A water-in-oil composition with excellent skin feel, a topical skin preparation and its preparation method

Abstract

This application provides an oil-in-water composition, characterized in that it comprises at least: water as a medium; optically isotropic oily particles; and optically anisotropic oily crystals; wherein both the oily crystals and oily particles are distributed in the water. Compared to conventional oil-in-water systems, the solid oil of this application exists in the aqueous phase in a crystalline form (physical morphology is plate-like or layered crystals, rather than emulsified spherical shapes), thus significantly improving spreadability and refreshing feel, and eliminating any sense of obstruction. Simultaneously, the solid oil can form a sealed film on the skin surface, providing excellent moisturizing properties.

Description

Technical Field

[0001] This application relates to the field of skin care products, and more specifically, to an oil-in-water composition with excellent skin feel, a topical skin preparation, and a method for preparing the same. Background Technology

[0002] Solid oils are widely used in skin care products due to their non-greasy feel, good occlusive properties, excellent moisturizing performance, and abrasion resistance. Especially in creams and lotions designed for moisturizing and preventing chapping, a large amount of solid oil is typically added.

[0003] Current cream systems mainly include water-in-oil and oil-in-water systems. In water-in-oil systems, the solid oil is primarily present in the outer phase of the product, resulting in a noticeably heavy and greasy feel upon application. This is because, after application to the skin, the oil phase spreads first, creating the heavy sensation. Most consumers prefer oil-in-water systems. However, known problems with oil-in-water systems still exist:

[0004] To emulsify the large amount of solid oil in an oil-in-water system, a large amount of emulsifier is required. In addition to causing some irritation, using a large amount of emulsifier can also create a strong feeling of resistance and make it difficult to spread.

[0005] In addition, many consumers do not want to use creams or lotions that appear very oily. Therefore, most water-in-oil creams use special water-based thickeners such as sodium polyacrylate or sodium polyacrylate grafted starch to give the product a matte finish. However, using water-based thickeners not only makes the product heavy and sticky, but also makes it prone to pilling. Summary of the Invention

[0006] The technical problem to be solved by this application is:

[0007] How to solve the problem of strong resistance when using products containing a large amount of solid oil in existing technologies.

[0008] Technical means used to solve technical problems:

[0009] Without any theoretical constraints, the inventors believe that the reason why water-in-oil system products feel heavy, have a strong sense of resistance, and are difficult to spread is that solid oil is emulsified into spherical particles and crystallized in the form of small particles, and then the friction between the particles and between the particles and the skin during use leads to a significant sense of resistance.

[0010] After extensive research, the inventors unexpectedly discovered a solution to the problem; specifically, they proposed a composition to solve the problem.

[0011] One aspect of this application provides an oil-in-water composition comprising at least:

[0012] Water as a medium;

[0013] Oily particles with optical isotropy;

[0014] Oily crystals exhibiting optical anisotropy;

[0015] Both the oily crystals and oily particles are distributed in the water.

[0016] In the composition of this application, the oil exists in two states: spherical emulsion particles, which are essentially composed of liquid oil, and solid oil crystals, which are essentially composed of solid oil, both of which exist in the aqueous phase. At room temperature, the oil particles do not contain solid oil in a crystalline state and exhibit optical isotropy, while the solid oil crystals in the outer phase exhibit optical anisotropy. The solid oil crystals in the outer phase have a near-plate-like or layered morphology, rather than a spherical granular morphology, and do not cause noticeable resistance when applied to the skin. At the same time, because the solid oil is distributed in crystalline form in the outer aqueous phase, the composition naturally has a matte texture, eliminating the need to add a large amount of water-based thickener to achieve a matte finish. Naturally, it also avoids the stickiness and pilling sensation that can occur with the addition of water-based thickeners.

[0017] Another aspect of this application provides an oil-in-water composition comprising at least:

[0018] water;

[0019] Emulsified particles;

[0020] At least one solid oil;

[0021] At least one first emulsifier with an HLB value of 6 to 12;

[0022] At least one second emulsifier with an HLB value of 2 to 6;

[0023] Both the solid oil and the emulsified particles are distributed in the water.

[0024] Using emulsifiers with low HLB values ​​alone makes it difficult for the composition to undergo phase inversion at low temperatures, and even after phase inversion, the liquid oil emulsion in the system remains unstable. Using emulsifiers with high HLB values ​​alone results in the composition existing mainly in an oil-in-water emulsion form during high-temperature emulsification, making it difficult to prepare the composition of this application. The inventors unexpectedly discovered that by using a first emulsifier with an HLB value of 6-12 and a second emulsifier with an HLB value of 2-6 in combination, the possibility of phase inversion increases at low temperatures due to factors such as reduced external phase and high-speed homogenization, making the composition of this application more prone to phase inversion.

[0025] Another aspect of this application provides a topical skin preparation comprising at least any of the aforementioned oil-in-water compositions.

[0026] Another aspect of this application provides a method for preparing an oil-in-water composition, comprising at least the following steps:

[0027] Provides liquid, oily feedstock mixtures;

[0028] Provides liquid aqueous feedstock mixtures;

[0029] The oily raw material mixture and the aqueous raw material mixture are mixed to obtain a water-in-oil mixture.

[0030] After adjusting the temperature of the water-in-oil mixture to 40-60°C, homogenization is performed to obtain an oil-in-water mixture, namely the oil-in-water composition.

[0031] The composition is a water-in-oil system at high temperatures. Through cooling during the preparation process, the solid oil in the external phase begins to crystallize, and the proportion of the external phase gradually decreases. High-speed homogenization then causes phase inversion, transforming the water-in-oil system into an oil-in-water system. In the water-in-oil state, solid and liquid oil coexist in the external phase (oil phase). Upon cooling, the solid oil precipitates out as crystals. During phase inversion, since the solid oil has already crystallized and cannot invert, it forms the external phase of the inverted oil-in-water system together with water. Simultaneously, the liquid oil is emulsified by an emulsifier, becoming the internal phase of the inverted oil-in-water system (i.e., oily particles as the dispersed phase). In the resulting composition, oil exists in two states: spherical emulsion particles composed primarily of liquid oil, and solid oil crystals composed primarily of solid oil, both existing in the aqueous phase.

[0032] Beneficial effects:

[0033] In the embodiments of this application, the solid oil exists in the aqueous phase in the form of crystals (the physical form is a plate-like crystal or a layered crystal, rather than a spherical shape after emulsification), so the spreadability and refreshingness are greatly improved compared with conventional water-in-oil systems, and there is no feeling of obstruction.

[0034] In the embodiments of this application, the solid oil exists in the aqueous phase in crystalline form, which can form a matte appearance and texture. Compared with conventional methods (using a large amount of thickener to obtain a matte texture), it does not cause obvious stickiness or pilling due to the large amount of thickener used. Attached Figure Description

[0035] This application also provides accompanying drawings in connection with the provided technical solutions to illustrate the technical solutions of this application. The drawings and descriptions are intended only to describe this application more clearly and should not be construed as limiting the scope of protection claimed in this application.

[0036] Figure 1 The appearance of the water-in-oil composition as a comparative example under polarized light microscopy is shown. The object marked A is oily particles.

[0037] Figure 2 The appearance of the water-in-oil composition as a comparative example under polarized light microscopy is shown. The object marked A is oily particles.

[0038] Figure 3 The appearance of the water-in-oil composition as a comparative example under polarized light microscopy is shown. The object marked A is oily particles.

[0039] Figure 4 The appearance of the water-in-oil composition as a comparative example under polarized light microscopy is shown. The object marked A is oily particles.

[0040] Figure 5 The image shows the appearance of the water-in-oil composition of this application under a polarizing microscope. Mark A points to oily particles, and mark B points to oily crystals.

[0041] Figure 6 The image shows the appearance of the water-in-oil composition of this application under a polarizing microscope. Mark A points to oily particles, and mark B points to oily crystals.

[0042] Figure 7 The image shows the appearance of the water-in-oil composition of this application under a polarizing microscope. Mark A points to oily particles, and mark B points to oily crystals.

[0043] Figure 8 The image shows the appearance of the water-in-oil composition of this application under a polarizing microscope. Marker A points to oily particles, and mark B points to oily crystals. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are not all the embodiments.

[0045] The elements and features described in one embodiment of this application may be combined with elements and features shown in one or more other embodiments. It should be noted that, for clarity, representations and descriptions of components and processes unrelated to this application and known to those skilled in the art have been omitted from the description.

[0046] definition

[0047] In this document, unless otherwise stated, the term "%" refers to "mass %".

[0048] In this document, unless otherwise stated, the term "%" refers to the total mass of the compositions of this application.

[0049] In this article, the term "all ranges" refers to both each specific range within a given range and combinations of subranges between given ranges. For example, the range 1–5 specifically includes 1, 2, 3, 4, and 5, and also includes subranges such as 2–5, 3–5, 2–3, 2–4, and 1–4.

[0050] In this paper, the range of ratios refers to the combination of each specific ratio within a given range and subranges between given ranges.

[0051] In this article, "oily particles" refers to particulate matter whose main component is oily substances and which is uniformly dispersed in water.

[0052] In this article, "having optical isotropy" means that a material does not refract or reflect back under polarized light.

[0053] In this article, "oily crystals" refers to crystalline substances with optical anisotropy whose main component is oily.

[0054] This application

[0055] On one hand, embodiments of this application provide an oil-in-water composition, which includes at least:

[0056] Water as a medium;

[0057] Oily particles with optical isotropy;

[0058] Oily crystals exhibiting optical anisotropy;

[0059] Both the oily crystals and oily particles are distributed in the water.

[0060] Optionally, the oily crystals reflect light when irradiated with polarized light in at least one direction.

[0061] Optionally, the oily crystals include at least one of flaky crystals, layered crystals, and massive crystals.

[0062] Optionally, the oily crystals include at least one solid oil.

[0063] Optionally, the oily particles do not reflect light when irradiated with polarized light.

[0064] Optionally, the oily particles are optically isotropic and do not contain solid oil.

[0065] Optionally, the oily particles are optically isotropic and contain at least one solid oil.

[0066] Optionally, the oily particles are emulsified particles.

[0067] Optionally, the light source for the polarized light is a 30W halogen lamp.

[0068] On the other hand, embodiments of this application also provide an oil-in-water composition, which includes at least:

[0069] water;

[0070] Emulsified particles;

[0071] At least one solid oil;

[0072] At least one first emulsifier with an HLB value of 6 to 12;

[0073] At least one second emulsifier with an HLB value of 2 to 6;

[0074] Both the solid oil and the emulsified particles are distributed in the water.

[0075] Optionally, the melting point of the solid oil is not lower than 50°C.

[0076] Optionally, the solid oil includes at least one of stearic acid, behenic acid, myristic acid, cetyl alcohol, stearyl alcohol, behenicol, myristic acid myristate, cetyl palmitate, and glycol palmitate.

[0077] Optionally, the first emulsifier with an HLB value of 6 to 12 includes at least one of octyl dodecanol xyloside, lecithin, hydrogenated lecithin, cocoyl glucoside, C12-20 alkyl glucoside, cetearyl oleate, and polyglycerol-10 dipalmitate.

[0078] Optionally, the second emulsifier with an HLB value of 2 to 6 includes at least one of PEG-30 dihydroxystearate, polyglycerol-3 diisostearate, polyglycerol-2 dihydroxystearate, polyglycerol-2 triisostearate, and polyglycerol-2 diisostearate.

[0079] Optionally, it also includes a liquid oil, said liquid oil comprising at least one of hydrogenated polyisobutylene, squalane, hydrogenated polydecene, liquid paraffin, petrolatum, polydimethylsiloxane, phenyl polytrimethylsiloxane, cyclopentadimethylsiloxane, octyl polymethylsiloxane, and methyl polysiloxane.

[0080] On the other hand, embodiments of this application also provide a topical skin preparation comprising at least any of the aforementioned oil-in-water compositions.

[0081] On the other hand, embodiments of this application also provide a method for preparing an oil-in-water composition, comprising at least the following steps:

[0082] Provides liquid, oily feedstock mixtures;

[0083] Provides liquid aqueous feedstock mixtures;

[0084] The oily raw material mixture and the aqueous raw material mixture are mixed to obtain a water-in-oil mixture.

[0085] After adjusting the temperature of the water-in-oil mixture to 40-60°C, homogenization is performed to obtain an oil-in-water mixture, namely the oil-in-water composition.

[0086] Optionally, the steps for obtaining a liquid aqueous feedstock mixture include at least:

[0087] Provide at least one oily raw material;

[0088] The oily raw materials are mixed and heated to 65-95°C to obtain the oily raw material mixture.

[0089] Optionally, the oily raw material mixture includes at least a solid oil with a melting point of not less than 50°C.

[0090] Optionally, the oily raw material mixture includes at least:

[0091] At least one first emulsifier with an HLB value of 6 to 12;

[0092] At least one second emulsifier with an HLB value of 2 to 6.

[0093] Optionally, the steps for obtaining a liquid aqueous feedstock mixture include at least:

[0094] Provide at least one aqueous raw material and a pH adjuster;

[0095] The aqueous raw materials are mixed and then heated to 65-95°C;

[0096] Add a pH adjuster and stir to obtain the aqueous raw material mixture.

[0097] Optionally, after obtaining the water-in-oil mixture, the method further includes:

[0098] First, the water-in-oil mixture is kept at a constant temperature for 5 to 15 minutes under stirring conditions. Then, the temperature of the water-in-oil mixture is adjusted to 40 to 60°C before homogenization.

[0099] Optionally, in the step of adjusting the temperature of the oil-in-water mixture to 40-60°C and then homogenizing it to obtain the water-in-oil mixture, the homogenization speed is 2000-4000 rpm and the homogenization time is not less than 10 minutes.

[0100] Optionally, after obtaining the oil-in-water mixture, the process further includes:

[0101] The temperature of the oil-in-water mixture is adjusted to 25-35°C, the active ingredient is added and stirred evenly to obtain the oil-in-water composition.

[0102] The oil-in-water composition of this application

[0103] Oily particles

[0104] The oily particles are optically isotropic. For example, when illuminated in a dark room with polarized light (e.g., using a Nikon Eclipse Ci-POL polarizing microscope with a 30W halogen lamp), the oil-in-water composition of this application can be observed to exhibit the following properties. Figures 2-6 The phenomenon described herein refers to the oily particles pointed to by the label A. The objects pointed to by label A (i.e., the oily particles) do not refract or reflect under illumination with polarized light from different directions, exhibiting optical isotropy. The reason for the optical isotropy of the oily particles is that they do not contain crystallized solid oil.

[0105] The oily particles in this application include:

[0106] emulsifier

[0107] The oil-in-water composition of this application contains:

[0108] At least one first emulsifier with an HLB value of 6 to 12;

[0109] At least one second emulsifier with an HLB value of 2 to 6.

[0110] Using emulsifiers with low HLB values ​​alone makes it difficult for the composition to undergo phase inversion at low temperatures, and even after phase inversion, the liquid oil emulsion in the system is unstable. Using emulsifiers with high HLB values ​​alone results in the composition existing mainly in an oil-in-water emulsion form during high-temperature emulsification, making it impossible to prepare the composition of this application. When the two are combined, at low temperatures, the reduced external phase and high-speed homogenization further facilitate phase inversion in the composition of this application.

[0111] First emulsifier with an HLB value of 6-12

[0112] The HLB value of the first emulsifier suitable for this application can be 6-7, 7-8, 8-9, 9-10, 10-11, or 11-12.

[0113] The specific type of the first emulsifier is not particularly limited in this application. Such a first emulsifier may include, for example, octyl dodecyl xyloside, lecithin, hydrogenated lecithin, cocoyl glucoside, C12-20 alkyl glucoside, cetearyl oleate, polyglycerol-10 dipalmitate, etc.

[0114] The content of the first emulsifier can be adaptively adjusted according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the first emulsifier may optionally be 0.15%–0.2%, 0.2%–0.3%, 0.3%–0.4%, 0.4%–0.5%, 0.5%–0.6%, 0.6%–0.7%, 0.7%–0.8%, 0.8%–0.9%, 0.9%–1.0%, 1.0%–1.1%, 1.1%–1.2%, 1.2%–1.3%, 1.3%–1.4%, or 1.4%–1.5%.

[0115] Preferably, the content of the first emulsifier is 0.3-0.4%, 0.4-0.5%, 0.5-0.6%, 0.6-0.7%, or 0.7-0.8%. When the content of the first emulsifier is 0.3-0.8%, the composition of this application is more prone to phase inversion.

[0116] Secondary emulsifier with an HLB value of 2-6

[0117] The HLB value of the second emulsifier suitable for this application can be 2-3, 3-4, 4-5, or 5-6.

[0118] The specific type of the second emulsifier is not particularly limited in this application. Such a second emulsifier can be exemplified by the following non-limiting examples, such as PEG-30 dihydroxystearate, polyglycerol-3 diisostearate, polyglycerol-2 dihydroxystearate, polyglycerol-2 triisostearate, and polyglycerol-2 diisostearate.

[0119] The content of the second emulsifier can be adaptively adjusted according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the second emulsifier may optionally be 0.15%–0.2%, 0.2%–0.3%, 0.3%–0.4%, 0.4%–0.5%, 0.5%–0.6%, 0.6%–0.7%, 0.7%–0.8%, 0.8%–0.9%, or 0.9%–1.0%.

[0120] Preferably, the content of the second emulsifier is 0.3-0.4%, 0.4-0.5%, or 0.5-0.6%. When the content of the second emulsifier is 0.3-0.6%, the composition of this application is more prone to phase inversion.

[0121] liquid oil

[0122] The liquid oil suitable for this application can be any common liquid oil, and this application does not impose any particular limitation. Examples of such liquid oils, without limitation, include sesame oil, jojoba oil, almond oil, isodecyl oleate, diisostearyl malate, palm oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, cinnamon oil, grape oil, almond oil, rapeseed oil, liquid paraffin, squalane, sunflower seed oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea oil, evening primrose oil, egg yolk oil, and liver oil. Oils, triglycerides, octyl isopalmitoate, isopropyl isostearate, tricaprylic acid glyceride, triisopalmitoate, octyl palmitate and other palmitate esters, isochetyl stearate, isopropyl myristate, octyl dodecyl myristate, hexadecyl octanoate and other caprylate esters, tri-2-ethylhexanoate, neopentyl tetraethyl terephthalate, diisopropyl adipate, diethyl sebacate, diadipate, disebacate, polyoxybutylene polyoxypropylene glycol, polydimethylsiloxane, etc.

[0123] Preferably, the liquid oil may include hydrogenated polyisobutylene, squalane, hydrogenated polydecene, liquid paraffin, petrolatum, polydimethylsiloxane, phenyl polytrimethylsiloxane, cyclopentadimethylsiloxane, octyl polymethylsiloxane, methyl polysiloxane, etc. By selecting the aforementioned low-polarity or non-polar liquid oils, and because solid oils are less easily mixed with these low-polarity or non-polar liquid oils, a superior skin feel and reduced stickiness can be achieved.

[0124] Oily crystals

[0125] Oily crystals are mainly distributed in water, which serves as the medium.

[0126] Oily crystals exhibit optical anisotropy. For example, when illuminated in a dark room with polarized light (e.g., using a Nikon Eclipse Ci-POL polarizing microscope with a 30W halogen lamp), the oil-in-water composition of this application can be observed to exhibit the following properties. Figures 2-6 The phenomenon described herein refers to the oily crystals, as indicated by the label B. When irradiated with polarized light in at least one direction, the oily crystals refract or reflect light, exhibiting optical anisotropy. This is because the oily crystals contain crystallized solid oil.

[0127] The oily crystals are in the shape of at least one of the following: needle-like crystals, plate-like crystals, layered crystals, or blocky crystals.

[0128] solid oil

[0129] As a solid oil suitable for this application, its melting point is not lower than 50°C. More preferably, the melting point of the solid oil is not lower than 60°C. Such solid oils can be exemplified by non-limiting examples such as stearic acid, behenic acid, myristic acid, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristic acid myristate, cetyl palmitate, ethylene glycol palmitate, jojoba ester, etc.

[0130] The content of solid oil can be adjusted adaptively according to different formulation requirements. In a non-limiting example of this application, the content of solid oil is 8-9%, 9-10%, 10-11%, 11-12%, 12-13%, 13-14%, 14-15%, 15-16%, 16-17%, 17-18%, 18-19%, 19-20%, 20-21%, 21-22%, 22-23%, 23-24%, 24-25%, 25-26%, 26-27%, 27-28%, 28-29%, 29-30%, 30-31%, 31-32%, 32-33%, 33-34%, or 34-35%.

[0131] Preferably, the content of solid oil is 13-14%, 14-15%, 15-16%, 16-17%, 17-18%, 18-19%, or 19-20%. When the content of solid oil in the composition of this application is 13-20%, the composition of this application is more prone to phase inversion, and the time required for phase inversion is shorter.

[0132] Under normal circumstances, solid oil and liquid oil are emulsified together by an emulsifier during the cooling and homogenization process, forming emulsion particles that serve as the dispersed phase (or internal phase) and are distributed within the aqueous phase (or external phase). In this case, after the solid oil cools to room temperature, the crystallization morphology within the emulsion particles is approximately spherical, causing a feeling of blockage.

[0133] In this application, the solid oil exists in the aqueous phase. On the one hand, the emulsion particles, which are the dispersed phase, do not contain solid oil, and the resistance of the emulsion particles is greatly reduced. On the other hand, the crystals formed by the solid oil in the aqueous phase are more similar to "plates", "layers" or "blocks", which also reduces the resistance.

[0134] emulsifier

[0135] The oil-in-water composition of this application contains:

[0136] At least one first emulsifier with an HLB value of 6 to 12;

[0137] At least one second emulsifier with an HLB value of 2 to 6.

[0138] Using emulsifiers with low HLB values ​​alone makes it difficult for the composition to undergo phase inversion at low temperatures, and even after phase inversion, the liquid oil emulsion in the system is unstable. Using emulsifiers with high HLB values ​​alone results in the composition existing mainly in an oil-in-water emulsion form during high-temperature emulsification, making it impossible to prepare the composition of this application. When the two are combined, at low temperatures, the reduced external phase and high-speed homogenization further facilitate phase inversion in the composition of this application.

[0139] First emulsifier with an HLB value of 6-12

[0140] The HLB value of the first emulsifier suitable for this application can be 6-7, 7-8, 8-9, 9-10, 10-11, or 11-12.

[0141] The specific type of the first emulsifier is not particularly limited in this application. Such a first emulsifier may include, for example, octyl dodecyl xyloside, lecithin, hydrogenated lecithin, cocoyl glucoside, C12-20 alkyl glucoside, cetearyl oleate, polyglycerol-10 dipalmitate, etc.

[0142] The content of the first emulsifier can be adaptively adjusted according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the first emulsifier may optionally be 0.15%–0.2%, 0.2%–0.3%, 0.3%–0.4%, 0.4%–0.5%, 0.5%–0.6%, 0.6%–0.7%, 0.7%–0.8%, 0.8%–0.9%, 0.9%–1.0%, 1.0%–1.1%, 1.1%–1.2%, 1.2%–1.3%, 1.3%–1.4%, or 1.4%–1.5%.

[0143] Preferably, the content of the first emulsifier is 0.3-0.4%, 0.4-0.5%, 0.5-0.6%, 0.6-0.7%, or 0.7-0.8%. When the content of the first emulsifier is 0.3-0.8%, the composition of this application is more prone to phase inversion.

[0144] Secondary emulsifier with an HLB value of 2-6

[0145] The HLB value of the second emulsifier suitable for this application can be 2-3, 3-4, 4-5, or 5-6.

[0146] The specific type of the second emulsifier is not particularly limited in this application. Such a second emulsifier can be exemplified by the following non-limiting examples, such as PEG-30 dihydroxystearate, polyglycerol-3 diisostearate, polyglycerol-2 dihydroxystearate, polyglycerol-2 triisostearate, and polyglycerol-2 diisostearate.

[0147] The content of the second emulsifier can be adaptively adjusted according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the second emulsifier may optionally be 0.15%–0.2%, 0.2%–0.3%, 0.3%–0.4%, 0.4%–0.5%, 0.5%–0.6%, 0.6%–0.7%, 0.7%–0.8%, 0.8%–0.9%, or 0.9%–1.0%.

[0148] Preferably, the content of the second emulsifier is 0.3-0.4%, 0.4-0.5%, or 0.5-0.6%. When the content of the second emulsifier is 0.3-0.6%, the composition of this application is more prone to phase inversion.

[0149] liquid oil

[0150] The liquid oil suitable for this application can be any common liquid oil, and this application does not impose any particular limitation. Examples of such liquid oils, without limitation, include sesame oil, jojoba oil, almond oil, isodecyl oleate, diisostearyl malate, palm oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, cinnamon oil, grape oil, almond oil, rapeseed oil, liquid paraffin, squalane, sunflower seed oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea oil, evening primrose oil, egg yolk oil, and liver oil. Oils, triglycerides, octyl isopalmitoate, isopropyl isostearate, tricaprylic acid glyceride, triisopalmitoate, octyl palmitate and other palmitate esters, isochetyl stearate, isopropyl myristate, octyl dodecyl myristate, hexadecyl octanoate and other caprylate esters, tri-2-ethylhexanoate, neopentyl tetraethyl terephthalate, diisopropyl adipate, diethyl sebacate, diadipate, disebacate, polyoxybutylene polyoxypropylene glycol, polydimethylsiloxane, etc.

[0151] Preferably, the liquid oil may include hydrogenated polyisobutylene, squalane, hydrogenated polydecene, liquid paraffin, petrolatum, polydimethylsiloxane, phenyl polytrimethylsiloxane, cyclopentadimethylsiloxane, octyl polymethylsiloxane, methyl polysiloxane, etc. By selecting the aforementioned low-polarity or non-polar liquid oils, and because solid oils are less easily mixed with these low-polarity or non-polar liquid oils, a superior skin feel and reduced stickiness can be achieved.

[0152] water

[0153] Suitable water for this application may include ultrapure water, deionized water, and floral water. Without affecting the technical effects of this application, the water may include other substances that can be directly or indirectly dissolved in water.

[0154] Without affecting the composition of this application or the technical effect of the topical skin formulation of this application, thickeners, polyols, chelating agents, moisturizers, preservatives, pH adjusters, and active ingredients, as well as other chemical substances usable in the skin care or cosmetic fields, may be added. Specifically, these chemical substances may be one or more chemical substances mentioned in the "Catalogue of Used Cosmetic Ingredients (2021 Edition)" issued by the China National Medical Products Administration.

[0155] Non-limiting examples of thickeners may be selected from acrylate / C10-30 alkanol acrylate crosspolymers, sodium polyacrylate, carbomer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate / behenol polyether-25 methacrylate crosspolymer, sodium acrylate copolymer, ammonium polyacryloyldimethyl taurate, sodium polyacrylate grafted starch, silica, bentonite, magnesium aluminum silicate, distearate dimethylammonium lithium montmorillonite, silachlor ammonium hydrate, and aluminum octenyl succinate.

[0156] The content of the thickener can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the thickener may optionally be 0.1% to 1%.

[0157] Non-limiting examples of polyols may be selected from propylene glycol, glycerol, sorbitol, propylene glycol, 1,3-propylene glycol, butylene glycol, caprylyl glycol, dipropylene glycol, hexanediol, pentanediol, etc.

[0158] The content of polyols can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of polyols may optionally be 3% to 18%.

[0159] Non-limiting examples of chelating agents may be selected from EDTA-2Na, EGTA (ethylenediaminetetraacetic acid), phytic acid, citric acid, sodium citrate, gluconic acid, sodium phytate, etc.

[0160] The content of the chelating agent can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the chelating agent may optionally be 0.01% to 0.1%.

[0161] Non-limiting examples of humectants may be selected from sodium hyaluronate, tremella polysaccharide, dextran, glycerin, hyaluronic acid, sodium polyglutamate, panthenol, saccharide isomers, etc.

[0162] The content of the humectant can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the humectant may optionally be 0.01% to 1%.

[0163] Non-limiting examples of preservatives may be selected from p-hydroxyacetophenone, phenoxyethanol, potassium sorbate, benzoic acid, p-hydroxybenzoic acid esters, chlorphenesin, etc.

[0164] The content of preservatives can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of preservatives may optionally be 0.1% to 1%.

[0165] Non-limiting examples of pH adjusters may be selected from arginine, sodium hydroxide, potassium hydroxide, triethanolamine, tromethamine, etc.

[0166] The content of the pH adjuster can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the pH adjuster may optionally be 0.01% to 1%.

[0167] Non-limiting examples of active ingredients include: whitening ingredients such as vitamin C, arbutin, and sake lees extract, used to lighten dark spots and even out skin tone. Moisturizing ingredients such as hyaluronic acid, glycerin, and panthenol, used to increase skin hydration and improve dry skin. Antioxidant ingredients such as vitamin E, polyphenols (e.g., tea polyphenols, resveratrol), and coenzyme Q10, used to combat free radical damage and delay aging. Anti-acne ingredients such as salicylic acid, tea tree oil, and aloe vera extract, used to control acne formation and reduce inflammation. Anti-wrinkle ingredients such as retinol and its derivatives, collagen, elastin, and small molecule peptides, used to improve skin elasticity and reduce fine lines and wrinkles. Soothing ingredients such as allantoin, aloe vera extract, and green tea extract, used to calm sensitive skin and reduce redness and irritation. Spot-reducing ingredients such as arbutin, ferulic acid, and licorice extract, used to reduce pigmentation and improve dull skin tone. Firming and lifting ingredients: such as protein peptides, polyglutamic acid, and marine collagen, are used to improve skin firmness and reduce sagging. Hair care ingredients: such as silk protein, natural oils (such as coconut oil and grapeseed oil), and bioactive peptides, are used to repair damaged hair and nourish hair roots. Sunscreen ingredients: such as titanium dioxide, zinc oxide, and sunscreen agents (such as benzoic acid derivatives), are used to protect against UV radiation and prevent sunburn.

[0168] The content of the active ingredient can be adjusted adaptively according to different formulation requirements or depending on other components in the formulation. In a non-limiting example of this application, the content of the active ingredient may optionally be 0.01% to 5%.

[0169] This application relates to topical skin preparations.

[0170] The topical skin preparation of this application can be a skin care product or a cosmetic product. The dosage form of the topical skin preparation of this application can be any one of the following: toner, serum, spray, lotion, cream, mask, gel, sunscreen, and makeup base.

[0171] Preparation method of this application

[0172] Provides liquid oily feedstock mixtures

[0173] Methods for obtaining liquid oily raw material mixtures can be common processing methods in the art. For example, oily components, including but not limited to solid oils, liquid oils, and emulsifiers, are first mixed, then the mixture is heated and stirred until it is homogeneous and free of particulate matter. A non-limiting example of this application is to mix oily components, including but not limited to solid oils, liquid oils, and emulsifiers, heat the oily mixture to 65–95°C, and then stir until it is homogeneous and free of particulate matter. Preferably, heating the oily mixture to 80–90°C before stirring can improve the fluidity and homogeneity of the components in the oily mixture.

[0174] Provide liquid aqueous feedstock mixtures

[0175] The method for obtaining a liquid aqueous raw material mixture can be a common processing method in the art. For example, aqueous components, including but not limited to water and aqueous gelling agents, are first mixed and heated, then stirred until the mixture is homogeneous and free of particulate matter. A neutralizing agent (or pH adjuster), including but not limited to arginine, is then added to the mixture, and stirring continues until the mixture is homogeneous and free of particulate matter. A non-limiting example of this application is heating an unneutralized aqueous mixture, including but not limited to water and aqueous gelling agents, to 65–95°C and homogenizing it at approximately 3000 rpm for 3–10 minutes until the aqueous mixture is uniformly dispersed and free of particulate matter. A neutralizing agent is then added, and stirring continues at 20–80 rpm until the aqueous mixture is uniformly dispersed and free of particulate matter. Preferably, heating the aqueous mixture to 80–90°C before stirring improves the fluidity and homogeneity of the components in the aqueous mixture.

[0176] The oily raw material mixture and the aqueous raw material mixture are mixed to obtain a water-in-oil mixture.

[0177] The method for obtaining a water-in-oil mixture can also be a common processing method in the art. In this application, an oily raw material mixture is first added to an aqueous raw material mixture, and then homogenized until the mixture is evenly and finely dispersed, thus obtaining a water-in-oil mixture. A non-limiting example of this application is that, at a temperature of 60–95°C, the oily raw material mixture is first slowly added to the aqueous raw material mixture, and then homogenized at a homogenization speed of about 2000 rpm for 3–5 minutes until the mixture is evenly and finely dispersed, thus obtaining the water-in-oil mixture. Preferably, at a temperature of 80–90°C, the oily raw material mixture is slowly added to the aqueous raw material mixture, and homogenized at a homogenization speed of about 2000 rpm for 3–5 minutes. At higher temperatures, it is easier to form a water-in-oil system, and the volume (or particle size) of the emulsion particles in the formed water-in-oil mixture is more similar.

[0178] After adjusting the temperature of the water-in-oil mixture to 40–60°C, homogenization is performed to obtain an oil-in-water mixture. The body, namely the oil-in-water composition

[0179] The method of converting a water-in-oil mixture into an oil-in-water mixture through homogenization is a common processing method in the art. In this application, under conditions where the water-in-oil mixture system can maintain a stable temperature, energy is input into the water-in-oil mixture through homogenization, causing the mixture to undergo phase inversion and thus obtain an oil-in-water mixture. A non-limiting example of this application is that the temperature of the water-in-oil mixture is controlled at 40-60°C, and then homogenization is started at a speed of 2000-4000 rpm for at least 10 minutes until the mixture is converted from a water-in-oil mixture to an oil-in-water mixture. Preferably, the temperature of the water-in-oil mixture is adjusted to 40-60°C before homogenization. To obtain a better skin feel, a portion of a solid oil with a relatively low melting point is added. In this case, adjusting the temperature of the water-in-oil mixture to 40-60°C makes the solid oil more stable overall, and the overall stability of the system is more stable. Preferably, the homogenization speed is 2500-3500 rpm. Preferably, the homogenization time is 10–20 min. Experiments have shown that a homogenization speed of 2500–3500 rpm is sufficient to induce phase inversion in the oil-in-water mixture, thus obtaining an oil-in-water mixture. Insufficient homogenization speed or time will result in a lower success rate of phase inversion.

[0180] Under the condition that the temperature of the oil-in-water mixture is 25-35℃, the active ingredient is added and stirred evenly.

[0181] Adding active ingredients to an oil-in-water mixture can be a common processing method known in the art. In this application, the active ingredient is added to the oil-in-water mixture after the temperature of the mixture has dropped to a level that does not affect the activity of the active ingredient, and then stirred until homogeneous. A non-limiting example of this application is that the active ingredient is added and stirred until homogeneous at a temperature of 25–35°C, and the resulting product is the oil-in-water composition of this application.

[0182] Experimental Section

[0183] Example 1

[0184] Preparation method of Example 1

[0185] Mix the A phase raw materials evenly, heat to about 65°C, and homogenize at a homogenization speed of 3000 rpm for 3 minutes until the material is evenly dispersed and free of particles.

[0186] Add phase B raw material to phase A, and keep the stirring speed at 30 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0187] Mix the C-phase raw materials evenly and heat to about 65°C until the material is evenly dispersed without particles.

[0188] Add the C phase material to the A+B phase, homogenize at 2000 rpm for 3 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start stirring at 30 rpm, keep warm for 10 minutes, and then start cooling.

[0189] When the temperature drops to around 60℃, start the homogenizer and homogenize at 2000 rpm for 20 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0190] When the temperature drops to about 25°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 1.

[0191] The components of Example 1 are shown in Table 1.

[0192] Table 1

[0193]

[0194]

[0195] Example 2

[0196] Preparation method of Example 2

[0197] Mix the A phase raw materials evenly, heat to about 70°C, and homogenize at a homogenization speed of 3000 rpm for 4 minutes until the material is evenly dispersed and free of particles.

[0198] Add phase B raw material to phase A, and keep the stirring speed at 35 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0199] Mix the C-phase raw materials evenly and heat to about 70°C until the material is evenly dispersed without particles.

[0200] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 35 r / min, keep it warm for 15 minutes, and then start cooling.

[0201] When the temperature drops to around 60℃, start the homogenizer and homogenize at 2500 rpm for 20 minutes until the oil-in-water mixture becomes a water-in-oil mixture.

[0202] When the temperature drops to about 30°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 2.

[0203] The components of Example 2 are shown in Table 2.

[0204] Table 2

[0205] Mutually Raw material name Example 2 A water margin A glycerin 6 A Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.4 A Acrylic (ester) crosspolymers / C10-30 alkanol acrylate crosspolymers 0.15 A Disodium EDTA 0.05 A Sodium hyaluronate 0.02 A Hexanediol 0.8 A p-Hydroxyacetophenone 0.5 B Arginine 0.2 C behenic acid 6 C Myristyl myristate 6 C squalane 3 C Ascorbate tetraisopalmitate 0.5 C Jojoba esters 5.8 C Lecithin 0.4 C PEG-30 Dimeric Hydroxy Stearate 0.33 D Ikdoin 1 D Palmitoyl tripeptide-5 0.1

[0206] Example 3

[0207] Preparation method of Example 3

[0208] Mix the A phase raw materials evenly, heat to about 75°C, and homogenize at a homogenization speed of 3000 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0209] Add phase B raw material to phase A, and keep the stirring speed at 40 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0210] Mix the C-phase raw materials evenly and heat to about 75°C until the material is evenly dispersed without particles.

[0211] Add the C phase material to the A+B phase, homogenize at 4000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start stirring at 40 rpm, keep warm for 15 minutes, and then start cooling.

[0212] When the temperature drops to around 50℃, start the homogenizer and homogenize at 3000 rpm for 15 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0213] When the temperature drops to approximately 35°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 3.

[0214] The components of Example 3 are shown in Table 3.

[0215] Table 3

[0216]

[0217]

[0218] Example 4

[0219] Preparation method of Example 4

[0220] Mix the A phase raw materials evenly, heat to about 80°C, and homogenize at a homogenization speed of 3000 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0221] Add phase B raw material to phase A, and keep the stirring speed at 40 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0222] Mix the C-phase raw materials evenly and heat to about 80°C until the material is evenly dispersed without particles.

[0223] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 45 rpm, keep warm for 15 minutes, and then start cooling.

[0224] When the temperature drops to around 45℃, start the homogenizer and homogenize at 3500 rpm for 20 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0225] When the temperature drops to about 35°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 4.

[0226] The components of Example 4 are shown in Table 4.

[0227] Table 4

[0228]

[0229]

[0230] Example 5

[0231] Preparation method of Example 5

[0232] Mix the A phase raw materials evenly, heat to about 80°C, and homogenize at a homogenization speed of 3500 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0233] Add phase B raw material to phase A, and keep the stirring speed at 50 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B;

[0234] Mix the C-phase raw materials evenly and heat to about 80°C until the material is evenly dispersed without particles.

[0235] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 4 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start stirring at 50 rpm, keep warm for 15 minutes, and then start cooling.

[0236] When the temperature drops to around 55℃, start the homogenizer and homogenize at 3500 rpm for 15 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0237] When the temperature drops to about 30°C, add phase D, continue mixing and stirring until uniform, and then discharge to obtain Example 5.

[0238] The components of Example 5 are shown in Table 5.

[0239] Table 5

[0240]

[0241]

[0242] Example 6

[0243] Preparation method of Example 6

[0244] Mix the A phase raw materials evenly, heat to about 85°C, and homogenize at a homogenization speed of 3500 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0245] Add phase B raw material to phase A, and keep the stirring speed at 40 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0246] Mix the C-phase raw materials evenly and heat to about 85°C until the material is evenly dispersed without particles.

[0247] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start stirring at 50 rpm, keep warm for 10 minutes, and then start cooling.

[0248] When the temperature drops to around 50°C, start the homogenizer and homogenize at 4000 rpm for 15 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0249] When the temperature drops to approximately 27°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 6.

[0250] The components of Example 6 are shown in Table 6.

[0251] Table 6

[0252]

[0253]

[0254] Example 7

[0255] Preparation method of Example 7

[0256] Mix the A phase raw materials evenly, heat to about 85°C, and homogenize at a homogenization speed of 3500 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0257] Add phase B raw material to phase A, and keep the stirring speed at 35 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0258] Mix the C-phase raw materials evenly and heat to about 85°C until the material is evenly dispersed without particles.

[0259] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 50 rpm, keep warm for 15 minutes, and then start cooling.

[0260] When the temperature drops to around 40℃, start the homogenizer and homogenize at 3500 rpm for 15 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0261] When the temperature drops to about 30°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 7.

[0262] The components of Example 7 are shown in Table 7.

[0263] Table 7

[0264] Mutually Raw material name Example 7 A water margin A glycerin 6 A Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.4 A Acrylic (ester) crosspolymers / C10-30 alkanol acrylate crosspolymers 0.15 A Disodium EDTA 0.05 A Sodium hyaluronate 0.02 A Hexanediol 0.8 A p-Hydroxyacetophenone 0.5 B Arginine 0.15 C stearic acid 6 C Cetyl palmitate 4 C squalane 2.5 C Ascorbate tetraisopalmitate 0.5 C Jojoba esters 4 C Octyl dodecanol xyloside 0.35 C PEG-30 Dimeric Hydroxy Stearate 0.35 D Ikdoin 1 D Palmitoyl tripeptide-5 0.1

[0265] Example 8

[0266] Preparation method of Example 8

[0267] Mix the A phase raw materials evenly, heat to about 90°C, and homogenize at a homogenization speed of 3500 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0268] Add phase B raw material to phase A, and keep the stirring speed at 35 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0269] Mix the C-phase raw materials evenly and heat to about 90°C until the material is evenly dispersed without particles.

[0270] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 35 rpm, keep warm for 10 minutes, and then start cooling.

[0271] When the temperature drops to around 60℃, start the homogenizer and homogenize at 3500 rpm for 10 minutes until the oil-in-water mixture becomes a water-in-oil mixture.

[0272] When the temperature drops to approximately 34°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 8.

[0273] The components of Example 8 are shown in Table 8.

[0274] Table 8

[0275]

[0276]

[0277] Example 9

[0278] Preparation method of Example 9

[0279] Mix the A phase raw materials evenly, heat to about 85°C, and homogenize at a homogenization speed of 3500 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0280] Add phase B raw material to phase A, and keep the stirring speed at 35 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0281] Mix the C-phase raw materials evenly and heat to about 85°C until the material is evenly dispersed without particles.

[0282] Add the C phase material to the A+B phase, homogenize at 3000 rpm for 5 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 45 rpm, keep warm for 15 minutes, and then start cooling.

[0283] When the temperature drops to around 50℃, start the homogenizer and homogenize at 4000 rpm for 10 minutes until the oil-in-water mixture becomes a water-in-oil mixture.

[0284] When the temperature drops to approximately 34°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 9.

[0285] The components of Example 9 are shown in Table 9.

[0286] Table 9

[0287] Mutually Raw material name Example 9 A water margin A glycerin 6 A Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.4 A Acrylic (ester) crosspolymers / C10-30 alkanol acrylate crosspolymers 0.15 A Disodium EDTA 0.05 A Sodium hyaluronate 0.02 A Hexanediol 0.8 A p-Hydroxyacetophenone 0.5 B Arginine 0.15 C stearic acid 6 C Cetyl palmitate 4 C squalane 2.5 C Ascorbate tetraisopalmitate 0.5 C Jojoba esters 4 C Polyglycerol-10-dipalmitate 0.35 C Polyglycerol-2-dihydroxystearate 0.35 D Ikdoin 1 D Palmitoyl tripeptide-5 0.1

[0288] Example 10

[0289] Preparation method of Example 10

[0290] Mix the A phase raw materials evenly, heat to about 90°C, and homogenize at a homogenization speed of 3000 rpm for 5 minutes until the material is evenly dispersed and free of particles.

[0291] Add phase B raw material to phase A, and keep the stirring speed at 40 r / min to make the material evenly dispersed without particles, thus obtaining phase A+B.

[0292] Mix the C-phase raw materials evenly and heat to about 90°C until the material is evenly dispersed without particles.

[0293] Add the C phase material to the A+B phase, homogenize at 3500 rpm for 3 minutes until the material is evenly and finely dispersed to obtain an oil-in-water mixture. After completion, start the stirring speed at 40 rpm, keep warm for 15 minutes, and then start cooling.

[0294] When the temperature drops to around 55℃, start the homogenizer and homogenize at 4000 rpm for 10 minutes until the oil-in-water mixture becomes an oil-in-water mixture.

[0295] When the temperature drops to approximately 27°C, add phase D, continue mixing and stirring until homogeneous, and then discharge to obtain Example 10.

[0296] The components of Example 10 are shown in Table 10.

[0297] Table 10

[0298]

[0299]

[0300] Comparative Example 1

[0301] The preparation method of Comparative Example 1 is basically the same as that of Example 1. The components of Comparative Example 1 are shown in Table 11.

[0302] Table 11

[0303]

[0304]

[0305] Comparative Example 2

[0306] The preparation method of Comparative Example 2 is basically the same as that of Example 1. The components of Comparative Example 2 are shown in Table 12.

[0307] Table 12

[0308]

[0309]

[0310] Sample testing

[0311] Sample appearance

[0312] The samples from Examples 1-10 and Comparative Examples 1-2 were observed in a dark room using a polarizing microscope (Nikon Eclipse Ci-POL, 30W halogen lamp as the light source). The appearance of the samples is as follows. Figures 1-8 .

[0313] Among them, the appearance of the sample in Comparative Example 1 is shown in Figure 1 and Figure 2 The appearance of the sample in Comparative Example 2 is shown below. Figure 3 and Figure 4 .

[0314] The appearance of the sample in Example 1 is shown below. Figure 5 and Figure 6 The appearance of the sample in Example 2 is shown below. Figure 7 and Figure 8 The appearance of the samples in Examples 3-10 is basically the same as that in Examples 1-2, so they are omitted.

[0315] from Figures 1-4 As can be seen, when the emulsifier is not a combination of a first emulsifier with an HLB value of 6 to 12 and a second emulsifier with an HLB value of 2 to 6, the solid oil in the composition of this application is mainly present in oily particles. Therefore, the reflection of oily particles can be observed under polarized light irradiation at a specific angle (the object pointed to by mark A).

[0316] from Figures 5-8 As can be seen, when the emulsifier is configured as a first emulsifier with an HLB value of 6 to 12 and a second emulsifier with an HLB value of 2 to 6, the composition of this application can undergo phase inversion. The oily particles do not contain solid oil, so they do not reflect light under polarized light irradiation (the object pointed to by mark A), while the oily crystals (the object pointed to by mark B) aggregate in the aqueous phase to form blocky crystals, needle-like crystals, and plate-like crystals, etc., which will reflect light under polarized light irradiation at a specific angle.

[0317] In Examples 1-10, the first emulsifier with an HLB value of 6-12 was octyl dodecanol xyloside, lecithin, hydrogenated lecithin, cocoyl glucoside, C12-20 alkyl glucoside, cetearyl oleate, and polyglycerol-10 dipalmitate, respectively; the second emulsifier with an HLB value of 2-6 was PEG-30 dihydroxystearate, polyglycerol-3 diisostearate, polyglycerol-2 dihydroxystearate, polyglycerol-2 triisostearate, and polyglycerol-2 diisostearate, respectively, and all of them were able to form the composition of this application.

[0318] Skin feel test

[0319] Skin feel tests were performed on the samples from Examples 1 to 10 and Comparative Examples 1 to 2.

[0320] The skin feel test is a subjective test item, with a rating of 0 to 10, where 10 represents very satisfactory.

[0321] Thirty volunteers were selected to use the above products and rate them. The average score was then calculated.

[0322] The results are shown in Table 13.

[0323] Table 13

[0324]

[0325]

[0326] Moisturizing performance and skin barrier function testing

[0327] The moisturizing properties and skin barrier function of the samples from Examples 1 to 10 were tested.

[0328] The moisturizing performance of the samples was tested using a skin moisture content meter (Cormeter CM825, CK, Germany), and the skin moisture content MMV value was determined by the capacitance method.

[0329] Among them, the MMV value represents skin moisture; the higher the MMV value, the higher the water content of the stratum corneum.

[0330] The skin barrier function of the samples was tested using a transepidermal water loss rate tester (Tewameter TM300: CK, Germany) and the transepidermal water loss (TEWL) value was determined. The water vapor pressure gradient at different points on the epidermis formed by water loss from the stratum corneum was measured using two sets of sensors with different temperatures and humidity. The amount of water evaporated through the epidermis was measured. The TEWL value is used to evaluate the skin barrier function and is an important parameter for assessing skin repair after using the product.

[0331] Among them, the lower the TEWL value, the better the skin barrier and the better the repair.

[0332] The testing steps are as follows:

[0333] Cleanse the skin on the inside of the arm with a cleansing product. Sit quietly in the laboratory for approximately 20 minutes, during which time the experimenter marks the test area on the inside of the arm. After the test preparation process is completed, the first initial skin data is collected. After the initial skin data collection, the test sample is applied. The experimenter uses a pipette to apply a quantitative amount (0.02g) of sample to the corresponding area and spreads the sample in the same direction. Data is collected at 2 and 4 hours after sample application. Measurements are taken three times at different locations within each area. The measurement results are expressed as the average of the three measurements. The statistical results are shown in Tables 14 and 15.

[0334] Table 14

[0335] Serial Number 0h 2h 4h Example 1 30.43 63.33 55.29 Example 2 31.37 61.55 51.74 Example 3 29.39 59.89 52.66 Example 4 30.15 60.89 54.37 Example 5 31.73 63.37 54.31 Example 6 32.91 64.21 55.78 Example 7 33.56 63.89 52.87 Example 8 31.16 60.64 53.52 Example 9 33.49 65.13 51.27 Example 10 31.75 64.64 55.71

[0336] Table 15

[0337]

[0338]

[0339] The results in Table 14 show that the composition of this application has a significant moisturizing effect over a long period of time, effectively regulating the skin's stratum corneum barrier function and prolonging the hydration and closure of the stratum corneum.

[0340] Transepidermal water loss values ​​can be used to evaluate the degree of skin repair; the lower the value, the better the skin barrier and the better the repair. Table 15 shows that the examples demonstrated a significant skin barrier function.

[0341] Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0342] Those skilled in the art can modify the technical solutions described in the above embodiments or make equivalent substitutions for some of the technical features; however, such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the protection scope of the technical solutions of the embodiments of this application.

Claims

1. An oil-in-water composition, characterized in that, It includes at least: water; Emulsified particles; At least one solid oil; At least one first emulsifier with an HLB value of 6 to 12; At least one second emulsifier with an HLB value of 2 to 6; It also includes liquid oil; Both the solid oil and the emulsified particles are distributed in the water; The emulsified particles do not reflect light when irradiated with polarized light; The solid oil is distributed in the water in the form of crystals; The first emulsifier with an HLB value of 6 to 12 includes at least one of octyl dodecanol xyloside, lecithin, hydrogenated lecithin, cocoyl glucoside, C12-20 alkyl glucoside, cetearyl oleate, and polyglycerol-10 dipalmitate. The second emulsifier with an HLB value of 2 to 6 includes at least one of PEG-30 dihydroxystearate, polyglycerol-3 diisostearate, polyglycerol-2 dihydroxystearate, polyglycerol-2 triisostearate, and polyglycerol-2 diisostearate. The liquid oil includes at least one of hydrogenated polyisobutylene, squalane, hydrogenated polydecene, liquid paraffin, petrolatum, polydimethylsiloxane, phenyl polytrimethylsiloxane, cyclopentadimethylsiloxane, octyl polymethylsiloxane, and methyl polysiloxane. The method for preparing the oil-in-water composition includes at least the following steps: Provides liquid, oily feedstock mixtures; Provides liquid aqueous feedstock mixtures; The oily raw material mixture and the aqueous raw material mixture are mixed to obtain a water-in-oil mixture. After adjusting the temperature of the water-in-oil mixture to 40-60°C, homogenization is performed to obtain an oil-in-water mixture, namely the oil-in-water composition.

2. The oil-in-water composition according to claim 1, characterized in that, The melting point of the solid oil is not lower than 50°C.

3. The oil-in-water composition as described in claim 1, characterized in that, The solid oil includes at least one of stearic acid, behenic acid, myristic acid, cetyl alcohol, stearyl alcohol, behenic acid, myristic acid myristic acid ester, cetyl palmitate, and glycol palmitate.

4. A topical skin preparation, characterized in that, It includes at least the oil-in-water composition as described in any one of claims 1 to 3.

5. The method for preparing the oil-in-water composition according to any one of claims 1 to 3, characterized in that, At least the following steps are included: Provides liquid, oily feedstock mixtures; Provides liquid aqueous feedstock mixtures; The oily raw material mixture and the aqueous raw material mixture are mixed to obtain a water-in-oil mixture. After adjusting the temperature of the water-in-oil mixture to 40-60°C, homogenization is performed to obtain an oil-in-water mixture, namely the oil-in-water composition.

6. The preparation method according to claim 5, characterized in that, The steps to obtain a liquid aqueous feedstock mixture include at least the following: Provide at least one oily raw material; The oily raw materials are mixed and heated to 65-95°C to obtain the oily raw material mixture.

7. The preparation method according to claim 5, characterized in that, The oily raw material mixture includes at least a solid oil with a melting point of not less than 50°C.

8. The preparation method according to claim 5, characterized in that, The oily raw material mixture includes at least: At least one first emulsifier with an HLB value of 6 to 12; At least one second emulsifier with an HLB value of 2 to 6.

9. The preparation method according to claim 5, characterized in that, The steps to obtain a liquid aqueous feedstock mixture include at least the following: Provide at least one aqueous raw material and a pH adjuster; The aqueous raw materials are mixed and then heated to 65-95°C; Add a pH adjuster and stir to obtain the aqueous raw material mixture.

10. The preparation method according to claim 5, characterized in that, After obtaining the water-in-oil mixture, the process further includes: First, the water-in-oil mixture is kept at a constant temperature for 5 to 15 minutes under stirring conditions, and then the temperature of the water-in-oil mixture is adjusted to 40 to 60°C before homogenization.

11. The preparation method according to claim 5, characterized in that, In the step of adjusting the temperature of the oil-in-water mixture to 40-60°C and then homogenizing it to obtain the water-in-oil mixture, the homogenization speed is 2000-4000 rpm and the homogenization time is not less than 10 min.

12. The preparation method according to claim 5, characterized in that, After obtaining the oil-in-water mixture, the process also includes: The temperature of the oil-in-water mixture is adjusted to 25-35°C, the active ingredient is added and stirred evenly to obtain the oil-in-water composition.

Images