Rhinopoma hardwickei lung cell line and its use

By establishing the RaL lung cell line from the Chinese horseshoe bat, the issues of stability and passageability of bat lung cell lines have been resolved, realizing the infrastructure for bat immunology and virology research and providing stable cellular tools and resources for bat immunology research.

CN117143803BActive Publication Date: 2026-07-24INST OF ZOOLOGY GUANGDONG ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF ZOOLOGY GUANGDONG ACAD OF SCI
Filing Date
2023-09-04
Publication Date
2026-07-24

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Abstract

The application discloses a middle leaf-nosed bat lung cell line RaL and application thereof. The middle leaf-nosed bat lung cell line RaL has an accession number of GDMCC.No:63056. The cell morphology of the middle leaf-nosed bat lung cell line RaL is mainly epidermoid cell, the growth state is good, the cell proliferation is stable, the cell line can be continuously subcultured, and the cell line can be cryopreserved and recovered in ultra-low temperature. Researches show that the cell is not only sensitive to an influenza A virus H1N1 (A / FM1 / a / 47) strain, but also can be used for overexpressing, knocking out or knocking down related genes by using a lentivirus system and applied to gene function research. The establishment of the cell line lays a foundation for bat germplasm resource preservation and bat immune related research.
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