Microcapsules containing green tea extract, and methods of making and using the same
Patent Information
- Application Number
- CN202310845151.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-07-10
- Publication Date
- 2026-08-21
- Estimated Expiration
- 2043-07-10
AI Technical Summary
但目前仍然缺乏具有较高绿茶活性的美白修复产品,也鲜少有含不同植物提取物且具有更高效、更好稳定性和生物活性的含绿茶提取物的微胶囊产品,用于化妆品领域,限制了天然植物提取的应用
[0034] This invention is the first to combine green tea extract with other plant extracts to prepare a whitening composition. Green tea extract, centella asiatica extract, and ginseng extract are formulated in a specific ratio, allowing each component to work synergistically to further enhance the inhibition of tyrosinase activity, thereby reducing melanin production. This results in whitening while also providing anti-wrinkle, moisturizing, and skin-rejuvenating effects, enhancing the whitening and skincare benefits from multiple perspectives, ultimately achieving healthy whitening. Furthermore, the whitening composition is prepared into microcapsules, and the green tea extract and other components are encapsulated using spray-drying encapsulation technology. This effectively controls the release of active substances, improves bioavailability and stability, and ensures product quality.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of cosmetic technology, specifically to a microcapsule containing green tea extract, its preparation method, and its application. Background Technology
[0002] Today, people face high work pressure and irregular lifestyles, leading to various skin problems such as dullness, sagging, fine lines, and age spots. Everyone desires beauty, and people are turning to various cosmetics to rescue their skin. However, most cosmetics on the market contain substances like lead, mercury, benzene, preservatives, and hormones. While these may temporarily make the skin appear bright and smooth, long-term use can cause the stratum corneum to thin and peel, leading to redness, swelling, and age spots—the opposite of the desired effect. Therefore, the safety of cosmetics has become a primary consideration for consumers. With the rapid development of the cosmetics industry, the call for "natural ingredients" and "returning to nature" has become a trend, and the naturalization of raw materials is receiving increasing attention. Pure natural whitening ingredients are increasingly becoming a major component of cosmetics. Melanin content is a significant factor influencing skin color; the more melanin, the darker the skin. Melanin is formed from tyrosine through a series of metabolic reactions, including the production of dopa and dopaquinone, catalyzed by tyrosinase. Therefore, inhibiting tyrosinase activity is key to reducing melanin production.
[0003] Green tea is one of China's major tea categories. It is made from the new leaves or buds of the tea plant, without fermentation, through processes such as fixation, shaping, and drying. This process preserves the natural substances of the fresh leaves, containing nutrients such as tea polyphenols, catechins, chlorophyll, caffeine, amino acids, and vitamins, which have anti-aging, antibacterial, lipid-lowering, and weight-loss effects. Currently, green tea extracts are used in food, health products, medicine, and daily chemical industries. However, because most active substances in green tea extracts are easily affected by sensitive factors such as temperature, light, pH, and oxygen, they are generally only used in foods with simple processing methods such as fresh milk, noodles, and candy, or directly as active additives. Furthermore, many studies have reported unpleasant tastes from green tea during food processing. Therefore, the production of functional foods must ensure the stability and bioactivity of active substances while also ensuring that product quality is not affected. To apply them to the development of natural bioactive product formulations, they must be protected from physical and chemical stresses.
[0004] Microencapsulation of bioactive substances protects them from physical and chemical stresses. The choice of encapsulation technology and wall material is crucial, as they significantly impact encapsulation stability and core material release. However, there is currently a lack of whitening and repairing products with high green tea activity, and very few microcapsule products containing different plant extracts that offer higher efficacy, better stability, and greater bioactivity for use in the cosmetics industry, thus limiting the application of natural plant extracts. Summary of the Invention
[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the above-mentioned problems and to provide a microcapsule containing green tea extract, its preparation method and application.
[0006] The purpose of this invention is to provide a whitening composition containing green tea extract.
[0007] Another object of the present invention is to provide a microcapsule containing green tea extract.
[0008] Another object of the present invention is to provide a method for preparing microcapsules containing green tea extract.
[0009] Another object of the present invention is to provide a whitening composition containing green tea extract, a product containing microcapsules of green tea extract, and its application.
[0010] The above-mentioned objective of this invention is achieved through the following technical solution:
[0011] This invention provides a whitening composition containing green tea extract, comprising green tea extract, centella asiatica extract, and ginseng extract. Research shows that by combining green tea extract, centella asiatica extract, and ginseng extract in a specific ratio, the components exert a synergistic effect, enhancing the inhibition of tyrosinase activity, reducing melanin production, and exhibiting whitening and repairing effects. It also demonstrates significant superoxide anion free radical scavenging ability, providing anti-aging and repairing benefits while whitening, thus enhancing the overall whitening and skincare effect.
[0012] Green tea is a non-fermented tea, and its characteristics allow it to retain more of the natural substances found in fresh leaves. It retains over 85% of the tea polyphenols and caffeine, about 50% of the chlorophyll, and experiences minimal vitamin loss, resulting in the characteristics of green tea: "clear broth, green leaves, and a strong astringent taste." The tea soup is clear and bright, with a fragrant and mellow flavor, and it is believed to have anti-aging, antibacterial, lipid-lowering, and slimming effects. Green tea extract, obtained through alcohol extraction from green tea, possesses excellent moisturizing, antioxidant, whitening, and anti-aging properties.
[0013] Centella asiatica mainly contains triterpenes and their glycosides, volatile oils, flavonoids, alkaloids, and other compounds. Total asiatic acid, as its main active ingredient, has been extensively studied in recent years. Among them, asiaticoside has multiple effects including neuroprotection, anti-tumor activity, resistance to ischemia-reperfusion injury, resistance to stent restenosis, and lung protection. Hydroxyasiaticoside is used clinically for anti-inflammatory and antioxidant effects, antidepressant effects, anti-tumor activity, skin whitening, treatment of burn scars, memory enhancement, and prevention and treatment of coronary heart disease, myocardial infarction, cerebral thrombosis, and cerebral infarction. Therefore, it is widely used in the production of pharmaceuticals and cosmetics.
[0014] Both ginseng root and ginseng seed oil have high medicinal and therapeutic value. In existing products, especially skin care products, the addition of ginseng root extract can have a cleansing and moisturizing effect, helping plant extracts to exert better efficacy.
[0015] Furthermore, in the composition containing green tea extract, the mass ratio of green tea extract, centella asiatica extract, and ginseng extract is (1-2):(2-3):3.
[0016] Preferably, the green tea extract is a green tea alcohol extract, the centella asiatica extract is a centella asiatica alcohol extract, and the ginseng extract is a ginseng alcohol extract.
[0017] More preferably, the present invention provides a method for preparing green tea extract, centella asiatica extract, and ginseng extract: green tea leaves, centella asiatica, and ginseng are pulverized, passed through a 60-100 mesh sieve, and subjected to alcohol extraction. The mixture is heated and stirred at 60-80°C for 0.5-1 h, and then centrifuged to obtain green tea alcohol extract, centella asiatica alcohol extract, and ginseng alcohol extract.
[0018] This invention provides microcapsules containing green tea extract. The core material of the microcapsules is a whitening composition containing green tea extract, and the wall material is one of maltodextrin-whey protein, maltodextrin-soy protein isolate, maltodextrin-gum arabic, or β-dextrin-chitosan. This invention is the first to prepare microcapsules by compounding green tea extract with other plant extracts. The encapsulation of green tea extract and other components using spray drying technology effectively controls the release of active substances, improves bioavailability and stability, and ensures product quality. The green tea extract-containing microcapsules provided by this invention can effectively inhibit tyrosinase activity, have strong antioxidant effects, and show significant efficacy in whitening and repair. The microcapsules prepared by this invention can fully utilize the effects of the green tea extract and other components, not only stabilizing the components and achieving a high encapsulation rate, but also effectively preventing the extract components from being degraded or altered by the external environment.
[0019] This invention provides a method for preparing microcapsules containing green tea extract, comprising the following steps:
[0020] S1. Prepare wall material solutions using maltodextrin-whey protein, maltodextrin-soy protein isolate, maltodextrin-gum arabic, or β-dextrin-chitosan for later use;
[0021] S2. Take green tea, centella asiatica and ginseng powder respectively, and extract them with alcohol to obtain green tea alcohol extract, centella asiatica alcohol extract and ginseng alcohol extract. Mix the green tea alcohol extract, centella asiatica alcohol extract and ginseng alcohol extract to prepare a mixed extract.
[0022] S3. Extract the mixed extract solution, concentrate it, dry it, mix it with the wall material solution, homogenize it, and spray dry it to obtain microcapsules containing green tea extract.
[0023] Preferably, the heating conditions are 70°C and stirring for 60 minutes.
[0024] Preferably, the mass ratio of the components of the wall material is (1-2):(1-3).
[0025] Preferably, the mass ratio of the core material to the wall material is 1:(6-8).
[0026] More preferably, the mass ratio of the core material to the wall material is 1:8.
[0027] Preferably, the wall material is maltodextrin-whey protein.
[0028] Whey protein can be obtained through ion exchange or membrane separation, followed by concentration and drying. Its film-forming, emulsifying, gelling, and droplet-stabilizing properties make it ideal for microencapsulation. Maltodextrin possesses low bulk density, anti-caking properties, high smoothness, good film-forming properties, effective adhesion, and oxygen barrier properties. Spray drying atomizes the feed liquid into the drying chamber, resulting in the formation of microspheres or microcapsules; this method offers shorter processing time and lower costs.
[0029] Preferably, the homogenization conditions are high-pressure homogenization three times at 40℃ and 40MPa; the spray drying conditions are an inlet air temperature of 110-140℃, an outlet temperature of not less than 50℃, and a feed rate of 50mL / h.
[0030] As the most preferred embodiment, the present invention provides a method for preparing microcapsules: the core material and wall material (maltodextrin, whey protein) of a composition containing plant extracts (green tea extract, centella asiatica extract, ginseng extract) are mixed and stirred together, homogenized, and then the mixture of wall material and core material is spray-dried to obtain microcapsules. The spray-drying conditions are: inlet air temperature of 110-140℃, outlet temperature of not less than 50℃, and feed rate of 50mL / h.
[0031] The present invention also provides whitening compositions containing green tea extract, and microcapsules containing green tea extract for use in anti-oxidation, whitening, skin repair, or in the preparation of whitening, anti-oxidation, anti-aging, and skin repair products.
[0032] The present invention also provides a skin whitening, antioxidant, anti-aging and skin repair product, including a whitening composition containing green tea extract or microcapsules containing green tea extract.
[0033] The present invention has the following beneficial effects:
[0034] This invention is the first to combine green tea extract with other plant extracts to prepare a whitening composition. Green tea extract, centella asiatica extract, and ginseng extract are formulated in a specific ratio, allowing each component to work synergistically to further enhance the inhibition of tyrosinase activity, thereby reducing melanin production. This results in whitening while also providing anti-wrinkle, moisturizing, and skin-rejuvenating effects, enhancing the whitening and skincare benefits from multiple perspectives, ultimately achieving healthy whitening. Furthermore, the whitening composition is prepared into microcapsules, and the green tea extract and other components are encapsulated using spray-drying encapsulation technology. This effectively controls the release of active substances, improves bioavailability and stability, and ensures product quality.
[0035] The microcapsules containing green tea extract provided by this invention can effectively control the release of its active substances, improve its bioavailability and stability, and give full play to the inhibitory tyrosinase and antioxidant effects of the composition containing plant extracts, thereby improving the anti-aging effect of the skin while whitening. The microcapsules prepared by this invention can not only stabilize the components and have a high encapsulation rate, but also effectively prevent the extract components from being degraded or changed by the external environment. Attached Figure Description
[0036] Figure 1 The graph shows the tyrosinase inhibition rate of microcapsules with different compositions.
[0037] Figure 2 The graph shows the results of superoxide anion free radical scavenging ability determination of microcapsules of different compositions. Detailed Implementation
[0038] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but the embodiments do not limit the present invention in any way. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in this technical field.
[0039] Unless otherwise specified, all reagents and materials used in the following examples are commercially available.
[0040] The green tea, centella asiatica, ginseng, and wall material used in this invention are all commercially available, and the tyrosinase used in the experiment was purchased from Sigma-Aldrich in the United States.
[0041] Example 1: Microcapsule preparation of a repairing and whitening composition containing green tea extract
[0042] (1) Preparation of wall material: Maltodextrin (MD) was swollen in sterile ultrapure water for 12 hours to prepare a 10% (w / w) solution. The solution was then magnetically stirred until fully dissolved. Maltodextrin and whey protein were mixed in a 2:1 ratio, and the pH was adjusted to 7.6 with 10M NaOH and 1M HCl. The mixture was then incubated overnight at 4°C to ensure complete hydration. The solution was then kept at 85°C for 3 hours to allow partial grafting between the whey protein and maltodextrin. The resulting reaction solution was the wall material solution. The solution was cooled to room temperature and stored at 4°C for later use.
[0043] (2) Preparation of core material: Green tea, centella asiatica, and ginseng were pulverized using a pulverizer and passed through a 60-100 mesh sieve to obtain green tea powder, centella asiatica powder, and ginseng powder, respectively. Then, 0.3g of dried green tea powder, centella asiatica powder, and ginseng powder were weighed out separately and extracted with 10mL of anhydrous ethanol. The mixture was then heated with magnetic stirring at 60-80℃ for 60min and centrifuged to obtain green tea extract, centella asiatica extract, and ginseng extract. The extracts were then mixed in a certain proportion to prepare a mixed extract solution.
[0044] Next, six liquid-liquid extractions were performed using equal volumes of CH2Cl2. The resulting mixed extract solutions were concentrated in a rotary evaporator, soaked in water, and filtered. The undissolved remaining concentrated mixture was mixed with 250 mL of ethyl acetate and 0.1 g of ascorbic acid (to prevent oxidation) in a separatory funnel, and then subjected to five more liquid-liquid extractions (without adding ascorbic acid) to obtain the extract mixture. The solution was then concentrated, the extract was dried, and the mixed extract was stored in a desiccator.
[0045] (3) Microencapsulation of the extract: The dried mixed extract was stirred together with the wall material solution (maltodextrin and whey protein) at a mass ratio of 1:8. The formulation was homogenized using a top-mounted stirrer at 4000 rpm for 5 min. The homogenized solution was then spray-dried using a dryer equipped with a 0.7 mm diameter nozzle. The inlet temperature range was 140℃, the outlet temperature was not lower than 50℃, the feed rate was 50 mL / h, and the homogenization conditions were high-pressure homogenization three times at 40℃ and 40 MPa to obtain microcapsules containing green tea extract.
[0046] According to the above method, this embodiment prepares different microcapsules containing green tea extract by adjusting the composition ratio of the core material composition. The composition ratio of the core material is shown in Table 1 below. Other methods are the same as above to prepare different microcapsules containing green tea extract for later use.
[0047] Table 1 Compositions with different mass ratios
[0048] Composition 1 1 2 4 Composition 2 1 3 3 Composition 3 2 2 3 Composition 4 2 3 2 Composition 5 0 3 4 Composition 6 3 0 4 Composition 7 3 4 0 Composition 8 7 0 0 Composition 9 0 7 0 Composition 10 0 0 7
[0049] This invention is the first to combine green tea extract with other plant extracts, using spray drying encapsulation technology to encapsulate the green tea extract and other components into microcapsules. This effectively controls the release of active substances, improves bioavailability and stability, and ensures product quality.
[0050] Example 2 Whitening and Anti-aging Efficacy Test – Tyrosinase Inhibition Rate Determination
[0051] The microcapsules prepared using the compositions in Table 1 of Example 1 (referred to as compositions 1-10 in the following experiments) were compared for their tyrosinase inhibitory activity. 1.0 g of each composition was weighed and dissolved in 10 mL of 50% ethanol. The solution was filtered through a 0.45 μm membrane, and the filtrate was used for determination. Phosphate buffer (pH 6.8, 0.1 mol / L), sample solution, and tyrosine solution were added to each test tube, respectively. The tubes were placed in a 37°C water bath for 10 min, then tyrosinase was added, and the reaction was repeated in a 37°C water bath for another 10 min. The absorbance was measured at 475 nm using a Spectronic GENESYS-5 spectrophotometer (Thermo Fisher Scientific, USA). A 50% ethanol solution containing tyrosinase was used as a blank control. The experiment was repeated three times, and the average value was calculated.
[0052] Tyrosinase inhibition rate = (absorbance value of blank control - absorbance value of sample) / absorbance value of blank control × 100%.
[0053] The measurement results are as follows Figure 1 As shown, the tyrosinase inhibition rate of each composition microcapsule was improved, but the combination of three components was more effective. When combined in a specific ratio, the components exerted a synergistic effect, further enhancing the inhibitory effect of tyrosinase activity. Composition 3 showed the best inhibition effect, reaching 52.3%, which fully demonstrated the inhibitory and antioxidant effects of each component, especially the green tea extract, thereby reducing melanin production and achieving the effect of inhibiting melanin production, thus having a whitening and anti-aging effect.
[0054] Example 3 Whitening and Repairing Efficacy Test – Determination of Superoxide Anion Free Radical Scavenging Ability
[0055] Take 5.7 mL of 50 mmol / L pH 8.2 Tris-HCl buffer into a 10 mL EP tube, add 0.2 mL of standard, mix well, and incubate at 25 °C for 10 min. Then add 0.1 mL of 10 mmol / L pyrogallol solution preheated at 25 °C, for a total volume of 6 mL. Shake quickly and record the increase in absorbance (As) at 320 nm wavelength within 1 min using a UV-Vis spectrophotometer, and calculate the increase in absorbance per minute within the linear range.
[0056] Microcapsules of each composition prepared in Table 1 of Example 1 (referred to as compositions 1-10 in the following experiments) were separately tested. The amount and concentration of each composition were the same. However, the compositions were replaced with an equal volume of water, and the increase in absorbance (A0) at a wavelength of 320 nm within 1 minute was measured. The superoxide anion radical scavenging rate was calculated according to the following formula: Superoxide anion radical scavenging rate (%) = (A0-As) / A0 x 100%.
[0057] The results are as follows Figure 2 The results showed that the superoxide anion scavenging rate of each composition was improved compared with the blank group, but the composition with three components was more effective. When the components were combined in a specific ratio, they exerted a synergistic effect. Among them, composition 3 had a DPPH superoxide anion scavenging rate of 21%, which has a good antioxidant effect and can achieve the effect of repairing the skin.
[0058] Example 4
[0059] Preparation of the wall material: Maltodextrin (MD) was swollen in sterile ultrapure water for 12 hours to prepare a 10% solution. The solution was then magnetically stirred until fully dissolved. Maltodextrin and whey protein were mixed in a 1:1 ratio, and the pH was adjusted to 7.6 with 10M NaOH and 1M HCl. The mixture was incubated overnight at 4°C to ensure complete hydration. The solution was then kept at 85°C for 3 hours to allow partial grafting between the whey protein and maltodextrin. The resulting reaction solution was the wall material solution. The solution was cooled to room temperature and stored at 4°C for later use.
[0060] The core material was prepared in the same manner as in Example 1, but the proportions of green tea extract, centella asiatica extract, and ginseng extract were mixed according to Composition 3 to prepare a mixed extract solution. Then, equal volumes of CH2Cl2 were used for liquid-liquid extraction six times. The resulting mixed extract solution was concentrated in a rotary evaporator, soaked in water, and filtered. The undissolved remaining concentrated mixture was mixed with 250 mL of ethyl acetate and 0.1 g of ascorbic acid (to prevent oxidation) in a separatory funnel, and then subjected to liquid-liquid extraction five more times (without adding ascorbic acid) to obtain the extract mixture. The solution was then concentrated, the extract was dried, and stored in a desiccator.
[0061] Spray-dried microencapsulated green tea extract: The extract and wall material were mixed at a mass ratio of 1:8 and stirred together with maltodextrin and whey protein. The formulation was homogenized using a top-mounted stirrer at 4000 rpm for 5 min. The homogenized solution was then spray-dried using a dryer equipped with a 0.7 mm diameter nozzle at an inlet temperature of 140 °C to prepare microcapsules containing green tea extract.
[0062] Example 5
[0063] Preparation of wall material: Maltodextrin (MD) was swollen in sterile ultrapure water for 12 hours to prepare a 10% solution. The solution was then magnetically stirred until fully dissolved. Wall material: Maltodextrin and whey protein were mixed in a 2:1 ratio. The pH was adjusted to 7.6 with 10M NaOH and 1M HCl, and the mixture was incubated overnight at 4°C to ensure complete hydration. The mixture was then kept at 85°C for 3 hours to allow partial grafting between the whey protein and maltodextrin. The resulting reaction solution was the wall material solution. The solution was cooled to room temperature and stored at 4°C for later use.
[0064] The core material was prepared in the same manner as in Example 1, but the proportions of green tea extract, centella asiatica extract, and ginseng extract were mixed according to Composition 3 to prepare a mixed extract solution. Then, equal volumes of CH2Cl2 were used for liquid-liquid extraction six times. The resulting mixed extract solution was concentrated in a rotary evaporator, soaked in water, and filtered. The undissolved remaining concentrated mixture was mixed with 250 mL of ethyl acetate and 0.1 g of ascorbic acid (to prevent oxidation) in a separatory funnel, and then subjected to liquid-liquid extraction five more times (without adding ascorbic acid) to obtain the extract mixture. The solution was then concentrated, the extract was dried, and stored in a desiccator.
[0065] Spray-dried microencapsulated green tea extract: The extract and wall material were mixed at a mass ratio of 1:8 and stirred together with maltodextrin and whey protein. The formulation was homogenized using a top-mounted stirrer at 4000 rpm for 5 min. The homogenized solution was then spray-dried using a dryer equipped with a 0.7 mm diameter nozzle at an inlet temperature of 140 °C to prepare microcapsules containing green tea extract.
[0066] Example 6
[0067] Preparation of wall material: Maltodextrin (MD) was swollen in sterile ultrapure water for 12 hours to prepare a 10% solution. The solution was then magnetically stirred until fully dissolved. Wall material: Maltodextrin and whey protein were mixed in a 3:1 ratio. The pH was adjusted to 7.6 with 10M NaOH and 1M HCl, and the mixture was incubated overnight at 4°C to ensure complete hydration. The mixture was then kept at 85°C for 3 hours to allow partial grafting between the whey protein and maltodextrin. The resulting reaction solution was the wall material solution. The solution was cooled to room temperature and stored at 4°C for later use.
[0068] The core material was prepared in the same manner as in Example 1, with the green tea extract, centella asiatica extract, and ginseng extract mixed in the same proportions as in Composition 3. Then, equal volumes of CH2Cl2 were used for liquid-liquid extraction six times. The resulting mixed extract solution was concentrated in a rotary evaporator, soaked in water, and filtered. The undissolved remaining concentrated mixture was mixed with 250 mL of ethyl acetate and 0.1 g of ascorbic acid (to prevent oxidation) in a separatory funnel, and then subjected to liquid-liquid extraction five more times (without adding ascorbic acid) to obtain the extract mixture. The solution was then concentrated, the extract dried, and stored in a desiccator.
[0069] Spray-dried microencapsulated green tea extract: A mixture of extract, maltodextrin, and whey protein was stirred together at a mass ratio of 1:8 (extract to wall material). The formulation was homogenized using a top-mounted stirrer at 4000 rpm for 5 min. The homogenized solution was then spray-dried using a dryer equipped with a 0.7 mm diameter nozzle at an inlet temperature of 140 °C to prepare microcapsules containing green tea extract.
[0070] Example 7
[0071] The method for preparing microcapsules containing green tea extract in this embodiment is the same as in Example 4, except that the wall material is prepared by mixing maltodextrin and soy protein isolate in a 2:1 ratio.
[0072] Example 8
[0073] The method for preparing microcapsules containing green tea extract in this embodiment is the same as in Example 4, except that the wall material is prepared by mixing maltodextrin and gum arabic in a 2:1 ratio.
[0074] Example 9
[0075] The method for preparing microcapsules containing green tea extract in this embodiment is the same as in Example 4, except that the wall material is prepared by mixing β-dextrin and chitosan in a 2:1 ratio.
[0076] The encapsulation efficiency of the microcapsules prepared in Examples 4-9 above was determined by mixing 0.1 g of microcapsule sample with 10 mL of 80% ethanol in a 15 mL centrifuge tube and vortexing for 5 min. The sample was then filtered, and the content of released composition 3 was measured at 290 nm using a UV-Vis spectrophotometer. The encapsulation efficiency EE was calculated using the formula: EE = m m / m t ×100%, where m m The mass of 1g of microcapsule release composition, m t The mass of the added composition.
[0077] The test results are shown in Table 2 below. The results indicate that the microcapsules prepared using maltodextrin and whey protein in a 2:1 ratio as wall materials have better encapsulation efficiency, effectively control the release of active substances, and improve bioavailability and stability, thus enabling the composition to exert its effects more effectively. Compared to wall materials formed with the same ratio of maltodextrin and other combinations, these two specific compositions exhibit better encapsulation efficiency for microcapsules.
[0078] Table 2 Embedding Efficiency
[0079]
[0080]
[0081] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.
Claims
1. A whitening microcapsule containing green tea extract, characterized in that, The core material of the microcapsules is green tea alcohol extract, centella asiatica alcohol extract, and ginseng alcohol extract in a mass ratio of 2:2:
3. The wall material is maltodextrin and whey protein in a mass ratio of (1-2):(1-3); The mass ratio of the core material to the wall material is 1:(6-8); The method for preparing the microcapsules includes the following steps: S1. Preparation of wall material solution; S2. Take green tea, centella asiatica and ginseng powder respectively, and extract them with alcohol to obtain green tea alcohol extract, centella asiatica alcohol extract and ginseng alcohol extract. Mix the green tea alcohol extract, centella asiatica alcohol extract and ginseng alcohol extract to prepare a mixed extract. S3. Extract the mixed extract, concentrate it, dry it, mix it with the wall material solution, homogenize it, and spray dry it to obtain microcapsules containing green tea extract.
2. The use of the microcapsules of claim 1 in the preparation of products with antioxidant, whitening, anti-aging and skin-repairing properties.
3. A skin-whitening, antioxidant, anti-aging, and skin-repairing product, characterized in that, Contains the microcapsule as described in claim 1.
Citation Information
Patent Citations
Preparation and application of green tea polyphenol microcapsules taking whey protein isolate (WPI) and maltodextrin (MD) as wall materials
CN109497161A