A multi-modal laser device and a laser ablation system integrating searching and hitting

Abstract

The application discloses a multimode laser device and a laser ablation system integrating searching and hitting. The multimode laser device comprises an ablation laser output module and an imaging laser output module; the ablation laser output module is used for outputting an ablation laser beam with a first wavelength and a first power; the imaging laser output module is used for outputting an imaging laser beam; and the laser ablation system realizes imaging of target tissue according to interaction between the imaging laser beam and a target lesion. The technical scheme of the embodiment of the application adopts a brand-new waveband laser, which has water molecule absorption efficiency of up to hundreds of times of that of a traditional wavelength laser, so that target lesions can quickly complete dehydration and collapse of tissue cells and interstitial fluid, and only ultra-low power energy is used, so that carbonization of an ablation lesion is completely avoided; meanwhile, an imaging light path signal for pathological biopsy diagnosis can be outputted, so that a double-mode integration can be completed, synchronous ablation laser and pathological biopsy ultra-depth and / or high-resolution diagnosis are supported, and a searching and hitting integrated target is realized.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a multimodal laser device and a laser ablation system that integrates scanning and dispersing. Background Technology

[0002] Laser interstitial thermal therapy (LITT) is a percutaneous minimally invasive surgery guided by magnetic resonance imaging (MRI). Neurosurgeons can clearly identify the locational relationship between the epileptic focus or tumor and the surrounding healthy brain tissue, thereby determining a precise surgical path. The procedure begins with a small incision of approximately 2-4 mm wide in the scalp of the affected area. A laser fiber optic probe is then inserted into the incision. Finally, the probe is guided to the target location of the lesion, where pulsed laser light is used to ablate or burn away the tumor and diseased tissue.

[0003] Traditional LITT typically uses a high-power single laser, such as a 12W 1064nm Nd:YAG or a 15W 980nm diode, to provide the laser excitation source. This limits its ability to perform a single ablation, making it impossible to guide doctors to make accurate ablation decisions based on real-time pathology. This can easily lead to severe bleeding and damage to healthy new nerves, causing complications. Furthermore, it cannot guarantee complete ablation and makes it difficult to minimize the risk of lesion recurrence. In addition, the high-power ablation excitation source uses a high-temperature protein denaturation ablation mechanism, which can lead to unavoidable carbonization of the ablation site during target lesion ablation, affecting the success of the surgery and patient rehabilitation. Summary of the Invention

[0004] This invention provides a multimodal laser device and an integrated laser ablation system for diagnosis and treatment. The multimodal laser device uses a new wavelength laser, which has hundreds of times the water molecule absorption efficiency compared to traditional wavelength lasers, enabling the target lesion to quickly undergo dehydration and collapse of tissue cells and tissue fluid. At the same time, it uses only ultra-low power energy, completely avoiding carbonization of the ablation lesion. It can also output imaging optical path signals for pathological biopsy diagnosis, achieving dual-modal integration and supporting simultaneous ablation laser and ultra-deep and / or high-resolution diagnosis of pathological biopsy, thereby achieving the goal of integrated diagnosis and treatment.

[0005] According to one aspect of the present invention, a multimodal laser device is provided for a laser ablation system integrating detection and crackdown, the multimodal laser device comprising an ablation laser output module and an imaging laser output module;

[0006] The ablation laser output module is used to output an ablation laser beam with a first wavelength and a first power. When the ablation laser beam is transmitted to the target lesion, it causes the tissue cells and tissue fluid to dehydrate and collapse.

[0007] The imaging laser output module is used to output an imaging laser beam, which is transmitted to the target lesion. The laser ablation system realizes imaging of the target lesion based on the interaction between the imaging laser beam and the target tissue.

[0008] Optionally, the first wavelength ranges from 1443nm to 1453nm, and the first power ranges from 345mW to 450mW.

[0009] Optionally, the first wavelength is 1448nm and the first power is 350mW or 380mW.

[0010] Optionally, the ablation laser output module includes a pump control unit and a pump laser excitation unit;

[0011] The pump control unit includes a cooling controller, a laser diode controller, and a laser current source controller; the pump laser excitation unit includes a cooling sensor, a laser diode chip, a pump coupler, a fiber Bragg grating, a polarization-maintaining fiber, and a multimode fiber.

[0012] The laser diode controller is used to control the laser diode chip to emit a seed laser of the first wavelength. The laser current source controller is used to drive the pump coupler to amplify the seed laser to the first power. The cooling controller is used to control the cooling sensor to keep the temperature of the laser diode chip and the pump coupler within a preset range. The beam output by the pump coupler passes through the fiber Bragg grating, the polarization-maintaining fiber and the multimode fiber in sequence before being output.

[0013] Optionally, the imaging laser output module includes a first imaging laser output submodule and / or a second imaging laser output submodule;

[0014] The first imaging laser output submodule outputs a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width.

[0015] The second imaging laser output submodule outputs a second imaging laser beam with a center wavelength of the third wavelength, the third power, and a swept frequency.

[0016] Optionally, the second wavelength ranges from 820 nm to 845 nm, the second power ranges from 6 mW to 15 mW, and the first spectral width is greater than or equal to 150 nm.

[0017] The third wavelength is 1300nm or 1060nm, and the third power ranges from 12mW to 35mW.

[0018] Optionally, the second wavelength is 840 nm, the second power is 10 mW, the first spectral width is 160 nm, and the third power is 25 mW.

[0019] Optionally, the first imaging laser output submodule includes a main control circuit board, a multi-level laser diode driving unit, a multi-level laser diode chip, a coupling unit, and a first single-mode optical fiber. The multi-level laser diode chip includes multiple laser diode chips with different output bands, and each laser diode driving unit drives one of the laser diode chips.

[0020] The main control circuit board is used to control the multi-level laser diode driving unit to drive the corresponding laser diode chip to emit laser light, and the coupling unit is used to couple the laser light emitted by the multiple laser diode chips to the first single-mode fiber to output a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width.

[0021] Optionally, the multi-level laser diode driving unit includes a multi-level laser diode driving board and a multi-level thermoelectric cooling control board, and the output optical power of the laser diode chip in the multi-level laser diode chip is controlled by the corresponding thermoelectric cooling control board.

[0022] Optionally, the second imaging laser output submodule includes a frequency sweep control unit and a frequency sweep laser excitation unit; the frequency sweep control unit includes an n-mode laser pump chip controller, and the frequency sweep laser excitation unit includes an n-mode laser pump chip group, a tunable laser cavity, a booster amplifier, an optical fiber isolator group, an optical fiber coupler group, and a second single-mode fiber;

[0023] The n-mode laser pump chip controller is used to excite the n-mode laser pump chip group to generate an initial optical signal. At the same time, the n-mode laser pump chip controller controls the cavity length of the adjustable laser cavity to adjust the output laser of a preset wavelength. The n-mode laser pump chip controller is also used to control the booster optical amplifier to amplify the laser of the preset wavelength, and transmit it sequentially to the fiber isolator group and the fiber coupler group and couple it into continuous n-mode different clock marks. The n different wavelength sweep frequency signals are output through the second single-mode fiber.

[0024] Where n is an integer greater than 100.

[0025] Optionally, the second imaging laser output submodule also includes a 14-bit deep ultra-wideband high-speed digital instrument, and the sweep frequency control unit is connected to the 14-bit deep ultra-wideband high-speed digital instrument via an RF coaxial SMA trigger cable.

[0026] The sweep frequency control unit also includes an optical fiber detection network controller, a signal generation circuit, a group of photodiode matching components, a transgroup amplifier, and a group of operational amplifiers;

[0027] The swept-frequency laser excitation unit also includes a Mach-Zehnder interferometer and a group of fiber Bragg gratings.

[0028] Optionally, the tunable laser cavity is a microelectromechanical tunable vertical cavity surface laser cavity, and the unidirectional scanning duty cycle of the microelectromechanical tunable vertical cavity surface laser cavity is >60%.

[0029] The Mach-Zehnder interferometer has a Mach-Zehnder delay (MZI) ≥ 44 mm.

[0030] The maximum k-clock frequency of the electronic signal generated after the signal generating circuit excites the Mach-Zehnder interferometer is ≥500MHz.

[0031] Optionally, the ablation laser output module is integrated with the first imaging laser output submodule in the same module, and / or the ablation laser output module is integrated with the second imaging laser output submodule in the same module.

[0032] According to another aspect of the present invention, a laser ablation system integrating detection and dismantling is provided, comprising the above-described multimodal laser device.

[0033] The technical solution of this invention involves outputting an ablation laser beam with a first wavelength and a first power through an ablation laser output module. The first wavelength can be a novel 1448nm band, distinct from the traditional 1064nm or 980nm, possessing hundreds of times the water molecule absorption efficiency compared to traditional wavelengths. When the ablation laser beam is transmitted to the target lesion, it causes the tissue cells and tissue fluid to dehydrate and collapse. Moreover, the first power (e.g., 380mW) is far less than the traditional 10-watt level (12W-15W) power, completely carbonizing the ablation lesion. An imaging laser beam is output through an imaging laser output module and transmitted to the target lesion. The laser ablation system achieves pathological biopsy diagnostic imaging of the target lesion based on the interaction between the imaging laser beam and the target tissue, realizing accurate integrated diagnosis and treatment.

[0034] It should be understood that the description in this section is not intended to identify key or essential features of the embodiments of the present invention, nor is it intended to limit the scope of the invention. Other features of the invention will become readily apparent from the following description. Attached Figure Description

[0035] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0036] Figure 1 This is a schematic diagram of the structure of a multimode laser device provided in an embodiment of the present invention;

[0037] Figure 2 This is a schematic diagram of another multimode laser device provided in an embodiment of the present invention;

[0038] Figures 3-5 These are schematic diagrams of another multimodal laser device provided in the embodiments of the present invention;

[0039] Figure 6 This is a schematic diagram of the structure of a first imaging laser output submodule provided in an embodiment of the present invention;

[0040] Figure 7 This is a schematic diagram of the structure of a second imaging laser output submodule provided in an embodiment of the present invention. Detailed Implementation

[0041] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0042] It should be noted that the terms "first," "second," etc., in the specification, claims, and accompanying drawings of this invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of the invention described herein can be implemented in orders other than those illustrated or described herein. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover a non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0043] Figure 1This is a schematic diagram of a multimodal laser device provided in an embodiment of the present invention. This multimodal laser device can be used in a laser ablation system that integrates diagnosis and treatment. The integration of diagnosis and treatment refers to achieving pathological biopsy diagnosis while invasively performing the procedure within the human body, and simultaneously emitting ablation lasers to ablate the target lesion based on the diagnostic results. The diagnostic laser can also simultaneously evaluate the pathological changes of the ablated lesion in real time; that is, imaging diagnosis (diagnosis) and ablation treatment (ablation) are performed concurrently. (Reference) Figure 1 The multimodal laser device 1 includes an ablation laser output module 10 and an imaging laser output module 20. The ablation laser output module 10 is used to output an ablation laser beam with a first wavelength and a first power. When the ablation laser beam is transmitted to the target lesion, it causes the tissue cells and tissue fluid to dehydrate and collapse. The imaging laser output module 20 is used to output an imaging laser beam. The imaging laser beam is transmitted to the target lesion. The laser ablation system realizes imaging of the target lesion based on the interaction between the imaging laser beam and the target tissue.

[0044] The multimodal laser device provided in this embodiment can simultaneously output laser beams for imaging diagnosis and ablation, enabling its use in a laser ablation system that integrates diagnosis and treatment. Specifically, the first wavelength can optionally range from 1443nm to 1453nm, and the first power can range from 345mW to 450mW. Further, the first wavelength can be 1448nm, and the first power can be 350mW or 380mW. Compared to the traditional 1064nm or 980nm wavelengths, water molecules have stronger absorption at 1448nm, allowing for ultra-low power (350mW or 380mW) to ablate target tissue while avoiding carbonization. The imaging laser beam output by the imaging laser output module can achieve high-precision biological biopsy and imaging using Optical Coherence Tomography (OCT). Compared to the millimeter-level resolution of MRI, OCT can achieve μm-level resolution, which improves the safety of laser ablation.

[0045] The technical solution of this invention involves outputting an ablation laser beam with a first wavelength and a first power through an ablation laser output module. The first wavelength can be a novel 1448nm band, distinct from the traditional 1064nm or 980nm, possessing hundreds of times the water molecule absorption efficiency compared to traditional wavelengths. When the ablation laser beam is transmitted to the target lesion, it causes dehydration and collapse of tissue cells and tissue fluid. Moreover, the first power (e.g., 380mW) is far less than the traditional 10-watt level (12W-15W) power, completely avoiding carbonization of the ablation lesion. An imaging laser beam is output through an imaging laser output module and transmitted to the target lesion. The laser ablation system achieves pathological biopsy diagnostic imaging of the target lesion based on the interaction between the imaging laser beam and the target tissue, realizing accurate integrated diagnosis and treatment.

[0046] Figure 2 This is a schematic diagram of another multimodal laser device provided in an embodiment of the present invention. (Reference) Figure 2 Optionally, the ablation laser output module 10 includes a pump control unit 11 and a pump laser excitation unit 12. The pump control unit 11 includes a cooling controller 111, a laser diode controller 112, and a laser current source controller 113. The pump laser excitation unit 12 includes a cooling sensor 121, a laser diode chip 122, a pump coupler 123, a fiber Bragg grating 124, a polarization-maintaining fiber 125, and a multimode fiber 126. The laser diode controller 112 is used to control the laser diode chip 122 to emit a seed laser of the first wavelength. The laser current source controller 113 is used to drive the pump coupler 123 to amplify the seed laser to the first power. The cooling controller 111 is used to control the cooling sensor 121 to keep the temperature of the laser diode chip 122 and the pump coupler 123 within a preset range. The beam output by the pump coupler 123 passes through the fiber Bragg grating 124, the polarization-maintaining fiber 125, and the multimode fiber 126 in sequence before being output.

[0047] In a specific implementation, the laser diode chip 122 can be a 1448nm diode excitation chip, the pump coupler 123 can be a 350mW or 380mW butterfly-packaged pump coupler, the cooling sensor 121 can be a thermistor thermoelectric cooler sensor, the cooling controller 111 can be a voltage measurement thermoelectric cooling controller, the center wavelength of the fiber Bragg grating 124 can be 1448nm, and the multimode fiber 126 can be a long-wavelength step-index multimode fiber.

[0048] The ablation laser output module 10 operates as follows: The electronic signal (control signal) emitted by the laser diode controller 112 acts on the 1448nm laser diode chip 122 to emit an optical signal (seed laser), which is transmitted to the 350mW or 380mW butterfly-packaged pump coupler 123. Simultaneously, the cooling controller 111 and the laser diode controller 112 emit electronic signals, which act on the cooler sensor 121, causing the 350mW or 380mW butterfly-packaged pump coupler 123 to generate a 350mW or 380mW 1448nm laser signal. This signal is then transmitted to the 1448nm fiber Bragg grating 124 to ensure high-quality and stable output of the spectrum to the polarization-maintaining fiber 125, ultimately generating an optical signal that is transmitted to the long-wavelength step-refractive multimode fiber 126. This beam is the ablation laser beam. The ablation laser beam and the imaging laser beam are further transmitted to the integrated detection and cracking multimode laser coupling fiber slip ring system (not shown in this embodiment), thus realizing the integrated detection and cracking application.

[0049] Optionally, the imaging laser output module includes a first imaging laser output submodule and / or a second imaging laser output submodule; the first imaging laser output submodule outputs a first imaging laser beam with a center wavelength of a second wavelength and a first spectral width; the second imaging laser output submodule outputs a second imaging laser beam with a center wavelength of a third wavelength and a swept frequency.

[0050] It is understood that the laser beam output by the imaging laser output module in the technical solution provided in this embodiment may include one or two beams. For example, it may include a beam that achieves high-resolution imaging, a beam that achieves ultra-depth imaging but with relatively low resolution, or both types of imaging beams that achieve both high resolution and ultra-depth imaging. For example, Figures 3-5 These are schematic diagrams of another multimodal laser device provided in the embodiments of the present invention, with reference to... Figure 3 The imaging laser output module 20 includes a first imaging laser output submodule 21, which outputs a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width; (Reference) Figure 4 The imaging laser output module 20 includes a second imaging laser output submodule 22, which outputs a second imaging laser beam with a center wavelength of a third wavelength, a third power, and a swept frequency; (Reference) Figure 5 The imaging laser output module 20 includes a first imaging laser output submodule 21 and a second imaging laser output submodule 22. The first imaging laser output submodule 21 outputs a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width. The second imaging laser output submodule 22 outputs a second imaging laser beam with a center wavelength of a third wavelength, a third power, and a swept frequency. The specific implementation can be designed according to the actual situation, and the embodiments of the present invention do not limit this.

[0051] Specifically, the first imaging laser beam with a center wavelength of the second wavelength, a second power, and a first spectral width is used to achieve high-resolution imaging, such as high-resolution imaging at the 1μm level. The second imaging laser beam with a center wavelength of the third wavelength, a third power, and a frequency sweep is used to achieve high-depth imaging, such as imaging at the centimeter depth level and 10μm resolution level. Optionally, the second wavelength ranges from 820nm to 845nm, the second power ranges from 6mW to 15mW, and the first spectral width is greater than or equal to 150nm; the third wavelength is 1300nm or 1060nm, and the third power ranges from 12mW to 35mW. Further, the second wavelength is 840nm, the second power is 10mW, the first spectral width is 160nm, and the third power is 25mW.

[0052] Figure 6This is a schematic diagram of the structure of a first imaging laser output submodule provided in an embodiment of the present invention. (Reference) Figure 6 Optionally, the first imaging laser output submodule 21 includes a main control circuit board 211, a multi-level laser diode driving unit 212, a multi-level laser diode chip 213, a coupling unit 214, and a first single-mode fiber 215. The multi-level laser diode chip 213 includes multiple laser diode chips with different output wavelengths, and each laser diode driving unit drives one laser diode chip. The main control circuit board 211 is used to control the multi-level laser diode driving unit 212 to drive the corresponding laser diode chip to emit laser light. The coupling unit 214 is used to couple the laser light emitted by multiple laser diode chips to the first single-mode fiber 215 to output a first imaging laser beam with a center wavelength of the second wavelength, the second power, and the first spectral width.

[0053] The multi-stage laser diode driving unit 212 corresponds to the multi-stage laser diode chip 213. Specifically, the laser diode driving unit 212 includes a laser diode driving board and a thermoelectric cooling control board. The output optical power of the laser diode chip in the multi-stage laser diode chip 213 is controlled by the corresponding thermoelectric cooling control board. The coupling unit 214 includes at least one coupler. Figure 6 The illustrated embodiment uses a four-stage laser diode driving unit, laser diode chips, and a two-stage coupler as examples. The four-stage laser diode driving unit includes a primary laser diode driving board, a primary thermoelectric cooling control board, a secondary laser diode driving board, a secondary thermoelectric cooling control board, a tertiary laser diode driving board, a tertiary thermoelectric cooling control board, a quaternary laser diode driving board, and a quaternary thermoelectric cooling control board. The four-stage laser diode chips include 760nm–800nm, 800nm–840nm, 840nm–880nm, and 880nm–920nm laser diode chips. The two-stage coupler includes a primary 100nm broadband coupler, a secondary 100nm broadband coupler, and a 300nm ultra-wideband coupler. The first single-mode fiber 215 is a professional high-refractive-index / bend-insensitive short-wavelength single-mode fiber.

[0054] The operation of the first imaging laser output submodule 21 is as follows: The main control circuit board 211 outputs control signals, and the 760nm-800nm ​​laser diode chip, 800nm-840nm laser diode chip, 840nm-880nm laser diode chip, and 880nm-920nm laser diode chip, respectively, are driven by electronic signals output from the corresponding laser diode driver board X level (X=1, 2, 3, 4) and thermoelectric cooling control board X level (X=1, 2, 3, 4), and provided with current and cooling support, respectively generate corresponding spectrally flat light signals with a width of 40nm. The 760nm-800nm ​​and 800nm-820nm laser diode chips generate corresponding spectrally flat light signals with a width of 40nm. A 40nm optical signal is transmitted to the first stage of a 100nm broadband coupler to generate a laser signal with an 80nm bandwidth and an 800nm ​​center wavelength. Optical signals of 840nm–880nm and 880nm–920nm are transmitted to the second stage of the 100nm broadband coupler to generate laser signals with an 80nm bandwidth and an 880nm center wavelength. These two sets of laser signals are then transmitted to a 300nm ultra-wideband coupler for efficient coupling, generating a laser signal with a 160nm bandwidth and an 840nm center wavelength. This signal is then transmitted to a specialized high-refractive-index / bending-insensitive short-wavelength first single-mode fiber 215. This beam is the first imaging laser beam, used for real-time 1μm-level pathological biopsy diagnosis. The first imaging laser beam and the ablation laser beam are further transmitted to an integrated multimode laser coupling fiber slip ring system for diagnosis and testing, forming the final integrated ultra-wideband 1448nm+840nm dual-mode laser signal.

[0055] Figure 7 This is a schematic diagram of a second imaging laser output submodule provided in an embodiment of the present invention. (Reference) Figure 7 The second imaging laser output submodule 22 includes a frequency sweep control unit 221 and a frequency sweep laser excitation unit 222. The frequency sweep control unit 221 includes an n-mode laser pump chip controller 2211, and the frequency sweep laser excitation unit 222 includes an n-mode laser pump chip group 2221, a tunable laser cavity 2222, a booster amplifier 2223, an optical fiber isolator group 2224, an optical fiber coupler group 2225, and a second single-mode fiber 2226. The n-mode laser pump chip controller 2211 is used to excite the n-mode laser pump chip group 2221. An initial optical signal is generated, and the n-mode laser pump chip controller 2211 controls the cavity length of the adjustable laser cavity 2222 to adjust the output laser of the preset wavelength. The n-mode laser pump chip controller 2211 is also used to control the booster amplifier 2223 to amplify the laser of the preset wavelength, and transmit it sequentially to the fiber isolator group 2224 and the fiber coupler group 2225 and couple it into continuous n-mode different clock marks and n different wavelength sweep frequency signals, which are output through the second single-mode fiber 2226. Here, n is an integer greater than 100.

[0056] The output optical power of the swept-frequency laser excitation unit 222 is controlled by the n-mode laser pump chip controller 2211. The second imaging laser output submodule also includes a 14-bit deep ultra-wideband high-speed digital instrument 223. The swept-frequency control unit 221 is connected to the 14-bit deep ultra-wideband high-speed digital instrument 223 via an RF coaxial SMA trigger cable. The swept-frequency control unit 221 also includes an optical fiber detection network controller 2212, a signal generation circuit 2213, two photodiode matching component groups 2214, an ultra-low noise, high-speed transimpedance amplifier 2215, and three operational amplifier groups 2216. The swept-frequency laser excitation unit 222 also includes a Mach-Zehnder interferometer 2227 and a fiber Bragg grating group 2228. The tunable laser cavity 2222 can be a microelectromechanical tunable vertical cavity surface laser cavity, and the second single-mode fiber 2226 can be a professional high-refractive-index / bend-insensitive short-wavelength compatible single-mode fiber.

[0057] The operation of the second imaging laser output submodule 22 is as follows: the electronic signal output by the n-mode laser pump chip controller 2211 (n>100) excites the greater than n-mode laser pump chip group 2221 (n>100) to generate an initial optical signal. In addition, the electronic signal output by the n-mode laser pump chip controller 2211 (n>100) is transmitted to the RF coaxial SMA trigger cable, and then to the 14-bit deep ultra-wideband ultra-high speed digital instrument 223, informing the computer that the second imaging laser output submodule 22 has been initialized and powered on. At the same time, the electronic signal output by the n-mode laser pump chip controller 2211 controls the tunable laser cavity 2222, and uses the micro-motor reflector system to change the cavity length of the laser, that is, adjust the output of a specific wavelength optical signal. The microelectromechanical tunable vertical-cavity surface mount laser (VCSEL) has a unidirectional scanning duty cycle greater than 60%. The electronic signal output from the n-mode laser pump chip controller 2211 controls the booster amplifier 2223, amplifying the optical signal as follows: 1. It is transmitted to the fiber Bragg grating group 2228. The electronic signal output from the fiber optic detection network controller 2212 of the fiber Bragg grating group 2228 is transmitted via a wavelength trigger to the corresponding wavelength electrical signal of the SMA trigger cable, which is then transmitted to the 14-bit deep ultra-wideband high-speed digital instrument 223. This allows the computer to synchronously confirm the specific wavelength optical signal transmitted to the fiber Bragg grating group 2228 at this time; 2. It is transmitted to the Mach-Zehnder interferometer 2227, where the Mach-Zehnder delay (MZI) of the Mach-Zehnder interferometer 2227 is ≥44mm (meeting the centimeter-level standard for imaging depth; when higher imaging depth is required, the MZI...). (delay≥72mm), at this time, the signal generation circuit 2213 listens to the optical signal to complete linear sampling in the "k-space" rather than in the time domain. This electronic signal is used as the data acquisition sampling clock. The signal generation circuit 2213 generates the electronic signal after exciting the Mach-Zehnder interferometer 2227. The maximum frequency of the k-clock is ≥500MHz (the imaging depth meets the cm-level standard. When the imaging depth requirement is higher, the maximum frequency of the k-clock (typical) is ≥900MHz). It is transmitted to the SMA trigger cable. The corresponding wavelength clock mark electrical signal is transmitted to the 14-bit deep ultra-wideband high-speed digital instrument 223 so that the computer can synchronously confirm the optical signal of the specific wavelength clock mark transmitted to the Mach-Zehnder interferometer 2227 at this time; 3. It is transmitted to the fiber optic isolator group 2224 and prevents the optical signal from propagating backward. After being protected by the fiber optic isolator group 2224, the optical signal is transmitted to the fiber optic coupler group 2225 and coupled into n different wavelength signals with different clock marks in n consecutive modes, which are then transmitted to the professional high refractive index / bend-insensitive short wavelength wave compatible second single-mode fiber 2226.At this point, most of the n different wavelength signals with different clock markers at the n-mode location are transmitted to the integrated multimode laser-coupled fiber optic slip ring system, and wait to be coupled with the optical signal generated by the ablation laser output module 10 to form a real-time ultra-deep centimeter-level 10μm-level sub-pathological biopsy diagnostic laser signal, one of the dual-mode spectral optical paths. At this point, a small portion of the n different wavelength signals with different clock markers at the n-mode location are transmitted to the two photodiode matching component groups 2214, and generate electronic signals as backup noise reduction signals. The aforementioned n different wavelength signals with different clock markers at the n-mode location transmitted to the integrated multimode laser-coupled fiber optic slip ring system are efficiently coupled with the optical ablation laser signal generated by the aforementioned ablation laser output module in the integrated multimode laser-coupled fiber optic slip ring system to form the final integrated microelectromechanical tunable vertical cavity surface emission 1448nm + swept frequency 1300nm dual-mode laser signal. The signals of different wavelengths in n are optical signals with a wide frequency sweep range of 1300nm±(50nm~75nm), and the values ​​are obtained by convolution using the point spread function of the PSF laser.

[0058] The dual-mode laser signal is further incident on the human tissue lesion, and after ablation of the target lesion, the 1448nm optical signal is absorbed by the tissue and completes the ablation purpose. The 1300nm real-time ultra-deep centimeter-level and 10μm-level sub-pathological biopsy diagnostic laser signal is then transmitted to two photodiode matching component groups 2214 via the integrated multimode laser coupling fiber slip ring system. It is then combined with the electronic signal output from the two photodiode matching component groups 2214 for final noise reduction processing. This processing is performed by an ultra-low noise, high-speed transimpedance amplifier 2215. The electronic noise-reduced signal is amplified by three operational amplifier groups 2216 and finally sent to a 14-bit deep ultra-wideband ultra-high-speed digital instrument 223 and handed over to a computer for real-time biopsy pathological change evaluation of the ablation pathology of the target lesion.

[0059] In some embodiments, optionally, the ablation laser output module and the first imaging laser output submodule are integrated into the same module, and / or the ablation laser output module and the second imaging laser output submodule are integrated into the same module. By integrating the ablation laser output module with the first imaging laser output submodule and / or the second imaging laser output submodule, the integration of the multimodal laser output device can be improved. Dual-mode (1448nm+840nm or 1448nm+1300nm / 1060nm) or tri-mode (1448nm+840nm+1300nm / 1060nm) laser devices can be designed according to actual needs, improving the flexibility of the integrated detection and strike system.

[0060] This invention also provides a laser ablation system, including any of the multimodal laser devices provided in the above embodiments, and possessing the same or corresponding beneficial effects as the multimodal laser devices.

[0061] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A multimodal laser device, characterized in that, A laser ablation system for integrated investigation and crackdown, wherein the multimodal laser device includes an ablation laser output module and an imaging laser output module; The ablation laser output module is used to output an ablation laser beam with a first wavelength and a first power. When the ablation laser beam is transmitted to the target lesion, it causes the tissue cells and tissue fluid to dehydrate and collapse. The imaging laser output module includes a first imaging laser output submodule and a second imaging laser output submodule; The first imaging laser output submodule outputs a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width. The second imaging laser output submodule outputs a second imaging laser beam with a center wavelength of the third wavelength, the third power, and a swept frequency. The imaging laser output module is used to output an imaging laser beam, which is transmitted to the target lesion. The laser ablation system realizes imaging of the target lesion based on the interaction between the imaging laser beam and the target tissue, and imaging diagnosis and ablation treatment are performed simultaneously. The first wavelength ranges from 1443nm to 1453nm, and the first power ranges from 345mW to 450mW. The ablation laser output module includes a pump control unit and a pump laser excitation unit; The pump control unit includes a cooling controller, a laser diode controller, and a laser current source controller; the pump laser excitation unit includes a cooling sensor, a laser diode chip, a pump coupler, a fiber Bragg grating, a polarization-maintaining fiber, and a multimode fiber. The laser diode controller is used to control the laser diode chip to emit a seed laser of the first wavelength. The laser current source controller is used to drive the pump coupler to amplify the seed laser to the first power. The cooling controller is used to control the cooling sensor to keep the temperature of the laser diode chip and the pump coupler within a preset range. The beam output by the pump coupler passes through the fiber Bragg grating, the polarization-maintaining fiber and the multimode fiber in sequence before being output.

2. The multimode laser device according to claim 1, characterized in that, The first wavelength is 1448nm, and the first power is 350mW or 380mW.

3. The multimode laser device according to claim 1, characterized in that, The second wavelength ranges from 820 nm to 845 nm, the second power ranges from 6 mW to 15 mW, and the first spectral width is greater than or equal to 150 nm; The third wavelength is 1300nm or 1060nm, and the third power ranges from 12mW to 35mW.

4. The multimode laser device according to claim 1, characterized in that, The second wavelength is 840nm, the second power is 10mW, the first spectral width is 160nm, and the third power is 25mW.

5. The multimode laser device according to claim 1, characterized in that, The first imaging laser output submodule includes a main control circuit board, a multi-level laser diode driving unit, a multi-level laser diode chip, a coupling unit, and a first single-mode optical fiber. The multi-level laser diode chip includes multiple laser diode chips with different output bands, and each laser diode driving unit drives one of the laser diode chips. The main control circuit board is used to control the multi-level laser diode driving unit to drive the corresponding laser diode chip to emit laser light, and the coupling unit is used to couple the laser light emitted by the multiple laser diode chips to the first single-mode fiber to output a first imaging laser beam with a center wavelength of a second wavelength, a second power, and a first spectral width.

6. The multimode laser device according to claim 5, characterized in that, The multi-level laser diode driving unit includes a multi-level laser diode driving board and a multi-level thermoelectric cooling control board. The output optical power of the laser diode chip in the multi-level laser diode chip is controlled by the corresponding thermoelectric cooling control board.

7. The multimode laser device according to claim 1, characterized in that, The second imaging laser output submodule includes a frequency sweep control unit and a frequency sweep laser excitation unit; the frequency sweep control unit includes an n-mode laser pump chip controller, and the frequency sweep laser excitation unit includes an n-mode laser pump chip group, a tunable laser cavity, a booster amplifier, an optical fiber isolator group, an optical fiber coupler group, and a second single-mode fiber; The n-mode laser pump chip controller is used to excite the n-mode laser pump chip group to generate an initial optical signal. At the same time, the n-mode laser pump chip controller controls the cavity length of the adjustable laser cavity to adjust the output laser of a preset wavelength. The n-mode laser pump chip controller is also used to control the booster optical amplifier to amplify the laser of the preset wavelength, and transmit it sequentially to the fiber isolator group and the fiber coupler group and couple it into continuous n-mode different clock marks. The n different wavelength sweep frequency signals are output through the second single-mode fiber. Where n is an integer greater than 100.

8. The multimodal laser device according to claim 7, characterized in that, The second imaging laser output submodule also includes a 14-bit deep ultra-wideband high-speed digital instrument, and the sweep frequency control unit is connected to the 14-bit deep ultra-wideband high-speed digital instrument via an RF coaxial SMA trigger cable; The sweep frequency control unit also includes an optical fiber detection network controller, a signal generation circuit, a group of photodiode matching components, a transgroup amplifier, and a group of operational amplifiers; The swept-frequency laser excitation unit also includes a Mach-Zehnder interferometer and a group of fiber Bragg gratings.

9. The multimodal laser device according to claim 8, characterized in that, The tunable laser cavity is a microelectromechanical tunable vertical-cavity surface laser cavity, and the unidirectional scanning duty cycle of the microelectromechanical tunable vertical-cavity surface laser cavity is >60%. The Mach-Zehnder interferometer has a Mach-Zehnder delay (MZI) ≥ 44 mm. The maximum k-clock frequency of the electronic signal generated after the signal generating circuit excites the Mach-Zehnder interferometer is ≥500MHz.

10. The multimode laser device according to claim 1, characterized in that, The ablation laser output module is integrated with the first imaging laser output submodule in the same module, and / or the ablation laser output module is integrated with the second imaging laser output submodule in the same module.

11. A laser ablation system integrating detection and punishment, characterized in that, Includes the multimode laser device as described in any one of claims 1 to 10.

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