一种含吲哚嗪的二芳基甲烷衍生物及其制备方法和应用
By synthesizing diarylmethane derivatives containing indoleazine and benzofuran or indole, the problem of single biological activity of existing compounds has been solved, achieving simultaneous antibacterial and anticancer activities, which has important biological activity and drug development potential.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGXI NORMAL UNIV
- Filing Date
- 2022-11-02
- Publication Date
- 2026-07-17
AI Technical Summary
Existing diarylmethane compounds containing indoleazine have limited biological activity, mainly exhibiting insufficient inhibitory activity against secretory phospholipase sPLA2, and lacking antibacterial and anticancer activities.
Diarylmethane derivatives containing indoleazine and benzofuran or indole are synthesized by tandem cyclization reactions of 2-iodophenylpropadiene compounds and propargylpyridine compounds in the presence of palladium catalyst and base. The preparation method includes steps such as extraction, drying, filtration, vacuum distillation and column chromatography.
The synthesized compounds possess both antibacterial and anticancer activities. As fluorescent probes, organic synthesis intermediates, or drug intermediates, they have significant biological activity and drug development value. The reaction steps are simple, the products are easy to purify, and the substrates have strong universality.
Smart Images
Figure CN116903612B_ABST