Imaging device and automated analysis system for multiplex immunoassay analyzers

Abstract

This application relates to the field of medical device technology, and more particularly to an imaging device and automated analysis system for a multiplex immunoassay analyzer. The imaging device includes a first light-emitting module with a first heating element; an imaging module with a second heating element; and a cooling module including a first heat exchange channel and a second heat exchange channel. The first heating element is located on the heat exchange circulation path of the first heat exchange channel, and the second heating element is located on the heat exchange circulation path of the second heat exchange channel. A first guide plate extends from the first air outlet side of the first cold channel of the first heat exchange channel toward the first heating element, and the extension line of the first guide plate is tangent to or separate from the first heating element. The second air outlet of the second cold channel of the second heat exchange channel is disposed toward the second heating element. This ensures the accuracy of the imaging results and improves the cooling efficiency.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to an imaging device and an automated analysis system for a multiplex immunoassay analyzer. Background Technology

[0002] With the development and application of in vitro diagnostic (IVD) medical technology, IVD has become an important auxiliary means of disease diagnosis, and automated diagnostic equipment is increasingly favored by society. Based on the detection principle, automated diagnostic equipment can be divided into nucleic acid detection equipment and protein detection equipment. Protein detection equipment includes chemiluminescence analyzers, enzyme immunoassay analyzers, colloidal gold analyzers, immunochromatographic analyzers, and multiplex immunoassay analyzers. Among them, multiplex immunoassay analyzers use multiplex liquid-phase chip analysis to detect different groups of laser-coded liquid-phase chips. Then, a recognition substance that binds to the target substance in the sample is chemically cross-linked onto the liquid-phase chip. After the target substance in the sample specifically binds to the corresponding recognition substance on the coded surface of the specific liquid-phase chip, a fluorescent labeling substance is added. The location of different coded liquid-phase chips is identified by photographing under a bright field, and the fluorescence signal corresponding to each liquid-phase chip is determined by photographing under a dark field. By converting the fluorescence intensity of the liquid-phase chip into the concentration of the corresponding target substance, qualitative or quantitative results are obtained. The multiplex immunoassay analyzer includes a pretreatment device and an imaging device for detecting the analyte. The imaging device includes a bright-field imaging element and a bright-field light source located in its imaging module, and a dark-field imaging element and a dark-field excitation light source located in its darkroom module.

[0003] However, in existing multiplex immunoassay analyzers, when the imaging device is used continuously for taking pictures, the bright field imaging element and bright field light source in the imaging module are prone to temperature rise due to repeated use. This can easily burn out the components and cause deviations in the imaging results. Therefore, it is necessary to cool them down. However, improper cooling structure can cause water mist or water droplets to appear on the lens of the imaging element, resulting in blurry images and affecting the imaging results. Summary of the Invention

[0004] The purpose of this application is to provide an automatic analysis system for a shooting device and its application, so as to ensure the accuracy of the shooting results of the shooting device and improve the cooling efficiency.

[0005] In a first aspect, this application provides an imaging device for a multiplex immunoassay analyzer, comprising:

[0006] The first light-emitting module includes a first heating element;

[0007] The camera module includes a second heating element;

[0008] A refrigeration module includes a first heat exchange channel and a second heat exchange channel, wherein the first heating element is located on the heat exchange circulation path of the first heat exchange channel, and the second heating element is located on the heat exchange circulation path of the second heat exchange channel.

[0009] The first heat exchange channel includes a first hot flow channel, a first AC channel and a first cold flow channel that are connected in sequence. The first cold flow channel has a first guide plate extending from the first air outlet side toward the first heating part, and the extension line of the first guide plate is tangent to or separate from the first heating part.

[0010] The second heat exchange channel includes a second hot flow channel, a second AC channel, and a second cold flow channel that are connected in sequence, with the second air outlet of the second cold flow channel facing the second heating element.

[0011] Furthermore, the first guide plate is located on the lower side of the first air outlet, the first guide plate is inclined upward, and the angle α formed by the first guide plate and the first AC channel satisfies 70°≤α<90°.

[0012] Furthermore, a second guide plate and a third guide plate are respectively extended from the upper and lower opposite sides of the second air outlet. The second guide plate and the third guide plate are inclined to each other and spaced apart. The included angle β formed by the extension lines of the two plates satisfies 60°≤β<180°.

[0013] Furthermore, the first hot runner is located below the first guide plate.

[0014] The second hot runner is located above the second guide plate;

[0015] The first hot runner and the second hot runner share the same hot runner;

[0016] The first communication channel and the second communication channel are located in the same flow cavity.

[0017] Furthermore, the axis of the same hot runner shared by the first hot runner and the second hot runner is perpendicular to the axis of the same flow cavity where the first AC channel and the second AC channel are located.

[0018] Furthermore, the first air outlet and the second air outlet are provided on one side of the flow cavity, and a first cooling section opposite to the first air outlet and a second cooling section opposite to the second air outlet are provided on the other side of the flow cavity.

[0019] The vertical axial height difference between the upper edge of the first cooling unit and the lower edge of the second cooling unit is the first axial height;

[0020] The distance between the central axis of the first cold runner and the central axis of the second cold runner is greater than half of the first axial height and less than the first axial height.

[0021] Furthermore, the shooting device also includes a second light-emitting module, which includes a first housing and a sliding cover mechanism disposed on the upper end of the first housing;

[0022] The first housing includes a reaction vessel support base, a light source mounted above the reaction vessel support base and arranged around the first housing, and a diffuse reflector plate arranged circumferentially with the light source;

[0023] A slidable top cover is provided on the top of the first housing, and a reflector is provided on the top cover facing the first housing.

[0024] Furthermore, a first through hole and a first groove are provided at the center of the reaction vessel support base. The first through hole and the first groove are coaxially arranged, and the radius of the first groove is greater than the radius of the first through hole.

[0025] A limiting guide block is provided in the first groove. A second through hole is opened in the center of the limiting guide block. The second through hole and the first through hole are coaxial and have the same diameter. The upper surface of the limiting guide block is higher than the upper surface of the reaction vessel support. The limiting guide block and the first groove are interference fit.

[0026] Furthermore, a reaction vessel placement seat is provided below the reaction vessel support base, and a third through hole is opened in the center of the reaction vessel placement seat, the diameter of the third through hole gradually decreasing;

[0027] The reaction vessel support is snapped into the reaction vessel placement seat and moves synchronously with the reaction vessel placement seat;

[0028] The third through hole is coaxially arranged with the first through hole and the second through hole.

[0029] Secondly, this application provides an automated analysis system, including the imaging device for a multiplex immunoassay analyzer as described in any of the preceding claims.

[0030] Compared with existing technologies, the imaging device provided in this application features a cooling module that opens to facilitate heat exchange, drawing away hot air and blowing out cold air. This effectively prevents damage to components such as the camera module and the first light-emitting module, ensuring the accuracy of the imaging results. Furthermore, for the main heat-generating parts of the camera module and the first light-emitting module—namely, the first and second heat-generating parts, specifically the light source and the camera—the first and second heat-generating parts are positioned on the heat exchange circulation paths of the first and second heat exchange channels of the cooling module, respectively, for further targeted cooling and improved cooling effect. Preferably, the first heat exchange channel includes a first hot flow channel, a first AC channel, and a first cold flow channel connected in sequence. A first guide plate extends from the first air outlet side of the first cold flow channel towards the first heat-generating part, and the extension line of the first guide plate is tangent to or separate from the first heat-generating part. The second heat exchange channel includes a second hot flow channel, a second AC channel, and a second cold flow channel connected in sequence, with the second air outlet of the second cold flow channel facing the second heat-generating part. This configuration not only ensures that the first and second air outlets are positioned to face the first and second heating elements respectively, but also avoids the objective lens located at the top, allowing for more targeted and accelerated cooling of the main heating elements, improving the cooling effect and shortening the cooling time. Furthermore, the first deflector increases the directionality of the blown cold air, improving the utilization rate of the cold air, reducing waste, and making the effective area blown onto the first heating element larger, resulting in higher cooling efficiency. Attached Figure Description

[0031] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0032] Figure 1 This is a schematic diagram of the overall structure of the imaging device provided in the embodiments of this application;

[0033] Figure 2 This is a schematic diagram of the internal structure of the imaging device provided in the embodiments of this application;

[0034] Figure 3 This is a schematic diagram of the airflow direction of the refrigeration module provided in the embodiments of this application;

[0035] Figure 4 This is a side view of the internal structure of the imaging device provided in the embodiment of this application;

[0036] Figure 5 This is a schematic diagram of the structure of the refrigeration module provided in the embodiment of this application;

[0037] Figure 6 This is a cross-sectional perspective view of the refrigeration module provided in an embodiment of this application;

[0038] Figure 7 This is a schematic diagram of the air guide plate structure of the refrigeration module provided in the embodiment of this application;

[0039] Figure 8 This is a schematic diagram of the internal structure of the imaging device provided in an embodiment of this application from another angle;

[0040] Figure 9 An exploded view of the second light-emitting module provided in the embodiments of this application;

[0041] Figure 10 A cross-sectional view of the imaging device provided in the embodiments of this application;

[0042] Figure 11 This is a schematic diagram of the structure of the fixing base provided in the embodiment of this application;

[0043] Figure 12 This is a schematic diagram of the structure of the reaction vessel placement base provided in the embodiments of this application;

[0044] Figure 13 This is a schematic diagram of the structure of the lampshade provided in the embodiment of this application;

[0045] Figure 14 This is a schematic diagram of the structure of the limiting guide block provided in the embodiment of this application.

[0046] Figure label:

[0047] 10-Shell;

[0048] 11-Top plate;

[0049] 12-Base plate;

[0050] 13-Pillars;

[0051] 21-Objective lens;

[0052] 22 - First light-emitting module;

[0053] 221-First heating section;

[0054] 23-Camera module;

[0055] 231-Second heating section;

[0056] 30 - Refrigeration module;

[0057] 311 - First air outlet;

[0058] 312 - Second air outlet;

[0059] 321 - First deflector plate;

[0060] 322 - Second deflector;

[0061] 323 - Third deflector;

[0062] 33-Hot runner;

[0063] 331 - Cooling Fan;

[0064] 34 - Flow cavity;

[0065] 341 - Upper fixing bracket;

[0066] 342-Lower fixing frame;

[0067] 343 - Fixed plate;

[0068] 3431 - Insulation layer;

[0069] 3432 - Cooling fins;

[0070] 344 - Side panel;

[0071] 345 - Condensate outlet;

[0072] 346 - First temperature sensor;

[0073] 351 - First Refrigeration Department;

[0074] 352 - Second Refrigeration Section;

[0075] 361 - First cooling fan;

[0076] 3611 - First cooling fan mounting plate;

[0077] 3612 - First heat dissipation fin;

[0078] 362 - Second cooling fan;

[0079] 3621 - Second cooling fan mounting plate;

[0080] 3622 - Second heat dissipation fin;

[0081] 40 - Focusing module;

[0082] 41-Staff;

[0083] 42 - First Motor;

[0084] 43-Lead screw;

[0085] 44 - Fasteners;

[0086] 50 - Second light-emitting module;

[0087] 51-Sliding cover drive mechanism;

[0088] 511 - Second Motor;

[0089] 512 - Drive wheel;

[0090] 513 - Driven wheel;

[0091] 514 - Belt;

[0092] 515 - Slider;

[0093] 5151 - Light-blocking sheet;

[0094] 516 - Slide rail;

[0095] 52-First shell;

[0096] 521 - Photoelectric sensor;

[0097] 522 - Diffuse reflector;

[0098] 53 - Sliding cover mechanism;

[0099] 541 - Top Cover;

[0100] 5411 - Reflector;

[0101] 542 - Support ring;

[0102] 543 - Light source;

[0103] 544 - Reaction Vessel Support;

[0104] 5441 - First through hole;

[0105] 5442 - First groove;

[0106] 545 - Limiting guide block;

[0107] 5451 - Second through hole;

[0108] 5452 - First fixing hole;

[0109] 5453 - First threaded hole;

[0110] 55-Fixed base;

[0111] 551 - Second groove;

[0112] 552 - Shooting slot;

[0113] 553 - Placement slot;

[0114] 554 - Elastic component;

[0115] 561 - Reaction vessel placement seat;

[0116] 5611 - Third through hole;

[0117] 562 - Pressure Plate;

[0118] 563-Filter. Detailed Implementation

[0119] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0120] Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0121] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0122] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this application is in use. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. In addition, the terms "first," "second," and "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0123] Furthermore, terms such as "horizontal," "vertical," and "sag" do not imply that components must be absolutely horizontal or suspended, but rather that they can be slightly tilted. For example, "horizontal" simply means that its direction is more horizontal relative to "vertical," and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0124] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "set up," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0125] The following detailed description of some embodiments of this application is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0126] like Figures 1 to 7 As shown, this application provides an imaging device and automated analysis system for a multiplex immunoassay analyzer. The imaging device is used to image and detect analytes on a liquid chromatography chip. The imaging device includes a first light-emitting module 22, a camera module 23, and a cooling module 30. The first light-emitting module 22 includes a first heating element 221, which may primarily house a light source. The camera module 23 includes a second heating element 231, which may be the location where the camera is positioned. Figure 3 As shown, the cooling module 30 includes a first heat exchange channel and a second heat exchange channel. The first heating element 221 is located on the heat exchange circulation path of the first heat exchange channel, and the second heating element 231 is located on the heat exchange circulation path of the second heat exchange channel. The first heat exchange channel includes a first hot flow channel, a first AC channel, and a first cold flow channel that are connected in sequence. The first air outlet 311 of the first cold flow channel extends towards the first heating element 221 and is provided with a first guide plate 321. The extension line of the first guide plate 321 is tangent to or separate from the first heating element 221. The second heat exchange channel includes a second hot flow channel, a second AC channel, and a second cold flow channel that are connected in sequence. The second air outlet 312 of the second cold flow channel is disposed towards the second heating element 231.

[0127] Compared with the prior art, in the shooting device provided in this application embodiment, the cooling module 30 is turned on to perform heat exchange, drawing away hot air and blowing out cold air, effectively preventing the burning of components such as the camera module 23 and the first light-emitting module 22, and ensuring the accuracy of the shooting results. Furthermore, for the main heat-generating parts of the camera module 23 and the first light-emitting module 22, namely the first heat-generating part 221 and the second heat-generating part 231, specifically the light source and the camera, the first heat-generating part 221 and the second heat-generating part 231 are respectively located on the heat exchange circulation paths of the first heat exchange channel and the second heat exchange channel of the cooling module 30, further targeted cooling is achieved, resulting in a better cooling effect. The preferred first heat exchange channel includes a first hot flow channel, a first AC channel, and a first cold flow channel that are connected in sequence. A first guide plate 321 extends from the first air outlet 311 of the first cold flow channel toward the first heating element 221, and the extension line of the first guide plate 321 is tangent to or separate from the first heating element 221. The second heat exchange channel includes a second hot flow channel, a second AC channel, and a second cold flow channel that are connected in sequence. The second air outlet 312 of the second cold flow channel is positioned toward the second heating element 231. This configuration not only ensures that the first air outlet 311 and the second air outlet 312 are respectively positioned toward the first heating element 221 and the second heating element 231, but also avoids the lens 21 located at the top, allowing for more targeted and accelerated cooling of the main heating parts, improving the cooling effect and shortening the cooling time. Furthermore, the first guide plate increases the guidance of the blown cold air, improving the utilization rate of the cold air, reducing waste, and resulting in a larger effective area blown onto the first heating element, leading to higher cooling efficiency.

[0128] Furthermore, such as Figures 3 to 7 As shown, a second guide plate 322 and a third guide plate 323 are respectively extended from the upper and lower opposite sides of the aforementioned second air outlet 312. The second guide plate 322 and the third guide plate 323 are inclined to each other and spaced apart. The arrangement of the second guide plate 322 and the third guide plate 323 further increases the guidance of the blown cold air, improves the utilization rate of the cold air, reduces waste, and makes the effective area blown to the second heating part larger, resulting in higher cooling efficiency.

[0129] The aforementioned first guide plate 321 is located on the lower side of the aforementioned first air outlet 311. The first guide plate 321 is inclined upward. Experimental testing shows that the angle α formed by the first guide plate 321 and the first AC channel preferably satisfies 70°≤α<90°; the angle β formed by the extension lines of the aforementioned second guide plate 322 and third guide plate 323 satisfies 60°≤β<180°. This arrangement provides better cooling effect, higher cooling efficiency, and faster cooling speed, and will not affect the clarity of the lens of the camera of the second heating unit 231, and will not produce water mist or water droplets. Furthermore, the extension length of the aforementioned first guide plate 321, second guide plate 322, and third guide plate 323 is preferably set to be greater than or equal to 10mm.

[0130] Preferably, the first hot runner is located below the first guide plate 321, and the second hot runner is located above the second guide plate 322. Preferably, the first and second hot runners share the same hot runner 33, which may be located between the first and second guide plates 321 and 322, and a cooling fan 331 may be installed on the hot runner 33. Preferably, the first and second AC channels may also be located in the same flow cavity 34. Preferably, the axis of the shared hot runner 33 and the axis of the first and second AC channels are perpendicular to the axis of the same flow cavity 34 where the second AC channel is located.

[0131] Furthermore, one side of the aforementioned flow cavity 34 may be provided with the aforementioned first air outlet 311 and second air outlet 312, and the opposite side of the flow cavity 34 may be provided with a first cooling section 351 opposite to the first air outlet 311 and a second cooling section 352 opposite to the second air outlet 312; as Figure 4 As shown, the vertical axial height difference between the upper edge of the first cooling section 351 and the lower edge of the second cooling section 352 is the first axial height H. The distance D between the central axis of the first cold flow channel and the central axis of the second cold flow channel is greater than half of the first axial height H and less than the first axial height H.

[0132] One specific embodiment is, as follows: Figures 3 to 7As shown, the refrigeration module 30 may specifically include an upper fixing frame 341; a lower fixing frame 342; a fixing plate 343 with an insulation layer 3431 laid on it, which is connected to the upper fixing frame 341 and the lower fixing frame 342 at both ends respectively; a side plate 344; refrigeration fins 3432 fixed on the fixing plate 343; a first refrigeration section 351 and a second refrigeration section 352 fixed on the refrigeration fins 3432 and arranged vertically; a first heat dissipation component corresponding to the heat-generating end of the first refrigeration section 351, and a second heat dissipation component corresponding to the heat-generating end of the second refrigeration section 352. The first heat dissipation component specifically includes a first cooling fan 361, first cooling fins 3612, and a first cooling fan mounting plate 3611 fixedly mounted on the aforementioned mounting plate 343. The second heat dissipation component specifically includes a second cooling fan 362, second cooling fins 3622, and a second cooling fan mounting plate 3621 fixedly mounted on the aforementioned mounting plate 343. This arrangement makes heat dissipation more targeted and improves the heat dissipation effect. The first cooling fan 361 and the second cooling fan 362 are arranged vertically. Preferably, the aforementioned insulation layer 3431 is made of insulating polystyrene material, and preferably, the aforementioned first cooling section 351 and second cooling section 352 are made of Peltier material.

[0133] Preferably, both the side plate 344 and the fixing plate 343 are vertically arranged, with a horizontal distance between them. The same flow cavity 34, which houses the first and second AC channels, can be formed by the side plate 344, the upper fixing frame 341, the lower fixing frame 342, and the fixing plate 343. The bottom of the flow cavity 34 may also be provided with a condensate outlet 345, from which condensate can flow out. Condensate produced when hot air carrying away heat enters the cooling fins 3432 for heat exchange is discharged from the condensate outlet 345, creating a drier shooting environment.

[0134] The aforementioned first air outlet 311, second air outlet 312, first guide plate 321, second guide plate 322, and third guide plate 323 can all be located on the side plate 344. Specifically, from top to bottom, the first air outlet 311, the hot runner 33, and the second air outlet 312 can be arranged sequentially. The cooling fan 331 is installed at the location of the hot runner 33, and the air inlet of the cooling fan 331 is directly aligned with the cooling fins 3432 on the fixed plate 343, so that the cooling fan 331 blows directly onto the cooling fins 3432. Furthermore, a first temperature sensor 346 can also be provided on the side plate 344 below the first guide plate 321.

[0135] Specifically, the rated airflow of the cooling fan 331, the first cooling fan 361, and the second cooling fan 362 can be set to 7m³ / h. 3 / h, the air outlet interface of the first air outlet 311 and the second air outlet 312 is approximately 350mm. 2With a wind speed of approximately 0.05 m / s and a room temperature of 30°C, the first guide vane 321 forms a 70° angle with the vertical direction, while the second guide vane 322 and the third guide vane 323 form a 60° angle. The sheet metal structures of the first guide vane 321, the second guide vane 322, and the third guide vane 323 extend outward by 10 mm. Under these conditions, the cooling effect is optimal, the time required is shortest, and the cooling speed is fastest, taking 301 seconds. At this time, the projected area of ​​the air from the second air outlet 312 onto the lens of the camera on the first heating element is approximately 1050 mm². 2 There will be no water mist or droplets, and it will not affect the clarity of the lens.

[0136] With the rated cooling capacity of the first cooling unit 351 and the second cooling unit 352 being approximately 50W, the optimal structure is the one that takes the shortest time to reach the required temperature, based on the temperature detected by the first temperature sensor 346 as the temperature dropping from room temperature of 30°C to 26±0.5°C and the temperature feedback from the temperature control point. When the center distance between the air inlet of the cooling fan 331 and the positions of the first air outlet 311 and the second air outlet 312 is 50mm, at a room temperature of 30°C, the cooling fan 331 blows air directly onto the cooling fins 3432. The wind speed measured at the first air outlet 311 is approximately 0.02m / s, and the wind speed measured at the second air outlet 312 is approximately 0.03m / s. When the aforementioned center distance increases by 60mm, the wind speed measured at the air outlets (first air outlet 311 and second air outlet 312) decreases by approximately 0.01m / s.

[0137] When the angle between the first guide plate 321 and the vertical direction increases by 10°, under the same conditions, the time to cool down to 26°C increases by 30-45 seconds compared to when the angle between the first guide plate 321 and the vertical direction is 70°; when the angle between the first guide plate 321 and the vertical direction is greater than 90°, the cooling effect is basically maintained at around 400 seconds; when the angle between the first guide plate 321 and the vertical direction is 60°, under the same conditions, the time to cool down to 26°C increases by 25 seconds compared to when the angle between the first guide plate 321 and the vertical direction is 70°; when the angle between the first guide plate 321 and the vertical direction is less than or equal to 50°, a slight water mist will appear on the bottom inner side of the top plate 11, and the cooling time is 416 seconds; when the angle between the first guide plate 321 and the vertical direction continues to decrease, the air volume of the first air outlet 311 decreases significantly, and a layer of water mist will be generated on the surface of the first guide plate 321.

[0138] Tests were conducted in an environment with a relatively high room temperature. The first guide plate 321 was at a 70° angle to the vertical direction, and the second guide plate 322 and the third guide plate 323 were at a 60° angle. The above experiment was repeated, and it was found that small water droplets of different degrees appeared at the upper and lower ends of the side plate 344, and the cooling time differed by 4-8 seconds. Specifically, when the first guide plate 321 forms a 70° angle with the vertical direction, and the second guide plate 322 and the third guide plate 323 form a 60° angle, 90% of the generated water droplets can flow back into the cooling space and be discharged from the condensate outlet 345. When the angle between the second guide plate 322 and the third guide plate 323 decreases by 10°, the wind speed of the second air outlet 312 decreases, and the projected area of ​​the air outlet 312 reaching the second heating element 231 decreases by about 60%, only reaching a local area of ​​the second heating element 231, thus reducing the effective utilization rate. When the angle between the first guide plate 321 and the vertical direction decreases, the cold air from the second air outlet 312 blows towards the inside of the top plate 11, cooling the inside of the top plate 11. In an environment with a relatively high room temperature, small liquid droplets will appear locally on the inside of the top plate 11.

[0139] like Figure 4 As shown, in another further embodiment, the horizontal distance between the first air outlet 311 and / or the second air outlet 312 and the longitudinal central axis of the first heating element 221 is the first horizontal distance L1, the longitudinal distance from the extended end of the first guide plate 321 to the center point of the first heating element 221 is the first height distance H1, and the longitudinal distance from the center of the second air outlet 312 to the center point of the first heating element 221 is the second height distance H2. Preferably, the first horizontal distance L1 is greater than or equal to 65.5 mm and less than or equal to 75.5 mm, the first height distance H1 is greater than or equal to 11 mm and less than or equal to 31 mm, and the second height distance H2 is greater than or equal to 64.5 mm and less than or equal to 84.5 mm. This configuration results in the best cooling effect and the shortest cooling time.

[0140] Specifically, when the first horizontal distance L1 is 70.5mm, the first height distance H1 is 21mm, and the second height distance H2 is 74.5mm, after repeated tests, the cooling module 30 under the current structure has the best cooling effect, with the shortest time being approximately 301 seconds. Furthermore, at this time, the projected area of ​​the airflow from the second air outlet 312 onto the second heating element 231 is approximately 1050mm². 2 It has a high utilization rate and reduces the generation of condensate.

[0141] The magnitudes of the aforementioned first horizontal distance L1, first height distance H1, and second height distance H2 all affect the cooling effect of the cooling module 30. Specifically, the magnitude of the first horizontal distance L1 affects the horizontal distance from the air outlet to the first heating element 221, directly affecting the cooling capacity acting on the surface of the first heating element 221; the magnitudes of the first height distance H1 and the second height distance H2 affect the position of the effective cooling area. When the first horizontal distance L1 increases, the distance from the air outlet to the second heating element 231 increases, resulting in a decrease in the amount of cold air acting on the surface of the second heating element 231, weakening the cooling effect, and causing the local temperature of the second heating element 231 to be 0.5℃ higher than the internal temperature of the imaging device. When the first horizontal distance L1 decreases, the distance between the second heating element 231 and the cooling fan 331 becomes closer, thus obstructing the air intake and reducing the air volume at the air outlet. At the same time, due to the presence of the first guide plate 321, if the distance between the second heating element 231 and the cooling fan 331 is too close, the cold air at the air outlet cannot fully act on the surface of the second heating element 231, which will cause the local temperature of the second heating element 231 to be 0.5℃ higher than the internal temperature of the imaging device. When the first height distance H1 and the second height distance H2 increase or decrease, they will affect the position angle of the air outlet of the first guide plate 321, the second guide plate 322 and the third guide plate 323, causing the cold air to deviate from the first heating element 221 and the second heating element 231.

[0142] like Figure 3The middle arrow indicates the direction. The airflow direction of the air inlet of the cooling fan 331 is from the inside to the outside, blowing from inside the housing 10 to the cooling fins 3432 and into the flow cavity 34. It draws in the hot air blown into the housing 10, and after heat exchange, it blows out cold air from the first air outlet 311 and the second air outlet 312. The airflow direction of the air inlets of the first cooling fan 361 and the second cooling fan 362 is from the outside to the inside, which dissipates heat from the heat-generating ends of the first cooling section 351 and the second cooling section 352. Conversely, if the airflow direction of the aforementioned cooling fan 331 is changed from inside to outside to outside to inside, the air enters from the first air outlet 311 and the second air outlet 312, and exits from the air inlet of the central cooling fan 331. The time required for the temperature detected by the first temperature sensor 346 to drop from room temperature of 30℃ to 26±0.5℃ is 620 seconds, which is a significant increase in time. Furthermore, the first air outlet 311 is positioned opposite the first heating element 221, and over time, water droplets will form on the outer surface of the first heating element 221, affecting the imaging results. In addition, there is less heat exchange on the cooling fins 3432, causing frost to form at the base of the cooling fins 3432. Therefore, the airflow direction of the cooling fan 331 must be from the inside, drawing air towards the cooling fins 3432. Otherwise, if the cooling fan 331 directly blows air onto the first light-emitting module 22 and the camera module 23, the rapid airflow will affect the focusing of the lens of the objective lens 21, potentially leading to out-of-focus issues or abnormal identification of the liquid phase chip. Furthermore, the convergence of hot and cold airflows can easily generate condensation, which may cause a short circuit in the circuit board. The condensation can also blur the lens of the objective lens 21, potentially leading to focusing failure. Therefore, this embodiment incorporates a guide vane structure at the first air outlet 311 and the second air outlet 312, ensuring that the airflow avoids the lens of the objective lens 21 while also targeting the main heat sources, the first heat-generating part 221 and the second heat-generating part 231, with cool air directed towards them.

[0143] Furthermore, the aforementioned cooling module 30 may also be equipped with a second temperature sensor. Upon detecting a temperature increase, the first cooling unit 351, the second cooling unit 352, the cooling fan 331, the first cooling fan 361, and the second cooling fan 362 can adjust their power according to the temperature, so that the internal ambient temperature of the imaging device reaches the target temperature as quickly as possible. Once the temperature is reached, the first cooling unit 351, the second cooling unit 352, the cooling fan 331, the first cooling fan 361, and the second cooling fan 362 will temporarily stop operating to prevent the temperature from becoming too low. Specifically, the second temperature sensor can be installed inside the first heating unit 221 and the second heating unit 231 for more accurate temperature detection.

[0144] like Figure 1 and 2As shown, the imaging device provided in this embodiment also includes a housing 10, which is preferably a cube or cuboid structure, encapsulated by a top plate 11, a bottom plate 12, and four side panels. Four pillars 13 can be respectively installed on the four vertical sides of the housing 10 to support the top plate 11 and the bottom plate 12. The camera module 23 and the focusing module 40 are located inside the housing 10 and fixedly mounted on the bottom plate 12. The second light-emitting module 50 is located outside the housing 10 and fixedly mounted on the upper side of the top plate 11, corresponding vertically to the first light-emitting module 22 located inside the housing 10. A reading and imaging hole is provided on the top plate 11, and the second light-emitting module 50 and the first light-emitting module 22 are vertically connected to this reading and imaging hole. After assembly, the housing 10 forms a relatively sealed space, reducing the entry of debris and dust from the belt 514, protecting the precision instruments inside the housing 10 such as the first light-emitting module 22, the camera module 23, and the focusing module 40, improving the overall stability of the imaging device and extending its service life. Furthermore, in order to increase the stability of the reading and the shock resistance, the base plate 12 can adopt a counterweight design to effectively reduce the impact of vibration on imaging and focusing.

[0145] In one specific embodiment, an opening is provided on one side wall of the housing 10 corresponding to the positions of the aforementioned first light-emitting module 22 and camera module 23. The aforementioned upper fixing bracket 341 and lower fixing bracket 342 are respectively fixedly installed on the upper and lower sides of the opening. Alternatively, the upper fixing bracket 341 and lower fixing bracket 342 are respectively fixedly installed on the top plate 11 and bottom plate 12 of the housing 10. The cooling fan 331 fixed on the side plate 344 is located inside the housing 10, and the first cooling fan 361 and the second cooling fan 362 are installed on the fixing plate 343 and located outside the housing 10.

[0146] like Figure 1 and Figure 2 As shown, an objective lens 21 is mounted above the first light-emitting module 22. A focusing module 40 is installed inside the aforementioned housing 10 and is driven to drive the objective lens 21 to move the objective lens 21 up and down. Specifically, the focusing module 40 includes a bracket 41 fixed on the base plate 12, a first motor 42 and a guide rail fixed on the bracket 41, a guide block slidably connected to the guide rail, a lead screw 43 with one end connected to the guide block and the other end connected to the bracket 41, a nut sleeved on the lead screw 43, and a fixing member 44 fixedly connected to the nut. The lens of the objective lens 21 is fixedly connected to the fixing member 44.

[0147] like Figure 1 and Figure 2 as well as Figures 8 to 10As shown, the aforementioned second light-emitting module 50 includes a sliding cover driving mechanism 51 fixed on the top plate 11; a first housing 52 fixed on the top plate 11; a top cover 541 located on top of the first housing 52, with a reflector 5411 disposed on the top cover 541 facing the first housing 52; a sliding cover mechanism 53 drivenly connected to the sliding cover driving mechanism 51 and capable of sliding horizontally above the top cover 541; the first housing 52 includes a support ring 542 fixed on the top cover 541, a reaction container support 544, a light source 543 mounted above the reaction container support 544 and disposed around the first housing 52, a diffuse reflector 522 coaxially and circumferentially disposed with the light source 543, a reaction container placement seat 561 disposed below the reaction container support 544, a fixing seat 55 disposed below the first housing 52, a filter 563 for filtering fluorescence noise fixed below the fixing seat 55, and a pressure plate 562 disposed on the fixing seat 55. The light source 543 can specifically be a white light source, specifically a white light lamp. In this embodiment, the light source 543 can be raised by the support ring 542, so that the lamp bead is suspended in the air, preventing the lamp bead from contacting the reaction vessel support base 544 and reducing the occurrence of lamp bead overheating.

[0148] With this configuration, the light emitted by the light source 543, under the diffuse reflection of the aforementioned diffuse reflector 522, will have part of the light passing through the reaction vessel support 544 and entering the bottom of the reaction vessel placement seat 561, i.e., the bottom of the reaction vessel. The other part of the light will pass through the reflector 5411, through the top cover 541 and the reaction vessel support 544 to supplement the light source from the side of the reaction vessel, making the photos taken under bright field conditions for liquid phase chip imaging clearer. Furthermore, in this embodiment, the light source 543 is fixed to the immovable top cover 541, with no relative movement. There is no need to consider the avoidance problem caused by the sliding cover drive mechanism 51. Therefore, in this embodiment, the top plate 11 can be made into a single plate, forming a relatively independent space inside the housing 10. This ensures that the contaminants generated when the sliding cover drive mechanism 51 moves the sliding cover mechanism 53 will only fall on the outside of the top plate 11 and will not enter the first light-emitting module 22 and the camera module 23 inside the housing 10. At the same time, it will also reduce the impact of dust on the first light-emitting module 22 and the camera module 23, thereby improving their stability and extending their service life to a certain extent.

[0149] Furthermore, the aforementioned reaction vessel support 544 has a first through hole 5441 and a first groove 5442 at its center. The first through hole 5441 and the first groove 5442 are coaxially arranged, and the radius of the first groove 5442 is larger than the radius of the first through hole 5441. A limit guide block 545 is provided in the first groove 5442, such as... Figure 14As shown, a second through hole 5451 is provided at the center of the limiting guide block 545. The second through hole 5451 and the first through hole 5441 are coaxial and have the same diameter. The upper surface of the limiting guide block 545 is higher than the upper surface of the reaction vessel support 544, and the limiting guide block 545 and the first groove 5442 are interference fit. The vertical adjustment of the second light-emitting module 50 can be completed through the limiting guide block 545. The limiting guide block 545 can be a disc-shaped structure. The second through hole 5451 is located at the center, and at least two first fixing holes 5452 and at least two first threaded holes 5453 can be provided evenly and sequentially along its circumference. This increases the tolerance for errors in placing the reaction vessel, making it more stable when placed within the limiting guide block 545. Then, by checking the image and observing the clarity of each point, it is determined whether the longitudinal and horizontal accuracy of the image meets the requirements. If there is some defocusing, the limiting guide block 545 is slightly raised by tightening the set screw, so that the bottom of the reaction vessel is relatively parallel to the lens of the objective lens 21, ensuring that there is no defocus at the bottom of the reaction vessel.

[0150] Furthermore, such as Figure 12 As shown, a third through hole 5611 is provided in the center of the reaction vessel placement seat 561, and the diameter of the third through hole 5611 gradually decreases; the reaction vessel support seat 544 is snapped into the reaction vessel placement seat 561 and moves synchronously with the reaction vessel placement seat 561; the third through hole 5611 is coaxially arranged with the aforementioned first through hole 5441 and second through hole 5451.

[0151] Furthermore, a fixing seat 55 is provided below the first housing 52, and a second groove 551 is formed inside the fixing seat 55. The reaction vessel placement seat 561 is placed in the second groove 551, and the radius of the second groove 551 is larger than the radius of the reaction vessel placement seat 561. Multiple placement slots 553 are formed on the wall of the second groove 551 for placing elastic elements 554. The elastic elements 554 abut against the reaction vessel placement seat 561, and the elastic elements 554 can specifically be springs. Figure 11As shown, the mounting base 55 has a concave circular area for matching and placing the reaction vessel placement base 561. A second groove 551 for placing a filter and a shooting groove 552 can be stacked at the center of this concave circular area. Correspondingly, a third through hole 5611 is provided at the center of the reaction vessel placement base 561. The inner wall of the concave circular area can be provided with a placement groove 553 for placing an elastic element 554, and a tightening screw can also be placed in the placement groove 553. With this configuration, the reaction vessel placement base 561 is first placed into the mounting base 55, and then the spring is locked with the tightening screw (no need to tighten), which serves as a guide and support for the spring to prevent it from slipping out. Then, the tightening screw is tightened so that the third through hole 5611 of the reaction vessel placement base 561 is positioned at the center of the mounting base 55. The tightness of the tightening screw is adjusted by the captured image until the captured image is centered on the display. At this point, the pressure plate 562 is locked onto the mounting base 55, thereby fixing the reaction vessel placement base 561 securely. This process completes the horizontal adjustment of the second light-emitting module 50.

[0152] In addition, such as Figure 1 and Figure 8 As shown, the aforementioned sliding cover drive mechanism 51 includes a second motor 511 located inside the housing 10 and fixed to the inner side of the top plate 11, a drive wheel 512 and a driven wheel 513 mounted on the side of the top plate 11. The drive wheel 512 is fixedly connected to the output shaft of the second motor 511. A belt 514 is sleeved on the drive wheel 512 and the driven wheel 513. A slide rail 516 is horizontally arranged on the side wall of the first housing 52. A slider 515 is slidably connected to the slide rail 516. The top and bottom of the slider 515 are fixedly connected to the sliding cover mechanism 53 and the belt 514, respectively. Preferably, a photoelectric sensor 521 may also be provided on the first housing 52, and a light-shielding plate 5151 may also be provided on the slider 515 in conjunction with the photoelectric sensor 521.

[0153] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. An imaging device for a multiplex immunoassay analyzer, characterized in that, include: The first light-emitting module includes a first heating element; The camera module includes a second heating element; A refrigeration module includes a first heat exchange channel and a second heat exchange channel, wherein the first heating element is located on the heat exchange circulation path of the first heat exchange channel, and the second heating element is located on the heat exchange circulation path of the second heat exchange channel. The first heat exchange channel includes a first hot flow channel, a first AC channel and a first cold flow channel that are connected in sequence. The first cold flow channel has a first guide plate extending from the first air outlet side toward the first heating part, and the extension line of the first guide plate is tangent to or separate from the first heating part. The second heat exchange channel includes a second hot flow channel, a second AC channel and a second cold flow channel that are connected in sequence. The second air outlet of the second cold flow channel is arranged facing the second heating part. A second guide plate and a third guide plate are respectively extended from the upper and lower opposite sides of the second air outlet. The first hot runner is located below the first guide plate, and the second hot runner is located above the second guide plate. The first hot runner and the second hot runner share the same hot runner, and the first AC channel and the second AC channel are located in the same flow cavity.

2. The shooting device as described in claim 1, characterized in that, The first guide plate is located on the lower side of the first air outlet. The first guide plate is inclined upward. The angle α between the first guide plate and the first AC channel satisfies 70°≤α<90°.

3. The shooting device as described in claim 2, characterized in that, The second guide plate and the third guide plate are inclined to each other and spaced apart, and the included angle β formed by their extended lines satisfies 60°≤β<180°.

4. The shooting device as described in claim 3, characterized in that, The axis of the same hot runner shared by the first hot runner and the second hot runner is perpendicular to the axis of the same flow cavity where the first AC channel and the second AC channel are located.

5. The shooting device as described in claim 4, characterized in that, The flow cavity is provided with a first air outlet and a second air outlet on one side, and a first cooling section opposite to the first air outlet and a second cooling section opposite to the second air outlet on the other side of the flow cavity. The vertical axial height difference between the upper edge of the first cooling unit and the lower edge of the second cooling unit is the first axial height; The distance between the central axis of the first cold runner and the central axis of the second cold runner is greater than half of the first axial height and less than the first axial height.

6. The shooting device as described in claim 1, characterized in that, It also includes a second light-emitting module, which includes a first housing and a sliding cover mechanism disposed on the upper end of the first housing; The first housing includes a reaction vessel support base, a light source mounted above the reaction vessel support base and arranged around the first housing, and a diffuse reflector plate arranged circumferentially with the light source; A slidable top cover is provided on the top of the first housing, and a reflector is provided on the top cover facing the first housing.

7. The shooting device as described in claim 6, characterized in that, The reaction vessel support base has a first through hole and a first groove at its center. The first through hole and the first groove are coaxially arranged, and the radius of the first groove is larger than the radius of the first through hole. A limiting guide block is provided in the first groove. A second through hole is opened in the center of the limiting guide block. The second through hole and the first through hole are coaxial and have the same diameter. The upper surface of the limiting guide block is higher than the upper surface of the reaction vessel support. The limiting guide block and the first groove are interference fit.

8. The shooting device as described in claim 7, characterized in that, Below the reaction vessel support is a reaction vessel placement seat, and the reaction vessel placement seat has a third through hole in the center, the diameter of the third through hole gradually decreasing. The reaction vessel support is snapped into the reaction vessel placement seat and moves synchronously with the reaction vessel placement seat; The third through hole is coaxially arranged with the first through hole and the second through hole.

9. An automatic analysis system, characterized in that, The imaging device for a multiplex immunoassay analyzer includes any one of claims 1-8.

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