一种盐酸艾司洛尔B晶型及其制备方法和应用
Esmolol hydrochloride B crystal form was prepared by water dissolution, evaporation crystallization and drying, which solved the problems of poor solubility and complicated production of existing esmolol hydrochloride crystal forms, achieved better solubility and stability and simplified the production process.
CN117126070BActive Publication Date: 2026-07-17HAINAN LINGKANG PHARMA CO LTD +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HAINAN LINGKANG PHARMA CO LTD
- Filing Date
- 2023-08-25
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing esmolol hydrochloride crystal forms suffer from poor solubility and complex production processes.
Method used
Using water as a solvent, esmolol hydrochloride B crystal form was prepared by evaporation crystallization, crystal growth, grinding and drying to form a single crystal form with characteristic peaks.
Benefits of technology
The prepared esmolol hydrochloride B crystal form has good solubility and chemical stability in water, with a 19% increase in solubility. The process is simple and environmentally friendly, and the product yield is high.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN117126070B_ABST
Abstract
本发明提供了一种盐酸艾司洛尔B晶型及其制备方法和应用，涉及医药分离技术领域。本发明提供的盐酸艾司洛尔B晶型化学稳定性好，在水中具有较好的溶解性，适合药物制剂的制造和长期储存。本发明的制备工艺简单，工艺稳定，耗能少，产品的收率均高达90％以上，该过程溶剂为水，绿色环保。
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