一种从混悬液或体液中快速提取和检测环泊酚的方法

By combining extraction with ion mobility spectrometry, the problems of long extraction and low accuracy of cyclopropofol in existing technologies have been solved, enabling rapid and sensitive detection of cyclopropofol, which is suitable for the analysis of samples such as whole blood and plasma.

CN117091929BActive Publication Date: 2026-07-17DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2022-05-12
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies make it difficult to quickly and accurately extract and detect cyclopropofol from suspensions or body fluids, especially due to interference from complex components in blood, which affects the real-time performance and accuracy of anesthesia depth monitoring.

Method used

Cyclopophenol was extracted from suspensions or body fluids using extractants such as n-hexane or chloroform, and then analyzed using ion mobility spectrometry. After obtaining the supernatant through dilution and centrifugation, rapid detection was performed using ion mobility spectrometry.

Benefits of technology

It enables rapid extraction of cyclopropofol from suspensions or body fluids, with a detection time of 1-10 minutes, improving the sensitivity and accuracy of detection, and is suitable for the analysis of complex samples such as whole blood and plasma.

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Abstract

本发明公开了一种从混悬液或体液中快速提取和检测环泊酚的方法,采用正己烷从混悬液或体液中萃取提取环泊酚,混合液离心的上清液用稀释液稀释后,进样到离子迁移谱仪器中分析,得到迁移时间对峰高强度的谱图,依据特征迁移常数和峰高来分析环泊酚的含量。本发明方法的检测时间在1‑10分钟之间,具有快速、灵敏的特点。
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