Matrix cabinet slide scanning device

Abstract

The application provides a matrix cabinet type slide centralized scanning device, which comprises a base, wherein the base is provided with a first matrix cabinet, a plurality of matrix-arranged partition cabinets are arranged in the first matrix cabinet, a slide scanning device is arranged in the partition cabinet, the slide scanning device comprises a scanning device base frame, a movable X-direction moving table is arranged on the scanning device base frame, a movable Y-direction moving table is arranged on the X-direction moving table, a slide clip placement position is arranged on the Y-direction moving table, the slide clip placement position is used for placing a slide clip, the slide clip is provided with a plurality of slide placement positions, the slide placement positions are used for placing slides, a Z-direction moving table is further arranged on the scanning device base frame, a scanning mirror is arranged on the Z-direction moving table, the moving directions of the X-direction moving table, the Y-direction moving table and the Z-direction moving table are perpendicular to each other, and the scanning mirror is used for scanning the slides on the slide clip, thereby solving the problems of slow scanning rhythm and low efficiency of a single machine type slide scanning device.

Description

Technical Field

[0001] This invention relates to the field of biological detection, and in particular to a matrix cabinet-type centralized scanning device for glass slides. Background Technology

[0002] After cervical cell samples are collected, they need to be prepared into slides and stained. After staining, a coverslip is placed on top to form a slide. Subsequently, the slide is placed in a slide holder and inserted into a slide scanner to scan the pathological areas into images.

[0003] Traditional stand-alone slide scanning devices have movement mechanisms in the X, Y, and Z directions. After the slide holder is placed on the slide, the scanning mirror can move freely relative to the slide to find the focal point and scan the pathological area. However, since a slide holder can generally only hold a few slides at a time, and the scanning time for a single slide is about one minute, the processing time for a single slide holder is several minutes, which cannot meet the needs of rapid, high-rate-of-use cell detection. Summary of the Invention

[0004] This invention provides a matrix cabinet-type centralized scanning device for glass slides, which solves the problems of slow scanning cycle and low efficiency of stand-alone glass slide scanning devices.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a matrix cabinet type centralized scanning device for glass slides, including a base, a first matrix cabinet on the base, a plurality of partitions arranged in a matrix within the first matrix cabinet, a glass slide scanning device within each partition, the glass slide scanning device including a scanning device base frame, a movable X-axis moving stage on the scanning device base frame, a movable Y-axis moving stage on the X-axis moving stage, a slide holder placement position on the Y-axis moving stage for placing slide holders, the slide holders having a plurality of glass slide placement positions for placing glass slides, a Z-axis moving stage on the scanning device base frame, a scanning mirror on the Z-axis moving stage, the moving directions of the X-axis moving stage, the Y-axis moving stage and the Z-axis moving stage being perpendicular to each other, and the scanning mirror being used to scan the glass slides on the slide holders.

[0006] In a preferred embodiment, a slide holder trolley is also provided, which is arranged side by side with the base. The slide holder trolley includes a mobile trolley, on which a second matrix frame is provided. The second matrix frame has multiple slide holder slots arranged in a matrix, which are used to store slide holders. A slide holder gripping mechanism is provided on one side of the base and the slide holder trolley. The slide holder gripping mechanism has a movable slide holder clamp, which is used to grip the slide holder from the slide holder slot and transfer it to the slide scanning device.

[0007] In a preferred embodiment, the sheet clamping mechanism includes a first linear motion mechanism, which has a first sliding table. A second linear motion mechanism is mounted on the first sliding table, and a second linear motion mechanism is mounted on the second sliding table. A third linear motion mechanism is mounted on the second sliding table, and a sheet clamp is mounted on the third sliding table. The first, second, and third linear motion mechanisms are arranged perpendicularly to each other. The sheet clamp includes an electric gripper, which has a clamping plate that clamps the sheet clamp. The electric gripper is connected to the third sliding table of the third linear motion mechanism.

[0008] In a preferred embodiment, the slide holders are arranged side-by-side, and the slide scanning device is equipped with a scanning mirror connecting plate. The scanning mirror connecting plate is provided with multiple scanning mirrors arranged side-by-side, and the center distance between adjacent slide holders is equal to the center distance between adjacent scanning mirrors.

[0009] In the preferred embodiment, each slide placement position has at least four perforated holes at its four corners, and also includes a slide leveling device. The slide leveling device has multiple independently adjustable slide top rods, each of which rises and passes through the perforated holes to abut against the lower end face of the slide.

[0010] In a preferred embodiment, the slide leveling device includes a fixed plate and a movable plate. The movable plate is height-adjustable, and its upper end is equipped with multiple guide rod devices, each of which is slidably sleeved with the fixed plate. An expansion bladder is located at the upper end of each guide rod device, with its upper end abutting against the slide top rod. The lower end of the expansion bladder is connected to an expansion bladder conduit. A precision amplification device is also included, comprising multiple narrow-diameter tubes, each containing a slidable magnetic piston. The precision amplification device includes a movable adjustment plate with multiple magnetic sleeves slidably sleeved with the narrow-diameter tubes. Each magnetic piston is attracted by a rotary valve device. The rotary valve device has a fixed outer ring and a rotating inner ring inside the fixed outer ring. The fixed outer ring has multiple small-diameter tube interfaces, and the rotating inner ring has a connecting channel. The connecting channel can be switched to connect with each small-diameter tube interface. The end of the connecting channel away from the small-diameter tube interface is connected to the outside. One end of each small-diameter tube is connected to the corresponding small-diameter tube interface, and the other end of each small-diameter tube is connected to each expansion bladder conduit. The cross-sectional diameter of the expansion bladder is larger than the diameter of the small-diameter tube. The expansion bladder, the expansion bladder conduit, and both sides of the magnetic piston in the small-diameter tube are filled with liquid.

[0011] In the preferred embodiment, the precision amplification device has a base frame, an adjusting screw is provided on the base frame, an adjusting motor is provided at one end of the adjusting screw, a screw nut is provided on the adjusting plate, the screw nut of the adjusting plate is sleeved with the adjusting screw, and the adjusting motor drives the adjusting plate to move.

[0012] In a preferred embodiment, a preview camera is also provided between the first matrix cabinet and the second matrix rack, and the preview camera is used to photograph the glass slides on the slide holder.

[0013] In a preferred embodiment, the sheet clamping cart also includes a second matrix frame, which is connected to the ground. The second matrix frame is equipped with a slide rail, and the lower end of the moving trolley is equipped with a slider that cooperates with the slide rail of the second matrix frame. The lower end of the moving trolley is also equipped with casters, and one end of the moving trolley is equipped with a suction block. An electric suction cup is provided on the side of the base near the sheet clamping cart, and the electric suction cup adsorbs the suction block.

[0014] In a preferred embodiment, the film clip holder is equipped with a vision inspection camera, which is used to photograph the film clip in the film clip slot.

[0015] The beneficial effects of this invention are as follows: Multiple slide scanning devices equipped with scanning mirrors are arranged in a matrix within the independent compartments of the first matrix cabinet, with slide holders centrally arranged for convenient centralized material supply; a slide holder trolley for material supply is placed beside the first matrix cabinet, also storing numerous slide holders in a matrix configuration. A Cartesian slide holder gripping mechanism facilitates the back-and-forth transfer of slides and scanned slide holders, significantly improving the efficiency of cell detection; in a preferred embodiment, multiple scanning mirrors are arranged side-by-side. When the X-axis and Y-axis moving stages move, multiple slides can be scanned simultaneously, reducing scanning time significantly. While maintaining the same efficiency, this indirectly reduces the total number of X-axis and Y-axis moving stages and the total length of the first matrix cabinet. The moving distance of the slide holder gripping mechanism is also reduced, increasing the cycle time; the precision amplification device and rotary valve device can be arranged outside the first matrix cabinet, without occupying space within the first matrix cabinet. Attached Figure Description

[0016] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0017] Figure 1 This is a schematic diagram of the present invention.

[0018] Figure 2 This is a schematic diagram of the installation position of the preview camera of the present invention.

[0019] Figure 3 This is a schematic diagram of the back side of the present invention.

[0020] Figure 4 This is a schematic diagram of the sheet clamp of the present invention.

[0021] Figure 5 This is an enlarged view of the clip groove of the present invention.

[0022] Figure 6 This is a structural diagram of the slide scanning device of the present invention.

[0023] Figure 7 This is an optimized schematic diagram of the present invention with added perforated holes.

[0024] Figure 8 This is a schematic diagram of the focal plane leveling system of the present invention.

[0025] Figure 9 This is a schematic diagram of the glass slide leveling device of the present invention.

[0026] Figure 10 This is a schematic diagram of the precision amplification device of the present invention.

[0027] Figure 11 This is a bottom view of the rotary valve device of the present invention.

[0028] Figure 12 This is a schematic diagram of the rotary valve device of the present invention.

[0029] In the diagram: Base 1; First matrix cabinet 101; Partition cabinet 102; Preview camera 103; Slide gripping mechanism 2; First linear movement mechanism 201; Second linear movement mechanism 202; Third linear movement mechanism 203; Slide clamp 3; Visual inspection camera 301; Electric gripper 302; Clamping plate 303; Slide trolley 4; Second matrix frame 401; Moving trolley 402; Slide clamping slot 403; Track seat 404; Casters 405; Electric suction cup 406; Suction block 407; Slide clamp 5; Slide 501; Hole 502; Slide scanning device 6; Scanning mirror 601; X-axis moving stage 602; Y-axis moving stage 603; Z-axis moving stage 604; scanning mirror connecting plate 605; slide leveling device 7; fixed plate 701; movable plate 702; guide rod device 703; expansion bladder 704; expansion bladder guide tube 705; slide top rod 706; lifting cylinder 707; precision magnification device 8; fine diameter tube 801; magnetic piston 802; adjusting plate 803; magnetic sleeve 804; adjusting screw 805; adjusting motor 806; rotary valve device 9; fixed outer ring 901; rotating inner ring 902; connecting channel 903; fine diameter tube interface 904; liquid seal funnel 905; rotary valve drive motor 906. Detailed Implementation

[0030] like Figures 1-12 A matrix cabinet-type centralized scanning device for glass slides includes a base 1, on which a first matrix cabinet 101 is mounted. The first matrix cabinet 101 contains multiple partitions 102 arranged in a matrix. Each partition 102 contains a glass slide scanning device 6. The glass slide scanning device 6 includes a scanning device frame, on which a movable X-axis stage 602 is mounted. A movable Y-axis stage 603 is mounted on the X-axis stage 602. The Y-axis stage 603 has slide holders for holding slide holders 5. Each slide holder 5 has multiple slide holders for holding glass slides 501. The scanning device frame also includes a Z-axis stage 604, on which a scanning mirror 601 is mounted. The moving directions of the X-axis stage 602, Y-axis stage 603, and Z-axis stage 604 are perpendicular to each other. The scanning mirror 601 is used to scan the glass slides 501 on the slide holders 5.

[0031] The slide scanning device 6 includes three mutually perpendicularly arranged moving stages: an X-axis moving stage 602, a Y-axis moving stage 603, and a Z-axis moving stage 604. Each stage is composed of stepper or servo motors, lead screws, and slide rails. Each moving stage consists of a base and a slide, connected by the slide rail. An X-axis slide rail is mounted on the scanning device's base frame. A slider is mounted on the lower side of the base of the X-axis moving stage 602 and slides along the X-axis slide rail. An X-axis lead screw device is mounted on the scanning device's base frame. The lead screw nut is connected to the base of the X-axis moving stage 602. One end of the X-axis lead screw device has an X-axis drive motor that drives the slide of the X-axis moving stage 602 to move laterally. A slider is mounted on the lower end of the base of the Y-axis moving stage 603. A Y-axis slide rail is mounted on the upper side of the slide of the X-axis moving stage 602, allowing the Y-axis moving stage 603 to slide on the X-axis moving stage 602. The scanning device has a vertical base on its frame, and a vertical Z-axis slide rail on the vertical base. The slider of the base of the Z-axis moving stage 604 slides on the Z-axis slide rail. The Y-axis moving stage 603 and the Z-axis moving stage 604 are also driven by a lead screw-motor similar to the X-axis moving stage 602. The Z-axis moving stage 604 is equipped with a scanning mirror 601 for scanning the slides 501 on the slide holder 5. A light source is also provided on the slide scanning device 6 near the lower side of the center of the slide 501 for illuminating the slide 501 from below.

[0032] In a preferred embodiment, a slide holder 4 is also provided, which is arranged side by side with the base 1. The slide holder 4 includes a mobile trolley 402, on which a second matrix frame 401 is provided. The second matrix frame 401 has multiple slide holder slots 403 arranged in a matrix. The slide holder slots 403 are used to store slide holders 5. A slide holder gripping mechanism 2 is provided on one side of the base 1 and the slide holder 4. The slide holder gripping mechanism 2 has a movable slide holder clamp 3, which is used to clamp the slide holders 5 from the slide holder slots 403 and transfer them to the slide scanning device 6.

[0033] In a preferred embodiment, the sheet clamping mechanism 2 includes a first linear motion mechanism 201, which has a first sliding table. A second linear motion mechanism 202 is provided on the first sliding table, and a second sliding table is provided on the second sliding table. A third linear motion mechanism 203 is provided on the second sliding table, and a sheet clamp 3 is connected to the third sliding table. The first linear motion mechanism 201, the second linear motion mechanism 202, and the third linear motion mechanism 203 are arranged perpendicularly to each other. The sheet clamp 3 includes an electric gripper 302, which has a clamping plate 303. The clamping plate 303 clamps the sheet clamp 5 in a centered manner. The electric gripper 302 is connected to the third sliding table of the third linear motion mechanism 203.

[0034] The first linear motion mechanism 201, the second linear motion mechanism 202, and the third linear motion mechanism 203 are all motor, lead screw, and slide rail structures, with the motor being a servo or stepper motor.

[0035] The clamping plate 303 is L-shaped, and the side has protrusions that can position the recesses on the clamping plate 5, which serve as positioning when clamped.

[0036] In a preferred embodiment, the slide holders 5 have slide placement positions arranged side by side, and the slide scanning device 6 is provided with a scanning mirror connecting plate 605. The scanning mirror connecting plate 605 is provided with a plurality of scanning mirrors 601 arranged side by side, and the center distance between adjacent slide placement positions is equal to the center distance between adjacent scanning mirrors 601.

[0037] Each scanning mirror 601 can scan one corresponding slide 501. Since the position of the cell sample on the slide is slightly off, the scanning area can be slightly larger than the sample area reported in the report, ensuring that each sample area is scanned.

[0038] Taking five glass slides placed in a slide holder 5 as an example, and using five scanning mirrors 601, the scanning time is reduced from one minute per slide, totaling five minutes, to scanning five slides simultaneously, totaling one minute, which improves efficiency by nearly five times.

[0039] Taking the five-layer, four-column cabinet in this case as an example, if the number of slides to be scanned is fixed, only one-fifth of the original number of slide scanning devices 6 needs to be retained. Although the total number of scanning mirrors 601 is not reduced, the total number of scanning device base, X-axis moving stage 602, Y-axis moving stage 603 and Z-axis moving stage 604 is effectively reduced to one-fifth. The total cost of the equipment is greatly reduced while the efficiency remains unchanged.

[0040] Due to errors in slide placement, processing errors in slide placement positions, and even glass processing errors, after the actual slide 501 is placed on the slide holder 5, the tilt angle of each slide relative to the horizontal plane is different, and this difference is random. The single Z-axis moving stage 604 can only adjust the height of the Z-plane, and the multiple scanning mirrors 601 are fixed during the initial installation and debugging, and their tilt cannot be adjusted at any time. Therefore, it often happens that the first scanning mirror 601 is in focus, but the second, third, fourth, and fifth scanning mirrors 601 are out of focus.

[0041] In a preferred embodiment, each slide placement position has at least four perforated holes 502 at its four corners, and also includes a slide leveling device 7. The slide leveling device 7 has multiple independently liftable slide top rods 706. Each slide top rod 706 rises and passes through the perforated holes 502 to abut against the lower end face of the slide 501.

[0042] When the slide scanning device 6 is working, each scanning mirror 601 first scans at least three boundary points of the cell sample area and records the X, Y, and Z values. Since the three points define the plane, the angle between the slide and the horizontal plane can be calculated and fed back to the controller. The controller controls the slide top rod 706 to lift it to different heights, raising the four corners of the slide 501 so that the focal planes of the cell samples on multiple slides 501 are on the same plane. In this way, only one Z-axis movement mechanism is needed, and it is not necessary to equip each scanning mirror 601 with a separate axis movement mechanism.

[0043] In a preferred embodiment, the slide leveling device 7 includes a fixed plate 701 and a movable plate 702. The movable plate 702 is liftable. Multiple guide rod devices 703 are provided at the upper end of the movable plate 702. Each guide rod device 703 is slidably sleeved with the fixed plate 701. An expansion bladder 704 is provided at the upper end of each guide rod device 703. The upper end of the expansion bladder 704 abuts against the slide top rod 706. The lower end of the expansion bladder 704 is connected to an expansion bladder conduit 705. A precision magnification device 8 is also provided. The precision magnification device 8 has multiple narrow-diameter tubes 801. A slidable magnetic piston 802 is provided inside each narrow-diameter tube 801. The precision magnification device 8 includes a movable adjustment plate 803. Multiple magnetic sleeves 804 are provided on the adjustment plate 803. The magnetic sleeves 804 are slidably sleeved with the narrow-diameter tubes 801. Each magnetic sleeve 804... 4. Each magnetic piston 802 is adsorbed, and a rotary valve device 9 is also provided. The rotary valve device 9 has a fixed outer ring 901, and a rotating inner ring 902 inside the fixed outer ring 901. The fixed outer ring 901 has multiple small diameter tube interfaces 904, and the rotating inner ring 902 has a connecting channel 903. The connecting channel 903 can be switched to connect with each small diameter tube interface 904. The end of the connecting channel 903 away from the small diameter tube interface 904 is connected to the outside. One end of each small diameter tube 801 is connected to each small diameter tube interface 904, and the other end of each small diameter tube 801 is connected to each expansion bladder conduit 705. The cross-sectional diameter of the expansion bladder 704 is larger than the diameter of the small diameter tube 801. The expansion bladder 704 and the expansion bladder conduit 705, as well as both sides of the magnetic piston 802 in the small diameter tube 801, are filled with liquid.

[0044] The fixing plate 701 is connected to the partition cabinet 102. The space of a single partition cabinet 102 needs to be modified to be slightly larger than the original design so that the glass slide leveling device 7 can be installed at the bottom.

[0045] The magnetic piston 802 divides the internal space of the narrow tube 801 into two sections. There is liquid above and below the magnetic piston 802. This liquid is difficult to expand and compress. What can expand and contract is the membrane covering the expansion bladder 704. If the narrow tube 801 is not connected to the outside, the liquid in the lower section of the narrow tube 801 cannot flow, and the magnetic piston 802 will not fall.

[0046] Since there are also moving mechanisms such as the X-axis moving stage 602 and the Y-axis moving stage 603 below the slide holder 5, in order to avoid interference, the fixed plate 701 is equipped with a lifting cylinder 707. The lifting cylinder 707 drives the movable plate 702 to move up and down. Normally, the guide rod device 703 is at the bottom. When the X-axis moving stage 602 and the Y-axis moving stage 603 stop, the guide rod device 703 rises again to load, passes through the central hollow of the X-axis moving stage 602 and Y-axis moving stage 603 mechanism, and causes the slide top rod 706 to pass through the hollow hole 502 to lift the slide 501.

[0047] The guide rod device 703 has a hollow structure, and most of the expansion bladder conduit 705 is located inside the guide rod device 703. It protrudes from the lower end of the hollow part of the guide rod device 703 and the movable plate 702 to facilitate communication with the thin diameter tube 801 through the pipeline.

[0048] The outlet of the connecting channel 903 faces upward and is connected to a liquid-sealed funnel 905, which is filled with liquid.

[0049] The rotating inner ring 902 is equipped with a central shaft and is connected to a rotary valve drive motor 906 to drive the rotating inner ring 902 to rotate. The connecting channel 903 can be connected to any small diameter pipe interface 904. The connecting channel 903 can also be aligned with the inner wall between the small diameter pipe interfaces 904 of adjacent rotating inner rings 902 so that all small diameter pipe interfaces 904 are isolated from the outside. At this time, the liquid under all magnetic pistons 802 cannot flow, and the magnetic pistons 802 cannot move.

[0050] Taking the narrow-diameter tube 801 with a diameter of one millimeter and the expansion bladder 704 with a cross-sectional diameter of ten millimeters as an example, the cross-sectional areas differ by nearly one hundred times. Since the liquids inside the two tubes are connected and incompressible, when the magnetic piston 802 rises one hundred millimeters inside the narrow-diameter tube 801, the expansion bladder 704 expands and lifts the glass slide rod 706 by one millimeter. This is the first level of precision magnification.

[0051] In the preferred embodiment, the precision amplification device 8 is provided with a base frame, an adjusting screw 805 is provided on the base frame, an adjusting motor 806 is provided at one end of the adjusting screw 805, a screw nut is provided on the adjusting plate 803, the screw nut of the adjusting plate 803 is sleeved with the adjusting screw 805, and the adjusting motor 806 drives the adjusting plate 803 to move.

[0052] Taking the adjusting motor 806 as a servo motor as an example, since the adjusting screw 805 is a screw pair, the controller sends multiple pulses to the adjusting motor 806 for the adjusting screw 805 to rotate one revolution, and the adjusting plate 803 to rise only a few millimeters. Therefore, the positioning accuracy of commonly used screw and nut pairs can be several micrometers, which is the second level of accuracy amplification.

[0053] With the combined action of two precision magnification devices, the precision resolution of the four corners of the glass slide 501 being lifted can be less than the μm level, meeting the needs of focal plane angle adjustment.

[0054] The workflow is as follows: Preview camera 103 previews the area of ​​each glass slide 501 on the same slide holder 5 and finds the approximate boundary coordinates of the cell sample;

[0055] After the slide holder 5 is placed in the slide scanning device 6, the scanning mirror 601 moves above the boundary point, and the Z-axis moving stage 604 drives the scanning mirror 601 to move up and down to focus and record the coordinates of the focal point.

[0056] Calculate the angle between the focal plane of the cell pattern on slide 501 and the horizontal plane;

[0057] Calculate the focal plane angle of each glass slide 501 in turn;

[0058] The lifting cylinder 707 pulls up the movable plate 702, causing all the guide rod devices 703 to rise as a whole, and the slide top rod 706 passes through the hollow hole 502 and rises to near the lower side of the slide 501.

[0059] Rotating the inner ring 902 causes the connecting channel 903 to align with the narrow diameter pipe interface 904. The rotary valve drives the motor 906 to work, causing the magnetic sleeve 804 to approach the magnetic piston 802 and attract the magnetic piston 802. Since this pipe is connected to the outside, as the adjusting plate 803 is raised, the magnetic piston 802 is attracted and rises with it, while the remaining narrow diameter pipe 801 pipe is closed, and the magnetic piston 802 cannot move.

[0060] The liquid in the narrow tube 801 flows through the expansion bladder conduit 705 into the expansion bladder 704. The side of the expansion bladder 704 is bound in the countersunk hole at the top of the guide rod device 703. Therefore, the expansion bladder 704 can only expand upward, pushing up the slide push rod 706. The slide push rod 706 pushes up one corner of the slide 501.

[0061] The other three slide rods 706 of the slide 501 work in the same way, allowing the height values ​​of the four corners of the slide 501 to be adjusted independently.

[0062] When the work is finished, the liquid flows back into the liquid seal funnel 905 for storage and forms a liquid seal.

[0063] In a preferred embodiment, a preview camera 103 is also provided between the first matrix cabinet 101 and the second matrix rack 401. The preview camera 103 is used to photograph the glass slide 501 on the slide holder 5.

[0064] Preview camera 103 shoots downwards. After slide clamp 3 takes the slide clamp from the second matrix frame 401, the first sliding stage of the first linear movement mechanism 201 moves laterally to the front of preview camera 103 and waits. Preview camera 103 shoots whether the slide 501 has a QR code on the slide clamp 5 and the slide 501, and the distribution position of the cell sample on the slide 501. The actual distribution position of the cell sample is fed back to the controller, reducing the area that the scanning mirror 601 needs to scan and reducing the scanning time.

[0065] In a preferred embodiment, the sheet clamping cart 4 further includes a second matrix frame 401, which is connected to the ground. The second matrix frame 401 is equipped with a slide rail. The lower end of the moving trolley 402 is equipped with a slider that cooperates with the slide rail of the second matrix frame 401. The lower end of the moving trolley 402 is also equipped with casters 405. One end of the moving trolley 402 is equipped with a suction block 407. The base 1 is equipped with an electric suction cup 406 on the side near the sheet clamping cart 4, which adsorbs the suction block 407.

[0066] The mobile trolley 402 is equipped with a handle that can be pulled out to replace the entire trolley clip. The base 1 can be equipped with a flared guide wheel. After replacement, the new clip trolley 4 is pushed close to the base 1 and guided by the guide wheel so that the slider at the lower end of the mobile trolley 402 can be locked on the slide rail of the track seat 404. When the clip trolley 4 is pushed all the way, it is held up by the suction block 407 against the electric suction cup 406 and is attracted.

[0067] In a preferred embodiment, the film clip holder 3 is equipped with a visual inspection camera 301, which is used to photograph the film clip 5 in the film clip slot 403.

[0068] Since the repositioning position of the film holder 4 deviates after each replacement, when the film holder 3 moves over to pick up the film holder for the first time, the visual inspection camera 301 needs to take pictures of the film holders 5 at the four corners of the second matrix frame 401, calculate the center point coordinates, and update the position of the origin of the coordinate system to ensure the accuracy of subsequent film picking.

[0069] The above embodiments are merely preferred technical solutions of the present invention and should not be considered as limitations on the present invention. The scope of protection of the present invention should be limited to the technical solutions described in the claims, including equivalent substitutions of the technical features described in the claims. That is, equivalent substitutions and improvements within this scope are also within the scope of protection of the present invention.

Claims

1. A matrix cabinet-type centralized scanning device for glass slides, characterized in that: The device includes a base (1), on which a first matrix cabinet (101) is mounted. The first matrix cabinet (101) contains multiple matrix-arranged partitions (102). Each partition (102) contains a slide scanning device (6). The slide scanning device (6) includes a scanning device frame, on which a movable X-axis moving stage (602) is mounted. The X-axis moving stage (602) contains a movable Y-axis moving stage (603), and the Y-axis moving stage (603) contains slide holders. The slide holder is used to place the slide holder (5). The slide holder (5) has multiple slide placement positions. The slide placement positions are used to place the slides (501). The scanning device base frame is also provided with a Z-axis moving stage (604). The Z-axis moving stage (604) is provided with a scanning mirror (601). The moving directions of the X-axis moving stage (602), Y-axis moving stage (603) and Z-axis moving stage (604) are perpendicular to each other. The scanning mirror (601) is used to scan the slides (501) on the slide holder (5). The slide holders (5) have slides placed side by side. The slide scanning device (6) is provided with a scanning mirror connecting plate (605). The scanning mirror connecting plate (605) is provided with multiple scanning mirrors (601) arranged side by side. The center distance between adjacent slides is equal to the center distance between adjacent scanning mirrors (601). Each slide placement position has at least four corners with perforated holes (502) and a slide leveling device (7). The slide leveling device (7) has multiple independently liftable slide top rods (706). Each slide top rod (706) rises and passes through the perforated holes (502) to abut against the lower end face of the slide (501). The slide leveling device (7) includes a fixed plate (701) and a movable plate (702). The movable plate (702) is adjustable in height. The upper end of the movable plate (702) is provided with multiple guide rod devices (703). Each guide rod device (703) is slidably sleeved with the fixed plate (701). The upper end of the guide rod device (703) is provided with an expansion bladder (704). The upper end of the expansion bladder (704) abuts against the slide top rod (706). The lower end of the expansion bladder (704) is connected to an expansion bladder conduit (705). The device also includes a precision amplification device (8). The precision amplification device (8) is provided with multiple thin-diameter tubes (801). Each thin-diameter tube (801) is provided with a slidable magnetic piston (802). The precision amplification device (8) includes a movable adjustment plate (803). The adjustment plate (803) is provided with multiple magnetic sleeves (804). The magnetic sleeves (804) are slidably sleeved with the thin-diameter tubes (801). Each magnetic sleeve (804) attracts... Each magnetic piston (802) is accompanied by a rotary valve device (9). The rotary valve device (9) has a fixed outer ring (901) and a rotating inner ring (902) inside the fixed outer ring (901). The fixed outer ring (901) has multiple small diameter pipe interfaces (904). The rotating inner ring (902) has a connecting channel (903). The connecting channel (903) can be switched to connect with each small diameter pipe interface (904). The end of the connecting channel (903) away from the small diameter pipe interface (904) is connected to the outside. One end of each small diameter pipe (801) is connected to each small diameter pipe interface (904), and the other end of each small diameter pipe (801) is connected to each expansion bladder conduit (705). The cross-sectional diameter of the expansion bladder (704) is larger than the diameter of the small diameter pipe (801). The expansion bladder (704) and the expansion bladder conduit (705) as well as the two sides of the magnetic piston (802) in the small diameter pipe (801) are filled with liquid.

2. The matrix cabinet-type centralized scanning device for glass slides according to claim 1, characterized in that: A slide holder (4) is also provided. The slide holder (4) is arranged side by side with the base (1). The slide holder (4) includes a moving trolley (402). The moving trolley (402) is provided with a second matrix frame (401). The second matrix frame (401) is provided with multiple slide holder slots (403) arranged in a matrix. The slide holder slots (403) are used to store slide holders (5). A slide holder gripping mechanism (2) is provided on one side of the base (1) and the slide holder (4). The slide holder gripping mechanism (2) is provided with a movable slide holder clamp (3). The slide holder clamp (3) is used to clamp the slide holder (5) from the slide holder slot (403) and transfer it to the slide scanning device (6).

3. The matrix cabinet-type centralized scanning device for glass slides according to claim 2, characterized in that: the slides... The gripping mechanism (2) includes a first linear motion mechanism (201), which has a first sliding table. A second linear motion mechanism (202) is provided on the first sliding table. A second linear motion mechanism (202) is provided on the second sliding table. A third linear motion mechanism (203) is provided on the second sliding table. A third linear motion mechanism (203) is provided on the third sliding table. A clamping fixture (3) is connected to the third sliding table. The first linear motion mechanism (201), the second linear motion mechanism (202), and the third linear motion mechanism (203) are arranged perpendicularly to each other. The clamping fixture (3) includes an electric gripper (302), which has a clamping plate (303). The clamping plate (303) clamps the clamping fixture (5) in the center. The electric gripper (302) is connected to the third sliding table of the third linear motion mechanism (203).

4. The matrix cabinet-type centralized scanning device for glass slides according to claim 1, characterized in that: The precision amplification device (8) is provided with a base frame, and an adjusting screw (805) is provided on the base frame. An adjusting motor (806) is provided at one end of the adjusting screw (805). A screw nut is provided on the adjusting plate (803). The screw nut of the adjusting plate (803) is sleeved with the adjusting screw (805). The adjusting motor (806) drives the adjusting plate (803) to move.

5. The matrix cabinet-type centralized scanning device for glass slides according to claim 2, characterized in that: A preview camera (103) is also provided between the first matrix cabinet (101) and the second matrix rack (401). The preview camera (103) is used to photograph the glass slide (501) on the slide holder (5).

6. The matrix cabinet-type centralized scanning device for glass slides according to claim 2, characterized in that: The film clamping cart (4) also includes a second matrix frame (401), which is connected to the ground. The second matrix frame (401) is equipped with a slide rail. The lower end of the moving trolley (402) is equipped with a slider that cooperates with the slide rail of the second matrix frame (401). The lower end of the moving trolley (402) is also equipped with casters (405). One end of the moving trolley (402) is equipped with a suction block (407). The base (1) is equipped with an electric suction cup (406) on the side near the film clamping cart (4). The electric suction cup (406) adsorbs the suction block (407).

7. The matrix cabinet-type centralized scanning device for glass slides according to claim 2, characterized in that: The film clip fixture (3) is equipped with a visual inspection camera (301), which is used to photograph the film clip (5) in the film clip slot (403).

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