一种N-甲基-4,5-苯并吲哚的合成方法
By using N-methyl-2-naphthylamine and ethylene glycol as raw materials and a supported palladium catalyst as the catalyst, the problems of limited raw material sources and complex reactions in the prior art were solved, and the efficient synthesis of N-methyl-4,5-benzoindole was achieved with a yield of 86%.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TAIYUAN UNIVERSITY OF TECHNOLOGY
- Filing Date
- 2023-06-05
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing N-methyl-4,5-benzoindole suffer from problems such as limited raw material sources, complex reactions, unfriendly solvents, and low yields.
N-methyl-2-naphthylamine and ethylene glycol were used as raw materials, and a palladium-supported catalyst was used as the catalyst to synthesize N-methyl-4,5-benzoindole by stirring and heating for 24 hours. Al2O3, TiO2, ZnO, γ-molecular sieve, ZrO2, ZSM-5 or MnO2 were used as supports, and Pd/ZnO was used as the supported catalyst. The reaction temperature was 150-190℃, and the product was separated and purified by thin-layer chromatography and column chromatography.
It achieves a wide range of raw material sources, simple reaction, convenient separation, and a yield of 86%.
Smart Images
Figure CN116903518B_ABST