一种蛇床子素8位衍生物及其制备方法、应用

By modifying the structure of osthol, an 8-position derivative of osthol was synthesized, which solved the problem of multidrug-resistant bacteria and achieved significant antibacterial effects against MRSA and FREC, which are superior to traditional antibiotics.

CN117105982BActive Publication Date: 2026-07-17ZUNYI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZUNYI MEDICAL UNIVERSITY
Filing Date
2023-08-07
Publication Date
2026-07-17

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Abstract

本方案公开了有机化学技术领域中的具有通式Ⅰ所示的蛇床子素8位衍生物，其中，R为苯基或取代苯基；或R为吡啶基或取代吡啶基；或R为呋喃基取代呋喃基；或R为噻吩基或取代噻吩基；或R为噻唑或取代噻唑；R1为1‑5个碳的饱和烷基。所述的通式Ⅰ所示的化合物具有较强的抗菌活性，可用作抗金黄色葡萄球菌(S.aureus)、大肠杆菌(E.coli)、耐甲氧西林金黄色葡萄球菌(MRSA)和耐氟喹诺酮大肠杆菌(FREC)的药物；同时，也可与其它抗菌活性物质组合使用。
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