Coumarin derivatives, process for their preparation and use as fungicides against plant pathogenic fungi

CN117164595BActive Publication Date: 2026-07-03XINJIANG AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XINJIANG AGRI UNIV
Filing Date
2022-05-26
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

There are currently no effective coumarin compounds for the antifungal application of plant-derived fungi, and existing antifungal drugs have problems with insufficient stability and biological activity.

Method used

By modifying the structure of the coumarin parent ring and introducing pyridine or imidazole heterocycles, coumarin derivatives with different side chains can be synthesized. Using specific reaction conditions and catalysts, coumarin derivatives of formula (I) and/or formula (II) can be prepared.

Benefits of technology

The prepared coumarin derivatives exhibited highly efficient antibacterial activity against the test bacteria. They have a simple structure and small molecular weight, and as potential novel antibacterial agents, they showed excellent antibacterial effects against plant pathogenic fungi.

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Abstract

The application discloses a coumarin derivative, a preparation method and application thereof, and the coumarin derivative has a structure as shown in formula (I) or (II). The method for preparing the coumarin derivative is simple and efficient, and the application is that the prepared coumarin derivative is used in mycelial growth rate method to carry out in-vitro inhibitory activity on four common plant pathogenic fungi of Botrytis cinerea, Fusarium oxysporum, Alternaria alternata and Alternaria solani. The compound shown in the application is used as a potential plant-derived fungicide, is more environmentally friendly, and meets the green chemistry concept.
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