乳头溢液中差异蛋白谱在乳腺癌诊断中的应用

By detecting the differential profiles of extracellular vesicle-associated proteins and RNA-binding proteins in nipple discharge from breast cancer patients, this study addresses the shortcomings in sensitivity and specificity of existing technologies for early breast cancer diagnosis, achieving highly efficient early breast cancer detection.

CN116973564BActive Publication Date: 2026-07-17SHANDONG UNIV QILU HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG UNIV QILU HOSPITAL
Filing Date
2023-06-08
Publication Date
2026-07-17

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Abstract

本发明属于生物医学领域，具体涉及乳头溢液中差异蛋白谱在乳腺癌诊断中的应用。本发明研究发现，在乳腺癌患者的乳头溢液中可检测到特定差异蛋白的上调，所述差异蛋白包括细胞外囊泡相关蛋白和 / 或RNA结合蛋白，所述细胞外囊泡相关蛋白RAB2A、GDF15、IMPDH2、ARHGAP1、SRI、RBMX、SUB1、PABPC1、CCT5、PSMD12、OLA1中的一种或多种的组合，所述RNA结合蛋白包括RBMX、SUB1、SNRPD1、PABPC1、IMPDH2、H1‑0、CCT5、CCAR2、SNRPG、ERH、SYNCRIP、GSPT1、KTN1、FKBP4中的一种或多种的组合，可能与肿瘤发生、进展相关，而在良性肿瘤患者的乳头溢液中未能检测到上述蛋白。乳头溢液中差异蛋白谱的联合检测可以作为乳腺癌潜在的诊断标志物。
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