快速光固化层粘蛋白改性丝素蛋白水凝胶、其制法与应用
By modifying silk fibroin and laminin with double bonds, a rapidly photocurable laminin-modified silk fibroin hydrogel was prepared, which solved the problems of low bioactivity and slow cross-linking speed of hydrogels, and achieved rapid cross-linking and good biocompatibility, thus promoting the three-dimensional culture and differentiation of stem cells.
CN117106142BActive Publication Date: 2026-07-17SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
- Filing Date
- 2022-05-17
- Publication Date
- 2026-07-17
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Figure CN117106142B_ABST
Abstract
本发明公开了一种快速光固化层粘蛋白改性丝素蛋白水凝胶、其制法与应用。所述制法包括：将甲基丙烯酸缩水甘油酯修饰到丝素蛋白上，获得甲基丙烯酸缩水甘油酯修饰的丝素蛋白；使N‑羟基琥珀酰亚胺‑聚乙二醇‑丙烯酸酯与层粘蛋白上的伯氨进行反应，获得丙烯酸酯修饰的层粘蛋白；使所述甲基丙烯酸缩水甘油酯修饰的丝素蛋白、光引发剂、缓冲体系、丙烯酸酯修饰的层粘蛋白混合均匀，形成凝胶前体溶液，之后以紫外线照射，获得快速光固化层粘蛋白改性丝素蛋白水凝胶。本发明制得的水凝胶的固化时间短、生物相容性好、可紧密粘合组织、可给细胞提供具有良好黏附位点的三维生存环境，促进神经元轴突的生长和轴突建立，并且实现干细胞的三维培养。
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