一种抗念珠菌Ssa1单克隆抗体及其应用

By developing an anti-Candida Ssa1 monoclonal antibody, the problem of poor efficacy of existing drugs in treating Candida infections has been solved, achieving effective blocking of Candida adhesion and invasion, and exhibiting significant pharmacodynamic activity.

CN116813763BActive Publication Date: 2026-07-17TONGJI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TONGJI UNIV
Filing Date
2023-06-30
Publication Date
2026-07-17

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Abstract

本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体内具有抗白念珠菌感染的药效学活性，对白念珠菌导致的小鼠感染具有保护作用，具有制备成为抗念珠菌感染药物的前景。
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