非酸胃食管反流性咳嗽豚鼠模型、建立方法及应用
By establishing a non-acid gastroesophageal reflux cough (GERC) guinea pig model, and using capsaicin and pepsin solutions with different pH values for perfusion, the problem that existing models are not suitable for studying non-acid GERC was solved, and a stable and reliable simulation and treatment plan exploration were achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI TONGJI HOSPITAL
- Filing Date
- 2023-07-04
- Publication Date
- 2026-07-17
AI Technical Summary
Existing animal models of gastroesophageal reflux are mostly suitable for studying typical GERD models such as reflux esophagitis and Berrett's esophagus, but not very suitable for studying non-acid GERC. The lack of stable and reliable non-acid GERC guinea pig models has led to insufficient research on non-acid GERC.
By establishing a non-acid gastroesophageal reflux cough (GERC) guinea pig model, chronic cough was induced by inhaling capsaicin solution using an ultrasonic nebulizer. Pepsin solutions with different pH values were then infused into the lower esophagus to simulate the pathophysiology of non-acid GERC. Cough responsiveness and histopathological changes were measured to verify the stability and reliability of the model.
A stable and reliable non-acid GERC guinea pig model was established, simulating the clinical pathophysiology of non-acid GERC, providing a foundation for the study of non-acid GERC, exploring potential treatment options, and conforming to the pathogenesis and airway disease characteristics of GERC.
Smart Images
Figure CN116999049B_ABST