Portable blood purification system

Abstract

A dialysis system can include a blood circuit, a cartridge, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing, a cartridge holder configured to removably receive the cartridge, and a loading system. The movable support is configured to hold the sensor and / or the blood pumping mechanism of the subsystem. The loading system can be configured to move the movable support relative to the housing, e.g., by axial movement, to a first position and a second position, while the cartridge holder is fixedly arranged in the housing. The loading system can have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guide assembly configured to cooperate with the drive assembly.

Description

[0001] Cross-references to related applications

[0002] This application is a divisional application of PCT international patent application No. 201880084803.6, filed on October 31, 2018, entitled "Easily Portable Blood Purification System". The international application number of that PCT international patent application is PCT / IB2018 / 058539, which claims priority to European applications No. EP17199362.9, EP 17199363.7, filed on October 31, 2017; European applications EP 17209117.5, filed on December 20, 2017; and European applications EP 17209126.6, filed on December 20, 2017, the entire contents of which are incorporated herein by reference. Technical Field

[0003] This invention generally relates to the field of blood purification systems and methods. For example, this invention relates to an extracorporeal blood treatment apparatus for performing dialysis treatments (e.g., hemodialysis treatments). Background Technology

[0004] Extracorporeal blood processing is typically used to remove harmful substances or molecules from a patient's blood and / or to add beneficial substances or molecules to the blood. Such processing is used for patients from whom substances cannot be effectively removed from their blood, such as when a patient has temporary or permanent kidney failure.

[0005] This process is typically achieved by removing blood from the patient and introducing it into a filtration unit (such as a dialyzer), where the blood is allowed to flow through a semipermeable membrane. Depending on the type of treatment, the semipermeable membrane selectively allows substances in the blood to pass through the membrane from the primary chamber to the secondary chamber, and also selectively allows substances in the secondary chamber to pass through the membrane into the blood in the primary chamber. Several different types of extracorporeal blood treatments can be performed: - Ultrafiltration (UF) treatment; -Hemofiltration (HF) treatment; - Hemodialysis (HD) treatment; - Hemodiafiltration (HDF) treatment.

[0006] Currently, the most widely used kidney dialysis method for treating end-stage renal disease is hemodialysis. In hemodialysis, the patient's blood is purified by passing it through a primary chamber and a dialysate solution through a secondary chamber. During dialysis, the arterial and venous portions of the blood tubing deliver the patient's blood to and from a filtration device (such as a dialyzer). Impurities and toxins are removed from the patient's blood through diffusion or convection across the membrane in the filtration device. Hemodialysis is typically performed three times a week, with each session potentially taking up to four to five hours at a dialysis center, or at home, where treatment may be more frequent (up to daily) and shorter (as little as two hours). During treatment, the patient is connected to a hemodialysis machine, and the patient's blood is pumped through the machine. Catheters are inserted into the patient's veins and arteries so that blood can flow in and out of the hemodialysis machine. A large amount of dialysate solution, such as approximately 120 liters, is consumed during a single hemodialysis treatment to dialyze the blood.

[0007] Currently, the trend is towards more home-based care. Home-based care offers patients a better quality of life and greater privacy, and is relatively inexpensive. However, extracorporeal blood processing devices are heavy, bulky, and complex to use.

[0008] For example, an extracorporeal blood processing system could be 1370×480×480 mm in size and weigh 86 kg. Even though some companies have attempted to design smaller systems, the smallest devices are, for example: NxStage SystemOne: 385×385×385 mm, 34 kg; and Quanta SC+: 480×370×450 mm, 30 kg. Therefore, these devices are not easily portable, and it would be impossible, or at least very difficult, to carry such a system when traveling. Thus, size (both dimensions and weight) is a significant disadvantage of such systems. Therefore, even if home systems were available, patients would still have to remain at home (in the same way they would in a hospital) due to the non-portability of such devices.

[0009] Furthermore, because dialysis equipment uses up to 25 or 40 liters of dialysis fluid per day (up to 120 or 200 liters in home treatment or in a dialysis center), patients must store large volumes of fresh dialysis fluid at home, and handle several dialysis fluid bags (fresh and used) daily. Other machines allow water to be converted into dialysis solution, but these machines use significant amounts of energy and water, and pose a potential risk of contamination. In both cases, environmental impact is important. Another disadvantage of these tap water-using dialysis systems is the need for a dedicated water treatment system, which includes large and heavy equipment, water connections, and discharge devices. Installing and using these components is a daunting and cumbersome task, potentially requiring changes to the patient's residence. As a result, water treatment systems make home hemodialysis systems even less portable.

[0010] Another significant drawback is that HD systems involve several fluid circuits coupled to the device during treatment. Older systems consisted of a dedicated cartridge for the dialysate circuit and a set of tubing for the blood circuit. These systems were difficult to use, requiring trained nurses to operate. To simplify use, some companies designed single cartridges suitable for coupling with the device. Such cartridges, including portions of both the blood and dialysate circuits, were quite large. While designed to simplify handling, these cartridges were practically too large, heavy, and difficult to use. Furthermore, in many cases, patients noticed coupling failures between the cartridge and the device. This made them quite strenuous to use. Summary of the Invention

[0011] The aforementioned drawbacks can be eliminated by means of the dialysis system according to the present invention.

[0012] One of the goals is to provide a more compact, safer, and easier-to-use dialysis system for home use, while also being transportable.

[0013] A first aspect of the present invention provides a blood treatment system comprising: a blood line including a blood cartridge (disposable after a single use); a dialysate line including a dialysate cartridge (disposable after a single use); a dialyzer (disposable after a single use) including a blood compartment in fluid communication with the blood line and a dialysate compartment in fluid communication with the dialysate line; and a dialysis unit (reusable for multiple treatments and preferably portable).

[0014] One advantage of using two boxes is that they facilitate coupling, and each box can be designed to be as compact as possible. Furthermore, by using two different boxes, the components within the dialysis unit can be arranged to be more compact and tolerancing can be improved.

[0015] A second aspect of the invention provides a blood processing system comprising at least one cartridge for a blood circuit and / or for a dialysate circuit, and a dialysis unit. The dialysis unit includes components for controlling dialysis processing, such as a processor, valve actuators, sensors, a blood pump mechanism adapted to cooperate with a blood line to move blood through the blood line when the blood line is in fluid communication with a blood source, and / or a dialysate pump mechanism adapted to cooperate with a dialysate line to move dialysate through the dialysate line when the dialysate line is in fluid communication with a dialysate source. The system also includes a housing in which the components of the dialysis unit are arranged. The housing may have a front panel and a pair of side panels, a (blood and / or dialysate) cartridge holder arranged in the housing for removably receiving the (blood and / or dialysate) cartridge, and an opening (e.g., a retaining slot) arranged through the housing to allow the cartridge (e.g., horizontally) to be inserted into the housing.

[0016] The cassette may include a handle designed to be gripped by the user's fingers. The cassette can be inserted into the housing by sliding horizontally (or vertically). When the cassette is inserted into the cassette holder, the handle may extend from the housing or be accommodated within the cassette compartment. Preferably, the blood circuit includes a dedicated cassette, and the dialysate circuit includes a dedicated cassette. In this case, two different openings can be arranged / designed / adjusted for each cassette. One opening can be designed to accept / receive / allow only its specific type of cassette.

[0017] A third aspect of the invention provides an easily portable system. It is not a system fixed to a patient, but rather a system that can be transported / carried to allow travel anywhere in the world. For example, the system includes all the components required for treatment, as well as a housing designed to be portable, small in size, and lightweight. For example, the housing of the system can be adapted to be stored in carry-on baggage during travel. The dimensions of the housing can be set to fit into or be smaller than carry-on baggage (e.g., for air travel), for example, at least one dimension less than 31 cm, another less than 51 cm, and / or another less than 61 cm. Furthermore, the carry-on baggage used to transport the system can serve as a support, so that the system can be placed in, on, or rested on the carry-on baggage during treatment. In other examples, the system may include a removable container holder for the solution bag, which can be operatively coupled to the housing of the machine (or to carry-on baggage, for example, the (retractable) handle of the carry-on baggage can serve as the removable container holder) to provide a first position and a second position. The first position may be adapted to perform processing (e.g., processing required in the operational configuration), and the second position may be adapted to facilitate the movement of the system, for example, during travel or for use in a transportation system.

[0018] The movable container support may include a rod secured to the system by a rotating fixing element adapted to move the rod from a first position to a second position, and / or from a second position to a first position. The movable container support may include a concave receiver portion designed to receive and store at least one solution bag.

[0019] The system may include a container receiver designed to receive and store at least one solution bag disposed in the upper part of the housing. A movable container support may be disposed on the upper part of the system. The movable container support may be disposed above the container receiver.

[0020] A fourth aspect of the invention provides a dialysis system with a convenient loading device. For example, the system may include a loading device with a drive mechanism for a cassette holder adapted to move the cassette holder to a first position and a second position. The first position may be adapted to allow insertion or removal of a cassette (insertion into or removal from the cassette holder), and the second position may be adapted to perform the procedure. In this case, the second position may be adapted to prevent the user from removing the cassette from the cassette holder and / or inserting the cassette into the cassette holder. The loading system can be operatively coupled to the aforementioned opening.

[0021] A fifth aspect of the invention provides a hemodialysis system comprising a pre-fill container (e.g., a bag) in fluid communication with at least one of a blood circuit and a dialysate circuit. In one embodiment, the bag may store a (single) solution (e.g., dialysate solution, saline solution, or other compatible solution) that can be supplied to the system for both circuits to pre-fill all or part of the system. The pre-fill container may include a first (removable) fluid connection and a second (removable) fluid connection for connection to at least one of the dialysate circuit and the blood circuit.

[0022] A sixth aspect of the present invention provides a blood processing system comprising at least one of the following: - Fluid (blood and / or dialysate) tubing, including fluid cartridges - A dialysis unit, which may include components for controlling dialysis treatment, the components including at least one of a processor, a valve actuator, a sensor, and a fluid pumping mechanism adapted to cooperate with a fluid line to move fluid through the fluid line when the fluid line is in fluid communication with a fluid source. - The housing, in which the components of the dialysis unit can be arranged, may have a front panel and a pair of side panels. - Component support, adapted to hold at least one of a valve actuator, sensor, and fluid pumping mechanism; and - Fluid cartridge holder, which is arranged in the housing and is used to removably receive the fluid cartridge.

[0023] The dialysis unit also includes a loading system comprising a first position required in the operating configuration and a second position allowing insertion or removal of a fluid cartridge. Preferably, the loading system includes a drive mechanism controlled by a processor and adapted to achieve access to the first and second positions.

[0024] In one embodiment, the fluid cartridge retainer is configured to move relative to the housing (or component support) when the component support is securely fixed to a non-moving part of the system (e.g., the system housing and / or frame).

[0025] In one embodiment, the component support is configured to move relative to the housing (or fluid box retainer) when the fluid box retainer is securely fixed to a non-moving part of the system (e.g., the system housing and / or frame).

[0026] In one embodiment, the component support and fluid cartridge retainer are configured to move relative to the housing (or non-moving parts of the system).

[0027] The drive mechanism can be adapted to move the box holder and / or component support substantially vertically according to the main plane of the box and / or according to the surface on which the system is placed.

[0028] The system may also include an indicator device adapted to notify the user of the current location of the loading system.

[0029] The system may include an alignment mechanism configured to align the fluid cartridge with components of the dialysis unit. The alignment mechanism may include a portion of a fluid pumping mechanism (e.g., a pump shaft that may mate with the pump portion of the fluid cartridge).

[0030] The system may also include an opening configured to allow a fluid cartridge to be inserted into the housing. This opening may be dedicated to a specific type of fluid cartridge. The opening may include a retaining slot. The opening may include elements with anti-pinch functionality.

[0031] A seventh aspect of the present invention provides a blood treatment system comprising at least one of the following: - Blood tubing used to receive blood from patients. - Dialysis fluid lines used to receive dialysate solutions. - A dialyzer comprising a blood compartment in fluid communication with a blood line and a dialysate compartment in fluid communication with a dialysate line. - The first box contains a portion of the blood tubing. - A dialysis unit, comprising components for controlling dialysis treatment, the components including at least one of the following: o processor, o First valve actuator o First sensor, and o A blood pumping mechanism, adapted to cooperate with blood lines to move blood through the blood lines when the blood lines are in communication with a source blood fluid. - The housing, in which the components of the dialysis unit are arranged, has a front panel and a pair of side panels. - A movable support member for the component, arranged within the housing and adapted to hold at least one of the first sensor and the blood pumping mechanism, and - First box holder, which is configured to removably receive the first box.

[0032] The dialysis unit may also include a loading system configured to move movable supports of components relative to the housing to a first position and a second position when the first cartridge holder is fixedly arranged in the housing (e.g., a non-moving part of the system, such as a frame). The first position may be required in an operational configuration, and the second position may allow insertion and / or removal of the first cartridge.

[0033] The blood pumping mechanism may include a shaft, and the first cartridge may include a roller assembly configured to be operatively coupled to the shaft and to at least partially align the cartridge with a movable support of the component, such that when the movable support of the component is in a first position, at least one of a first valve actuator and a first sensor is aligned with a dedicated area of ​​the cartridge.

[0034] The system or housing may include at least one of a fixed slot and a sliding door, the fixed slot being configured to insert a first box into or through the housing. The sliding door may be mechanically coupled to at least one of a movable support member and a loading system to open the sliding door when the movable support member moves to a second position.

[0035] The first valve actuator may be fixedly disposed within the housing. The first valve actuator may include a movable shaft configured to close and open the blood tubing, and the movable shaft may include a position configured to allow insertion and / or removal of the first cartridge.

[0036] Preferably, the first box holder includes a detection sensor configured to send a signal to the processor when the first box is inserted into the first box holder. The processor can be configured to initiate displacement of the movable support of the component based on the signal from the detection sensor.

[0037] The system (e.g., an opening and / or a box retainer) may include an encoding element configured to prevent other types of box insertion.

[0038] The system (e.g., an opening and / or a box retainer) may include a locking system configured to engage with the first box to prevent the first box from being pulled out when the movable support of the component is in a first position.

[0039] One embodiment of the system also includes at least one of the following: - A second box, different from the first, which includes a portion of the dialysate tubing. - A dialysate pumping mechanism adapted to work with a dialysate line to move dialysate through the dialysate line when the dialysate line is in communication with the dialysate source fluid. - Second sensor, and - Second valve actuator.

[0040] One embodiment of the system also includes at least one of the following: - A second box holder, which differs from the first box holder and is configured to removably receive the second box, and - An additional movable support for the component, which is different from the movable support for the component arranged in the housing, and is adapted to hold at least one of the second sensor, the second valve actuator, and the dialysate pumping mechanism.

[0041] The loading system can be configured to move the movable support of the additional component relative to the housing in third and fourth positions when the second box retainer is fixedly arranged in the housing (e.g., fixed to a non-moving part of the system, such as a frame). The third position may be required in the operational configuration, and the fourth position may allow for the insertion and / or removal of the second box. Attached Figure Description

[0042] The invention will be better understood from the following detailed description, which includes non-limiting examples shown in the following figures: Figure 1 A schematic diagram of the fluid circuit is shown; Figures 2a-2f Different views of an embodiment of the blood circuit are shown; Figure 3 A dialysate circuit according to one embodiment is shown; Figure 3a A dialysate circuit with a sensor is shown according to one embodiment; Figure 4 The interaction between the disposable portion and the reusable portion is illustrated. Figures 5a-5c' A cross-sectional view of the box is shown; Figure 6 The components of a fluid pump are shown; Figure 7The system is shown in an operational configuration where no usable, discarded portion is available. Figure 8 The system is shown in an operational configuration where no usable, discarded portion is available. Figure 9 A dedicated opening for inserting the blood cartridge into the system is shown; Figure 10 A dedicated opening for inserting the dialysate cartridge into the system is shown; Figures 11a-12c The apparatus is shown in a first configuration (required for processing), a second configuration (capable of saving space), and a third configuration (option 12b) (enabling the prepared treatment, for example, to access the container receiver); Figures 13a-13g Different views of the box loading process are shown; Figure 14 An exploded view of one embodiment of the loading system is shown; Figures 15a-15d Different locations of loading systems with or without boxes are shown; Figure 16 An exploded view of one embodiment of the loading system is shown; Figure 17 A 3D view of one embodiment of the loading system is shown; Figure 18 The drip chamber and its support structure are shown; Figure 19 The dialysis system stored in carry-on luggage is shown; Figure 20 and 21 An illustration of a system using a pre-filled container is shown; Figure 22 , 23a -23c, 24, 25 and 26 illustrate several embodiments of the opening and box according to the invention; Figure 27 A flowchart of the box detection process is shown; Figure 28 A flowchart of the loader position detection process is shown; Figure 29 A schematic diagram of the device's electronic equipment is shown; Figures 30a to 30h Several locations of the door device are shown; Figure 31a and 31b Two embodiments of the door device are shown; Figure 32 yes Figure 31a or Figure 31b Internal view; Figure 33 , 34Views 35 and 36 show different views of potential embodiment 600; Figure 37 , 38 Views 39 and 39 show different views of potential embodiment 700; Some diagrams do not show all features in order to make the diagrams clearer.

[0043] Component list 1. Extracorporeal blood processing system 2. Dialyzer 3. Blood Circuit 4. Dialysis fluid circuit 4' Additional loops / piping, such as (concentrate or initial supply loop) 5 patients 6. Arterial tubing 7. Intravenous lines 8. Blood pump 9. Infusion Chamber 10 First Chamber 11 Second Chamber 12 membranes 13 bags / container 14 First Dialysis Fluid Pump 15. Dialysis fluid pipeline 15' Bypass pipeline 16 Second Dialysis Fluid Pump 17. Element for receiving solution from dialyzer 18 Ring Road 19 Containers (Health Regeneration Containers) 19' Discharge container or discharge compartment 20 pipelines 21 valve 22 pipelines 23 valves 24 Arterial valve 25. Vein valve 26 Artery Connectors 27 Vein Connector 28 Initial Supply Container 29 Weight Scale 30 pumps 31 Supply containers (e.g., concentrate supply bags) 32 Supply Containers 33 Single pre-filled containers 34 First Connector 35' Second Connector 36 Third Connector 37 Dialysis fluid loop connector 38. Normal flow direction (blood circuit) 39. Normal flow direction (dialysis fluid loop) The potential limit of 40 boxes 41 Supply Container 42 Normal pumping direction 43 Reverse pumping direction 44 Adsorbent Connector 45 First Spike 46 Second Spike 100 Blood Purification System 101 Discardable parts after use 102 Reusable parts / devices 103 Dialyzer 104 Adsorbent 105 bags 106 boxes 107 Rigid Frame 108 membrane 109 Handle 110 processor 111 Screen (device, such as a tablet with a touchscreen) 112 Other components, such as buttons 113 Sensors 114 Actuator 115 Connected to the processor and operatively and removably coupled to other components of the disposable part after use. 116 pipes 120 cavity Port 121 122 Handle 123 Valve seat 124 Fluid Path 200 Box containing part of a pump 201 Flexible Pipe Fluid path of box 202 203 Pump inlet port 204 Pump outlet port 205 Roller Assembly 206 Roller Support 207 axis 208 rollers 300 Units (Reusable Part) 301 housing 302 Display device 303 Screen Support 304 Container Support 305 Additional Screen 306 Power Button 307 Emergency Button 308 Dialyzer Support 309 Drip chamber support 310 First Opening 311 Second opening 312 strokes 313 Hook 314 Rotary fixed element 315 Movable container support 316 Container Receiver 317 Fixed Components 318 concavity 319 Part One 320 Part Two 321 Front Panel 322 Side Panel 323 Side Panel 324 Opening on the first side 325 Opening on the second side 326 Insertion Direction 327 First side of the casing 328 The second side of the casing 400 Loading System 401 Box Retainer 402 Dedicated active components (e.g., sensors) 403 Dedicated active components (e.g., valve actuators) 404 Specialized active components (e.g., pump motors) 405 motor shaft 406 Support for dedicated active components 407 Box Retainer Movement 408 Movement of dedicated active components 409 Drive Mechanism 410 motor 411 Driver Components 412 Bootstrap Components 412' Guide or sliding element 413 Support for guiding elements 414 sales 415 doors 416 door actuator 417 Inside the casing 418 Locking System 419 Opening Part of the 420 housing 421 Elastic element 422 Coupling Component 423 Flexible Components 500 drip chamber support 501 Infusion Chamber 502 Main Body 503 lock 504 Mechanical Coding System 600 dialysis system Device 601 602 Blood Box 603 Dialysis Fluid Box 604 First Door 605 Second Door 606 Dialyzer 607 housing 608 Dialyzer Support 609 strokes 610 Display Device 611 Weighing Scale 612 Adsorbent Equipment 613 pipe 614 Weighing Bag 615 Device Support 700 dialysis system Device 701 702 Blood Box 703 Dialysis Fluid Box 704 doors 705 Heated Chamber 706 Dialyzer 707 housing 708 Dialyzer Support 709 strokes 710 Display Device 711 Weighing Scale 712 Adsorbent Equipment 713 tube 714 Weighing Bag 715 Device Support Detailed Implementation

[0044] In the following detailed description, reference is made to the accompanying drawings, which form a part of the description, and several embodiments of the apparatus, system, and method are illustrated by way of example. It should be understood that other embodiments are conceived and can be made without departing from the scope or spirit of this disclosure. It should be understood that while a hemodialysis system is described herein, some of the embodiments described herein can also be used in or arranged in peritoneal dialysis systems or other blood processing and purification systems (e.g., continuous renal replacement therapy (CRRT)). Therefore, the following detailed description should not be considered limiting.

[0045] Unless otherwise stated, all scientific and technical terms used herein have the meanings commonly used in the art. The definitions provided herein are for the purpose of understanding certain terms frequently used herein and are not intended to limit the scope of this disclosure.

[0046] As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” cover embodiments having a plurality of indicators, unless otherwise expressly stated.

[0047] As used in this specification and the appended claims, any orientation referred to herein, such as “top,” “bottom,” “left,” “right,” “upper,” “lower,” and other orientations or features, is for clarity of description with reference to the accompanying drawings and is not intended to limit the actual device or system. The devices and systems described herein can be used in many orientations and features.

[0048] As used in this article, words such as “have,” “possess,” “include,” “contain,” “include,” “including,” and “include” are used in their open-ended sense and usually mean “including but not limited to.”

[0049] As used herein, “at least one of A, B and C”, “at least one of A, B or C”, “selected from the group consisting of A, B, C and combinations thereof”, etc., are used in their open-ended sense, including “only A, or only B, or only C, or any combination of A, B and C”, unless the context clearly indicates otherwise.

[0050] As used in this specification and the appended claims, the terms “or” and “ / ” are generally used to mean “and / or” unless the content expressly indicates otherwise.

[0051] As used in this article, "blood-compatible solution" usually refers to "a physiologically compatible solution for contact with blood, a physiologically compatible solution for infusion into a subject, or a solution for flushing blood back into the subject."

[0052] Text or terms enclosed in parentheses should be understood as optional features, synonyms, similar terms, or examples.

[0053] fluid circuit

[0054] refer to Figure 1 The extracorporeal blood processing system 1 may include a dialyzer 2, a blood circuit 3, and a dialysate circuit 4.

[0055] Blood circuit 3 (also referred to as extracorporeal circuit) connects patient 5 to dialyzer 2. More specifically, blood circuit 3 includes an arterial (blood) line 6 and a venous (blood) line 7 connecting patient 5 to dialyzer 2. Arterial line 6 may include a removable arterial connector 26 for connection to the patient, while venous line 7 may include a removable venous connector 37 for connection to the patient. Blood circuit 3 includes at least one pump 8 for pumping fluid through the blood circuit, such as pumping blood to or from dialyzer 2. Blood pump 8 may be, for example, a peristaltic pump, a pump chamber, etc. Additionally, clamps, such as valves, may be arranged and positioned in blood circuit 3. Furthermore, an air sensor may be located within the extracorporeal circuit. The air sensor may, for example, detect the presence of air within the extracorporeal circuit. Infusion chamber may be arranged and positioned within the extracorporeal circuit, for example, in venous line 7. Infusion chamber may, for example, remove air bubbles present in the blood circuit. The air sensor may be arranged downstream of the infusion chamber and / or upstream of at least one of the valve and removable venous connector 27. Prior to processing, air (or other fluids or gases) may be present in the blood circuit 3. Therefore, the patient or other healthcare professional may need to pre-fill it by removing the external circuit 3, as described below.

[0056] The dialyzer 2 has a first chamber / compartment 10 through which blood flows, an arterial (blood) port through which blood enters, and a venous (blood) port through which blood exits. The dialyzer 2 has a second chamber / compartment 11 through which a dialysate solution moves, a first (dialysate) port through which a dialysate solution (more particularly, fresh or regenerated dialysate) enters, and a second (dialysate) port through which a dialysate solution (more particularly, used dialysate) exits. The used dialysate is the dialysate solution exiting from the second dialysate port and may include ultrafiltrate (mixed with other fluids). Ultrafiltrate is a fluid containing excess water from the patient. The dialyzer 2 has a membrane 12 separating the first chamber from the second chamber. This membrane may be adapted (e.g., the membrane may be semi-permeable) to allow fluid or components to flow from the first chamber to the second chamber (and / or vice versa).

[0057] The dialysate circuit 4 includes at least one pump adapted to deliver fluid through the dialysate circuit 4 (e.g., to or from the dialyzer 2). Preferably, the dialysate circuit 4 may have a first dialysate pump 14 adapted to pump a solution (e.g., a solution stored in bag 13) to the dialyzer 2. Bag 13 may store a dialysate solution as fresh dialysate or another solution as a pre-fill solution. Bag 13 may be initially empty. Bag 13 may be in fluid communication with the dialyzer 2 via a fluid line. This fluid line may include the first dialysate pump 14, or may be a bypass adapted to bypass the fluid line including the first dialysate pump 14. The fluid line may include a valve to open or close the fluid communication between bag 13 and dialyzer 2. The dialysate circuit 4 may have a second dialysate pump 16 adapted to pump a solution exiting the dialyzer 2, such as used dialysate and / or ultrafiltrate. The solution can move upwards to element 17, which is adapted to receive, for example, used dialysate and / or ultrafiltrate. This element can be a bag (suitable for storing the solution) or an adsorbent device (suitable for cleaning or regenerating the solution). The dialysate circuit can include a loop 18 adapted to allow fluid communication between bag 13 and element 17 (particularly when element 17 is an adsorbent). In this case, bag 13 includes an outlet in fluid communication with dialyzer 2 and an inlet in fluid communication with element 17 (e.g., an adsorbent device). The dialysate circuit can include at least one of a valve and a sensor, such as a pressure sensor, level sensor, weighing scale, flow meter, blood sensor, ammonia sensor, etc. The dialysate pump can be, for example, a peristaltic pump, a pump chamber, etc. Air (or other fluids or gases) may be present in the dialysate circuit before processing. Therefore, patients or other healthcare professionals may need to pre-fill the dialysate circuit by removing it, as described below. A bypass can be arranged between the second dialysate pump 16 and the bag 13 to bypass the element 17 (e.g., to bypass the adsorbent device when the adsorbent is no longer available).

[0058] Blood circuit

[0059] Now go to Figures 2a-2f The blood circuit may include a bag 19 adapted to receive and / or store solutions and to be in direct fluid communication with arterial and / or venous lines. The term "direct fluid communication" is used herein to mean "physically and fluidly connected to and at least temporarily in fluid communication with" without bypassing another fluid path, filter, dialyzer, adsorbent, or pump. A valve may be used to control the direct fluid connection (automatically or non-automatically via this device). The bag 19 may be empty at the start of treatment. The bag 19 may be filled with saline solution or other solutions compatible with blood. The bag 19 may be used to prefill the blood circuit and / or push blood back to the patient, as described below.

[0060] Preferably, bag 19 may initially be substantially empty (without liquid and / or gas) and sterilized. During the prefilling process of the blood circuit, bag 19 may be filled with a prefilling solution (which may be a saline solution, dialysate solution, or other solution) and / or fluids (e.g., gases) initially stored in the fluid path of the blood circuit prior to processing. Bag 19 may include a degassing device, such as a vent with a hydrophobic membrane, to expel gases (e.g., air) that may be stored or injected into the bag (the storage compartment of the bag). The dimensions of bag 19 may be configured to store a fluid volume that is substantially equal to or greater than (e.g., approximately twice the previously defined volume) the volume defined by the inner walls of the blood circuit (e.g., the volume defined by the interior of the tube, cartridge, dialyzer blood compartment, and / or drip chamber, etc.). Bag 19 may advantageously be filled with a prefilling solution during the prefilling process, then the bag stores the solution during processing, and at the end of processing, the solution may be used to push blood back to the patient.

[0061] If the patient's blood pressure drops during treatment, a volume fraction of the solution stored in bag 19 can be injected into the blood circuit. Therefore, the system limits the amount of fluid required for pre-filling and backfilling processes, and even more so when the pre-filling solution is a dialysate solution or a saline solution. Thus, only one liquid solution (or a limited number of different solutions) can be prepared, added, or used for treatment (or at least a limited number of bags). When the system uses an adsorbent and a concentrate solution, only two (or fewer than three) solutions can be used as dialysate solutions (and / or saline solutions) and one or more concentrate solutions for overall treatment.

[0062] Stored in connection with the dialysate circuit (and optionally with the blood circuit) (e.g., as...) Figure 20 The solution in bag 28 or 33 (as shown in 21) (which is in direct fluid communication with it) can be used to prefill the blood circuit and / or fill bag 19. This solution can be a saline solution or a dialysate solution.

[0063] according to Figure 2a The blood circuit includes tubing 20, which is in direct fluid communication with the arterial tubing and the interior of the bag 19 (e.g., a storage compartment). The connection between tubing 20 and the arterial tubing 6 is arranged or located upstream of the pump 8 (“upstream” according to the normal flow direction) and preferably downstream of the arterial connector 26. The normal flow direction is... Figure 1 Arrow 38 indicates the blood circuit and arrow 39 indicates the dialysate circuit. Line 20 may include a (removable) connector and / or valve 21 (V3), which can be controlled to open or close the fluid communication via a controller device (e.g., a processor).

[0064] according to Figure 2b The blood circuit includes a line 22 that is in direct fluid communication with the arterial line and with the interior of the bag 19 (e.g., a storage compartment). The connection between line 22 and the arterial line 6 is arranged or located downstream of the pump 8 ("downstream" according to the normal flow direction) and preferably upstream of the venous connector 27 (e.g., upstream of at least one of a venous valve, infusion chamber, and dialyzer). Line 22 may include a (removable) connector and / or a valve 23 (V4) that can be controlled to open or close the fluid communication via a controller device (e.g., a processor). Figure 2d In another embodiment described in part, the blood circuit may include a line 22 in direct fluid communication with the venous line 7 and the interior of the bag 19 (e.g., a storage compartment). The connection between line 22 and the venous line 7 is arranged or located downstream of the pump 8, for example, upstream or downstream of the dialyzer (depending on the normal flow direction). Line 22 may include a valve 23 (V4) that can be controlled to open or close the fluid communication via a controller device (e.g., a processor).

[0065] according to Figure 2c The blood circuit includes line 20, which is in direct fluid communication with the arterial line and the interior of bag 19 (e.g., storage compartment). The connection between line 20 and the arterial line 6 is arranged or located upstream of pump 8 ("upstream" according to the normal flow direction). Line 20 may include valve 21 (V3), which can be controlled to open or close the fluid communication by, for example, a processor. The blood circuit also includes line 22, which is in direct fluid communication with the arterial line and the interior of bag 19 (e.g., storage compartment). The connection between line 22 and the arterial line 6 is arranged or located downstream of pump 8 but upstream of dialyzer. Line 22 may include valve 23 (V4), which can be controlled to open or close the fluid communication.

[0066] according to Figure 2d The blood circuit includes line 20, which is in direct fluid communication with the arterial line 6 and the interior of the bag 19 (e.g., storage compartment). The connection between line 20 and the arterial line 6 is arranged or located upstream of pump 8 ("upstream" according to the normal flow direction). Line 20 may include valve 21 (V3), which can be controlled to open or close the fluid communication by, for example, a processor. The blood circuit also includes line 22, which is in direct fluid communication with the venous line 7 and the interior of the bag 19 (e.g., storage compartment). The connection between line 22 and the venous line 7 is arranged or located downstream of pump 8 (and / or dialyzer and / or infusion chamber). Line 22 may include valve 23 (V4), which can be controlled to open or close the fluid communication.

[0067] The blood circuit may include an arterial valve 24 (V1) disposed and positioned in an arterial line 6. The arterial valve 24 can be controlled to open or close the arterial line. The arterial valve may be disposed / positioned upstream of the pump 8 and / or upstream of lines 20 and / or 22. The blood circuit may include a venous valve 25 disposed and positioned in a venous line 7. The venous valve 25 can be controlled to open or close the venous line 7. The venous valve may be disposed / positioned downstream of the pump 8 and / or downstream of lines 20 and / or 22 and / or downstream of the infusion chamber 9. The arterial valve 24 and / or venous valve 25 may be disposed within a blood cartridge and may include a flexible tube that can be clamped by a clamping valve.

[0068] according to Figure 2e The blood circuit includes an arterial connector 26 disposed / positioned at the end of the arterial line 6. The arterial connector 26 is adapted for and used to connect to a patient's catheter. The blood circuit also includes a venous connector 27 disposed / positioned at the end of the venous line 7. The venous connector 27 is adapted for and used to connect to a patient's catheter.

[0069] Arterial connector 26 and venous connector 27 may be adapted to connect together to allow fluid communication between arterial line 6 and venous line 7 (without needing to pass through a dialyzer) and form a (closed) loop of blood circulation. If arterial connector 26 and venous connector 27 cannot be directly connected together, the system may include an interconnecting device comprising a first end adapted for connection to arterial line 6 and a second end adapted for connection to venous line 7. The interconnecting device allows fluid communication between arterial line 6 and venous line 7 and forms a (closed) loop of blood circulation.

[0070] according to Figure 2fThe blood circuit may further include at least one of an air sensor (As1, As2) and a pressure sensor (Ps1, Ps2, Ps3). Preferably, the first air sensor may be configured to mate with the arterial line 6, and the second air sensor may be configured to mate with the venous line 7. The air sensors may be configured to mate with the fluid path of the blood cartridge. The first air sensor may be located downstream of the arterial connector, but preferably upstream of the arterial valve. The second air sensor may be located upstream of the venous connector, but preferably downstream of the venous valve. Preferably, the first and second pressure sensors may be configured to mate with the arterial line 6, and the third pressure sensor may be configured to mate with the venous line 7. The pressure sensors may be configured to mate with the fluid path of the blood cartridge. The first pressure sensor may be located upstream of the blood pump 8, but preferably downstream of the connection to line 20. The second pressure sensor may be located downstream of the blood pump 8, but preferably upstream of the connection to line 22. The third pressure sensor may be located upstream of the venous valve, but preferably downstream of the infusion chamber.

[0071] Dialysis fluid circuit

[0072] Now for reference Figure 3 The dialysate circuit may have a bag 28 that can store a solution, such as a dialysate solution (e.g., the initially supplied dialysate) or a prefill solution (which may be a dialysate solution, saline solution, or other solution). The bag 28 can be used to add liquid solutions to the dialysate circuit or to initially fill the bag 13 (if, for example, the bag is initially empty before processing begins) or to prefill at least a portion of the circuit. The bag 28 may be in direct fluid communication with the first dialysate pump 14 via a line that may include a valve v5. The bag 28 may also be in direct fluid communication with a bypass line 15 via a line that may include a valve v5, in which case the bag 28 can be used to remove a portion of the volume of solution from the dialysate circuit, for example, from the bag 13 (closing V8 and V7, opening V6 and V5, and actuating the first dialysate pump). The bypass line 15' may include a valve v8. The circuit 18 may include a valve v12. The bag 13 may be in direct fluid communication with the first pump via a line that includes a valve v6.

[0073] The dialysate circuit may have a supply circuit / line 4' (also known as an additive circuit or concentrate circuit). The supply circuit 4' may include at least one supply pump (e.g., concentrate pump 30) in fluid communication with the dialysate loop, for example connected to loop 18 or bag 13, to add a solution (e.g., concentrate, saline, dialysate, or a liquid different from dialysate) to the dialysate loop upstream of bag 13 or directly to bag 13. The supply circuit may have a flow meter or balance chamber to control or monitor the amount of concentrate added to the dialysate loop. The supply pump may be adapted to control and / or monitor the amount of concentrate added to the dialysate loop. The supply circuit may include a valve v10 located downstream of the supply pump 30 and / or upstream of its connection to the dialysate loop. The supply circuit 4' may include one or more bags (31, 32) that may store solutions such as concentrate solutions (also known as dilution solutions or additive solutions), saline solutions, and / or solutions of dialysate, such as the initially supplied dialysate or a solution different from dialysate. The supply loop can also be used to remove a portion of the solution volume from the dialysate loop. In this case, the supply pump 30 is accurate in reverse mode, and the bag 32 can receive the removed solution. The bag 32 can be weighed to monitor the volume of the removed solution.

[0074] In one embodiment, supply bag 32 stores saline solution or pure water, and the system does not include any initial dialysate supply bag. Therefore, dialysate is prepared from saline solution or pure water and a concentrate solution before treatment begins to bag 13, which may initially be empty. The processor may take into account the fact that the prepared dialysate solution will be regenerated / recovered multiple times by the adsorbent device during treatment, and thus a predetermined initial volume of dialysate solution is prepared before treatment begins. In particular, the volume of the initially prepared dialysate solution may be smaller than the volume of dialysate solution used at the end of treatment due to UF and / or the volume of added concentrate accumulated during treatment.

[0075] The dialysate circuit 4 can be adapted to allow fluid to flow, pump, and circulate in two opposite directions (e.g., through bypass line 15). The dialysate pump can be adapted to pump in two directions (e.g., in a first direction from bag 13 to dialyzer and in a second direction that is opposite to the first direction).

[0076] Bag 28 can be used to fill bag 13 by actuating the dialysate pump in a first direction (if bag 28 is connected to the pump's tubing). In this case, the solution initially stored in bag 28 passes through pump 14, then through tubing 15, and reaches bag 13. V6 and V7 are closed, and V5 and V8 are open. If bag 28 (via the dotted line) is connected to tubing 15, bag 28 can be used to fill bag 13 by actuating the dialysate pump in a second direction. The solution initially stored in bag 28 passes through tubing 15, then through pump 14, and reaches bag 13. V7 and V8 are closed, and V5 and V6 are open.

[0077] The system may include one or more balances (weighing scales) and / or heaters 29, which are adapted to weigh or heat solutions stored in at least one of bags 13, 13, 28, 31 and 32.

[0078] Preferably, the dialysate circuit includes an adsorbent device suitable for cleaning the used dialysate, allowing for multiple uses of the dialysate solution. In this case, a concentrated solution can be added to the dialysate circuit during treatment. Therefore, treatment can be performed with less than 10 liters of initial dialysate, preferably less than 5 liters, and more preferably less than 4 liters.

[0079] according to Figure 3a The dialysate circuit may further include at least one of an air sensor (As3), a pressure sensor (Ps4, Ps5, Ps6, Ps7, Ps8, Ps9), and a blood sensor (Bs1). Preferably, the third air sensor (As3) can be configured to cooperate with the dialysate line. The air sensor can be configured to cooperate with the fluid path of the dialysate cartridge. The third air sensor can be located upstream of the dialyzer 2, but is preferably located downstream of the bag 13.

[0080] Preferably, at least one pressure sensor in the dialysate circuit can be configured to cooperate with the fluid path of the dialysate cartridge, and more specifically with at least one pumping device of the dialysate circuit (or connected tubing). Thus, each pumping device may include a pressure sensor located upstream of the pumping device and another pressure sensor located downstream of the pumping device.

[0081] Preferably, the blood sensor (Bs1) can be configured to mate with the dialysate line. The blood sensor can be configured to mate with the fluid path of the dialysate cartridge. The blood sensor can be located downstream of the dialyzer 2, but is preferably located upstream of the pump 16.

[0082] Single pre-filled container

[0083] The system may include a (single) prefill container 33 in fluid communication with at least one of the blood circuit and dialysate circuit during the prefilling process (e.g., as shown in the image). Figure 20 and 21 (As shown), to pre-fill at least a portion of two loops. As another bag in the system, a single pre-filled container 33 may be a bag with one or more flexible walls that are sealed to a rigid wall or another flexible wall.

[0084] The system may include a dialysate circuit with a dialysate connector 37, a blood circuit with an arterial connector 26 and a venous connector 27, and a pre-filled container with a storage compartment. The system may be adapted to provide fluid connection between the storage compartment of the pre-filled container 33 and the connectors (dialysis fluid connector, arterial connector, and venous connector) (only during the pre-filling process of the system before treatment begins).

[0085] The system may also include at least one of a first pump dedicated to the blood circuit, a second pump dedicated to the dialysate circuit, a memory having computer-executable instructions dedicated to the pre-filling process, and a processor connected to the memory and the pumps. Both pumps may be adapted to move the pre-filling solution (initially stored in a pre-filling container) through the fluid circuit. The processor is adapted to control the pumps (sequentially or simultaneously) according to the computer-executable instructions to automatically perform all or part of the pre-filling process.

[0086] A single prefilled container can store saline solution, dialysate solution or other compatible solutions (compatible with blood and / or dialysate).

[0087] If a single pre-filled container stores a saline solution or other compatible solution (e.g., pure water) for preparing the dialysate solution, at least a portion of the dialysate solution (for treatment) can be automatically prepared from the stored solution. In this case, a portion of the volume of the solution initially stored in the single pre-filled container is added to bag 13 to prepare the dialysate solution before treatment begins, and a concentrate solution can also be added to bag 13. In this case, the processor can be programmed to automatically move a predetermined portion of the solution (initially stored in container 33) to bag 13 and a predetermined portion of the concentrate solution (initially stored in container 31) to bag 13. The processor can take into account the fact that the prepared dialysate solution will be regenerated / recovered multiple times by the adsorbent device during treatment, and thus prepare a predetermined initial volume of dialysate solution before treatment begins. In particular, the volume of the initially prepared dialysate solution may be smaller than the volume of the dialysate solution used at the end of treatment due to UF and / or the volume of the added concentrate accumulated during treatment. In addition, a pre-filled solution can be added to bag 19 (of the blood circuit) and used at the end of the treatment as described above.

[0088] If the single prefill container stores dialysate solution or other blood-compatible solutions, a portion of the volume of solution initially stored in the single prefill container can be added to bag 13 (e.g., if bag 13 is empty at the start of treatment). Alternatively, prefill solution can be added to bag 19 and used at the end of treatment as described above.

[0089] Therefore, a (single) prefill container can be used to supply solution to bag 19 and / or to bag 13 and / or prefill blood circuit 3 and / or dialysate circuit 4. In other words, the volume of the storage compartment of a single prefill container can take into account the required volume of bag 13, the required volume of bag 19, and / or the required volume of the fluid pathways (e.g., pathways, dialyzers, adsorbents, etc.) for prefilling both circuits.

[0090] A single pre-filled container may include one, two, or three outlets.

[0091] Now for reference Figure 20 Each pre-filled container 33 includes three outlets, such as three tubes and / or three connectors. Each outlet is in fluid communication with the solution stored in the container and may include a dedicated connector. A first connector 34 may be adapted or used to connect to a dialysate circuit connector 37. This dialysate circuit connector may connect to a tube that extends upwards to the dialysate cartridge. This fluid path may be clamped or closed using a clamp or valve V5. Within the cartridge, this fluid path may be in fluid communication with the dialysate circuit, for example, to a fluid path between bag 13 and pump 14 (as bag 28 used in another embodiment). A second connector 35 may be adapted or used to connect to a venous connector 27, and a third connector 36 may be adapted or used to connect to an arterial connector 26.

[0092] Now for reference Figure 21 A single pre-filled container includes two outlets, such as two tubes and / or two connectors. Each outlet is in fluid communication with the solution stored in the container and may include a dedicated connector. The first connector 34 may be connected to the solution described above via... Figure 20 The connector 34 described is identical. The second connector may have one or two ports. If the second connector 35 has only one port, the system requires an adapter to connect the second connector to the arterial connector 26 and the venous connector 27. If the second connector 35 has two ports, the first port may be adapted or used to connect to the venous connector 27, and the second port may be adapted or used to connect to the arterial connector 26.

[0093] If a single pre-filled container includes only one outlet, such as a tube and / or a connector, the connector may have three ports (one for the dialysate circuit and two for the blood circuit, as described above), or the system may use an adapter with one inlet port and three outlet ports, as described above.

[0094] Overall System

[0095] The overall system may have reusable and disposable components. Disposable components include elements that must be discarded after a predetermined number of uses, such as after a single use. The service life of disposable components may be directly dependent on the number of treatments. These components may be those that have been wetted by dialysate or blood, for example, at least a portion of the blood circuit and / or at least a portion of the dialyzer and / or dialysate circuit.

[0096] The disposable portion of a blood circuit may include at least one of tubing, connectors, ports, boxes, valves, etc. The disposable portion of a dialysate circuit may include at least one of tubing, connectors, ports, boxes, valves, etc.

[0097] Preferably, the reusable portion includes expensive components such as sensors, electronics, screens, actuators for valves or pumps, processors, and memory. The reusable portion is used continuously with multiple disposable portions after use. The reusable portion may include components that can be replaced when they become too worn, damaged, or after a predetermined period of time, but much longer than a single treatment. Replacement of the reusable portion may depend on component wear.

[0098] according to Figure 4 The overall system 100 may include a disposable portion 101 and a reusable portion 102 (also referred to as a device). The disposable portion 101 may include at least one of a dialyzer 103, an adsorbent 104, a bag 105, and a cartridge 106. The reusable portion 102 may include one or more processors 110, one or more screens 111, other elements 112 (e.g., one or more buttons) connected to the processors, one or more sensors 113, one or more actuators 114, and other elements 115 connected to the processors 110 and operatively and removably coupled to the disposable portion. The elements (111, 112, 113, 114, 115, 110) may be arranged within a housing of the reusable portion. The screen 111 may be a touchscreen and may be removably coupled to the housing including the other elements of the reusable portion 102. All or some of the elements may be connected or coupled to the processor to control or monitor treatment. The processor 110 may execute computer-executable instructions stored in the system's memory. Sensor 113 can be adapted and used to be operatively coupled to the disposable portion 101.

[0099] The active portion (e.g., the sensing portion) of sensor 113 may be located in the reusable portion. In this case, the disposable portion may include coupling elements suitable for removably coupling the sensor to the disposable portion 101. The active portion of the sensor (e.g., a probe) may be located / arranged in the disposable portion, in which case the sensor portion located in the reusable portion may be a connection element that allows communication between the processor 110 and the active portion of the sensor located in the disposable portion.

[0100] Actuator 114 can be operatively coupled to a disposable part, such as opening / closing a valve, actuating a pump, etc.

[0101] Component 115 can be a weighing scale or a heater controlled by a processor.

[0102] box

[0103] The system may include one or more cartridges that define at least a portion of the fluid path for the blood circuit and / or dialysate circuit. The cartridge is preferably part of the disposable portion 106 (e.g., ...). Figure 4 (As shown). The system may include a single cartridge comprising a portion of a blood circuit and a portion of a dialysate circuit. Preferably, the system comprises two distinct cartridges: a first cartridge dedicated to the blood circuit, adapted for and used to receive blood (and optionally for receiving a prefill solution, saline solution, purified water solution, dialysate solution, or other blood-compatible solution); and a second cartridge dedicated to the dialysate circuit, adapted for and used to receive dialysate solution or other compatible solutions for treatment. Figure 2e and 3 The potential limits 40 for the cartridges (blood cartridges and dialysate cartridges) are shown. The pumping device can be part of the cartridge or can be arranged outside the cartridge.

[0104] The (blood and / or dialysate) cartridge 106 includes at least one valve adapted for operatively coupling to the actuator 114 of the reusable portion. The (blood and / or dialysate) cartridge 106 may include at least a portion of a pump adapted for operatively coupling to the actuator 114 of the reusable portion.

[0105] Box 106 includes a rigid frame 107 that is a portion of the fluid path for receiving the circuit (blood or dialysate). For example... Figures 5a-5c' As shown, the box includes a fluid cavity 120 (e.g., arranged in a rigid frame), one or more ports 121, and / or one or more flexible membranes 108 adapted to cover the fluid cavity 120.

[0106] The flexible membrane may include a coupling region suitable for operatively coupling with a valve actuator and / or a measurement region suitable for operatively coupling with a sensor in a reusable part of the system.

[0107] The box (blood and / or dialysis fluid box) may further include a handle 122 suitable for being held by the user's fingers.

[0108] The membrane may include a valve portion adapted to close and open the fluid path of the housing. Within the housing, a lug / head of the valve actuator, a reusable portion of the system, can push the valve portion against a rigid portion (e.g., the inner wall of a cavity in a rigid frame) to close the fluid path. The membrane may be formed / molded / configured to have a defined shape at the contact portion 124 with the valve seat 123 to improve valve sealing. The membrane (particularly the coupling region) may be formed / molded / configured to have a defined shape, such as a clamping element (not shown) adapted for removable coupling to the head of the valve actuator.

[0109] Figure 5b and 5b’ A schematic diagram (cross-section) of housing 106 is shown, in which the valve is in the open position. The diaphragm (particularly the contact portion 124) is spaced apart from the valve seat 123. Figure 5b In this design, the diaphragm and rigid frame valve seat are configured to have the valve in a resting position when it is in the open position. Figure 5b' In this design, the valve seat of the diaphragm and rigid frame is designed to have an open position when the diaphragm is pulled (e.g., by a valve actuator).

[0110] Figure 5c and 5c’ A schematic diagram (cross-section) of housing 106 is shown, in which the valve is in the closed position. The diaphragm is in contact with valve seat 123. Figure 5c In this design, the diaphragm and rigid frame valve seat are configured to have a static position where the valve is in the closed position. Figure 5c' In this design, the valve seat of the diaphragm and rigid frame is designed to have a closed position when the diaphragm is pushed against the valve seat 123 (e.g., by a valve actuator).

[0111] In one embodiment, the box may include one or more flexible tubes secured within the box by a frame. To limit hemolysis, the valve actuator may be a clamp valve actuator including a lug configured to clamp the flexible tubes passing through the blood box.

[0112] The (blood and / or dialysate) cartridge may include a portion of a pump. In one embodiment, the pump is a peristaltic pump. In this case, the cartridge includes a flexible tube that is in fluid communication with a first fluid path and a second fluid path of the cartridge via a dedicated port. The flexible tube is used to be pressed against a rigid wall (e.g., a portion of the cartridge's rigid frame) by at least two rollers of the pump. The cartridge may further include a roller assembly comprising at least two rollers, roller support devices, and coupling devices for operatively coupling to a pump actuator in a reusable portion of the system.

[0113] refer to Figure 6 The box includes a flexible tube 201, which is connected to a fluid path 202 of the box 200, for example, via an inlet port 203 and an outlet port 204. A roller assembly 205 is movably (by rotation) disposed in a cavity of the rigid frame of the box. The roller assembly 205 includes at least two rollers 208 held by at least one support member 206. Figure 6 Shaft 207, which is part of the pump actuator of the reusable portion, is also shown. Shaft 207 is used to actuate roller assembly 205. In this embodiment, roller support 206 includes a through-hole into which shaft 207 of the pump actuator is inserted when the cassette is loaded. Roller 208 can be driven by friction and / or may include coupling devices (coupled to roller support 206), such as lugs and bores or gears. When the cassette is fully loaded, the pump portion of the cassette is operatively coupled to the pump actuator of the reusable portion.

[0114] Roller 208 can move relative to its support. For example, when the shaft of the pump actuator is inserted into the roller support 206, the outer wall of the shaft pushes roller 208, thereby pushing the roller in the direction of the outer periphery of the support.

[0115] As described below, the box may be adapted to be inserted into the opening of the reusable portion (device). To prevent any fingers from getting caught between the box and the opening of the reusable portion, the box may be adapted to substantially fit into the opening (so that the opening is at least partially or completely blocked or blocked when the box is inserted). When the box is fully inserted into the opening, the handle and / or tube may protrude from the housing of the box and the device. Preferably, the opening and the box are designed so that when the box is fully inserted into the opening, it never exposes any opening with a size greater than 25 mm, preferably greater than 10 mm, more preferably greater than 8 mm or 5.6 mm. For example, the box may include an edge that substantially blocks the opening when the box is fully inserted into the opening (as described below for...). Figure 22 (as described in 23). One purpose of this design is to prevent any patient's fingers or similarly sized objects from entering the area where the box is located, even in the presence of the box.

[0116] The blood circuit includes at least two tubes (arterial line and venous line), but preferably, the blood circuit includes a dedicated box and five or six tubes (or more) extending from the (blood) box. These include a first tube (arterial line) connected to the patient, a second tube (venous line) connected to the patient, a third tube connected to the blood return bag 19, a fourth (optional) tube connected to the blood return bag 19, a fifth tube (arterial line) connected to the dialyzer 2, and a sixth tube (venous line) connected to the dialyzer 2 (or infusion chamber 9).

[0117] The dialysate circuit includes at least two tubes (downstream and upstream of the dialyzer), but preferably, the dialysate circuit includes a dedicated cartridge and at least seven tubes extending from the cartridge: a first tube to dialyzer 2, a second tube to dialyzer 2, a third tube to adsorbent device 17, a fourth tube to adsorbent device 17, a fifth tube to concentrate container 31, a sixth tube to weighing container 13, and a seventh tube to weighing container 13. Optional tubes and connections may include: from initial supply container 28 or pre-fill container 33, from additional supply container 32, from (in-line) heating system, etc.

[0118] Other fluid paths can be arranged in the housing, and at least a portion of the fluid path including the valve can be arranged in the housing. Figure 3 The potential limit of the dialysate cartridge is shown at 40. Figure 2e The potential limits for the blood box are shown in Figure 40. The shape and / or size of these limits are merely examples and should not be considered restrictive.

[0119] Device (reusable part)

[0120] The device (also known as a dialysis unit) is a reusable part of the system. The device is designed to be portable by the user; however, it is not designed to be fixed to the patient. As used in this specification and the appended claims, the term “portable” is used in its intended sense, including “light and small enough to be easily carried or moved” or “to be taken with you if you move to another place” or “easy to carry or move by hand.”

[0121] Figures 7 to 12a -12c illustrates a first potential embodiment of the dialysis system. Figures 33 to 36 A second potential embodiment of the dialysis system is shown, and Figures 37 to 39 A third potential embodiment of the dialysis system is shown. Even though each embodiment has a specific shape, these embodiments may also include the same or substantially the same components or sub-components described in this document (e.g., rods, container supports, scales, sensors, loading systems, door devices, boxes, supports, fluid loops, container receivers, functional elements, electronics, handles, display devices, etc.).

[0122] Now for reference Figure 7The device 300 includes a housing 301 in which components for controlling dialysis treatment are arranged. These include, for example, a processor, valve actuators, sensors, a blood pump adapted to cooperate with a blood line to move blood through the last portion of the blood line when the blood line is in fluid communication with a blood source (patient), and a dialysate pump adapted to cooperate with a dialysate line to move dialysate through the last portion of the dialysate line when the dialysate line is in fluid communication with a dialysate source. The housing 301 has a front panel and side panels.

[0123] The housing may have at least one recess 318 (see Figure 11a The recess 318 is designed to be gripped by a user's hand, and the at least one recess may have a gripping element (e.g., a shape or structure that is easy to grip). Preferably, the device includes two recesses having gripping elements arranged on two opposite sides of the housing. The recesses may be located in the lower part of the housing.

[0124] Preferably, the device includes a display device 302, which may be a movable screen (e.g., a tablet) removably attached to the device via a screen support 303. The display device may include multiple screens displaying the current treatment status, settings screens, text and video instructions, patient data, treatment data, etc. The display device may include a processor connected to a memory including text and video instructions, patient data, treatment data, audio files, video files, etc. The display device 302 may be removably attached to at least one of a container support 304 (e.g., a lever 312 (not shown)), a housing 301, and a lever 312. The display device may include a display communication unit having a receiver and a transmitter wirelessly coupled to a device communication unit disposed in the housing 301. Therefore, the electronics disposed in the housing 301 of the device can communicate wirelessly with the display device. A link cable may provide communication between the device and the display device or be used to recharge the display device's battery. The link cable may include a USB connector or other standard connectors (e.g., an Apple standard connector). Using a USB connector or a standard connector, a standard tablet (iPad, Android tablet, etc.) can be used as a display device. Therefore, if the original display device fails, the user can replace it with a standard tablet.

[0125] Display device 302 can be used as an electronic health record for treatment. The patient brings their display device to the doctor, who can then monitor the patient's treatment history and other health data. The doctor can change treatment parameters via the display device. Furthermore, the doctor can wirelessly or via a wired connection (e.g., USB connection) download treatment parameters or other data from their computer (PC or other computing device) to the display device. Additionally, the display device may include applications or computer-executable instructions adapted to download data from and / or upload data to the doctor's computer, as well as internal memory configured to record treatment history, patient data (weight, blood pressure, alarms, UF, performed treatments, etc.), new treatment parameters, etc.

[0126] The device may include a power management device connected to the device and / or a standard connection port (e.g., a USB port) connected to the processor of the device, and the display device may include a power management device (connected to the battery of the display device) connected to the display device and / or a standard connection port (e.g., a USB port) connected to the processor of the display device.

[0127] The device may further include an additional screen 305, a power button 306, or an emergency button 307. The additional screen 305 is designed to display information to the user in a concise manner.

[0128] Compared to attached screens (alarms, faults, current processing, progress bars, etc.), the display device provides more detail (video, instructions, suggestions, etc.). The power button 306 can be designed to turn the device on or off or turn off all or some of the device lights. The emergency button 307 can be designed to be activated during treatment, for example, to command premature termination of treatment (e.g., to initiate a blood return process before the end of treatment). These buttons and screens are preferentially (via wired connection) connected to the device's processor. In one embodiment, similar buttons can be arranged on the display device and can be enabled via the display device (e.g., via a touchscreen).

[0129] The device may include a dialyzer support 308 (configured and used to removably secure the dialyzer) and a drip chamber support 309 (configured and used to removably secure the drip chamber), which may be arranged on the front panel of the housing 301, the side panel of the housing 301, or the container support 304 (e.g., fixed to a rod).

[0130] Preferably, the housing includes at least one opening (slot or groove) adapted to allow one or both boxes of the disposable portion to be inserted into the device. Figure 7 A single opening is shown. Figure 8Two different openings are shown. The openings may extend substantially horizontally (or vertically or obliquely) on the front panel and / or side panel of housing 301. Figure 33 It shows two vertical (and preferably horizontal) openings that are closed by a vertical door (such as a sliding door, retractable door, revolving door, or swing door). Figure 37 A horizontal opening is shown that is closed by a door (single or double door) (e.g., a sliding door, a retractable door, a revolving door, or a swing door), which can be adapted or configured to serve as a container receiver.

[0131] In cases where the disposable portion comprises two different boxes, a single opening may be used for both boxes, or the two openings may be arranged through the housing. In cases where the device includes two different openings for inserting a box through the housing, the first opening may be arranged in a first portion of the housing, and the second opening may be arranged in a second portion (which may be opposite the first portion).

[0132] For example, Figure 8 A housing 301 with a first opening 310 and a second opening 311 is shown. The first opening extends horizontally through a first portion 319 of the housing 301. For example, the first opening 310 extends horizontally from a portion of the front panel 321 to a portion of the side panel 322 of the first portion 319. The second opening 311 extends horizontally through a second portion 320 of the housing 301. For example, the second opening 311 extends horizontally from a portion of the front panel 321 to a portion of the side panel 323 of the second portion 320.

[0133] Between the two openings, the device may include a rigid structure adapted to support the weight of the components arranged above the openings without deforming the overall structure of the device.

[0134] The first opening 310 can be used exclusively for blood boxes, and the second opening can be used exclusively for dialysate boxes. Figure 8 A first opening smaller than the second opening is shown. The device and / or cartridge may further include a mechanical code to prevent the cartridge from being inserted into a non-dedicated opening. Therefore, the user cannot insert the blood cartridge into the second opening and / or the dialysate cartridge into the first opening. Preferably, a dialyzer support 308 is arranged between the two openings and the infusion chamber support at the first portion 319. The dialyzer support is configured not to obstruct any openings when the dialyzer is secured to its support, thereby allowing the cartridge to be loaded into or unloaded from the device.

[0135] The first part can be referred to as the blood side of the device, because this side receives a dedicated blood container with an opening. The second part can be referred to as the dialysate side of the device, because this side receives a dedicated dialysate container with an opening.

[0136] Now for reference Figure 9The user inserts the blood box through a first opening. In this embodiment, the blood box includes a handle 122 by which the user grips the blood box. The blood box engages and slides into the device according to an axis (Y or X axis) defined by the device 300. The box 106 also includes at least one tube 116 extending from one side of the box (preferably, the side perpendicular to the side including the handle, or the side other than the side including the handle, or the same side as the side including the handle). At least one opening is adapted to allow the tube to exit the device 300 through an opening in, for example, a side panel of a second portion. To insert the blood box, the user manipulates the blood box through the handle, allowing the blood box to enter through the opening (e.g., an opening in the front panel or side panel), and slides the blood box until the end of the path. At the end of the path, a sensor is adapted to detect the presence of the inserted box. The sensor sends data (to the processor) to notify the processor that the box has been inserted.

[0137] Now for reference Figure 10 The user inserts the dialysate cartridge through a second opening. In this embodiment, the dialysate cartridge includes a handle 122 by which the user grips the cartridge. The dialysate cartridge is engaged and slid into the device 300 according to an axis (Y or X axis) defined by the device. The insertion axis of the dialysate may be the same as or opposite to the insertion axis of the blood cartridge. The cartridge 106 also includes at least one tube 116 extending from one side of the cartridge (preferably, the side perpendicular to the side including the handle, or the side other than the side including the handle, or the same side as the side including the handle). At least one opening is adapted to allow the tube (e.g., through an opening in the side panel of the second portion) to extend outside the device 300. To insert the dialysate cartridge, the user manipulates the cartridge through the handle, allowing the dialysate cartridge 106 to enter through the opening (e.g., an opening in the front panel or side panel), and slides the cartridge until the end of the path. At the end of the path, a sensor is arranged, adapted to detect the presence of the cartridge 106. The sensor sends data to the processor to notify the processor that the cartridge has been inserted.

[0138] The loading system can be automatically activated / started when the cassette is inserted. During treatment, the opening can be closed by a door and / or a locking mechanism can prevent the cassette from being in the operating position. One or both of the loading systems can be activated when treatment begins. The locking mechanism can be a lever that is inserted through a hole arranged in the cassette during loading (e.g., via the loading system).

[0139] Now for reference Figure 2223, cassette 106 includes tube 116 and optional handle 109. Device 102 includes an opening 324 disposed on a first side 327 of the housing and an additional opening disposed on a second side 328 of the housing. Preferably, the first side 327 is substantially perpendicular to the second side 328. Opening 324 and the additional opening 325 provide passageway to a cassette holder (for at least insertion or removal of the cassette). Opening 324 and the additional opening 325 provide continuous apertures such that a portion of the device hangs over the cassette compartment. Opening 324 and the additional opening 325 define a horizontal, inclined, or vertical plane (relative to the device) in which the cassette will be inserted during at least a portion of the loading process or during treatment.

[0140] The opening 324 is adapted to allow insertion and removal of the box, so that the opening 324 may be at least larger than the side of the box through which it is inserted. At least during the insertion or removal phase, the guide elements (e.g., tracks) of the box retainer are aligned with one or more openings and arranged along the plane defined by the openings.

[0141] Additional opening 325 is adapted to allow at least one component to protrude from the housing, such as a tube, handle, etc. Additional opening 325 may be smaller than the side through which the component protrudes from the housing. For example, opening 324 (as...) Figure 23a (as shown in b and c) has substantially the same dimensions as one side of the box including the processing element 109, while the additional opening (side opening) 325 (as shown in b and c) has the same dimensions as one side of the box including the processing element 109, while the additional opening (side opening) 325 has the same dimensions as one side of the box including the processing element 109. Figure 23c (As shown) is shorter than the corresponding side of the box. The dashed line indicates the boundary of the box in the device.

[0142] Figure 23a Figures 1 and 2 show reference numerals “XX” and “YY”, which indicate the recess formed by the box and the housing of the device when the box is fully inserted. The dimensions of XX and / or YY can be as small as possible (e.g., depending on manufacturing tolerances) to provide an area of ​​a substantially flat surface on at least one side of the device (including the opening) when the box is fully inserted.

[0143] Figure 24 , 25 Figures 26 and 26 show other possible designs. Figure 25 A single opening 324 for the box (no opening 325) is shown, along with a box including a tube and a handle optionally arranged on the same side. In another embodiment, as... Figure 26 As shown, some tubes are arranged on the same side of the handle, and other tubes are arranged on the other side of the box.

[0144] pass Figure 22 All the features shown in 23, 24, 25 and 26 can be implemented in blood boxes and / or dialysate boxes as well as dedicated openings in the device.

[0145] The device may include a container support 304 (e.g., a rod or receiver) (e.g., such as...) Figure 7 As shown), it is used to receive one or more containers (e.g., bags, syringes, etc.) during treatment. The container may be part of a disposable portion, and the container support 304 may be part of a reusable portion. At least one container stores at least one of dialysate solution, saline solution, concentrated solution, and other solutions (heparin, calcium, purified water, etc.).

[0146] As described above, the device may include a container support 304 for receiving or holding the solution bag during treatment. The container support may be adapted to have a first position and a second position (and optionally a third position). The first position is required during treatment, while the second position may be needed during transport, storage, or when the device is not performing any treatment. The second position allows for a compact device with optimized dimensions.

[0147] refer to Figure 11a and 11b The device 300 includes a rod 312 adapted to hold at least one solution bag (e.g., dialysate, concentrate, saline, empty bag, UF bag, drain bag, etc.). The solution bag can be removably secured to the rod 312 by one or more hooks 313. The rod 312 includes a first position that allows support of the bag during treatment. The rod 312 can be telescopic: the length (l1) of the rod 312 (when in the first position) can be greater than the length (l2) of the rod 312 (when in the second position). When the rod 312 is in the second position, the user can move the device 300 by using the rod 312 as a handle. The rod 312 may include a rotatable retaining element 314 adapted to secure the rod to the housing of the device and move the rod from the first position to the second position and / or vice versa. A locking device (not shown) may be adapted to stop the rod in a predetermined position. Preferably, containers 19, 28, 32 and / or 33 (e.g., Figure 3 , 20 (As shown in 21) It is removably attached to rod 312 in the preparation, pre-filling and / or treatment configuration. The rod may include an electronic scale.

[0148] refer to Figure 12aa, b, and c, the device may include a movable container support 315 adapted to receive solution bags (e.g., dialysate, concentrate, saline, empty bags, UF bags, drain bags, etc.). The movable container support may include a concave receiver portion designed to receive and store at least one solution bag during treatment. The device 300 may include a fixing element 317 adapted to be removably fixed to / aggregate against the housing 301, removably positioned, or removably located on the movable container support. The movable container support 315 includes three positions: a first position required during treatment, a second position potentially required during transport of the device, during storage, or when the device is not performing any treatment, and a third position providing access to a container receiver 316 disposed below. The fixing element 317 may be a protrusion. The protrusion may include a protruding position allowing the movable container support to be positioned in the first position and a retracted position allowing the movable container support to be positioned in the second position.

[0149] Figure 12a A movable container support 315 in a second position is shown. The movable container support is configured for dimensional optimization. The shapes of the movable container support 315 and the container receiver 316 are designed such that the container receiver 316 can receive at least a portion of the movable container support, such as the receiver portion of the movable container support 315. Another portion of the movable container support may be designed to surround a portion of the housing 301 when the movable container support is in the second position.

[0150] Figure 12b A movable container support is shown in a third position to allow access to the container receiver 316. The movable container support can be removed from the device (e.g., from the housing).

[0151] Figure 12c The diagram illustrates that when the movable container support 315 is positioned in a first position, it is located on or positioned on or fixed to a fixing element 317 (e.g., a protrusion). In this position, a first solution bag (e.g., a concentrate solution bag) can be stored in the movable container support 315, while a second solution bag (different from the first solution bag, such as a dialysate solution bag or a saline solution bag) can be stored in a container receiver 316 (arranged below the movable container support). The container receiver 316 may include a heating element adapted to heat the bag stored in the container receiver. When the movable container support is positioned above the heated bag, the bag stored in the movable container support can receive residual heat. The container receiver can be securely fixed to the device.

[0152] The container receiver 316 may further include a weighing scale for weighing the bag stored in the container receiver. The movable container support 315 may be designed such that the weighing scale is not disturbed by the weight of the movable container support or the bag stored in the movable container support. In other words, when the movable container support is in a first position (e.g., due to the shape of the fixing element and the container support or container receiver), the receiver portion of the movable container support 316 is spaced sufficiently far from the receiver portion of the container receiver 316 to store a predetermined volume of fluid stored in the bag (received by the container receiver 316). The system includes an adsorbent device and a container receiver for storage. Figure 3 In the case of bag 13, the fluid volume is determined by taking into account the dialysate volume and the ultrafiltration produced by the treatment. The dialysate volume can be a number equivalent to the amount recovered multiple times through the adsorbent cartridge.

[0153] Preferably, the movable container support 315 receives a supply solution bag (e.g., concentrate supply bag 31 or other bag), and the container receiver 316 receives a dialysis solution bag 13 (also called a weighing bag) for mixing and / or weighing a portion of the volume of cleaned dialysate (cleaned by an adsorbent and including ultrafiltration) and concentrate (added gradually during treatment).

[0154] Now for reference Figure 33 The dialysis system 600 includes a device 601 having a housing 607, a first door 604, and a second door 605. The first door 604 is configured to allow access (e.g., to a holder of a blood cartridge 602). The second door 605 is configured to allow access (e.g., to a holder of a dialysate cartridge 603). The dialysis system 600 may include a loading system as described later. The loading system can horizontally move the holder (with or without doors) or functional element supports.

[0155] Figure 34 Two views of a dialysis system 600 are shown, which has an extended and preferably retractable rod 609, a removable display device 610, and a weighing scale 611. Figure 35 The system 600 in a functional state is shown. The system further includes an adsorbent device 612, a fluid loop tube 613, and a weighing bag 614.

[0156] Figure 36 A device support 615 is shown, which can be modular and can be used as luggage with rollers (described below). The device support 615 can be configured to store the device 601 in a cavity in the device support 615 in a transport state. Optionally, the device support 615 can be configured to support or receive the device on a surface of the device support in a functional state.

[0157] The device support 615 may further include an adsorbent support 616, which is disposed on one side of the device support and retractable into the device support. The device support may include rollers, a flat surface, and a side door.

[0158] Figure 37 Another potential embodiment 700 is shown, which includes a device 701, a display device 710, a door 704 allowing access to the cassette holder, and a heated compartment 705. In this embodiment, the loading system can move the cassette holder up and down together with the door.

[0159] Figure 39 The system 700 in a functional state is shown. The system further includes an adsorbent device 712, a fluid loop tube 713, and a weighing bag 714.

[0160] Loading system

[0161] Two different loading systems can be used for the device (e.g., such as...) Figures 13a-13g to Figure 17 (As shown). For both systems, the loading system 400 includes at least one of a drive mechanism and a box holder 401 for removably receiving the box. The box holder 401 is arranged within the housing of the device. The purpose of this loading system may be to achieve coupling between the device's dedicated active elements 404 (also referred to as components), 403, 402 and the box 106. Preferably, the dedicated active elements are active elements for operatively coupling to the box (e.g., to the coupling area of ​​the box and / or the measurement area of ​​the box) during operation (e.g., during a portion of a treatment or testing process). The dedicated active elements may be at least one of a sensor 402 (air, pressure, blood detector, etc.), an actuator of pump 404, a valve 403, etc. Some or all of the dedicated active elements may be arranged on a support 406. The support may be a plate or frame constructed and / or for receiving and / or contacting or approaching the operating surface of the box (in the operating configuration). The operating surface of the box is a surface or part of a surface that includes a measuring area (for mates with the pressure sensor of the device) and / or a coupling area (for mates with a valve actuator, pump mechanism, or other actuator of the device).

[0162] The drive mechanism is adapted to achieve a first position and a second position, in which the cassette can be operatively coupled to a dedicated active element of the device, and in the second position, the cassette is not coupled to (e.g., spaced apart from) the dedicated active element of the device. The second position also allows the cassette to be inserted into or removed from the cassette holder. When the loading system is in the second position, the opening and / or the cassette holder can be illuminated to notify the user that he / she can insert or remove the cassette. The illumination can be a specific color, for example, a first color when the loading system is in the first position and a second color (different from the first color) when the loading system is in the second position. Another indicator device can inform the patient about the position of the loading system, such as sound, voice, movie, text on a display device or attached display, or a light illuminating a portion of the dialyzer support.

[0163] The box holder 401 includes at least one of the following: a guide (e.g., a track or (linear) guide element), a mechanical stop, and a sensor adapted to cooperate with the box to allow sliding (relative) movement of the box (relative to at least one of the box holder, components, and housing). The sensor may be adapted to detect insertion and / or full insertion of the box. The sensor may be adapted to determine whether the element inserted (in the opening) is the box or another object (e.g., a finger). For example, the sensor may be an optical sensor connected to a processor of the device. For example, a transmitter emits an invisible infrared beam towards a receiver. When the receiver does not receive the (infrared) beam, the processor detects a finger or other object. The box may be substantially transparent, so the receiver can identify the box due to the scattered light detected by the sensor. The sensor may be positioned near the opening and / or near the mechanical stop.

[0164] In one embodiment, a first sensor may be positioned near a first end (e.g., an opening) of the receiving compartment of the box holder to detect the insertion of an object. A second sensor may be positioned near the other end (e.g., the opposite end of the first end) of the receiving compartment of the box holder and is adapted to detect that the box is fully inserted. In this embodiment, the first sensor may be optional. When the loading system is in the second position, a display device may display a message to notify the user that a box has been inserted. After a predetermined period of time, if the first sensor does not detect any passage, the display device may display a message to notify the user that a box has not been detected and may trigger an audible alarm. If the first sensor detects an object after a predetermined period of time but the second sensor does not detect any object, the display device may display a message to notify the user that the box is not fully inserted and may trigger an audible alarm. If both the first and second sensors (or at least only the second sensor) detect a box, the processor may authorize the loading process (e.g., passage from the second position to the first position, which will also be described below) or may automatically activate a drive mechanism (e.g., change of position). When the user commands the loading process (e.g., by pressing a button, as described below), the safety loading mechanism (also described below) can check for the complete insertion of the two sensors, or at least the second sensor detection cartridge, and initiate a position change. If the user does not command the loading system, the display device can show a message prompting the patient, for example, to press a button.

[0165] In short, the insertion method may include the following steps: - Insert the box through the opening of the device; - Detection kit; and - Allows activation of the loading system when the box is fully inserted.

[0166] In other words, the processor that operates in conjunction with the loading system is suitable for: - Receive signals from at least one sensor, which correspond to the detection of the cartridge in the cartridge holder. - Allows activation of the loading system when the box is fully inserted. The processor can be further adapted (as described similarly below): - Receive signals corresponding to the activation of one or more buttons, the activation and permission being verified by a secure loading mechanism; - The position change of the loading system is initiated by activating the drive mechanism.

[0167] The system can be adapted to terminate treatment if requested by the user before treatment begins (e.g., before the cartridge is wetted with fluid). Therefore, the system may include buttons (e.g., a cancel button) arranged on the housing or displayed on a display device to allow the process to be stopped and unused cartridges to be saved. In this case, the processor can control the drive mechanism to change position (from a first position to a second position) as needed, and the user can remove the cartridge for use at another time.

[0168] A cassette retainer includes one or more specific areas (holes, openings, etc.) where a dedicated active element is used to couple to the cassette.

[0169] According to the first embodiment, the drive mechanism is adapted to move the box holder (also referred to as a movable holder of the box) relative to the device (e.g., relative to at least one of the housing, opening, and fixed support of the component). The support 406 of the dedicated active element 406 (also referred to as a fixed support of the component) can be securely fixed to the device and will not be moved by the drive mechanism.

[0170] According to a second embodiment, the drive mechanism is adapted to move one or more dedicated active components (e.g., supports (also referred to as movable supports for components)) relative to the device (e.g., relative to at least one of a housing, an opening, and a retainer for a box). The box retainer (also referred to as a retainer for a box) can be securely fixed to the device and will not be moved by the drive mechanism.

[0171] According to another embodiment, the drive mechanism is adapted to move one or more dedicated active components and a cassette holder relative to the device. Therefore, the drive mechanism is used to bring the dedicated active components and the cassette holder closer to or away from the device.

[0172] In all cases, preferably, one or more openings of the housing do not move with the drive mechanism. In other words, one or more openings of the housing may be fixed and / or may have a fixed perimeter. Therefore, according to the first embodiment described above, the opening of the box holder is aligned with the opening of the housing only when the loading system is in the second position. According to the second embodiment described above, the opening of the box holder is aligned with the opening of the housing when the loading system is in the first position and when the loading system is in the second position. Due to this embodiment, there is no risk of fingers being pinched.

[0173] refer to Figure 13a The first and second embodiments can be used here. The loading system 400 is in the open position, thereby allowing the cassette to be inserted into the cassette holder. Dedicated active components are spaced apart from specific areas.

[0174] according to Figure 13b'The cassette holder is moved relative to a dedicated active element via a drive mechanism to position the loading system (or cassette holder) in a first position. Figure 13b” A dedicated active element (or support) is moved relative to the box holder by a drive mechanism to place the loading system (or dedicated active element or support 406) in a first position.

[0175] Figure 13c The loading system 400 is shown in a first position, wherein the cartridge can be coupled to a dedicated active element. This position is maintained during operation, such as during treatment.

[0176] according to Figure 13d' The cassette holder is moved relative to a dedicated active element via a drive mechanism to place the loading system (or cassette holder) in a second position. According to... Figure 13d” A dedicated active element (or support) is moved relative to the box holder by a drive mechanism to place the loading system (or dedicated active element or support 406) in a second position.

[0177] Figure 13e The loading system 400 is shown in its second position. Dedicated active components are spaced apart from specific areas. The cassette can be removed from the cassette holder.

[0178] Figure 13f The loading system 400 is shown in the first position but without a box. Figure 13g A loading system 400 is shown in the second position but without a box. Figure 13f and 13g The diagram shows the possible stationary positions when the device is not in use or is not moving.

[0179] In one embodiment, an active element (e.g., a (clamp) valve actuator or pumping mechanism) may act in the opposite direction to the drive mechanism and may cause unintentional displacement of the loading system. For example, when a valve actuator is actuated to close a fluid path, the valve actuator may push the cartridge and cause unintentional displacement of at least one of the cartridge's movable retainer and the component's movable support. A first solution may be a locking device configured to lock the position of at least one of the cartridge's movable retainer and the component's movable support. A second solution may be that one or more components that may cause such unintentional displacement are not arranged on the component's movable support. Thus, embodiments may include a fixed support for the component and a movable support for the component. One or more components (e.g., valve actuators, sensors, pumping devices, or other components) may be arranged (attached to) the component's fixed support, while one or more components (e.g., valve actuators, sensors, pumping devices, or other components) may be arranged (attached to) the component's movable support. The movable support may be configured to be moved by the drive mechanism to move the component or the movable support to a defined position. The fixed support can be fixed to at least one of the box retainer, the device (frame) and the housing, and is configured not to be moved by the drive mechanism (or not to cooperate with the drive mechanism).

[0180] For example, to prevent or limit hemolysis, the valve in a blood line can be a pinch valve configured to clamp a flexible tube (e.g., the flexible tube of a blood container). This type of valve can cause unintentional displacement; therefore, the pinch valve can be positioned on a fixed support, while at least one other component (pumping device, sensor, other actuator, etc.) can be positioned on a movable support. In this case, the pinch valve (and the other components fixed to the fixed support) can have at least one of the following states: an actuated state (e.g., closing the fluid path when the loading system is in a first position), a non-actuated state (for example, opening the fluid path and / or when the loading system is in a second position), and a disengaged state (e.g., when the loading system is in the second position).

[0181] The loading system 400 may include a locking system that locks the inserted cartridge to prevent movement of the cartridge during treatment. The locking system may be at least one pin that engages with at least one cavity (e.g., a hole) of the cartridge. The locking system may be activated by a drive mechanism. Thus, when the drive mechanism places the loading system in a first position, the pin enters the cavity of the cartridge. And when the drive mechanism places the loading system in a second position, the pin is removed from the cavity of the cartridge. The locking system may be used as a guide element to perform fine alignment of the cartridge with a dedicated active element when the drive mechanism places the loading system in the first position. The alignment of the cartridge with the dedicated active element may be ( wholly or partially) ensured by the shaft of the pump. When inserted between rollers, the locking system may be the shaft of the pump.

[0182] The dialysate holder may include a dedicated loading system for "dialysis fluid," and the blood holder may include a dedicated loading system for "blood." Both dedicated loading systems may be activated or started substantially simultaneously. Alternatively, each dedicated loading system must be activated or started individually. In the case of dedicated loading systems, each dedicated loading system may include a dedicated drive mechanism, or both dedicated loading systems may be driven by a single drive mechanism.

[0183] The drive mechanism of the (dedicated or non-dedicated) loading system can be automatically activated by the processor or enabled when the sensor of the box holder detects that the box is fully inserted into the box holder. The drive mechanism can be activated by the user. The device may include a safety loading mechanism that prevents fingers from being pinched when the user activates the drive mechanism. The safety loading mechanism can be a software solution and / or a hardware solution. For example, the device may include two different buttons, for example, arranged on the housing or a touchscreen. The user may have to activate both buttons substantially simultaneously to initiate a change in the position of the loading system (from a second position to a first position). Preferably, the buttons are spaced far enough apart from each other to force the user to use both hands (e.g., at least the average length of a child's hand). The buttons may also be spaced far enough from the opening that the safety distance is equal to the length of the hand (e.g., at least the average length of a child's hand).

[0184] This safety loading mechanism can be adapted to prevent unintentional initiation by the patient to change position. For example, the safety loading mechanism can be configured to prevent the processor from changing position unless the user activates a button (arranged on or spaced from the housing or on a touchscreen) according to an activation sequence and a sensor detects full insertion of the cartridge. The activation sequence can force the user to remain active or press the button for a predetermined time period (e.g., until the loading system reaches a first position). Therefore, if the user no longer presses the button, the safety loading mechanism can send a signal to the processor to stop the loading process and return to a second position of the loading system. Thus, the loading process can include the following steps: • The processor receives a signal corresponding to the user's activation of one or more buttons according to an activation sequence, the activation being verified by a secure loading mechanism; • Initiating a position change of the loading system (or loading the launch box to the operating configuration) by activating the drive mechanism; and, • In the event of a malfunction (e.g., if the user no longer presses the button according to the activation sequence), the drive mechanism is stopped by the safety loading mechanism or the loading is placed in the initial position (e.g., in the second position).

[0185] The device may include a sensor suitable for monitoring or detecting at least one of a first position and a second position of the loading system 400. The sensor may be an optical sensor, a Hall effect sensor, etc. The first sensor may be used to detect the first position, and the second sensor may be used to detect the second position.

[0186] In the operational configuration, if the processor detects a change in position, it can (temporarily or continuously) activate the drive mechanism to maintain the correct position. In other embodiments, the cassette is held in the correct position by friction throughout the treatment. The loading system (by design) applies residual force to the cassette, and the processor does not apply any additional power to the drive mechanism.

[0187] Electrical load data (of the drive mechanism) is transmitted to the processor (also called the processing unit). The electrical load data can be the voltage applied to the motor of the drive mechanism. When the voltage reaches a predetermined value, the processor can stop the motor. The electrical load data can also be used to detect jamming conditions. To determine whether a change in the electrical load data (a peak or a threshold) is caused by the end of the loading process or by a jamming condition, the system can use data sent by position sensors. For example, when the loading system moves from a second position to a first position, the second position sensor sends a signal to the processor to, for example, notify that the loading system is no longer in the second position (or conversely, from the first position to the second position, the first position sensor sends a signal to the processor). The processor monitors the electrical load data, and if a predetermined threshold is reached before receiving a signal from the first sensor (e.g., to notify of arrival at the first position), the processor determines a jamming condition. The processor triggers an alarm, and the loading system automatically returns to the second position. If the predetermined threshold is reached after receiving a signal from the first sensor (e.g., to notify of arrival at the first position), the processor determines that the first position has been reached and stops the motor of the loading mechanism. The processor then allows the process to proceed to the next step.

[0188] In short, the loading method may include the following steps: - The location of the loading system is changed (e.g., from the second position to the first position, or vice versa); - Detect position changes (optional) (e.g., via a position sensor); - Increased sensing of electrical load data; and - Causes the loading process to stop in case of jamming or when the loading system reaches the required position.

[0189] In other words, the processor that operates in conjunction with the loading system is suitable for: - Start the loading process (e.g., if all conditions as described above are normal) (e.g., start the motor of the loading mechanism). - Receive signals from at least one position sensor (e.g., signals from a second position sensor); - Receive electrical load data from the motor; - When a predetermined threshold is reached (e.g., a predetermined threshold for electrical load data), the loading process (e.g., the motor) is automatically stopped.

[0190] If the processor receives a signal from another position sensor (e.g., the first position sensor) before reaching a predetermined threshold, the processor will determine that the desired position has been reached and proceed to the next step.

[0191] If the processor does not receive any signal from other sensors (e.g., the first position sensor) when a predetermined threshold is reached, the processor will determine the jamming condition and may optionally start the motor in reverse mode to return to the initial position.

[0192] The predetermined threshold for jamming conditions can be higher than, less than, or equal to the predetermined threshold for the end of the loading process.

[0193] This method describes the loading process in more detail, but the same concept can be applied to the unloading process.

[0194] Figure 14 This is an exploded view of the loading system 400. The loading system 400 includes a box retainer 401, a support 406 for a dedicated active element (e.g., a movable support), and a drive mechanism 409. In this embodiment, the drive mechanism may include an electric motor 410, a drive assembly 411 (e.g., a toothed drive assembly), and a guide assembly 412. The guide assembly 412 may include one or more linear guide elements (e.g., rods) (preferably two, more preferably three) and one or more sliding elements (e.g., through holes (preferably two, more preferably three)) for sliding along the rods. The sliding elements may be arranged on or fixed to the support for the dedicated active element.

[0195] Figures 15a-15d A 3D view of one embodiment of the loading system is shown, wherein a drive mechanism is adapted to move a support member of a dedicated active element relative to the device. Figure 15a The loading system in the first position without the box is shown. Figure 15b The loading system in the second position without the box is shown. Figure 15c The loading system in the first position with the box shown is illustrated, and Figure 15d The figure shows a loading system in a second position with the box included. In this figure, the box is inserted through a first opening in the box support, and the box retainer also includes a second opening to allow the box's tube to pass laterally (perpendicular to the first opening).

[0196] Figure 16An exploded view of an example of a first embodiment of a loading system 400 is disclosed. The loading system 400 includes a box holder 401 (e.g., a movable box holder), a support 406 for a dedicated active element, and a drive mechanism 409. The drive mechanism may include an electric motor 410, a drive assembly 411 (e.g., a toothed drive assembly), and a guide assembly. The guide assembly may include one or more guide elements 412' (preferably two, more preferably four) and one or more sliding elements 412' (e.g., pins (preferably two, more preferably four)) for sliding along or against the guide elements. The sliding elements may be arranged on or fixed to the support of the dedicated active element. The guide elements are arranged on a support 413 (e.g., a plate or frame) that moves relative to the device. The guide elements are used to convert a first axial movement into a second axial movement different from the first axial movement (e.g., vertical). The guide elements may have an open L-shape, a comma shape, etc. The actuated motor 410 rotates a pinion that moves the guide element support 413 according to the Y-axis. The loading system is designed such that movement of the guide element support causes movement of the box retainer along the Z-axis (perpendicular to the Y-axis). For example, the box retainer has a movement limiter adapted to prevent movement other than Z-axis movement. Therefore, Y-axis movement of the guide element causes Z-axis movement of the pin (relative to the device).

[0197] Door equipment

[0198] To protect the active components of the device and / or substantially block the opening (with or without a housing), the system may include a door device comprising a door assembly (also referred to as a door) and / or a flexible element. For example, the door may be a sliding door, a retractable door, a revolving door, or a swing door. For example, the flexible element may be a sheet material and may at least partially cover the opening. The flexible element may be adapted to bend when the housing is inserted into the opening or when a tube or handle extends from the opening. Figure 30g An example of flexible element 423 is shown. In this case, the flexible element is fixed to the device, for example, to the device body (e.g., housing), or to a movable part of the device body (e.g., housing).

[0199] The opening and / or closing of the door device can be manual and / or automatic, for example, controlled by a processor. Preferably, door 415 is (initially) closed and can be opened only to insert a box into the opening. The door may include two positions: an open position that allows the box to be loaded into or unloaded from the box holder, and a closed position that substantially or at least partially blocks the opening.

[0200] Figure 31a and 31b A portion of the housing of a door device, including a sliding door, is shown. Figure 31aThe illustrated embodiment also includes a manual door actuator 416 configured to manually open and / or close the sliding door. A user can lower (or pull up) the manual door actuator to slide the door open or close it.

[0201] Door devices may include locking systems 418 (e.g., such as...) Figure 32 (as shown) and / or restraint system 419 to hold the door in a defined position, such as in an open or closed position. At least a portion of locking system 418 and / or at least a portion of restraint system 419 may be rigidly fastened to the (rigid) body of the device (e.g., a portion of the housing).

[0202] Figure 32 This is an internal view of the (rigid) body of the device (e.g., part of the housing), with certain elements not shown to highlight the locking system 418 and the restraint system 419.

[0203] The door device may include a protrusion adapted to be removably coupled to the locking system 418 when the door is in a defined position (e.g., when the door is open), allowing the user to easily insert the lock. The locking system may include a resilient element (spring, elastic band, etc.) that restrains a retaining element (lug, clip, protrusion, anchor, etc.) adapted to be coupled to the door protrusion. The user may disable the locking system by pushing a manual door actuator (e.g.). The locking system may be disabled by a dedicated (connected) actuator (not shown) or by a processor via a loading system. In the latter case, the loading system may be adapted to disable the locking system when it is actuated (when moving from a first position to a second position and / or vice versa).

[0204] Door devices may include a sliding element adapted to slide through a guide element of the device's (rigid) body (e.g., a portion of a housing) to restrict door movement (or conversely, the device body may include a sliding element, and the door may include a guide element). The sliding element may be a through-hole or protrusion of the door device, while the guide element may be a rod (e.g., a steel rod) or a recess, arranged, for example, on the device's (rigid) body (e.g., a portion of a housing).

[0205] The restraint system 419 can apply force to the (rigid) body of the door and device (e.g., part of the housing) to close the door or force the door to the closed position. The restraint system 419 may include elastic elements (springs, elastic bands, etc.).

[0206] In a preferred embodiment, the door is opened by the loading system and closed by the restraint system. In this case, the door device and / or loading system may include coupling element 422 (such as...). Figures 30a-30h (As shown).

[0207] The coupling element 422 can be configured to mechanically engage with the loading system according to at least one dimension. The coupling element may include a protrusion disposed on at least one of the movable support 406 and the door device 415. The coupling device may also include associated means (e.g., contact space, sliding element, hole, slot, or recess) to engage with the protrusion (e.g., by contact or sliding). The coupling device can engage with the loading system when the loading system moves the movable support in at least one direction (e.g., from a first position to a second position, and / or vice versa). Thus, for example, when the loading system moves to the second position, the loading system pushes the door device downward to open the door (and the restraint system can be compressed). When the loading system moves to the first position, the restraint system can push the door upward to close the door, and the coupling device or inserted box can restrict the displacement of the door.

[0208] It can be done via a processor (e.g., via an actuator) or via a button pressed by the user (e.g., ... Figure 31a (As shown) to disable the coupling element, so that the door can be closed even when the loading system is in the second position by disabling the coupling element.

[0209] In one embodiment, when the loading system moves to the second position, the loading system opens the door via a coupling element, and then a locking system holds the door in the open position. As described above, the coupling element or locking system can be disabled by a processor or a user to close the door (even if the loading system is in the first or second position).

[0210] Figure 30a A door 415 in the closed position and a loading system in a first position without the box are shown. The system includes a resilient element 421, which may be a spring, elastic band, or arm that restrains the door 415 in the closed position. Figure 30b As shown, the door and / or loading system also includes a coupling element 422, which is configured to (only) allow the loading system to move the door upward to an open position (e.g., from a closed position to an open position). Figure 30c and 30d An embodiment with an inserted box is shown. Box 106 is inserted and the loading system is in a first position. Figure 30c In this configuration, the door is no longer held in the open position by the loading system but by the box itself. When the loading system is in the first position, the door can be used to block the insertion of the box. Figure 30d In the middle, the door is in the closed position when the inserted box is present.

[0211] The door device may include multiple parts of a door such that a first part of the door device can completely close the opening (e.g., where the box does not include any protrusions extending outside the device (no tube, no handle)), and a second part of the door device can be held in an open position or a partially closed or open position (e.g., where elements of the box protrude and extend outside the device (e.g., handle, tube, etc.)).

[0212] Figures 30e to 30h Another embodiment is disclosed, in which the loading system moves the box holder; for example, this embodiment can be applied to... Figure 37 The device shown. In this embodiment, the loading system can move the container receiver or top housing up and down (and has a sliding door as described above). Figures 30e to 30h The last scenario is shown. The system includes a sliding door 415, a top housing 420', a (movable) box retainer 401, and a (fixed) component support 406. The loading system is configured to move the box retainer. The sliding door is held in a first position by a resilient element (spring or other similar element). When the loading system is in the first position without a box, the sliding door 415 is held in the first position by the resilient element, causing the door to close the opening. Figure 30f In the middle, the loading system moves to the second position, and the sliding door is essentially in the same previous position (the mechanical limiter can hold the sliding door in the first position), but the box retainer is in the open position. Figure 30g and 30h The box has been inserted and the loading system is in the first position. (Reference) Figure 30g The box's components extend from the opening, and the door is held in an open or intermediate position by these components, such as in a partially closed or partially open position. (Reference) Figure 30h The box was inserted and the door was closed.

[0213] In another potential embodiment, the door device may include a swing door that opens at the top or side.

[0214] Infusion chamber support

[0215] like Figure 18 As shown, the infusion chamber 501 is used to remove air bubbles from the blood circuit. A support 500 for the infusion chamber 501 is used to removably secure the infusion chamber to the device. The infusion chamber support 500 can be arranged on a surface of the device housing or in a rod. Figure 18An embodiment of a drip chamber support 500 having a drip chamber 501 is shown. The drip chamber support may include a body 502 fixed to the device and a level sensor. The level sensor may be an optical sensor, a wave sensor, or a capacitive sensor. The level sensor is preferably disposed in the body of the drip chamber support. The drip chamber support may further include a mechanical coding system 504 for maintaining or ensuring a good / desired position of the drip chamber relative to the drip chamber support or relative to the level sensor. The coding system 504 is designed to force the position of the drip chamber relative to the drip chamber support. For example, the drip chamber support may have a protrusion. This protrusion may be adapted to adjust the vertical position of the drip chamber according to the level sensor. The drip chamber support may have a locking system 503.

[0216] luggage

[0217] To improve the travel experience, the system may include a device support (e.g., a bag or luggage or movable furniture) suitable for storing the device during travel, such as carry-on luggage. The size of the device (with or without a container support, or a housing with or without a dialyzer support) may be set smaller than the size of a bag (carry-on luggage), with at least one dimension less than 31 cm, another dimension less than 51 cm, and / or another dimension less than 61 cm.

[0218] Figure 19 A device stored in carry-on baggage is shown. The carry-on baggage is drawn in dashed lines and includes a handle. The size shown in this figure is for illustrative purposes only. The bag may include at least two different receiving cavities, a first receiving cavity for receiving the device and a second receiving cavity for receiving a display device 302 (e.g., a tablet).

[0219] Hand luggage may include a door having an open position and a closed position. The open position of the door allows the device to be placed into the hand luggage (e.g., into a dedicated receiving cavity), while the closed position allows the hand luggage to be moved in a secure manner. Hand luggage may also include rigid parts designed to protect the device (e.g., side walls, top walls, or bottom walls of the hand luggage).

[0220] Hand luggage can be used as a device support, which may include a platform configured to support the device in an operating configuration.

[0221] Hand luggage may include retractable handles and / or retractable rollers (or wheels).

[0222] Figure 36 Another embodiment of the device support is shown.

Claims

1. A medical system for treating a patient, the medical system comprising: -A device including a housing, - A first movable container support, configured to receive a first solution bag and move relative to the housing. - A container receiver, configured to receive a second solution bag, and The first movable container support includes: - A first position, required during treatment, which allows the container receiver to store the second solution bag beneath the first movable container support, and - A second position, which allows for optimization of the size of the medical system for transportation. The first movable container support includes a wall configured to surround at least a portion of the container receiver in a first position and a second position, such that the first movable container support and the container receiver define at least a partially enclosed cavity, the volume of which varies depending on the position of the first movable container support. Furthermore, the second position is configured to allow the medical system to have a more compact size than the first position.

2. The medical system according to claim 1, wherein, The first movable container support also includes a third position configured to allow the container receiver to receive the second solution bag.

3. The medical system according to claim 1, wherein, The container receiver includes a weighing scale to weigh the second solution bag stored in the container receiver.

4. The medical system according to claim 3, wherein, The first movable container support is configured such that the weight scale is not disturbed by the weight of the first movable container support or the first solution bag stored in the first movable container support.

5. The medical system according to claim 1, wherein, The second movable container support is used to hold the third solution bag and has a first position required during treatment and a second position that allows for size optimization of the medical system.

6. The medical system of claim 1 further comprises at least one of a processor, a valve actuator, a sensor, and a pumping mechanism.

7. The medical system according to claim 1, wherein, The housing includes at least one recess configured to be gripped by a user's hand.

8. The medical system of claim 1 further includes a movable display device removably attached to the device.

9. The medical system according to claim 8, wherein, The movable display device includes a communication unit having a receiver and a transmitter wirelessly coupled to the communication unit of the device.

10. The medical system of claim 8 further includes a wired link that provides data communication between the device and a movable display device, or for recharging the battery of the movable display device.

11. The medical system according to claim 10, wherein, The wired link includes a connector configured to be removably connected to a movable display device.

12. The medical system according to claim 1, wherein, The device includes a fixed display configured to present information to the user in a concise manner.

13. The medical system according to claim 1, wherein, The first movable container support includes a concave receiver portion for receiving a first solution bag.

14. The medical system according to claim 1, wherein, When the first movable container support is in the first position and the second position, the first movable container support is arranged above the container receiver.

15. The medical system according to claim 1, wherein, A portion of the first movable container support is configured to surround a portion of the housing.

16. The medical system according to claim 1, wherein, The first position is configured to allow the first solution bag to be stored on the first movable container support, at least during treatment.

17. The medical system according to claim 1, wherein, The second position does not allow the container receiver to store the second solution bag.

18. The medical system according to claim 1, wherein, When the first movable container support is in the first position, the volume of the cavity allows the second solution bag to be stored on the container receiver.

19. The medical system according to claim 1, wherein, When the first movable container support is in the second position, the volume of the cavity does not allow the second solution bag to be stored on the container receiver.

20. A dialysis treatment system, the system comprising: - A device with a housing, - A movable container support, the movable container support being configured to move relative to the housing, and - A container receiver, which is arranged on the device and configured to store a solution bag during processing. The movable container support includes: - The first position is required during processing, and - A second position, which allows for optimization of the size of the dialysis treatment system for transportation. The movable container support further includes a wall configured to surround at least a portion of the container receiver in a first position and a second position, such that the movable container support and the container receiver define a cavity whose volume varies depending on the position of the movable container support. The movable container support is configured such that the cavity is at least partially closed when the movable container support is in a first position and a second position. The second position is configured to allow the medical system to have a more compact size than the first position.

21. The dialysis treatment system according to claim 20, wherein, When the movable container support is in the first position, the volume of the cavity allows the solution bag to be stored on the container receiver.

22. The dialysis treatment system according to claim 20, wherein, When the movable container support is in the second position, the volume of the cavity does not allow the second solution bag to be stored on the container receiver.

23. A medical system, the medical system comprising: - A device with a housing, - A container receiver configured to receive a solution bag during treatment, and - A movable container support, configured to move relative to the housing and the container receiver. The movable container support includes: - First position, required during treatment to store the solution bag on the container receiver, and - Second position, which allows for optimized size of the dialysis medical system for transportation. The movable container support further includes a wall configured to surround and cover at least a portion of the housing when the movable container support is in a first position and a second position, such that the movable container support and the container receiver define a cavity whose volume varies depending on the position of the movable container support, and the container receiver receives at least a portion of the movable container support. The movable container support is configured such that, when in a first position and a second position, the cavity is at least partially closed. The second position is configured to allow the medical system to have a more compact size than the first position.

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