on the plane in which the first motion is performed.

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