A method for synthesizing iron-catalyzed condensed ring [1,2-a] indole compounds
By using cheap iron complex catalysts, the efficient synthesis of indole compounds of fused ring [1,2-a] is achieved, which solves the problem of precious metal catalysts in the prior art, reduces costs, and simplifies reaction conditions, and has good industrial application prospects.
CN116925069BActive Publication Date: 2025-03-28HUBEI ENG UNIV
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Patent Information
- Application Number
- CN202210375094.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-04-11
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2042-04-11
AI Technical Summary
Technical Problem
The existing synthetic methods for the indole compounds of fused ring [1,2-a] have the problem of using precious metals as catalysts, and the raw material synthesis is complex and the cost is high.
Method used
The inexpensive metal iron complex is used as a catalyst, and the catalyst, raw material enamine ketone, alkali and solvent are added at room temperature, and the reaction is carried out under heating conditions to achieve efficient synthesis of the fused ring [1,2-a] indole compounds.
Benefits of technology
This method achieves the efficient synthesis of indole compounds with a wide range of raw materials, low catalyst costs, simple reaction conditions, and good industrial prospects.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a method for synthesizing an iron-catalyzed condensed ring [1,2-a] indole compound, comprising the following steps: at room temperature, adding catalyst A, raw material enaminoketone, alkali and solvent to a reaction tube respectively; reacting under heating conditions, monitoring the reaction process by TLC, and after the reaction is completed, obtaining a condensed ring [1,2-a] indole compound by separation and purification; wherein catalyst A is a complex formed by metallic iron / ligand; the reaction temperature is 60 to 120 degrees Celsius; separation and purification include but are not limited to extraction, column chromatography, and recrystallization. The present invention uses widely available and cheap and easily available commodities as raw materials for the reaction, and synthesizes various substituted condensed ring [1,2-a] indole compounds under the catalytic action of a very cheap iron catalyst, and the entire reaction conditions are relatively simple, and the post-reaction treatment is convenient, with very good industrial prospects.
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