一种含膦螺旋手性化合物及其制备方法和应用
By employing addition and addition/oxidation strategies, phosphine-containing helical chiral compounds were prepared under specific conditions using chiral quaternary phosphonium salt catalysts. This solved the problems of limited substrate range and low catalytic activity in existing technologies, and achieved efficient and environmentally friendly synthesis of helical chiral compounds.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SICHUAN UNIV
- Filing Date
- 2023-07-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies struggle to efficiently construct helical chiral compounds, especially phosphine-containing helical chiral compounds, due to limitations in substrate scope, low catalytic activity, and poor enantioselectivity.
Phosphorus-containing helical chiral compounds, including compounds A and B, were prepared by reacting chiral quaternary phosphonium salt catalysts with basic substances and oxidants in organic solvents using addition and addition/oxidation strategies. The reaction temperatures ranged from -60 to 50 °C, and the reaction times ranged from 6 to 72 h.
The efficient construction of phosphine-containing helical chiral compounds was achieved. The synthetic method is simple, the conditions are mild, the catalyst is stable, the method is environmentally friendly, and the catalytic activity is good. It is suitable for asymmetric catalysis and drug synthesis.
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