A method for the synthesis of a beta-lactam
By using MAC reagents and amino acid-derived thiourea compounds as catalysts, β-lactams can be synthesized in dichloromethane solvent. This solves the problems of environmental pollution and harsh reaction conditions caused by heavy metal catalysts in existing technologies, and realizes an efficient, green, and mild synthetic route suitable for pharmaceutical and organic synthesis.
CN117105838BActive Publication Date: 2026-07-21SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
- Filing Date
- 2023-03-17
- Publication Date
- 2026-07-21
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Abstract
The application relates to a synthesis method of a beta-lactam, and the specific synthesis steps are as follows: taking trans-nitrostyrene and 2-(methoxymethoxy) propanedinitrile as raw materials, taking Catalyst A as a catalyst, and taking dichloromethane as a solvent to react to obtain an intermediate 3; the compound 3 is reacted with acid and water to obtain a compound 4; the compound 4 is reduced by hydrogen to obtain a compound 5; the compound 5 is subjected to a condensation reaction to obtain a final product 6; the synthesis raw material is simple and easy to obtain, the condition is mild, no metal catalyst is used, the synthesis route is short, the reaction operation condition is not harsh, the method is cheap, low-toxic, green and pollution-free, meanwhile, the method can be applied to efficiently synthesize beta-lactam molecules in a large amount, and is used for widely exploring the biological activity of a beta-lactam parent nucleus.
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