A method for preparing a carbamazepine intermediate
By using the one-pot reaction using the supported catalyst Ir/CuO-Al2O3 in the presence of Ir catalyst, phosphorus ligand and alkali, the problem of high cost of preparing iminostillation in the prior art is solved, and an efficient and low-cost preparation method is achieved.
CN117050016BActive Publication Date: 2025-03-28JIANGSU CIXING PHARM CO LTD
3 Cites 0 Cited by
Patent Information
- Application Number
- CN202310773329.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-06-28
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2043-06-28
AI Technical Summary
Technical Problem
In the prior art, when preparing carbamazepine intermediate iminostilbene, there are problems such as large investment in equipment, expensive catalysts, large amounts of water vapor, and high cost.
Method used
Halogenated toluene and ortho-toluidine were used as raw materials, and a one-pot reaction was carried out in the presence of Ir catalyst, phosphorus ligand and alkali to form iminostillation, and the supported catalyst Ir/CuO-Al2O3 was used to improve the catalytic efficiency.
Benefits of technology
It has achieved simplification of the reaction route, reduced costs, improved yield and purity, conformed to the trend of green chemicals, and has good industrial production application prospects.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a method for preparing a carbamazepine intermediate. The method uses halogenated toluene and o-toluidine as raw materials, and generates iminostilbene through a one-pot reaction in the presence of an Ir catalyst, a phosphorus ligand and a base. The method has the advantages of short reaction route, simple operation, high yield and purity, good safety, conforming to the trend of green chemical industry, and good industrial production application prospect.
Need to check novelty before this filing date? Find Prior Art