一种南海海百合来源真菌及其应用
By isolating the fungus Penicillium brocae SYSU-CJ-17 from sea lilies in the South China Sea, pyridine carboxylic acid alkaloids with anticancer effects were prepared, solving the problem of underutilization of active substances in marine microorganisms and realizing the development and industrial application of anticancer drugs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUN YAT SEN UNIV
- Filing Date
- 2023-08-24
- Publication Date
- 2026-07-17
AI Technical Summary
A large number of microorganisms or active substances in marine microorganisms have not been fully explored, especially the application of fungi derived from sea lilies in the preparation of pyridine carboxylic acid alkaloids with anticancer effects has not been reported.
The fungus *Penicillium brocae* SYSU-CJ-17 was isolated from crinoids in the South China Sea. It was cultured on PDA, PDB or Bengal red medium, and fermented. The fermentation was then scaled up on rice medium. Pyridine carboxylic acid alkaloids (I) and (II) were prepared by ethyl acetate extraction and high performance liquid chromatography purification.
The prepared pyridine carboxylic acid alkaloids have a significant inhibitory effect on cancer, are suitable for the preparation of anticancer drugs, are easy to scale up and industrialize without disrupting the ecological balance, and provide a rich source of raw materials for marine microbial drugs.
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Figure CN117126749B_ABST