Closure device for closing a medical container and system for handling a medical container

Abstract

The present invention relates to a sealing device for sealing a medical container (12) with a sealing element (34), wherein the sealing element (34) includes a first side (52) and a second side (54), and the first side (52) faces the inner side (56) of the container (12) sealed with the sealing element (34), while the second side (54) faces away from the inner side (56) of the container. The sealing device (32; 42; 176; 182) includes a supply unit (45) having a supply track (48) in which the sealing elements (34) can be individually and at least partially or preferably completely separated from the first side. The container is supplied in a side (52) contact manner; a receiving body (76) having a receiving portion (90) for a closure element (34), wherein the closure element (34) can be transferred from the supply track (48) to a receiving posture entering the receiving portion (90); a flipping mechanism (74) for flipping the receiving body (76) from an initial position to an end position and for transferring the closure element (34) from the receiving posture to a placement posture, in which the closure element (34) is positioned at the container (12) or positioned at a distance from the container (12) with its first side (52) pointing toward the inside of the container (56). The invention also relates to a system for handling pharmaceutical containers.

Description

Technical Field

[0001] The present invention relates to a sealing device for sealing a medical container with a sealing element, wherein the container is, for example, a vial, syringe or cartridge.

[0002] The present invention also relates to a system for processing pharmaceutical containers, such as vials, syringes, or cartridges, the system comprising at least one sealing device. Background Technology

[0003] In this type of system, pharmaceutical containers (also referred to as "vessels"), such as vials, syringes, or cartridges, are typically filled with medication via a filling station. The medication is, in particular, a medically effective substance (pharmaceutical). After filling, the container is sealed with a sealing element using a sealing device. For this purpose, vials (also known as "injection vials" or "tubular vials") are typically sealed with a mushroom-shaped stopper. It may be specified that a cap in the form of a rolled-edge cap is also attached. Other sealing elements. For example, a piston-shaped stopper can be used to seal a syringe. For example, a piston-shaped stopper and / or a combination of rolled-edge stoppers can be used to seal a cartridge, wherein the sealing element is integrated into the rolled-edge stopper (so-called "rolled-edge stopper with an inserted sealing element").

[0004] In systems of the aforementioned type, especially when handling toxic and highly sensitive drugs, so-called isolation mechanisms (also known as "isolation elements") are typically used. Isolation mechanisms include covering elements that shield the surfaces on which the system's components are assembled. Containers are filled in an atmosphere, for protective and / or purifying purposes, such as a protective gas (e.g., H₂O₂), and sealed by means of a sealing element. It is known, for example, in this type of environment, that the sealing element is lifted from stock using a negative pressure mechanism and a pickup element applying negative pressure, placed, and pressed onto the container. In this case, it may be disadvantageous for the protective gas and / or material, in vapor or powder form, to be drawn into the negative pressure mechanism. For reliability reasons, considerable effort may be required to filter the drawn-in medium or, in the case of a protective gas, to resupply it to the environment. Summary of the Invention

[0005] The purpose of this invention is to provide a sealing device for sealing medical containers and a system for processing medical containers, which have higher operational reliability.

[0006] This objective is achieved by a sealing device according to the invention for sealing a pharmaceutical container with a sealing element, wherein the sealing element includes a first side and a second side, the first side facing the inside of the container in the container sealed by the sealing element, and the second side facing away from the inside of the container, the sealing device comprising:

[0007] A supply unit having a supply track in which closure elements can be supplied one by one and in a manner that is at least partially or preferably completely not in contact with the first side; a receiving body having a receiving portion for the closure elements, wherein the closure elements can be transferred from the supply track to a receiving posture in the receiving portion; and a flipping mechanism for flipping the receiving body from an initial position to an end position and for transferring the closure elements from the receiving posture to a placement posture, in which the closure elements are positioned at the container or positioned at a distance from the container with the first side pointing inwards.

[0008] The sealing element for sealing the container has a first side. In the sealed container, the first side points inward and is arranged, for example, within the container opening. The first side faces the material filled in the container. The second side of the sealing element points away from the inside of the container, and particularly towards the outside of the container, away from the drug. In the supply track, the individually supplyable sealing elements are arranged such that the first side is at least partially and preferably completely out of contact with the supply track, and more preferably out of contact with other parts of the sealing device. In particular, the first side can be exposed to a protective and / or purifying atmosphere by means of a protective gas, such as H2O2. The protective gas removes any possible foreign particles and / or contaminants. For example, the first side can be sterilized. The received sealing element can be flipped and transferred to a placement position, either to the container or spaced from it, by means of a flipping mechanism and a receiving body. In the placement position, the first side points inward. The container can then be sealed by means of the sealing element. For this purpose, a pressing mechanism can be provided, for example, which will be discussed below. Compared with traditional sealing devices, the feasible approach of applying protective gas to the sealing element at the first side can improve the operational reliability of the device.

[0009] In the sealing device according to the invention, it is preferably specified that, within a protected environment equipped with a protective and / or purifying atmosphere, the sealing element can be arranged at the container without the need for a negative pressure mechanism and a corresponding pickup element, which can be described as "vacuum-free" to a certain extent. This reduces the requirements for possible filter elements and / or recirculation of the protective gas.

[0010] Needless to say, sealing devices and systems for handling containers may in particular include control mechanisms. These control mechanisms preferably operate and / or regulate all processes of the sealing devices and systems.

[0011] In the supply track and / or in the receiving posture, the first side preferably points upward relative to the direction of gravity, i.e., against the direction of gravity, while the second side points downward, i.e., along the direction of gravity. In this way, a protective gas flowing downward can be applied to the first side.

[0012] In the placement orientation, the second side preferably points upward relative to the direction of gravity, while the first side points downward. This largely avoids further contamination before placement and, if necessary, pressing of the closure element, following possible cleaning and / or contamination of the closure element and after flipping it.

[0013] In a conventional, closed container, the first side may be or form the lower side of the closing element, while the second side may be or form its upper side.

[0014] For example, positional and / or directional descriptions such as "up," "down," "vertical," and "horizontal" refer to the specific usage orientation of the sealing device and system. Specifically, it is specified that the system's mounting structure is positioned, for example, on the floor of a workshop or laboratory, and the sealing device is arranged on the upper side of the mounting structure. Covering elements of the isolation mechanism, for example, cover the sealing device. "Up" and "down" are interpreted here specifically with reference to the direction of gravity.

[0015] The sealing device preferably includes a stock of sealing elements, from which sealing elements can be supplied to a supply track. The stock is, for example, held in a conveyor tank. Sealing elements are supplied one by one from the conveyor tank to the supply track, particularly in such a manner that sealing elements with an undesirable orientation (e.g., facing a second side upward) fall back into the conveyor tank. Sealing elements with the correct orientation (particularly facing a first side upward) are guided one by one through the supply track to a receiving body.

[0016] In the supply track, the first side of the sealing element preferably points upward, with the supply track particularly open on the upper side. This allows the protective gas to reach the first side particularly well. Preferably, any contact between the sealing element and parts of the sealing device and / or system that could lead to contamination can be avoided.

[0017] In the supply track, the closure element is preferably placed flat on the bottom of the supply track with its second side facing down.

[0018] In its placement, the closure element is advantageously positioned on the upper side of the container or above it. In particular, the closure element can be positioned linearly above the container along the direction of gravity. In this case, the closure element can be lowered by moving it linearly towards the container.

[0019] Enclosed elements are supplied, for example, horizontally, in the supply track.

[0020] It can be specified that the receiving body contacts the supply rail and / or is positioned above the supply rail in the initial position for receiving the closed element in the receiving posture.

[0021] Advantageously, the sealing device includes a pushing element that pushes the sealing element, located at the end of the supply track, into the receiving portion in its initial position within the receiving body. Particularly advantageously, the pushing element can apply a pushing force to a second side of the sealing element toward the receiving portion. The first side may not contact the pushing element. In a preferred embodiment, the pushing element can push the sealing element upward into the receiving portion. The pushing element can be or constitute a pressing element to press the sealing element into the receiving portion, such that the sealing element is reliably held in the receiving body, for example, in a form-fit manner.

[0022] A locking mechanism can be arranged at the supply track to prevent subsequent closing elements from entering the receiving section when a closing element is introduced from the supply track. The locking mechanism may include, for example, a locking element that can be pushed laterally into the supply track to block the supply track.

[0023] The closure element is preferably held in the receiving portion by force fit and / or form fit. Here, the dimensions of the receiving body are preferably set such that it fits the contour of the closure element, which is received, for example, by press fit. The receiving body may, for example, be a specification component for the corresponding closure element.

[0024] The outer edge of the closure element preferably rests at least partially against the edge of the receiving portion.

[0025] The receiving portion may include, for example, an inlet opening for closing the element and an outlet opening opposite thereto, wherein the closing element can move into the receiving portion through the inlet opening and out of the receiving portion through the outlet opening. The closing element can be moved into the receiving portion through the inlet opening, for example, by means of the aforementioned push-in element. The closing element can be moved out of the receiving portion, for example, through the outlet opening, by a corresponding push-pull element.

[0026] The receiving part can be designed, for example, as a perforation of the receiving body, wherein the closing element rests against the edge of the perforation in the receiving posture.

[0027] The receiving part may be, for example, sleeve-shaped and include lateral perforations. These lateral perforations create free space, allowing the receiving body to move through other parts of the sealing device, as described below. In the initial position of the receiving body, the perforations preferably point in the direction of the supply track.

[0028] In a preferred embodiment of the invention, the receiving body includes, for example, a suction tube having suction openings disposed at the edge of the receiving portion, and the sealing device includes a negative pressure mechanism for applying negative pressure to the suction tube, wherein the sealing element is held in the receiving portion by means of negative pressure. This type of receiving form is used, for example, for placing a rolled cap on a container that has already been sealed by means of a sealing element. The “sealing” of the container is hereby understood accordingly to mean that other sealing elements may be arranged in addition to the sealing element. If, in this embodiment, the container has already been sealed with a sealing element, for example in an environment provided with a protective gas, other sealing elements, especially rolled caps, can be held in the receiving body by means of a negative pressure mechanism. In this case, the use of negative pressure (“vacuum positioning”) of the sealing element can prove to be without problem, because the container has been sealed and no more contaminants will appear inside the container. This type of device can be applied, for example, to environments other than those with protective and / or purified atmospheres.

[0029] In a preferred embodiment of the invention, the flipping mechanism is a pivoting mechanism or includes a pivoting mechanism, through which the receiving body can pivot about a pivot axis to move from an initial position to an end position. The pivot axis is preferably horizontally oriented. The closure element can pivot from a corresponding receiving posture to a corresponding placement posture via the pivoting mechanism.

[0030] In one embodiment of the invention, the receiving body includes a plurality of receiving portions arranged in a row, and it may be specified that the pivot axis is oriented parallel to the receiving portions. Alternatively, it may be specified that the pivot axis extends through the receiving portions.

[0031] The pivot angle for pivoting from the initial position to the end position is preferably greater than 90°, and more preferably greater than 135°. In a preferred embodiment of the invention, the pivot angle is 180° or substantially 180°. Thus, the closure element can be completely flipped by means of the pivoting mechanism, wherein the first side preferably points upward in the initial posture and downward in the placement posture.

[0032] The height of the enclosing element, especially along the direction of gravity, is preferably the same or substantially the same in the receiving and placement postures. The receiving body can have the same height in the direction of gravity in the initial and end positions.

[0033] Preferably, the flipping mechanism used to transfer the receiving body from the initial position to the end position does not involve linear lifting or lowering movement, thereby simplifying the working principle of the sealing device. In particular, only a pivoting movement for flipping the sealing element can be provided.

[0034] Advantageously, the flipping mechanism may be, or include, a lifting mechanism for raising or lowering the receiving body. The lifting mechanism, for example, allows the sealing device to adapt to containers of different sizes. For instance, the containers may have varying heights. The sealing device can be adapted in multiple ways via lifting movement, which only needs to be set once when changing the size to a higher or lower container.

[0035] The supply track can, for example, define the supply direction for the sealing element and can be equipped with a transport mechanism for the container, which transports the container in a transport direction toward the sealing device, wherein the angle between the supply direction and the transport direction is less than 90°, preferably less than 70°, and preferably about 40° to 60°. In practice, it has been found that this allows for a relatively compact configuration of the system for handling containers with a sealing device. A protective gas can preferably be applied to a single sealing element along the length of the supply track to ensure process reliability. At an angle of about 40° to 60°, the assembly mechanism for the system can, for example, be designed substantially L-shaped in a top view, with the transport mechanism arranged along the sides of the L and the sealing device substantially arranged in the intersection area of ​​the two sides of the L.

[0036] Advantageously, the flipping mechanism includes or constitutes a pivoting mechanism for pivoting the receiver about a pivot axis and moving the receiver from a position away from the container to a position closer to the container, wherein the distance between the receiver and the container in the position closer to the container is less than the distance between the receiver and the container in the position away from the container. The pivot axis can be vertically oriented in particular.

[0037] Advantageously, during the pivoting of the flipping mechanism from a position away from the container to a position closer to the container, the receiving body can transfer from the initial position to the end position. The feasible scheme of simultaneous and / or synchronized pivoting can keep the cycle time of the sealing device short.

[0038] The pivot angle for pivoting from a position away from the container to a position closer to the container is preferably less than 90°, preferably less than 70°, and preferably about 40° to 60°. In particular, the pivot angle can substantially correspond to the angle between the supply direction and the transport direction.

[0039] The sealing device preferably includes a pressing mechanism for pressing the sealing element onto the container or for pressing the sealing element into the container opening. This ensures reliable positioning of the sealing element within the container. The pressing mechanism may have at least one pressing element.

[0040] The sealing device preferably includes a support for supporting the container with a force opposite to the pressing force of the pressing mechanism. For example, in this case, the container can stand upright on the support, at least during the pressing of the sealing element.

[0041] In a preferred embodiment of the invention, the sealing element can be positioned abutted against the container opening. Correspondingly, a receiving body can be specified to allow the sealing element to move directly to the container opening. The sealing device may include a pressing mechanism having a pressing element for pressing the sealing element into or onto the container opening and applying pressure to a second side. In this embodiment, the container may be either not yet sealed or already sealed by means of the sealing element.

[0042] The pressing element can be, for example, a pivoting element or a pushing element, which can pivot or be pushed to a second side and can contact the second side. Needless to say, an associated actuator is provided for the pressing element.

[0043] The sealing device may be specified to include: a pickup element for picking up a sealing element in a positioned position; a negative pressure mechanism that allows the pickup element to apply negative pressure to remove the sealing element from the receiving portion of the receiving body; and an adjustment mechanism for moving the sealing element to the container using the pickup element, wherein the sealing element is removable when the negative pressure is released at the container. This type of device is used, for example, to place a sealing element outside of an environment with a protective and / or purified atmosphere. Accordingly, for example, a crimped cap can be picked up by the pickup element and placed on top of a sealing element already present at the container.

[0044] The adjustment mechanism is preferably a pushing mechanism for moving the pickup element, especially linearly. Advantageously, the pushing mechanism can be a lifting mechanism in which the closure element is lowered from above onto the container or an already arranged closure element by means of the pickup element.

[0045] Preferably, the closure element can be picked up at the second side by means of a pickup element, wherein preferably the first side does not contact the pickup element.

[0046] In a preferred embodiment of the invention, the sealing device includes a retainer and is provided with a push-in element, wherein the sealing element can be pushed from a receiving portion of the receiving body into a corresponding receiving portion of the retainer by means of the push-in element at the end position of the receiving body. In this way, the sealing element can be transferred to the retainer and, for example, subsequently arranged by the retainer at the container.

[0047] Preferably, a pushing force can be applied to the second side of the closing element by means of a pushing element in the direction of the receiving portion of the retainer.

[0048] The receiving parts of the receiving body and the retaining body can advantageously be formed equally to each other.

[0049] The push-in element can be designed as a press-in element, through which the closing element can be pressed from the receiving portion of the receiving body into the receiving portion of the retaining body.

[0050] Preferably, the closing element moves out of the receiving part of the receiving body through the aforementioned lead-out opening.

[0051] The receiving parts of the receiving body and the retaining body can preferably be constructed to correspond to each other.

[0052] The closure element is held in the receiving portion of the retainer, for example, by force fit and / or form fit. The receiving portion may be adapted to the contour of the closure element, which is received, for example, by press fit. The retainer may in particular be a specification component adapted to the closure element.

[0053] The outer edge of the closure element preferably rests at least partially against the edge of the receiving portion of the retainer.

[0054] The receiving portion of the retainer preferably includes an inlet opening for closing the element and an outlet opening opposite thereto. The closing element, for example, can move into the receiving portion through the inlet opening and out of the receiving portion through the outlet opening. The receiving portion may, for example, be formed in the form of a perforation in the retainer.

[0055] The receiving part is, for example, sleeve-shaped and includes lateral perforations.

[0056] In a preferred embodiment, the retainer may be defined as or include at least one tube or sleeve, and is preferably sized such that the tube or sleeve can be introduced into the container without contacting the edge of the container opening. In this way, for example, a piston-like plug can be placed by introducing the tube or sleeve into the container opening. Because the tube or sleeve does not contact the edge of the container opening, potential contamination can be avoided. For example, as described below, the sealing element can be removed from the tube or sleeve using a clamp.

[0057] The pushing element is preferably constructed as a propeller.

[0058] After the closure element is pushed into the retainer, the receiver can preferably be moved back to the initial position from the end position. For example, it has proven advantageous that the receiving portion of the receiver includes a lateral perforation. In a preferred embodiment, the receiver can be pivoted away from the push-in element, for example, by moving the push-in element through the perforation.

[0059] The sealing device advantageously includes at least one adjusting mechanism for moving the retainer and / or pusher element, which receive the sealing element, toward the container opening. It can be specified that the retainer and pusher element are equipped with corresponding dedicated adjusting mechanisms. For example, simultaneous and / or synchronous movement can be achieved via a control mechanism. Alternatively, separate movement of the retainer and pusher element can be realized.

[0060] At least one adjusting mechanism is preferably a pushing mechanism for pushing the retainer and / or pushing element, especially in a straight line, toward the container. The pushing mechanism can advantageously be a lifting mechanism.

[0061] The retainer and the push-in element are preferably moved synchronously toward the container, wherein the push-in element is preferably abutted against the closure element during the movement.

[0062] In a preferred embodiment of the invention, the sealing element can be abutted against the edge of the container opening by means of a retainer, and the sealing element can be pressed into the container opening from the receiving portion of the retainer by means of a push-in element to close the container. In this case, the push-in element can be used as a pressing element for the sealing element. Accordingly, the sealing device may include a pressing mechanism. Advantageously, the container is supported by means of the aforementioned support during pressing of the sealing element.

[0063] For example, after the container is closed, it is advantageous to remove the retainer and the push-in element from the container by means of at least one adjusting mechanism. It can be specified here that the retainer can be removed from the container before the push-in element is moved.

[0064] Accordingly, it can be specified that the closing element is pressed into the container opening by means of a push-in element, wherein the retainer is initially arranged in a fixed position relative to the container. The retainer can then be removed from the container by an adjustment mechanism, and subsequently the push-in element can be removed from the container by the adjustment mechanism.

[0065] In a preferred embodiment of the invention, the retainer is engaged with the received closure element into the container opening, wherein the push-in element forms a clamping device for applying a limiting force to the closure element, wherein the retainer can be removed from the container during this period by means of at least one adjusting mechanism, so that the closure element can be pushed out from the receiving portion and retained in the container opening. This type of design is used, for example, for arranging piston-shaped plugs. For example, a tubular or sleeve-shaped retainer is engaged into the container opening. It is applied to the closure element by means of the push-in element. The retainer is then removed simultaneously. In this way, pressing pressure on the container can be avoided, and it is also used, for example, for arranging mushroom-shaped plugs.

[0066] As previously mentioned, the sealing element can be a mushroom-shaped plug, a piston-shaped plug, a rolled-edge plug, or a rolled-edge cap. In particular, it can be specified that the rolled-edge cap is placed on the already arranged mushroom-shaped plug.

[0067] The sealing device preferably includes at least one inspection mechanism that can check the presence and / or proper positioning of the sealing element on the container. The inspection mechanism is, for example, designed to be optical. In the event of a missing sealing element, for example, it can be stipulated that the container be moved back to the sealing device by means of a transport mechanism to provide the sealing element. Alternatively, the container can be discharged via a transport mechanism in the event of a missing sealing element. In the event of an incorrectly positioned sealing element, the container can be discharged via a transport mechanism, for example.

[0068] Alternatively or supplementarily, it can be specified that an inspection mechanism can be used to check whether the closure element is received in at least one receiving portion (preferably all receiving portions) of the receiving body, wherein, for example, the receiving portion is pre-defined or can be pre-defined, or alternatively, any receiving portion. Preferably, the inspection has been performed before the receiving body is flipped and / or during the flipping of the receiving body; however, it is advantageous to perform the inspection before lowering the closure element onto the container. If a closure element is missing, the corresponding receiving portion is preferably occupied or reoccupied with the missing closure element. For example, the aforementioned push-in element for the closure element can be selectively operated. If multiple closure elements can be processed simultaneously, as described below, other push-in elements are not operated, for example, if the corresponding receiving portion at the receiving body is already occupied by a closure element. For inspection, for example, an optical inspection mechanism (e.g., using optical fiber) can be used, through which the receiving body pivots.

[0069] Therefore, it is advantageous that the receiving body can be reoccupied with a single enclosing element when necessary.

[0070] Alternatively, one or more receiving portions can be selectively occupied by corresponding closing elements, for example, by manipulating the corresponding push-in element. At least one receiving portion of the receiving body can remain free.

[0071] Particularly preferred is that the sealing device is designed to simultaneously seal multiple containers using corresponding sealing elements. Although not described in detail above, it can be specified that it includes multiple supply tracks, multiple receiving parts in the receiving body, multiple pushing elements, multiple receiving parts in the holding body, multiple pressing elements, etc. By simultaneously sealing multiple containers, the cycle time of the sealing device can be shortened. In particular, the corresponding parts of the sealing device for handling multiple sealing elements are designed to be identical.

[0072] The above embodiments demonstrate that the present invention may particularly possess the following characteristics and / or advantages:

[0073] - A unified supply and / or placement technology for different types of closure elements (e.g., mushroom plugs, piston plugs, and crimp caps);

[0074] - Feasibility options for repositioning missing (even single) enclosure components;

[0075] - For example, a feasible solution for using vacuum-free technology for sealing components at the filling machine;

[0076] - Feasibility of applying protective gas to the sealing element on the product contact side.

[0077] According to the present invention, a system for handling pharmaceutical containers, such as vials, syringes, or cartridges, which achieves the purpose mentioned at the beginning of this document, the system includes: a transport mechanism for transporting the container along at least one transport direction; a filling station arranged at the transport mechanism for filling the container with a drug; and a sealing device of the aforementioned type located downstream of the filling station in the transport direction for sealing the container after filling.

[0078] The advantages that can be achieved using the sealing device according to the invention have been described and can also be achieved in the system according to the invention. Refer to the above embodiments.

[0079] Advantageous embodiments of the system according to the invention are derived from advantageous embodiments of the sealing device according to the invention. Related details can also be found in the above-described embodiments.

[0080] The system according to the invention utilizes a sealing element, particularly arranged as a mushroom-shaped plug, a piston-shaped plug, a rolled-edge cap, or a rolled-edge plug cap.

[0081] Transportation mechanisms can have multiple parts, especially linear transportation systems used for the linear transport of containers.

[0082] Preferably, the container should be closed as soon as possible after it has been filled with material, and if necessary, it should be closed as soon as possible after a filling inspection is performed using a weighing station.

[0083] Advantageously, the system includes: a mounting mechanism on which a sealing device and a transport mechanism for sealing the container are arranged; and an isolation mechanism covering the sealing device and the transport mechanism, having a covering element and preferably used to provide a protective and / or purifying atmosphere between the covering element and the mounting mechanism, and for applying a protective atmosphere to a first side of the sealing element. The protective and / or purifying atmosphere particularly includes a protective gas, such as H₂O₂. The protective gas can be applied to the first side of the sealing element, which preferably points upwards.

[0084] In a preferred embodiment, the system may include additional sealing devices for closing the container, located downstream of the initially mentioned sealing device in the transport direction. These additional sealing devices are used to further close the container, particularly by means of a sealing element in the form of a rolled-up cap, for sealing the container. The mushroom-shaped cap is arranged, in particular, by means of a first sealing device, and the rolled-up cap is arranged by means of a second sealing device. The system may include a rolling station located downstream in the transport direction for rolling the rolled-up cap.

[0085] In a preferred embodiment of the invention, the system includes additional sealing devices and a tipping station at the transport mechanism, located upstream of the filling station in the transport direction. The first container opening can be closed by means of the sealing elements of the additional sealing devices, followed by tipping the container by means of the tipping station, and then filling the container by means of the filling station. This type of implementation is used, for example, for sealing cartridges on both sides. Upstream of the filling station, the cartridge can be sealed at the container opening and then tipped. After filling, the cartridge is sealed at the openings of other containers.

[0086] Feasibility schemes for using the specified components have been explored. The parts of the sealing device and / or system preferably possess the characteristic that they can encompass a variety of different specifications. In this context, "specification" is particularly understood to mean different types of containers that differ from one another in their container type (vial, syringe, or cartridge) and / or in their container characteristics (e.g., especially size). This demonstrates the comprehensiveness of the invention.

[0087] The sealing device and / or system preferably includes multiple sets of sized components, each with corresponding sized parts. The most suitable sized component can be selected according to the specific requirements. In this way, the sealing device and / or system can be fully adapted to the intended use. Attached Figure Description

[0088] The following description of preferred embodiments of the present invention illustrates the invention in more detail by way of the accompanying drawings. In the drawings:

[0089] Figure 1 A schematic top view of a system for processing containers according to the present invention is shown;

[0090] Figure 1A A schematic diagram of a pharmaceutical container and its closure element is shown;

[0091] Figure 2 It shows Figure 1 A magnified detail view of part A in the image;

[0092] Figure 3 It shows Figure 1 A magnified detail view of part B in the image;

[0093] Figure 4 The system is shown in a 3D diagram. Figure 2 A partial view taken in the direction of observation indicated by arrow "4" in the figure, showing the sealing device according to the invention;

[0094] Figure 5 Shown in 3D Figure 4 An enlarged partial view of the sealing device in the image;

[0095] Figure 6 A schematic diagram of the sealing element and supply track of the sealing device is shown;

[0096] Figure 7 It shows Figure 4 A top view of the receiving body of the sealing device;

[0097] Figure 8 It shows along Figure 7 Sectional view of line 8-8 in the middle;

[0098] Figure 9 It shows Figure 8 An enlarged partial view of a sealing device, wherein the sealing element is guided to the retainer by means of a receiving body and pushed into the retainer by means of a pushing element;

[0099] Figure 10 A side view of the sealing device is shown before the retainer and push-in element are lowered toward the container to be sealed;

[0100] Figures 11 to 13 It shows a closed container ( Figure 11 ), enhance the maintenance body ( Figure 12 ) and subsequently, the push-in element ( Figure 13 ) Detail view at time;

[0101] Figure 14 The system is shown in a 3D diagram. Figure 3 A partial view taken in the direction of observation indicated by arrow "14" in the figure, showing the sealing device according to the invention;

[0102] Figure 15 It shows Figure 14 A perspective view of the receiving body of the sealing device and the sealing element held therein;

[0103] Figure 16 and Figure 17 It shows Figure 14 A detailed diagram of the sealing device, showing the sealing element held in place by a negative pressure pickup element before being lowered onto the container. Figure 16 ), or a closing element placed on the container ( Figure 17 );

[0104] Figure 18 With Figure 4 A perspective view of the sealing device according to the present invention is shown in a corresponding manner, through which a piston-shaped plug can be arranged at the container;

[0105] Figure 19 A schematic diagram shows a piston-shaped plug arranged in a container opening via a retainer;

[0106] Figure 20A schematic side view of the sealing device according to the present invention is shown;

[0107] Figure 21 It shows the relationship with Figure 20 Corresponding illustrations for closing other types of containers; and

[0108] Figure 22 A schematic top view of a system according to the invention, having two sealing devices according to the invention, is shown. Detailed Implementation

[0109] Preferred embodiments of the system for processing pharmaceutical containers according to the invention and preferred embodiments of the sealing device for sealing containers with sealing elements according to the invention are described below. The same reference numerals are used for the same or identical features and components, wherein the first system according to the invention and the first sealing device according to the invention are discussed first. The related descriptions also apply to the various embodiments, and thus only the main differences are described below.

[0110] Figure 1 A schematic top view illustrates an overview of a system for processing a medical container 12 according to the present invention (the system is labeled with reference numeral 10). Figure 1A The pharmaceutical container is schematically shown. The container may be, for example, a vial, syringe, or cartridge. First, the invention will be described using a vial-shaped container 12 as an example for sealing.

[0111] System 10 includes Figure 2 The first section 14 is shown in detail view and in Figure 3 The second section 16 is shown in detail view.

[0112] exist Figure 14 and Figure 16 The top view shows the assembly mechanism 18 for sections 14 and 16 respectively. The assembly mechanism 18 is, for example, a frame or base positioned on the floor of a workshop or laboratory. A cleanroom environment can be advantageous.

[0113] As described, the description of the location and orientation relates to the specific and prescribed use of system 10.

[0114] System 10 accordingly includes an isolation mechanism 22 that covers the erection mechanism 18 with a covering element 20. The isolation mechanism 22 can apply a protective and / or purifying atmosphere to the environment covered by the covering element 20 and defined below by the erection mechanism 18. The protective and / or purifying atmosphere includes a protective gas, such as H2O2.

[0115] The covering element 20 may preferably extend to the assembly mechanism via a sidewall.

[0116] For example, the isolation mechanism 22 provides a downward flow of protective gas to apply protective gas to the components of system 10 arranged in the environment. The downward flow allows the action to be applied, especially from above.

[0117] System 10 includes a transport mechanism 24 having a linear transport system 26. The supplied container 12 can be transported along the transport system 26 in the transport direction 28. A filling station 30 is arranged at the transport system 26, which is used to fill the container 12 with a drug, such as a liquid.

[0118] An advantageous embodiment of the sealing device according to the invention is arranged downstream of the filling station 30 in the transport direction 28, and is generally marked with reference numeral 32.

[0119] In order to seal the container 12, a sealing element 34, in this example a mushroom-shaped plug 36, is applied at the sealing device 32 as described below to engage with the container opening and abut against the edge of the container 12.

[0120] The sealed container 12 is transferred from the first section 14 to the second section 16 via the transport mechanism 24 and the transport wheel 38. The second section 16 also includes a transport system 26, in which the now sealed container 12 can be transported along the transport direction 28.

[0121] An advantageous embodiment of the sealing device according to the invention is arranged at the transport system 28, generally indicated by reference numeral 42. The sealing device 42 allows a sealing element 34, in the form of a rolled-up cap 44, to be placed on a mushroom-shaped plug 36 to completely seal the container 12.

[0122] See in particular the following text. Figure 2 as well as Figures 5 to 13 The sealing device 32 is described, especially with reference to Figure 3 as well as Figures 14 to 17 The sealing device 42 is described.

[0123] Firstly, especially from Figure 2 As can be clearly seen, the sealing device 32 includes a supply unit 45 for sealing elements 34. A conveying tank 46 is provided for storing the sealing elements 34. The sealing elements 34 are supplied to multiple supply tracks 48 of the supply unit 45. The supply tracks 48 are filled from the conveying tank 46 via a sorting mechanism 50.

[0124] The characteristic of the sorting mechanism 50 is that the sealing elements 34 are fed into the supply track 48 one by one and inverted. "Inverted" here should be understood in particular as the first side 52 of the sealing element 34 pointing upwards, while the second side 54 of the sealing element 34 points downwards. The first side 52 is in the closed container 12 ( Figure 1AThe first side is the side facing the inside of the container 56. The second side 54 is the side facing away from the inside of the container 56 in the closed container 12.

[0125] like Figure 1A As further illustrated in the schematic diagram, container 12 has a container opening 58 surrounded by an edge 60. Depending on the type of container 12, the edge 60 may be designed as a flange.

[0126] The sorting mechanism 50 is designed such that enclosing elements 34 in the supply track 48 that are not oriented upwards on the first side 52 (i.e., particularly on the second side 54) and are not oriented upwards as desired fall back into the conveyor tank 46. Only those enclosing elements 34 with the first side 52 pointing upwards reach the supply track 48. Figures 4 to 6 ).

[0127] As shown in the figure, the sealing device 32 is configured to simultaneously seal multiple containers 12. Related parts of the sealing device 32, such as the supply track 48, the receiving portion of the receiving body, the receiving portion of the retaining body, and the pushing element, are all designed to be identical. To simplify the discussion below, only one of these parts will be discussed representatively here. It goes without saying that the related descriptions also apply to the other parts accordingly.

[0128] The supply tracks 48 are oriented parallel to each other and define a supply direction 62 in which the sealing elements 34 are supplied one by one. The supply direction 62 forms an angle with the transport direction 28. In this embodiment, the angle is approximately 45°. This allows for a compact configuration in the system 10. The assembly mechanism 18 is substantially L-shaped in top view. The transport system 26 extends along one side of the L in the transport direction 28. The sealing device 32 is arranged in the area where the two sides of the L intersect.

[0129] The supply track 48 is formed in a groove shape and includes a bottom 64, on which the sealing element 34 rests flat with its second side 54. The sealing element 34 is arranged transversely to the supply direction 62 between the walls 66 of the supply track 48 in a form-fitting manner. In particular, during transport in the supply track 48, the sealing element 34 does not come into contact with the supply track 48, the sealing device 32, or other parts of the system 10 at its first side 52.

[0130] In this way, the sealing element 34 can be reliably supplied with a flow of protective gas from above at the first side 52 during transport. For example, any particles may be removed by purging. Alternatively or additionally, contaminants may be removed and the sealing element 34 may be sterilized, for example, at the first side 52.

[0131] In this case, the supply track 48 extends substantially horizontally and, in particular, parallel to the plane of the transport system 24.

[0132] The sealing element 34 moves in the supply track 48 via the sorting mechanism 50, wherein subsequent sealing elements 34 push the sealing elements 34 arranged in front of them.

[0133] The supply track 48 has an end 68 ( Figure 5 , Figure 7 and Figure 8 The sealing device 32 includes a push-in element 70 at its end 68, which in this case is designed as a pressing element for closing element 34. The push-in element 70 is formed as a pusher and is arranged below the end 68 of the supply track 48. The push-in element 70 can be raised and lowered periodically by means of a drive.

[0134] As previously stated, all components of system 10, and thus the operation of system 10, are controlled and / or regulated by control mechanism 72.

[0135] The sealing device 32 includes a flipping mechanism 74, which includes a receiving body 76 for closing the element 34. The flipping mechanism 74 is designed as a pivoting mechanism 78, wherein the receiving body 76 is pivotable about a rotation axis 80. The pivot axis 80 is horizontally oriented in this embodiment.

[0136] The tilting mechanism 74 includes additional pivoting mechanisms 82 for pivoting about a pivot axis 84. The pivot axis 84 is vertically oriented in this case. "Vertical" here can be understood in particular as "in the direction of gravity." Reference numeral 85 indicates the direction of gravity.

[0137] The receiving body 76 can pivot about a pivot axis 78 relative to the holding member 86 of the flipping mechanism 74. The holding member 86 itself can pivot about a pivot axis 84 relative to the base member 88 by means of a pivot mechanism 82. The base member 88 is positioned on and held in place on the erection mechanism 18. Figure 4 ).

[0138] The receiving body 76 includes a receiving portion 90 for closing the element 34. The receiving portion 90 is formed at a receiving section 92 and is connected to a rod section 96 of the receiving body 76 oriented along the pivot axis 80 via a connecting section 94. In this embodiment, a plurality of receiving portions 90 are formed side-by-side in a row in the laterally direction at the receiving section 92. The pivot axis 80 extends parallel to the receiving portions 90.

[0139] The receiving portion 90 is formed as a through-hole 98 in the receiving section 92. Within the region of the receiving portion 90, the receiving section 92 is substantially sleeve-shaped. In the insertion direction of the closing element 34, the receiving portion 90 includes an inlet opening 100. The inlet opening 100 is opposite to the outlet opening 102.

[0140] The receiving part 90 includes an edge 104. The edge 104 is interrupted at the perforation 106.

[0141] The receiving body 76 can occupy an initial position when pivoting about the pivot axis 78. In the initial position, the receiving part 90 is arranged above the end 68 of the supply track 48. Figure 8 Perforation 106 points in the direction of supply track 48.

[0142] The closing element 34 can be pushed into, and in particular pressed into, the receiving portion 90 by means of the pushing element 70. The size of the receiving portion 90 is set such that the closing element 34 is held in the receiving portion 90 by form-fitting against the edge 104 via the outer edge. A press fit is formed here.

[0143] In order to push it into the receiving part 90, the pushing element 70 applies a pushing force to the closing element 34 at the second side 54. In particular, the first side 52 does not contact the receiving body 76 and can continue to be applied from above with protective gas.

[0144] Before activating the push-in element 70, the locking mechanism 108 at the supply track 48 can be activated. Figure 5 The locking mechanism 108 includes a locking member 110. The locking member 110 is movable laterally to the supply track 48. If a closing element 34 has reached the end 68, the locking member 110 is moved to block other closing elements 34 from entering the supply track 48. Figure 5 The corresponding next closing element, indicated by reference numeral 112 in the accompanying drawings, is pushed laterally out of the supply track 48. After the receiving body 76 pivots, the locking member 110 is again pushed laterally across the supply track 48, and the closing element 112 reaches the end 68 under the push of the subsequent closing element 34.

[0145] The receiving body 76, together with the closing element 34, pivots from the initial position to the end position. In this case, it pivots 180° about the pivot axis 80. In this way, the receiving body 76 is flipped so that the first side 52 points downward and the second side 54 points upward.

[0146] In its initial position, the receiver 76 with the closure element 34 is located away from the container. By pivoting about the pivot axis 84, the receiver 76 moves from the position away from the container to the position closer to the container. Figure 4 and Figure 9 The distance between the receiving body 76 and the container 12 when it is close to the container is less than the distance between it and the container when it is far away from the container.

[0147] To achieve a short cycle time, it is beneficial to simultaneously perform the pivoting of the receiving body 76 from the initial position to the end position and from the position away from the container to the position closer to the container.

[0148] In this embodiment, no change in the height of the receiving body 76 occurs when pivoting about the pivot axis 80 to the end position. To accommodate different sizes of container 12, the flipping mechanism 74 may include a lifting mechanism to change the height of the receiving body 76, for example, during modification. For instance, the retaining member 86 may be height-adjustable relative to the base member 88.

[0149] In this example, the pivot angle is approximately 45° when pivoting around pivot axis 84 to a position close to the container. This pivot angle corresponds to the angle between the transport direction and the supply direction 62.

[0150] In this case, the end position of the receiver 76 is the same as its position near the container. The above embodiment shows that, for example, it can be specified that pivoting can only occur about a single pivot axis 80, so that the closure element 34 flips and the receiver is moved into the end position.

[0151] In particular, it can be clearly seen from the figure that when the receiving body 76 occupies the end position, the first side 52 of the closing element 34 points in the direction of the inner side 56 of the container in its placement posture.

[0152] In the sealing device 32, the sealing element 34 is positioned in a placement posture, spaced apart from and above the container 12. To close the container opening 58, the sealing element 34 needs to be lowered. Advantageously, the sealing element 34 can be lowered linearly and pressed into the container opening 58.

[0153] The sealing device 32 includes a retainer 114. The retainer 114 includes a plurality of receiving portions 116 arranged at a common bearing section 118. The bearing section 118 is held at an adjusting mechanism 120, which in this embodiment takes the form of a lifting mechanism 122 (pushing mechanism). In this way, the bearing section 118 can be lowered and raised in a particularly linear manner.

[0154] Receiving portion 116 corresponds to and is preferably formed identically to receiving portion 90. For example, receiving portion 116 includes a through hole 124 having an inlet opening 126 and an outlet opening 128 for the closing element 34. Receiving portion 116 includes an edge 130. The dimensions of receiving portion 116 are set such that the closing element 34 can be received therein in a form-fit manner as in receiving portion 90 and held at edge 130 via the outer edge, particularly by press fit.

[0155] The sealing device 32 also includes a pushing element 132, which allows the sealing element 34 to be pushed into the receiving portion 90, and in particular pressed into the receiving portion 116. Accordingly, the pushing element 132 is a pressing element.

[0156] The push-in element 132 is held together at the bearing section 134. The bearing section 134 can be moved linearly, and especially in the height direction, by means of the adjustment mechanism 136, which is designed as a lifting mechanism 138 (pushing mechanism) in this embodiment. Here, the push-in element 132 can be lowered in the direction of the container 12, or conversely, the push-in element can be raised again.

[0157] The adjusting mechanisms 120 and 136, designed as lifting mechanisms 122 and 138, are preferably movable independently of each other. As described below, this may be advantageous, for example, for the modification of sealing devices 32 for sealing various containers 12. In particular, the two lifting mechanisms 122 and 138 can also move synchronously with each other.

[0158] Starting from the placement position, when the receiving body 76 is in the end position, a pushing force can be applied to the closing element 34 at the second side 54 by means of the pushing element 132, which moves together with the lifting mechanism 138. Here, the closing element 34 is pushed out from the exit opening 102 and into the receiving part 116 through the entry opening 126. Thus, the closing element 34 is held at the retainer 114. Figure 9 ).

[0159] Subsequently, the receiver 76 can pivot again about pivot axes 80, 84 to return to its initial position and away from the container. The perforation 98 proves advantageous here, allowing the receiver 76 to pivot through the push-in element 132.

[0160] Subsequently, the retainer 114 and the pusher element 132 are lowered synchronously toward the container 12. Figure 10 (See arrow 140) until the closing element 34 engages with the container opening 58.

[0161] The push-in element 132 acts as a pressing element on the second side 54, and presses the closing element 34 into the container opening 58 to close the container 12. Figure 11 ).

[0162] Sealing device 32 includes Figure 11 The support 142 is schematically shown in the diagram. The support 142 applies a supporting force to the container 12 in opposition to the pressing force of the pushing element 132, so as to achieve a secure placement of the closing element 34 in the container opening 58.

[0163] Subsequently, the retaining body 114 is first lifted using the lifting mechanism 122. Figure 12 (See arrow 144). Here, you can continue pressing the closing element 34. Next, the pushing element 132 is also lifted using the lifting mechanism 138. Figure 13 Arrow 146 in the middle.

[0164] As mentioned above, multiple sealing elements 34 can be processed simultaneously to seal multiple containers 12. In this embodiment, six containers 12 can be sealed simultaneously using the corresponding sealing elements 34.

[0165] For example, especially from Figure 2 It is understood that the sealing device 32 includes an inspection mechanism 148. For example, the inspection mechanism 148 is designed to be optical and inspects the presence of the sealing element 34 at the corresponding container 12. If the sealing element 34 is missing, the transport system 26 moves back in the opposite transport direction 28 and seals the corresponding container 12 using the sealing element 34. The sealing element 34 can be selected for the container 12 to be sealed by selectively activating the corresponding push-in element 70 at the end 68 of the appropriate supply track 48. Accordingly, other push-in elements 70 remain inactive during this period. Thus, any integer number of sealing elements 34 from 1 to (in this example) 6 can be transferred from the receiving posture to the placement posture by means of the receiving body 76.

[0166] Preferably, alternatively or additionally, it may be specified that the presence of the closure element 34 on the receiving portion 90 of the receiving body 76 is checked by an inspection agency, for example, optically. For example, the inspection may also be performed before or during the flipping or pivoting of the receiving body 76, but especially before the closure element 34 is lowered onto the container.

[0167] This type of testing institution Figure 2 It is schematically shown and labeled with reference numeral 149.

[0168] If the closing element 34 is missing in the receiving section, it can wait as the receiving body 76 moves, or it can be moved back into the receiving position. Preferably, the push-in element 70 corresponding to an unoccupied receiving section 90 can be selectively identified so that the missing closing element 34 can be pressed into the receiving section 90. In this case, the other push-in elements 70 remain idle.

[0169] As previously stated, it can be specified that only one or more receiving portions 90 are selectively occupied by the corresponding closing element 34.

[0170] As from Figure 3 It is understood that system 10 includes other inspection agencies 150. Inspection agency 150 is arranged upstream of sealing device 42 in the second section 16 in the transport direction 28.

[0171] In this example, the inspection mechanism 150 is also designed to be optical and is used to inspect the correct placement of the sealing element 34 at the container 12. If the inspection result is negative, the corresponding container 12 is discharged from the system 10 after the transport system 26.

[0172] In the following text, refer to Figure 3 as well as Figures 14 to 17 The sealing device 42 is discussed, which allows the rolled-edge cap 44 to be placed on the mushroom-shaped plug 36.

[0173] In the sealing device 42, the receiving body 76 includes a base, and the receiving section 92 is held in the base. The corresponding receiving portion 90 includes a recess 154 formed in the receiving section 92. The contour of the recess 154 is adapted to the contour of the closing element 34. Thus, the edge 104 can be flush against the outer edge of the closing element 34.

[0174] The sealing device 42 includes, particularly at edge 104, a suction opening 156 for a suction conduit 158. The suction conduit 158 ​​is guided through the receiving section 92 and the substrate 152. Multiple suction conduits 158 may converge in the direction of the suction flow.

[0175] The sealing device 42 includes a negative pressure mechanism 160. The negative pressure mechanism 160 applies negative pressure to the suction line 158 and thereby to the suction opening 156.

[0176] If the receiver 76 corresponds to Figure 5 If the diagram shows the sealing element 34 in its initial position within the sealing device 32, then the sealing element 34 can be held in the receiving portion 90 and assume a receiving posture by means of negative pressure. As described above, pushing can be achieved by means of the pushing element 70.

[0177] Subsequently, the receiver 76 was moved to the end position and the position close to the container. Figure 14 The closed element 34 occupies the placement position.

[0178] The sealing device 42 also includes a corresponding pickup element 162 for picking up the sealing element 34. The pickup element 162 is a negative pressure pickup element, to which the suction line 164 is connected. The pickup element 162 may also be referred to as a suction pusher.

[0179] A negative pressure mechanism 166 is provided to apply negative pressure to the suction line 164 and the pickup element 162.

[0180] This enables the closure element 34 to be picked up using the pickup element 162. The closure element 34 can be removed from the receiving part 90 by disabling the negative pressure mechanism 160. For this purpose, for example, the adjustment mechanism 168, which is designed as a lifting mechanism 170 (pushing mechanism), can be activated to raise the pickup element 162. Subsequently, in particular, the receiving body 76 is pivoted back to its initial position.

[0181] Pick-up element 162, together with closure element 34 held therein, is lifted by means of lifting mechanism 170 in the direction toward container 12 having mushroom-shaped plug 36 arranged therein. Figure 16Arrow 172 in the middle is lowered. The closing element 34, in the form of a rolled-edge cap 44, is placed on the mushroom-shaped plug 36, and then the negative pressure mechanism 166 is deactivated in order to disengage from the pickup element 162. For example, the pickup element 162 can be raised again by means of the lifting mechanism 170.

[0182] It can be specified that the crimped cap 44 is pressed onto the container 12 having the mushroom-shaped stopper 36. Alternatively, the crimped cap 44 can be placed loosely.

[0183] The sealing device 42 includes a crimping station 174 located downstream in the transport direction 28 for crimping the crimped cap 44.

[0184] Figure 18 An advantageous embodiment of the sealing device according to the invention, labeled with reference numeral 176, is shown. This illustration corresponds to... Figure 4 The illustration.

[0185] The sealing device 176 is used to seal the container 12 by means of a sealing element 34 in the form of a piston-shaped plug 178. For example, the container 12 may be a syringe or a cartridge.

[0186] For example, especially from Figure 18 and Figure 19 It is understood that the sealing device 176 also includes a retainer 114. The retainer 114 includes a sleeve 180 associated with the corresponding sealing element 34. The sleeve 180 is sized so that it can engage with the container opening 58 in a lowered state without contacting the edge 60.

[0187] Sleeve 180 forms a receiving portion 116 for closing element 34. Sleeve 180 is held at the bearing section 118.

[0188] As described above, the push-in element 132 pushes the closing element 34 from the receiving body 76 into the sleeve 180, and here in particular serves as a pressing element for applying action to the second side 54.

[0189] After lowering the sleeve 180 and the pusher element 132, the piston-shaped plug 178 is positioned within the container opening 58. The pusher element 132 applies a downward limiting force to the second side 54 and acts as a clamp for the piston-shaped plug 178. Figure 19 (Arrow 181 in the image).

[0190] The sleeve 180 is lifted using the lifting mechanism 122. The piston-shaped plug 178 reaches the container opening 58 through the outlet opening 128, expands, and abuts against the edge 60.

[0191] When using the piston-shaped plug 178 for sealing, this method avoids the pressure applied to the container 12. It also eliminates the need for the support body 142.

[0192] Preferably, sealing devices 32 and 176 can be converted to each other through modification. For example, the receiving body 76, the retaining body 114, the pushing element 132, and / or the carrying section 134 can be implemented as standard components. The adjusting mechanisms 120 and 136 can be adapted to the container 12 to be processed for placement and movement by operating them independently. In a preferred embodiment, instead of two complete sealing devices in system 10, a modifiable sealing device can be provided, which is implemented as sealing device 32 or sealing device 176 depending on the container 12.

[0193] Figure 20 and Figure 21 An advantageous embodiment of the sealing device according to the invention, marked with reference numeral 182, is shown.

[0194] In the sealing device 182, the sealing element 34 is transferred to a placement posture in its end position by means of the receiving body 76, in which the sealing element 34 is positioned at the container 12 and, for example, abuts against its edge 60.

[0195] A pressing mechanism 184 with a pressing element 186 is provided to press the sealing element 34 into the container opening 58. In the example of the sealing device 182, the pressing element 186 is a pivoting element that can pivot about a pivot axis 188 onto the sealing element 34 by means of an actuator. In an alternative design, the pressing element 186 may be, for example, a pushing element that is pushed onto the sealing element 34 from above.

[0196] The lifting mechanism for the sealing element can be eliminated, thereby eliminating the need for lifting and moving during operation. Therefore, for example, it can prevent contamination caused by wear. Thus, the sealing device 182 is particularly suitable for use with toxic or highly sensitive materials.

[0197] Figure 21 It shows the use of closure and Figure 20 The sealing device 182 of the different container 12. Container 12 here is larger than Figure 20 The container in the example.

[0198] Height compensation can be achieved by having the sealing device 182 with the previously mentioned lifting mechanism 190 used during modification. Alternatively or supplementarily, the pressing element 186 may be provided with the lifting mechanism 192.

[0199] Figure 22 A top view shows an advantageous design of the system according to the invention, labeled with reference numeral 200. This illustration is similar to that according to… Figure 2 and Figure 3 The illustration.

[0200] System 200 is used, for example, to process containers 12 in the form of cartridges. A filling station 30 is provided here, as in system 10, followed by a sealing device. In this case, a sealing device 176 for arranging a piston-shaped plug 178 is used in particular.

[0201] Another sealing device is provided upstream of the filling station 30 in the transport direction 28. It is designed, for example, to be the same as the sealing device 176.

[0202] When handling the cartridge, one side of the container opening 58 is first sealed with a piston-shaped plug 178 using a first sealing device in the transport direction 28. Next in the transport direction 28 is a turning station 202, which is used to turn the cartridge over. After filling, the other container openings 58 are sealed with other piston-shaped plugs 178.

[0203] Alternatively, a combined rolled-edge cap can be used to seal the cartridge during the sealing process. This can be done in the sealing device before or after the filling station 30, referring to transport direction 28.

[0204] List of reference numerals

[0205] 10 System

[0206] 12 containers

[0207] 14 First Section

[0208] 16 Second Section

[0209] 18. Construction organization

[0210] 20 Covering elements

[0211] 22. Quarantine facilities

[0212] 24 Transportation agencies

[0213] 26. Transportation System

[0214] 28. Transportation Direction

[0215] 30 filling stations

[0216] 32 Sealing device

[0217] 34 Enclosed Components

[0218] 36 Mushroom-shaped plug

[0219] 38 transport ships

[0220] 42 Sealing device

[0221] 44 Rolled Edge Cap

[0222] 45 Supply Units

[0223] 45 Supply Units

[0224] 46 Conveying Tank

[0225] 48 Supply Tracks

[0226] 50 sorting agencies

[0227] 52 First side

[0228] 54 Second side

[0229] 56. Inside of the container

[0230] 58 Container opening

[0231] 60 Edge

[0232] 62 Supply Direction

[0233] 64 Bottom

[0234] 66 Wall section

[0235] 68 end

[0236] 70 Push-in element

[0237] 72 Control mechanism

[0238] 74 Tilting Mechanism

[0239] 76 Recipients

[0240] 78 Pivoting mechanism

[0241] 80 Pivot axis

[0242] 82 Pivoting Mechanism

[0243] 84 Pivot axis

[0244] 85. Gravity direction

[0245] 86 Retaining components

[0246] 88 Basic Components

[0247] 90 Reception Department

[0248] 92 Acceptance Section

[0249] 94 Connecting Section

[0250] 96 pole section

[0251] 98 perforations

[0252] 100 Introduction opening

[0253] 102 Leading out the opening

[0254] 104 Edge

[0255] 106 perforations

[0256] 108 Locking device

[0257] 110 Locking component

[0258] 112 Enclosed element

[0259] 114 Maintain body

[0260] 116 Reception Department

[0261] 118 Bearing Section

[0262] 120 Adjustment Agency

[0263] 122 Lifting Mechanism

[0264] 124 perforations

[0265] 126. Introduction of opening

[0266] 128. Opening

[0267] 130 Edge

[0268] 132 Push-in element

[0269] 134 Bearing Section

[0270] 136 Adjustment Mechanism

[0271] 138 Lifting Mechanism

[0272] 140 arrows

[0273] 142 Support

[0274] 144 arrows

[0275] 146 arrows

[0276] 148 Inspection Agency

[0277] 149 Inspection Agency

[0278] 150 Inspection Agencies

[0279] 152 matrix

[0280] 154 recess

[0281] 156 Suction opening

[0282] 158 Suction Pipeline

[0283] 160 Negative Pressure Mechanism

[0284] 162 Pick-up Components

[0285] 164 Suction Pipeline

[0286] 166 Negative Pressure Piping

[0287] 168 Adjustment Mechanism

[0288] 170 Lifting Mechanism

[0289] 172 arrows

[0290] 174 Curled-edge station

[0291] 176 Sealing device

[0292] 178 Piston-shaped plug

[0293] 180 sleeve

[0294] 181 arrows

[0295] 182 Sealing device

[0296] 184 Pressing Mechanism

[0297] 186 Pressing element

[0298] 188 Pivot axis

[0299] 190 Lifting Mechanism

[0300] 192 Lifting Mechanism

[0301] 200 system

[0302] 202 Flip Station.

Claims

1. A sealing device for sealing a medical container (12) with a sealing element (34), wherein the sealing element (34) includes a first side (52) and a second side (54), and the first side (52) faces the inner side (56) of the container (12) sealed with the sealing element (34), while the second side (54) faces away from the inner side (56) of the container, the sealing device (32; 42; 176; 182) comprising: A supply unit (45) having a supply track (48) in which closure elements (34) can be supplied one by one and in a manner that at least partially does not contact the first side (52); at least one receiving body (76) having a receiving portion (90) for the closure element (34), wherein the closure element (34) can be transferred from the supply track (48) to a receiving posture into the receiving portion (90); A flipping mechanism (74) for flipping at least one of the receiving bodies (76) from an initial position to an end position and for transferring the closure element (34) from the receiving posture to a placement posture, in which the closure element (34) is positioned at the container (12) with the first side (52) pointing toward the inside of the container (56) or is positioned at a distance from the container (12). At least one retainer (114) and at least one first push-in element (132), wherein the closing element (34) can be pushed from the receiving portion (90) of at least one of the receiving bodies (76) into the corresponding receiving portion (116) of at least one of the retainers (114) at the end position of the receiving body by means of at least one first push-in element (132), wherein a pushing force can be applied to the second side (54) of the closing element (34) in a direction toward the receiving portion (116) of at least one of the retainers (114) by means of at least one first push-in element (132); and An adjustment mechanism (120) for moving at least one retainer (114) receiving the closure element (34) toward the container opening (58) of the container (12), and another adjustment mechanism (136) for moving at least one of the first push-in elements (132) toward the container opening (58) of the container (12), wherein the adjustment mechanism (120) and the other adjustment mechanism (136) are capable of moving independently of each other. The sealing device (32; 176) is adaptable to different types of containers (12) to be processed, wherein at least one of the receiving bodies (76), at least one of the retaining bodies (114), and at least one of the first pushing elements (132) are specification components adapted to different types of containers. At least one of the receiving bodies (76), at least one of the retaining bodies (114), and at least one of the first pushing elements (132) include receiving bodies (76), retaining bodies (114), and first pushing elements (132) for handling a closing element (34) in the form of a mushroom plug (36). And at least one of the receiving bodies (76), at least one of the retaining bodies (114) and at least one of the first pushing elements (132) include receiving bodies (76), retaining bodies (114) and first pushing elements (132) for handling a closed element (34) in the form of a piston plug (178).

2. The sealing device according to claim 1, characterized in that, In the supply track, the enclosing element (34) can be supplied in a manner that completely avoids contact with the first side (52).

3. The sealing device according to claim 1, characterized in that, Applicable to at least one of the following characteristics: - In the supply track (48), the first side (52) of the closure element (34) points upward, wherein the supply track (48) is open; - In the supply track (48), the closure element (34) is laid flat on the bottom (64) of the supply track (48) with the second side (54); - In the placement posture, the closure element (34) is arranged on the upper side of the container (12) or above the container (12).

4. The sealing device according to claim 3, characterized in that, The supply track (48) is open on the upper side.

5. The sealing device according to claim 3, characterized in that, In the placement posture, the sealing element (34) is arranged in a straight line above the container (12) along the direction of gravity (85).

6. The sealing device according to claim 4, characterized in that, In the placement posture, the sealing element (34) is arranged in a straight line above the container (12) along the direction of gravity (85).

7. The sealing device according to any one of claims 1 to 6, characterized in that, The sealing device (32; 42; 176; 182) includes a second pushing element (70) by which the closing element (34) disposed at the end (68) of the supply track (48) can be pushed into the receiving part (90) in the initial position of at least one of the receiving bodies (76).

8. The sealing device according to claim 7, characterized in that, A pushing force is applied to the second side (54) of the closing element (34) by the second pushing element (70) in the direction toward the receiving part (90).

9. The sealing device according to any one of claims 1 to 6, characterized in that, Applicable to at least one of the following characteristics: - The closing element (34) is held in the receiving portion (90) by force engagement and / or form engagement; - The outer edge of the closing element (34) at least partially abuts against the edge (104) of the receiving part (90); - The receiving part (90) includes an inlet opening (100) for the closing element (34) and an outlet opening (102) opposite to the inlet opening, wherein the closing element (34) can move into the receiving part (90) through the inlet opening (100) and move out of the receiving part (90) through the outlet opening (102). - The receiving part (90) is sleeve-shaped and includes lateral perforations (98).

10. The sealing device according to claim 9, characterized in that, The perforation in the initial position of the receiving body (76) points in the direction of the supply track (48).

11. The sealing device according to any one of claims 1 to 6, characterized in that, The receiving body (76) includes a suction tube (158) having a suction opening (156) arranged at the edge (104) of the receiving portion (90), and the sealing device (32; 42; 176; 182) includes a negative pressure mechanism (160) for applying negative pressure to the suction tube (158), wherein the sealing element (34) is held in the receiving portion (90) by means of negative pressure.

12. The sealing device according to any one of claims 1 to 6, characterized in that, The flipping mechanism (74) is a pivoting mechanism (78) or includes the pivoting mechanism, and the receiving body (76) is pivotable about a pivot axis (80) via the pivoting mechanism to transfer from the initial position to the end position.

13. The sealing device according to claim 12, characterized in that, The pivot angle for pivoting from the initial position to the end position is greater than 90°, and / or the height of the closure element (34) is the same or substantially the same in the receiving posture and the placement posture.

14. The sealing device according to claim 13, characterized in that, The pivot angle for pivoting from the initial position to the end position is greater than 135°, and / or the height of the closure element (34) along the direction of gravity (85) is the same or substantially the same in the receiving posture and the placement posture.

15. The sealing device according to claim 14, characterized in that, The pivot angle for pivoting from the initial position to the end position is 180° or substantially 180°, and / or the height of the closure element (34) along the direction of gravity (85) is the same or substantially the same in the receiving posture and the placement posture.

16. The sealing device according to any one of claims 1 to 6, characterized in that, The supply track (48) defines a supply direction (62) for the sealing element (34) and is provided with a transport mechanism (24) for the container (12), by means of which the container can be transported in a transport direction (28) toward the sealing device (32; 42; 176; 182), wherein the angle between the supply direction (62) and the transport direction (28) is less than 90°.

17. The sealing device according to claim 16, characterized in that, The angle between the supply direction (62) and the transport direction (28) is less than 70°.

18. The sealing device according to claim 17, characterized in that, The angle between the supply direction (62) and the transport direction (28) is 40° to 60°.

19. The sealing device according to any one of claims 1 to 6, characterized in that, The flipping mechanism (74) includes or constitutes a pivoting mechanism (82) for pivoting the receiving body (76) about a pivot axis (84) and moving the receiving body (76) from a position away from the container to a position near the container, wherein the distance between the receiving body (76) and the container (12) in the position near the container is less than the distance between the receiving body and the container in the position away from the container.

20. The sealing device according to claim 19, characterized in that, The pivot axis (84) is oriented vertically.

21. The sealing device according to claim 19, characterized in that, During the pivoting of the flipping mechanism (74) from the position away from the container to the position near the container, the receiving body (76) can be transferred from the initial position to the end position.

22. The sealing device according to claim 20, characterized in that, During the pivoting of the flipping mechanism (74) from the position away from the container to the position near the container, the receiving body (76) can be transferred from the initial position to the end position.

23. The sealing device according to any one of claims 1 to 6, characterized in that, The sealing device (32; 42; 176; 182) includes a pressing mechanism (184) for pressing the sealing element (34) onto the container (12) or for pressing the sealing element (34) into the container opening (58), and / or the sealing device (32; 42; 176; 182) includes a support (142) for supporting the container (12) with a force opposite to the pressing force of the pressing mechanism (184).

24. The sealing device according to claim 23, characterized in that, The container (12) stands upright on the support (142) at least during the pressing of the closure element (34).

25. The sealing device according to any one of claims 1 to 6, characterized in that, The sealing element (34) rests against the container opening (58) in the placement posture, and the sealing device (32; 42; 176; 182) includes a pressing mechanism (184) having a pressing element (186) for pressing the sealing element (34) into the container opening (58) or onto the container (12) and applying a pressing force to the second side (54).

26. The sealing device according to any one of claims 1 to 6, characterized in that, Applicable to at least one of the following characteristics: - The closing element (34) is held in the receiving portion (116) of at least one of the retainers (114) by force engagement and / or form engagement; - The outer edge of the closure element (34) at least partially abuts against the edge (130) of the receiving portion (116) of at least one of the retainers (114); - The receiving portion (116) of at least one of the retainers (114) includes an inlet opening (126) for the closing element (34) and an outlet opening (128) opposite to the inlet opening, wherein the closing element (34) can move through the inlet opening (126) into the receiving portion (116) and through the outlet opening (128) out of the receiving portion (116); - The receiving part (116) is sleeve-shaped and includes lateral perforations.

27. The sealing device according to any one of claims 1 to 6, characterized in that, The retainer (114) for handling the piston-shaped plug (178) is or includes at least one tube or sleeve (180).

28. The sealing device according to claim 27, characterized in that, The size of the retainer (114) is set such that the tube or the sleeve (180) can be introduced into the container (12) without contacting the edge (60) of the container opening (58).

29. The sealing device according to any one of claims 1 to 6, characterized in that, At least one of the adjustment mechanisms (122) and / or the other adjustment mechanisms (136) are configured to push at least one of the retainers (114) and / or at least one of the first push-in elements (132) in the direction toward the container (12).

30. The sealing device according to claim 29, characterized in that, At least one of the adjustment mechanisms (122) and / or the other adjustment mechanisms (136) are configured to linearly push at least one of the retainers (114) and / or at least one of the first push-in elements (132) in the direction toward the container (12).

31. The sealing device according to any one of claims 1 to 6, characterized in that, The closing element (34) can be abutted against the edge (60) of the container opening (58) by means of at least one of the retainers (114), and the closing element (34) can be pressed into the container opening (58) from the receiving portion (116) of at least one of the retainers (114) to close the container (12).

32. The sealing device according to claim 31, characterized in that, At least one of the retainers (114) can be removed from the container (12) by means of the adjustment mechanism (120) and at least one of the first push-in elements (132) can be removed from the container (12) by means of the other adjustment mechanism (136).

33. The sealing device according to claim 32, characterized in that, At least one of the retainers (114) can be removed from the container (12) before at least one of the first push-in elements (132) is pushed.

34. The sealing device according to claim 31, characterized in that, The retainer (114) for handling the piston plug (178) engages together with the receiving closure element (34) into the container opening (58), and the first push-in element (132) for handling the piston plug (178) forms a clamp for applying a limiting force to the closure element (34), and during this time the retainer (114) for handling the piston plug (178) can be removed from the container (12) by means of the adjustment mechanism (120, 136) so that the closure element (34) can be pushed out from the receiving part (90) and retained in the container opening (58).

35. The sealing device according to any one of claims 1 to 6, characterized in that, The sealing device (32; 42; 176; 182) includes at least one inspection mechanism (148) which can check the presence of the sealing element (34) and / or its proper placement in the container (12).

36. The sealing device according to any one of claims 1 to 6, characterized in that, The sealing devices (32; 42; 176; 182) are designed to simultaneously seal multiple containers (12) with corresponding sealing elements (34).

37. A system for processing a medical container (12), comprising: A transport mechanism (24) for transporting the container (12) along at least one transport direction (28); A filling station (30) located at the transport mechanism (24) for filling the drug into the container (12); and A sealing device (32; 42; 176; 182) according to any one of the preceding claims is located downstream of the filling station (30) in the transport direction (28), the sealing device being used to close the container (12) after filling.

38. The system according to claim 37, characterized in that, The system (10) includes: a setup (18), a sealing device (32; 42; 176; 182) for closing the container (12) and the transport mechanism (24) arranged on the setup; and an isolation mechanism (22) covering the sealing device (32; 42; 176; 182) and the transport mechanism (24), the isolation mechanism having a covering element (20) and for providing a protective and / or purifying atmosphere between the covering element (20) and the setup (18).

39. The system according to claim 37 or 38, characterized in that, The system (10) includes additional sealing devices (32; 42; 176; 182) for closing the container (12), the additional sealing devices being located downstream of the originally mentioned sealing devices (32; 42; 176; 182) in the transport direction (28), the additional sealing devices being used to further close the container (12) by means of a sealing element (34) in the form of a rolled cap (44), and the system (10) including a rolled cap station (174) located downstream in the transport direction (28) for rolled cap (44).

40. The system according to claim 39, characterized in that, The container (12) is sealed by a mushroom-shaped plug (36).

41. The system according to claim 37 or 38, characterized in that, The system (10) includes additional sealing devices (32; 42; 176; 182) and a flipping station (202) at the transport mechanism (24) for closing the container (12), the additional sealing devices and the flipping station being located upstream of the filling station (30) in the transport direction (28), wherein the first container opening (58) can be closed by means of the closing element (34) of the additional sealing devices (32; 42; 176; 182), the container (12) is then flipped by means of the flipping station (202), and the container is then filled by means of the filling station (30).

42. The system according to claim 37 or 38, characterized in that, The container is a vial, syringe, or cartridge.

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