一种表面糖聚合物接枝荧光纳米凝胶及其制备方法和应用
By employing a 'click' reaction and RAFT polymerization on nanogels, surface sugar polymer-grafted fluorescent nanogels with uniform particle size were prepared, solving the problems of low grafting reaction efficiency and difficulty in controlling density in existing technologies, and achieving high efficiency and uniform particle size in targeted drug delivery.
CN116925367BActive Publication Date: 2026-07-17JINLING INST OF TECH
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JINLING INST OF TECH
- Filing Date
- 2023-07-07
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing methods for modifying nanogel surfaces suffer from low grafting efficiency and difficulty in controlling grafting density, resulting in poor target recognition performance.
Method used
A surface sugar polymer was grafted onto a nanogel using a click reaction. The nanogel with uniform particle size was prepared by combining the click reaction of the alkynylated nanogel with the thiolized sugar polymer with RAFT controlled free radical polymerization.
Benefits of technology
It improved grafting efficiency, controlled grafting density, and enhanced the recognition of galactose with hepatocyte surface receptors, thus achieving high efficiency and uniform particle size in targeted drug delivery.
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Figure CN116925367B_ABST
Abstract
本发明公开了一种表面糖聚合物接枝荧光纳米凝胶及其制备方法和应用，属于生物医用材料技术领域。一种表面糖聚合物接枝荧光纳米凝胶的制备方法是利用光引发巯基‑炔基之间的点击反应，在纳米凝胶表面接枝巯基化糖聚合物链及荧光分子，制备表面糖聚合物接枝荧光纳米凝胶。本发明在纳米凝胶表面引入糖聚合物链，半乳糖与肝细胞表面过表达的去唾液酸糖蛋白受体具有特异性识别作用，特别地，含糖聚合物刷与凝集素的识别作用更强，负载纳米凝胶的药物能够靶向到肝细胞，用于肝细胞癌的治疗。
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