Use of compound GSK2643943A in preparing drugs for preventing or treating pancreatic cancer

CN116983300BActive Publication Date: 2025-09-16LANZHOU UNIV SECOND HOSPITAL
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Patent Information

Application Number
CN202310903650.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-07-23
Publication Date
2025-09-16
Estimated Expiration
2043-07-23

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Abstract

This invention belongs to the field of cancer prevention and treatment, specifically to the use of the compound GSK2643943A in the preparation of a drug for the prevention or treatment of pancreatic cancer. The present invention discovered that the compound GSK2643943A can effectively reduce the grade and area of ​​tumors in animal models of pancreatic precancerous lesions, inhibiting the progression of pancreatic precancerous lesions. Furthermore, GSK2643943A can effectively inhibit the growth of pancreatic cancer organoids and pancreatic cancer xenografts in mice. At the humanized level, it was found to have a strong biotherapeutic effect against pancreatic cancer.
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Citation Information

Patent Citations

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